ライフサイエンスコーパス: base pair

1 A752 and U2609, that were proposed to form a base pair.

2 tal ions prior to incorporation of a correct base pair.

3 nguishing alleles differing by even a single base pair.

4 sing a steric filter fashioned from a wobble base pair.

5 ient absorption or buffering of at least one base pair.

6 llele counts and frequencies for each target base pair.

7 he entire Hoogsteen edge of the Watson-Crick base pair.

8 NA junction, consequently breaking the first base-pair.

9 NA but which is unusual for the free neutral base pairs.

10 A tertiary structures involving cross-linked base pairs.

11 ed nucleotides with neighboring Watson-Crick base pairs.

12 utY-mediatedadenine excision from G:A or T:A base pairs.

13 g the duplication of upward of three billion base pairs.

14 antiparallel G-tetrads and six i-motif C-C+ base pairs.

15 long reads that contain as many as 2 million base pairs.

16 nts on RNA global fold than non-cross-linked base pairs.

17 owed a 22q11.23 duplication of 1.306 million base pairs.

18 re, and stacking interaction between the end base pairs.

19 aintained to the same extent as canonical WC base pairs.

20 ndant and structurally similar undamaged DNA base pairs.

21 A duplex consisting entirely of Watson-Crick base-pairs.

22 interact with native d-RNA via Watson-Crick base pairing.

23 n as target sites for the 18S rRNA by direct base pairing.

24 logs designed to bind to RNA by Watson-Crick base pairing.

25 partially lack intramolecular complementary base pairing.

26 e at position -1, which is not recognized by base pairing.

27 cterized by the iconical Watson-Crick nucleo-base pairing.

28 based on overall 3' UTR structure formed by base pairing.

29 y an artificial tRNA not dependent on wobble base-pairing.

30 f 8-oxodG, while 3'-preinserted noncanonical base pairs (3'-rA or 3'-rC) on NHEJ repair intermediates

31 s a substantial improvement on long-distance base pairs (500+ nt apart).

32 s well as improved accuracies for long-range base pairs (500+ nucleotides apart), both of which are w

33 urs, approximately, was associated with a 27-base-pair (95% confidence interval (CI): 6, 48) longer L

34 nvolving the unpaired nucleotide U40 and the base pair A43-U66 in the GAUC/GAUC repeat.

35 anscription through a nucleosome with single-base-pair accuracy.

36 Formation of 14 base pairs activates the nickase activity, and 28-bp hyb

37 ing the nucleosomal DNA by approximately two base pairs along the histone octamer accommodates the ne

38 A, the transition pathway primarily involved base paired and intrahelical intermediates with transiti

39 dified RNA oligonucleotides, conducted their base pairing and bioactivity studies, and solved three n

40 aling ability relies solely on interterminal base pairing and is an independent cis-acting signaling

41 ical structure of DNA results from canonical base pairing and stacking interactions.

42 varied tendencies of modifications to alter base pairing and their interactions with DNA repair enzy

43 nt EVEs reached sizes greater than 1 million base pairs and contained as many as around 10% of the to

44 icable strategy for directly visualizing RNA base pairs and dynamics in cells.

45 ency for incorporation of various mismatched base pairs and have uncovered a mechanism in which the r

46 unwinding by stabilizing the unpaired first base-pair and engaging the second base-pair poised for b

47 ock multiple functional DNAs through DNA-RNA base pairing, and the resulting RNA/DNA hybrids self-ass

48 truction of homo purine DNA, silver-mediated base pairs, and expansion of the four letter genetic cod

49 tured RNAs are folded into Watson-Crick (WC) base pairs, and sequence changes that preserve these pai

50 binds to single stranded DNA, mismatched DNA base pairs, and three-way DNA junctions.

51 These sRNAs recognize transcripts through base-pairing, and sRNA-mRNA annealing consequently alter

52 tches where guanines and/or cytosines are 30 base pairs apart and the intervening sequence harbors se

53 e per generation in baboons of 0.57x10-8 per base pair, approximately half that of humans.

