ライフサイエンスコーパス: base analogue

1 ition by 2-aminopurine (2-AP), a fluorescent base analogue.

2 NA is the highest reported for a fluorescent base analogue.

3 could be successfully performed with several base analogues.

4 mplexes on the regiochemistry of fluorinated base analogues.

5 tners, consistent with previous nonpolar DNA base analogues.

6 ted by alkylation of DNA or incorporation of base analogues.

7 emical properties relative to the original O-based analogue.

8 yst, which is more active than its phosphine-based analogue.

9 c activity with that of the less acidic urea-based analogue.

10 , but closer pi-pi spacing than does the TPD-based analogue.

11 performance over 2D benzene- and cyclohexane-based analogues.

12 be realized by utilizing metals- or silicon-based analogues.

13 icacy in murine tumor models compared to SCP-based analogues.

14 no reports on successful synthesis of Cu(I) -based analogues.

15 s of these BN heterocycles with their carbon-based analogues.

16 tovoltaic efficiency in comparison to the Pb-based analogues.

17 hat C18-based analogues were superior to C20-based analogues.

18 nt of the blood-brain barrier for nucleoside-based analogues.

19 ifiers than the univariate feature selection based analogues.

20 2 SH2 domain-binding affinity of phosphonate-based analogues.

21 y more active toward ROP than the thiazolium-based analogues.

22 This system utilizes the fluorescent base analogue 1,3-diaza-2-oxophenothiazine (tC) as the F

23 epared oligonucleotides containing the novel base analogue 2'-aminoethoxy,5-propargylamino-U in place

24 The fluorescent base analogue 2-aminopurine (2-AP) is commonly used to s

25 emission in a quartz substrate from the DNA base analogue 2-aminopurine (2-AP).

26 In both cases, the base analogue 2-aminopurine (2AP) proved tremendously us

27 ime, and increase in photostability of a DNA base analogue 2-aminopurine and a coumarin derivative (7

28 Use of the fluorescent base analogue 2-aminopurine has provided a direct demons

29 In this approach, we insert the fluorescent base analogue 2-aminopurine in place of A1492 in an E. c

30 clease I, grow poorly in the presence of the base analogue 2-aminopurine, and exposure to the base an

31 The fluorescent adenine base analogue, 2-aminopurine (2-AP), placed opposite an

32 Two carbohydrate-based analogues, (2-hydroxyethyl)-alpha-D-glucopyranosid

33 en replaced with the NMR-sensitive thymidine base analogue 5-fluoro-2'-deoxyuridine (5-F-dUrd).

34 y fluorescence anisotropy of the fluorescent base analogue, 6-methyl isoxanthopterin, incorporated in

35 We demonstrate that the unnatural base analogue 7-deazaguanine (7dG) will suppress tGTP mi

36 Furthermore, introducing the base analogue 7-deazaguanosine in the ((G/U)AGCC)11 RNAs

37 nt interests, universal/non-hydrogen-bonding base analogues and photochemical backbone cleavage, have

38 stability of triplexes containing different base analogues and to confirm the selectivity of a tripl

39 nuclease resistance among all phosphodiester-based analogues and its RNA binding affinity surpasses t

40 65R) using DNA templates containing nonpolar base analogues, and find that one of these (F61A) is a h

41 obtaining a small library of novel curcumin-based analogues, and a number of potent and balanced dua

42 Fluorescent nucleic acid base analogues are important spectroscopic tools for und

43 =49+/-9 nM) confirmed that the aminothiazole-based analogues are competitive with ATP.

44 Nucleoside-based analogues are mainstays in the treatment of cancer

45 tamer oligonucleotides tailed with different base analogues as primers in cycle sequencing reactions.

46 trategy to prepare a collection of TFOs with base analogues at a defined position.

47 Consequently, our base analogues can now measure base-base FRET between 3

48 ymbol Digit Modalities Test, or its computer-based analogues, can be used to monitor episodes of acut

49 wed high induction levels, with one triazole-based analogue, CliMB-325, also enhancing T cell activat

50 Specifically, wave-based analogue computers which impart spatial transforma

51 Electromagnetic wave-based analogue computing has become an interesting compu

52 ctivities compared to its direct thalidomide-based analogue dBET1, but similarly poor in vivo pharmac

53 Although there have been a number of base analogues described that appear to be promising as

54 ssociated with adverse sensitivity to purine base analogue drugs.

55 Importantly, while the base analogues enhanced probe-target stability, they did

56 ical dNTP production, (ii) inhibition of the base analogue excision from DNA and (iii) enhancement of

57 patterns can emerge and change within agent-based analogues, expecting that those mechanisms may hav

58 ive mapping of the upstream fork junction by base analogue fluorescence and nucleic acids crosslinkin

59 e tC(O) a highly interesting fluorescent RNA base analogue for detailed FRET-based structural measure

60 titution of a single 3-deazzaadenosine (c3A) base analogue for residues A6, A9, A13, A14, or A15.1.

61 the substitution of a single 2-pyridone (2P) base analogue for residues U4, U7, and U16.1.

62 These properties make BAU a useful base analogue for the sequence-specific creation of stab

63 Although ground-based analogues for human spaceflight have provided insi

64 A universal base analogue forms 'base pairs' with each of the natura

65 nt with various methylating agents and other base analogues has been well reported and is believed to

66 binogenic, and toxic incorporation of purine base analogues [i.e., ITP, dITP, XTP, dXTP, or 6-hydroxy

67 l nucleotide (position 5) were replaced with base analogues in plus and/or minus strands.