54 air hydrogen bonds, in which both bases of a base pair are involved in forming hydrogen bonds with am

55 It has long been assumed that RNA or DNA base pairs are broken by the concerted symmetric movemen

56 In SaMBA, mismatched base pairs are introduced to pre-induce structural disto

57 Four metal-mediated base pairs are observed between the N7 atoms of G and Co

58 lts demonstrate that an aptamer in which the base pairs are preformed also experiences a reduction in

59 l sequencing technologies (1 in 100 or 1,000 base pairs) are several orders of magnitude higher than

60 ption of a spatially broad inosine-adenosine base pair at the wobble position of the codon cannot be

61 ow that native transcripts are recognized by base pairing at positions -2 to -5 of the PFS and by a g

62 btle changes in all 12 possible noncanonical base pairs at the 3'-end of the nicked repair intermedia

63 pairs before internship to 6321.5 +/- 630.6 base pairs at the end of internship (t(246) = 2.69; p =

64 ension (SHAPE) to investigate intramolecular base-pairing at single-nucleotide resolution.

65 p year, from mean +/- SD of 6465.1 +/- 876.8 base pairs before internship to 6321.5 +/- 630.6 base pa

66 mer of dimers of PC4, which is stabilized by base pairing between homologous regions of the ASOs boun

67 e-telomerase scanning interactions, and then base pairing between hTR and telomere ssDNA promotes lon

68 In many bacteria, the base pairing between most small regulatory RNAs (sRNAs)

69 is results from disruption of the continuous base pairing between SD and rRNA.

70 efficiency of translation repression is the base pairing between the 'seed' region of the miRNA and

71 d kissing-loop motif, involving Watson-Crick base pairing between the single-stranded regions of a bu

72 ts accumulate at the template position three base pairs beyond the lesion.

73 post-transcriptional gene silencing through base-pair binding on their target mRNAs.

74 nerated diverse mutations encompassing a 643-base pair (bp) deletion (100% efficiency), a stop codon

75 We describe a novel mutation within a 15 base pair (bp) region of the PDE3A gene and define this

76 APN2 also suppresses 2-base pair (bp) slippage mutagenesis in RNH201-deficient

77 ISPR-Cas9 to insert sequences of up to 2,049 base pairs (bp), including enhancers and promoters, into

78 tion (7,281) and deletion (5,464) calls >=50 base pairs (bp).

79 ically important, highly variable, 5 million base-pair (bp) region where diploid assembly is particul

80 As greater than or equal to approximately 60 base-pairs (bp) are required for DvSSJ1 insecticidal act

81 First, guanine of a G:C DNA base pair can be oxidized.

82 tions, contributing to more insight into how base pairs can bind when a proton is removed and highlig

83 o meta-DNAs that contain complementary 'meta-base pairs' can form double helices with programmed hand

84 make modifications from as small as a single-base-pair change to insertion of DNA fragments.

85 TL analysis, as well as those predicted from base-pair changes in intergenic enhancer sites, coding-r

86 ow that it is possible to connect individual base-pair changes to the overall selection response.

87 We find that the base pairs close to the ligand-binding site become stron

88 ly gives rise to a methylation spacing of 14 base pairs, consistent with the previous structural obse

89 n-silico pipeline to predict regions of high base pair content across long genomes and to pinpoint ho

90 ct alignment methods that capture nested RNA base-pairing correlations (stochastic context-free gramm

91 tion [c.1265G>T/p.(Gly422Val)], and a 62,138-base pair deletion (NG_017034.2: g.35441_97578del62138)

92 the rr strain is profoundly linked with a 16-base pair deletion in the proximal promoter and inabilit

93 Introduction of 11-base pair deletions to the homologous pmela in zebrafish

94 bability a G/U will form a Watson-Crick (WC) base pair depends on sequence context.

95 -methylated m42C also results in the loss of base pairing discrimination between C:G and other mismat

96 ogether form a central tunnel to entrap a 72-base pair DNA.

97 the intrinsic cyclizabilities of 270,806 50-base-pair DNA fragments that span Saccharomyces cerevisi

98 to reveal solution conditions in which an 18-base-pair DNA oligomer indeed remains bound to yNhp6A wh

99 system for image-based readout of short (20-base-pair) DNA barcodes.

100 ation with a preference for short (17- to 19-base-pair) DNA fragments.

101 Tested with 1k base-pair double-stranded DNA, the SaS nanopore enabled

102 ctionally inserting segments of DNA 60 to 66 base pairs downstream of the protospacer.

103 tructure of a D1D2 core in complex with a 23-base pair dsRNA at pre-unwound state, revealing that two

104 an transition between parallel-stranded homo-base paired duplex and antiparallel unimolecular hairpin

105 ures are converted to parallel-stranded homo-base paired duplexes.

106 ular analysis revealed a novel homozygous 22 base pair duplication (c.55_76dup) in the coding exon 1

107 g(2+)-reinforced DNA binding to validate DNA base pairing during the adenylyl transfer and nick-seali

108 ISPRi, dCas9-tiling guides and Cas9-mediated base-pair editing.

109 s reduced to ~40-fold for A(syn)-T Hoogsteen base pairs embedded in a DNA-drug complex.

110 an R-loop includes four terms-junctional and base-pairing energies and energies associated with super

111 attractive for screening for metal-mediated base pairing events.

112 ing, achieved at the energetic cost of a G-C base pair, explains how a single 5'-guanosine modifies t

113 d that a nonfunctional target site unable to base-pair extensively with the miRNA seed sequence can r

114 ansition pathway between Watson-Crick and HG base pairs for both naked B-DNA and A-RNA duplexes.

115 vides the basis to further develop unnatural base-pairs for synthetic biology applications.

116 ased on minimal constitutive promoters (~120 base pairs), for which rules are developed to insert ope

117 An additional three base pairs form at the non-open end of P1, and the ligan

118 lity of reaching a transition state with one base pair formed.

119 n (T4706M) engineered into 1 allele and a 16 base pair frameshift deletion engineered into the second

120 Furthermore, our model highlights that base pair fraying and internal loop formation are import

121 ranscription factor 3 (ATF3) at -258 to -250 base pairs from the HSF1 transcriptional start site, and

122 ibility to undergo self-organization through base pairing has been conceptualized and accomplished.

123 RNA positions, we show that integrity of the base pair helps to modulate the ribosomal response to re

124 cA-D-loop complexes containing a 10- or a 12-base-pair heteroduplex.

125 ovalent interactions, including Watson-Crick base pairing, Hoogsteen H-bonding, and pai-pai stacking,

126 nophosphate (AMP) during incorporation, this base pair hydrogen bonding is not sufficient to hold an

127 Protein-base pair hydrogen bonds, in which both bases of a base

128 introducing G38A in hmtRNAIle or the A28:U42 base pair in a chimeric tRNA containing the anticodon st

129 ation of RNA duplexes with an internal Psi-A base pair in different nearest-neighbor sequence context

130 the anticodon sequence is correlated with a base pair in the anticodon loop (nucleotides 32 and 38)

131 witch-based on the rearrangement of a single base pair in the miRNA-mRNA duplex-that elongates a weak

132 heteroplasmy, which disrupts a Watson-Crick base pair in the T-stem-loop.

133 However, the existence of this base pair in the translating ribosome, its possible func

134 epeats that had motifs with a length of 2-20 base pairs in 17,231 genomes of families containing indi

135 on of new purine-purine or purine-pyrimidine base pairs in DNA and RNA.

136 re used to covalently cross-link interstrand base pairs in DNA bonds that, in part, define colloidal

137 Watson-Crick base pairs in dsDNA exist in dynamic equilibrium with Ho

138 paired adenines in a bulge, Watson-Crick A-T base pairs in dsDNA only conferred ~130-fold protection

139 sequences for DNA engineering up to 11 kilo base pairs in length and with up to 80 base pair termina

140 by the M/R complex, which extend hundreds of base pairs in length.

141 UBPs that function as third base pairs in replication, transcription, and/or transla

142 and parts of stem 3 are formed and that the base pairs in stem 1 become structured or more rigid upo

143 encing error rates and a large proportion of base pairs in these long reads is incorrectly identified

144 method for characterizing A(syn)-T Hoogsteen base pairs in vitro and also lays the foundation for a s

145 their spliced counterparts, suggesting that base-pairing in the exonic segments upstream of retained

146 agents in canonical dsDNA and that Hoogsteen base pairs increase this accessibility.

147 ion (FIT) of the dye between oligonucleotide base pairs, increasing its fluorescence by up to 20-fold

148 hereas (CG)12 forms a stacking motif of four base pairs independent of supercoiling density.

149 ension, and we identify a previously unknown base-pairing interaction between the 5' end and the 3' e

150 tions in U3 that destabilize the U3/pre-rRNA base-pair interactions or reduce the length of their lin

151 rrelated chemical probing to directly detect base-pairing interactions in cells.