68 e a new binding model for several of the CPI-based analogues, in which the aromatic secondary rings f

69 araquats and diquat relative to the 30-crown-based analogue; in these systems, 2:1 H:G complexes were

70 By monitoring fluorescent base analogues incorporated at various positions in the

71 Finally we used mutagenesis and base analogue incorporation to show that the non-B DNA s

72 odified DNA, on which EndoV nicking near the base analogues initiates excision repair.

73 nce energy transfer (FRET) using fluorescent base analogues is a powerful means of obtaining high-res

74 the cellular nucleotide pools from mutagenic base analogues is necessary for the accuracy of transcri

75 dditionally, a comparison with hydrogen bond-based analogues is provided.

76 However, like most reported base analogues, it has not been thoroughly characterized

77 , we not only develop the use of fluorescent base analogue labeling of nucleic acids in live-cell mic

78 This new base analogue may find broad applications in biotechnolo

79 Further, a variety of other nucleotide-based analogues, not normally considered antiretrovirals

80 urea (component 3) with nucleic acid bases, base analogues, nucleosides, and nucleotide monophosphat

81 features that closely resemble those of free base analogues of chlorophyll b.

82 By using base analogues of G and T we have explored the functiona

83 elopment of sonogenetics: a non-invasive, US-based analogue of optogenetics.

84 Here we report an aptamer-based analogue of the widely used sandwich enzyme-linked

85 velop more powerful and efficient likelihood-based analogues of "model-free" tests of linkage and/or

86 of the 3 alpha-substituent of the piperidine-based analogues of cocaine and can be used to design nov

87 eries of druglike 3alpha-modified piperidine-based analogues of cocaine were designed, synthesized, a

88 s of novel N- and 3alpha-modified piperidine-based analogues of cocaine were synthesized and tested f

89 A 3D-QSAR CoMFA study of piperidine-based analogues of cocaine with flexible 3 alpha-substit

90 f the 3 alpha-substituents of the piperidine-based analogues of cocaine.

91 tivity of imidazoquinoxalines, benzimidazole-based analogues of indole-based pyrroloiminoquinone mari

92 Recently developed DNA-based analogues of membrane proteins have advanced synth

93 Two configurationally stable carbon-based analogues of pyochelin have been prepared from Boc

94 A variety of 9-substituted, acridine-based analogues of quinacrine were synthesized, which de

95 of quinazoline- and pyrido[3,4-d]pyrimidine-based analogues of the irreversible pan-erbB inhibitor,

96 A series of benzimidazole-based analogues of the potent MTP inhibitor BMS-201038 w

97 potency of stable fluorinated or phosphonate-based analogues of the tetrahedral reaction intermediate

98 is more easily overstretched than two carbon-based analogues, polycyclooctene and polybutadiene, with

99 east 20 times faster than that of its carbon-based analogue, presumably a result of Coulombic repulsi

100 ar dichroism and fluorescence spectra of DNA base analogue probes placed site specifically to show th

101 r UV CD and fluorescence spectra of pairs of base analogue probes, substituted either at the primer t

102 the development of further time domain wave-based analogue processors by exploiting waveguide juncti

103 The corresponding C2"-based analogues proved to be unstable.

104 rovement in activity of the set, terfenadine-based analogues provide a novel structural class of anti

105 analogue 2-aminopurine, and exposure to the base analogue results in filament formation, indicative

106 Quinoline-based analogues showed lower inhibitory activity and sel

107 rium dissociation constants of wild-type and base-analogue sites were also measured for the weakly ac

108 g reactions of the wild-type enzyme with DNA base-analogue substrates, as it provides identical Delta

109 f EcoRV endonuclease to DNA, for a series of base-analogue substrates, demonstrate that expression of

110 utagenic and toxic effects of N-hydroxylated base analogues, such as 6-N-hydroxylaminopurine (HAP).

111 ve modeling, synthetic biology, robust Earth-based analogue systems, and reliable space-based instrum

112 By using a series of adenosine base analogues tagged with phosphorothioate substitution

113 ed patients contains 6-thioguanine (6-TG), a base analogue that is particularly susceptible to oxidat

114 ion anisotropy approach that utilizes a rare base analogue that retains substantial fluorescence when

115 ation of a highly orally bioavailable purine-based analogue that reverses obesity-induced diabetes in

116 defined key structural features of the urea-based analogues that contribute to their properties and

117 with fixed orientation, compared to the free-base analogues, the related mono- and di-Zn(II) complexe

118 Compared to the free-base analogue, these complexes showed a remarkable shift

119 t properties of site-specifically introduced base analogues to map and quantify the equilibrium bindi

120 ated derivatives than the corresponding free-base analogues to produce the corresponding excited trip

121 Notably, pairing among the nonpolar base analogues was considerably more stable, and some of

122 A series of omeprazole-based analogues was synthesized and assessed for inhibit

123 Base analogues were used to identify Hoogsteen base pair

124 ory activity of IdeS, but several piperidine-based analogues were identified as inhibitors.

125 l bioavailability in dogs indicated that C18-based analogues were superior to C20-based analogues.

126 Use has been made of base analogues, which delete hydrogen bonds between the

127 and excited state characteristics of the Bi-based analogues, which according to DFT calculations sho

128 ructure-activity studies on 1,2,4-oxadiazole-based analogues, which are potent inhibitors of human Si

129 rated TNA molecules to include a hydrophobic base analogue with strong fluorescent properties that is

130 relationship studies yielded 84 terfenadine-based analogues with several modifications providing inc

131 ed DNA site was assessed using photoreactive base analogues within specific DNA substrates to allow s

132 rogen-bonding purine derivatives or aromatic base analogues without hydrogen-bonding capabilities.

133 -WN-7 and the previously reported salicylate-based analogue WN-8 are described.

134 A universal, photochemically cleavable DNA base analogue would add desirable versatility to a numbe