152 Such action requires specific base-pairing interactions of piRNAs with target mRNAs in

153 ormation of complex and intricate long-range base-pairing interactions which make the direct detectio

154 By forming base-pairing interactions with the 3' end of 16S rRNA, m

155 We identified hundreds of novel sRNA base-pairing interactions, including many sRNA-sRNA inte

156 Although the integrity of this base pair is necessary for proper splicing, it is not su

157 Understanding HG base pairing is important because the underlying "breath

158 nding our calculation to A-RNA, for which HG base pairing is not observed experimentally, resulted in

159 en the Lewis acid-base adducts and free acid-base pairs is examined.

160 derive accurate NN parameters with modified base pairs is expensive and time consuming.

161 e level of individual nucleic acid bases and base pairs is important for elucidating molecular proces

162 NA in which a specific motif (typically < 10 base pairs) is repeated multiple times.

163 A long-range, 5-nucleotide, base-pairing kissing loop interaction between the 3'BTE

164 ers to inspect and refine their designs with base-pair level interventions.

165 icity and predictability of the Watson-Crick base pairing make DNA an excellent building material for

166 densely sampled alignment provides a single-base-pair map of selection, has more than doubled the fr

167 006 Cas12a (LbCas12a) at non-pathogenic 4-36-base-pair microduplications within the genome indicates

168 l was achieved through the introduction of a base-pair mismatch in the duplex of the hairpins.

169 ns), yet longer than the dynamic motions of base pair mismatches (0.1-10 ns).

170 ecting local dynamic motions associated with base pair mismatches.

171 ld effectively distinguish and reject single base-pair mismatches.

172 architectures through specific Watson-Crick base-pairing, molecular plasticity, and intermolecular c

173 l ion for cleavage and that the central four base pairs need to be stretched between the two catalyti

174 ns are widely buffered by the conjugate acid-base pair NH(4) (+)/NH(3) (ammonium/ammonia).

175 ion, which corroborated with the presence of base-paired nucleic acids.

176 It does so by creating a coaxially base-paired obstacle that impedes scanning from a monoph

177 Notably, base pairing of A with OG uniquely positions the 2-amino

178 e excision leads to the disruption of wobble base pairing of SsrA due to site-specific recombination,

179 form of linear B-form double-helix with the base pairs of adenine (A) and thymine (T) or cytosine (C

180 g conformers bind and unwind several hundred base pairs of duplex DNA at an average rate of ~240 bp/m

181 StXPB and Bax1 together spirally encircle 10 base pairs of duplex DNA at the double-/single-stranded

182 The presence of billions of base pairs of genomic DNA in all nucleated cells raises

183 ows the CcrM dimer disrupts four of the five base pairs of the (5'-GANTC-3') recognition site.

184 cal theory to study the effect of mismatched base pairs on DNA supercoiling.

185 ees C to determine the thermodynamics of the base pair opening for MN4.

186 By analyzing thousands of base-pair opening and closing events from molecular simu

187 with the specific response dependent on the base pair order.

188 t presence of an alternative, Hoogsteen (HG) base pairing pattern in naked DNA duplexes, and estimate

189 demonstrated that m4C retains a regular C:G base pairing pattern in RNA duplex and has a relatively

190 n average mutation rate of 0.58 x 10(-8) per base pair per generation (at an average parental age of

191 tion rate to be 1.78 x 10(-10) mutations per base pair per generation.

192 n an estimate of 1.29 x 10(-8) mutations per base pair per meiosis with a 95% confidence interval of

193 neration mutation rate by 4.27 x 10(-10) per base pair per year.

194 tation rates (1 in 10,000,000 or 100,000,000 base pairs per generation).

195 a robust helicase capable of rapidly (~70-80 base pairs per second) unwinding extensive tracts (~8-10

196 degrees and is perpendicular to the upstream base pair planes.

197 ired first base-pair and engaging the second base-pair poised for breaking.

198 utes using reversible covalent chemistry for base-pairing pose unique synthetic challenges.

199 en for candidate structured regions based on base pairing potential and provides a readily interpreta

200 interactions identified by CLASH have strong base-pairing potential and are highly enriched for compl

201 the reproducibility of the interaction, not base-pairing potential, is a stronger predictor for a re

202 res of salts of free anionic nucleobases and base pairs previously studied only computationally and i

203 les and can therefore estimate structure and base pair probabilities.

204 More interestingly, the resulting base-pairing probabilities are even better correlated wi

205 n, to approximate the partition function and base-pairing probabilities, which is shown to be orders

206 l edges and structural edges weighted by the base-pairing probabilities.

207 pool of nucleotides with various sugars and base pairing properties, which is critically important f

208 rchers have begun to exploit the predictable base-pairing properties of RNA and DNA in order to utili

209 tion particle RNA about 12 nt lengths before base-pair rearrangement.

210 The DNA contacts at the 5-base pair recognition site results in dramatic DNA disto

211 NA duplexes and through the non-Watson-Crick base-paired region of an RNA aptamer.

212 tron transport also through non-Watson-Crick base-paired regions might be required.

213 ent in mammals and can be captured at single base pair resolution by whole genome bisulfite sequencin

214 r assays with mass spectrometry to produce a base pair resolution dissection of more than a E. coli p

215 le-molecule fluorescence assay with a single base pair resolution.

216 an simultaneously monitor DNA unwinding with base-pair resolution and binding of fluorescently labele

217 and position of individual D-loops with near base-pair resolution and deep coverage, while also revea

218 methylation levels at imprinted regions with base-pair resolution and over 1000-fold coverage.

219 ntified putative causal variants with double base-pair resolution at 24 of these loci, and between th

220 and translatome during lytic infection with base-pair resolution by computational integration of mul

221 swab samples, and presented superior single base-pair resolution of this assay.

222 Bisulfite sequencing allows base-pair resolution profiling of DNA methylation and ha

223 within Hi-C data with breakpoints at single base-pair resolution.

224 perating at room temperature and with single base-pair resolution.

225 idues predicted to recognize the central C:G base pair resulted in an altered enzyme that recognizes

226 r system, mutagenesis to disrupt and restore base pairing revealed that the MTE interacts with the 5'

227 Mutating base-paired RNA regions can also compromise this structu

228 Base pairing RNAs modulate gene expression in all studie

229 We sequenced an 815 base-pair section of the COI gene for 441 specimens of B

230 miRNA-mRNA duplex-that elongates a weak five-base-pair seed to a complete seven-base-pair seed.

231 weak five-base-pair seed to a complete seven-base-pair seed.

232 flanked by a short ( 70 nucleotide), highly base-paired segment upstream and a predominantly single-

233 backbone conformations for sufficiently long base pair separations.

234 donuclease, recognizes and cleaves the seven base pair sequence 5'-CCTCAGC-3', generating 3-base, 5'-

235 er, existing genome-wide methods lack either base pair sequence resolution or direct spatial localiza

236 through both homogeneous and non-homogeneous base-pair sequences.

237 tidine is a molecular mechanism to fine tune base pairing specificity and affect the coding efficienc

238 lex and has a relatively small effect on its base pairing stability and specificity.

239 Three 3' cytosine metallo-base pairs stabilize a parallel A-form-like duplex with

240 tructures of RNA molecules using consecutive base-pairs (stacks) as anchors and generates an optimal

241 modulate conformational fluctuations at each base-pair step, which accumulate to impact RNA tertiary

242 res a precisely positioned pyrimidine-purine base-pair step, whose location has been shown to modulat

243 ected the intrinsic stacking energies at the base pair steps depending on the sequence context.

244 ion, which can be restored by re-introducing base-paired structures of different sequences.

245 e, involved in lignin biosynthesis, showed a base-pair substitution that is associated with decreased

246 24 with cysteine in TGFBI via ssODN-mediated base-pair substitution using CRISPR/Cas9 technology.

247 ial G4 is a source of mutagenesis leading to base-pair substitutions.

248 read quadruplet codons, use non-natural DNA base pairs, synthesize completely recoded genomes and cr

249 kilo base pairs in length and with up to 80 base pair terminal non-homology.

250 Through the development of unnatural base pairs that are compatible with native DNA and RNA p

251 exist in dynamic equilibrium with Hoogsteen base pairs that expose the Watson-Crick faces of purine

252 dreds of unique DNA strands and thousands of base pairs, thus in principle providing many degrees of

253 e-cell technique that harnesses nucleic acid base pairing to detect the abundance and positioning of

254 2 to the transcriptionally active TE loci by base pairing to nascent transcripts, however the downstr

255 We find that NarS acts by Hfq-dependent base pairing to repress the synthesis of the nitrite tra

256 ety of deletions, ranging from a few hundred base pairs to 100 kilobases, are created upstream of the

257 the MTE lacks the pyrimidine-rich tract that base pairs to a G-rich bulge to form the pseudoknot.

258 f DNA mutation (ranging in scale from single base pairs to multiple chromosomes), (c) developmental c

259 silenced by an antitoxin sRNA, IstR-1, that base pairs to the standby site.

260 d structure across length scales from single base pairs to whole organisms.

261 MicroRNAs (miRNAs) base-pair to messenger RNA targets and guide Argonaute p

262 ator tRNA with the ribosome when the tRNA is base-paired to the AUG codon in the P-site.

263 intrinsically to regulate gene expression by base-pairing to complementary mRNA targets while in asso

264 ation speed including mRNA structure, wobble base pairing, tripeptide motifs, positively charged upst

265 tic organism (SSO) that retains an unnatural base pair (UBP) in its DNA, transcribes it into mRNA and

266 Unnatural base pairs (UBPs) have been developed and used for a var

267 o identify variants that replicate unnatural base pairs (UBPs), unnatural backbones, tags, or other e

268 on of artificial extra base pairs (unnatural base pairs, UBPs) are opening the door to a new research

269 ncements in the creation of artificial extra base pairs (unnatural base pairs, UBPs) are opening the

270 sequence, itself a short AT-tract, resides 5 base pairs upstream of otherwise cryptic -10 elements.

271 lly due to concomitant unwinding of a weakly base-paired [UUUU]:[GGAG] helical element.

272 ct of both large-scale structural and single base-pair variations.

273 This base pairing was shown to prevent the action of Rho over

274 Most putative G/U base pairs were experimentally supported by selective 2'

275 of a DNA duplex containing the unnatural P.Z base-pair when an imidazole unit is aligned with a P nuc

276 ures due to the primacy of a net increase in base pairing, whereas rebinding of 'recovery' strands is

277 cocrystal includes the anionic [Ad(-)(HThy)] base pair which is a stable formation in the solid state

278 Telescripting requires U1:pre-mRNA base-pairing, which can be disrupted by U1 antisense oli

279 rate the methodology with studies of the 153-base pair Widom DNA molecule that is simultaneously meth

280 lix and forms a trans Hoogsteen-Watson-Crick base pair with a uridine, thus becoming an integral part

281 However, its ability to base pair with adenosine in this conformation is not suf

282 8-oxo-dGTP, r8-oxo-GTP did not form a planar base pair with either templating base.

283 erotonin (HTR2C) receptor via its ability to base pair with its pre-mRNA and regulate alternative RNA

284 28-fold brighter fluorescence intensity when base paired with A as compared to T or C.

285 rate by directing ribosome targeting through base pairing with 18S rRNA.

286 ion of DNA polymerases by adopting Hoogsteen base pairing with adenine in a Watson-Crick-like geometr

287 ze edA in the syn conformation for Hoogsteen base pairing with the correct nucleotide.

288 In the syn conformation, 8-oxodG base pairs with dA.

289 ll nuclear RNA (snRNA) nucleotides that form base pairs with the branch site are initially sequestere

290 ly three nucleotides and forms two canonical base pairs with the RNA substrate.

291 nction when an upstream adenosine is able to base-pair with a post-transcriptionally added uridine in

292 oreover, we show that circulating miRNAs can base-pair with a target mimic in a seed-based manner, an

293 ppABCDF and carAB operons, respectively, and base-pair with their own transcripts to inhibit translat

294 tion is to stabilize sRNAs and to facilitate base-pairing with trans-encoded target mRNAs.

295 The ADP component of these metabolites base-pairs with the DNA template and provides a 3'-OH gr

296 grammability based on canonical Watson-Crick base pairing, with crystal assembly in all three dimensi

297 be used to detect the formation of a metallo-base pair within a duplexed strand and is therefore attr

298 lesions are not resolved into a mutated DNA base pair within a single cell cycle.

299 Mutations that stabilize base pairing within this element eliminate NC binding to

300 hanges in genome sequence, as small as a few base pairs, within segments of genome called simple sequ

301 NN predictions for Watson-Crick and modified base pairs yielded an overall RMSD of 0.32 kcal/mol when