ライフサイエンスコーパス: basement

1 ally connected to the underlying crystalline basement.

2 lar start-up could emerge from an attic or a basement.

3 ea of 700-1600 m(2), the volume of a typical basement.

4 e within, and assimilation of, local granite basement.

5 Zircon (U-Th)/He dates for basement below the Great Unconformity are 975 to 46 Ma a

6 humed mantle basement rather than an oceanic basement below the Vavilov basin.

7 cumulation along pre-existing faults in deep basement contribute to recent occurrence of seismic even

8 ies were similar across most room types, but basements exhibited more unique community compositions.

9 from saprolitic remnants constrains original basement exposure in the Late Triassic (221.3+/-7.0-206.

10 around Tavakaiv bodies and intensely altered basement fragments within unweathered injectites imply s

11 al geological record, separating Precambrian basement from Phanerozoic sedimentary rocks.

12 Reflectors onlap basement highs with growth geometry against these faults

13 crobial populations persist from seafloor to basement in the slowly accumulating oxic sediment of the

14 gical evidence that some of the low-altitude basement landforms on- and offshore southwestern Scandin

15 We identified basement membrane (BM) and collagen IV in Ctenophora, an

16 Cell invasion through basement membrane (BM) barriers is crucial in developmen

17 obust mechanical anisotropy in the ECM-based basement membrane (BM) but not in the underlying epithel

18 th retention of collagen IV, reiterating the basement membrane (BM) changes observed in vivo.

19 cause endoplasmic reticulum (ER) stress and basement membrane (BM) defects, and recent data suggest

20 ail to accumulate F-actin in the OF prior to basement membrane (BM) degradation.

21 of the follicle cell basal domain, oriented basement membrane (BM) fibrils and F-actin stress fibers

22 is one of the constituent components of the basement membrane (BM) in adult rat testes.

23 ctive oxygen species (ROS) and damage of the basement membrane (BM) in all neoplastic, but not hyperp

24 The islet basement membrane (BM) influences islet function and sur

25 The endothelial cell basement membrane (BM) is a barrier to migrating leukocy

26 The basement membrane (BM) is a thin layer of extracellular

27 vasive cells use small invadopodia to breach basement membrane (BM), a dense matrix that encases tiss

28 IV scaffold is a principal component of the basement membrane (BM), a specialized extracellular matr

29 The emergence of the basement membrane (BM), a specialized form of extracellu

30 dings of a local regulatory axis between the basement membrane (BM), the blood-testis barrier (BTB),

31 in is a well-defined component of the airway basement membrane (BM).

32 find that MMPs hasten invasion by degrading basement membrane (BM).

33 etween the muscle fiber cytoskeleton and the basement membrane (BM).

34 irway subepithelial eosinophils per mm(2) of basement membrane (cells/mm(2) ).

35 The glomerular basement membrane (GBM) is a key component of the glomer

36 by immigration of cells along the glomerular basement membrane (GBM) is under debate.

37 During follow-up, glomerular basement membrane (GBM) width, mesangial fractional volu

38 eutral dextrans permeate into the glomerular basement membrane (GBM), in general agreement with Ogsto

39 ion of immune complexes along the glomerular basement membrane (GBM), phospholipase A2 receptor (PLA2

40 l thickening and splitting of the glomerular basement membrane (GBM).

41 (LAMB2), a major component of the glomerular basement membrane (GBM).

42 constitute the axial core of the glomerular basement membrane (GBM).

43 rtment: epithelium (basal region), reticular basement membrane (Rbm) and underlying lamina propria (L

44 ion, whereas endothelial cell and glomerular basement membrane abnormalities were associated with pro

45 ng cells and the leakage of laminin from the basement membrane across a compromised blood-brain barri

46 case of laminin111, Matrigel(TM), a complete basement membrane analog, also causes the clustering of

47 blood vessels, such as the expansion of the basement membrane and a loss of vascular cells(2-4).

48 cells to constrict basally, detach from the basement membrane and become internalised.

49 l cells (BMECs) and pericytes, which share a basement membrane and comprise the microvessel structure

50 o disrupt laminin expression in the vascular basement membrane and demonstrate that microglia respond

51 sting of podocyte foot processes, glomerular basement membrane and endothelial cells.

52 n specialized areas of irregular endothelial basement membrane and enriched with vesicular activity.

53 Basement membrane and extracellular matrix (ECM) protein

54 vation, has multiple binding partners in the basement membrane and interacts genetically with the bas

55 thelium and is transmitted to the supporting basement membrane and internal elastic lamina macromolec

56 We have discovered that basement membrane and its major components can induce ra

57 GF-A165 b rescues the increase in glomerular basement membrane and podocyte slit width, as well as th

58 ibroblasts upon disruption of the epithelial basement membrane and that they induce signaling events

59 Signalling between the basement membrane and these tissues is critical for cell

60 he BBB through their proteolytic activity on basement membrane and tight junction proteins.

61 fter posterior vitreous detachment is a true basement membrane and to postulate its origin.

62 ted by their microenvironment, including the basement membrane and underlying mesenchymal cells.

63 tissue extracts had significantly more anti-basement membrane antibodies than sera from patients wit

64 Ts via DNase I did not alter anti-glomerular basement membrane antibody-induced glomerular injury, as

65 sted in an attenuated passive antiglomerular basement membrane antibody-induced glomerulonephritis mo

66 e with MPO and a low dose of anti-glomerular basement membrane antibody.

67 iche cell wrapping templates a laminin-based basement membrane around the gonad primordium.

68 cific proteoglycan, Col18a1, pointing to the basement membrane as part of the stem cell niche.

69 hibitory role, suggesting that regulation of basement membrane assembly requires a complex interplay

70 ve role, alpha9beta1 has an opposing role in basement membrane assembly/maturation through reduced la

71 Our findings suggested that basement membrane attachment provided survival signals.

72 Cell invasion across basement membrane barriers is important in both normal d

73 How cells breach basement membrane barriers remains an area of active res

74 In particular, the basement membrane below the pial meninx (pBM) is require

75 ent serum, and control serum and assayed for basement membrane binding by means of ELISA.

76 tein netrin 1 (Ntn1), which is necessary for basement membrane breakdown, although the underlying mol

77 sion, including experiencing disturbed flow, basement membrane breakdown, endothelial cell death, and

78 lls lose their epithelial morphology and the basement membrane breaks down.

79 l vascular digests, a subsequent increase in basement membrane bridges was also observed.

80 on silk films mimic features of the corneal basement membrane by providing biophysical cues to direc

81 dynamic distribution of perforations in the basement membrane by regulating the expression of matrix

82 s had no source of immune cells and that the basement membrane capsule surrounding the lens was a bar

83 t that allows LOXL2-mediated crosslinking of basement membrane collagen IV.

84 d cancer cell invasion through reconstituted basement membrane compared with serum from saline contro

85 Perivascular access to smooth muscle basement membrane compartments also exhibited size-depen

86 er and putative smooth muscle and astroglial basement membrane compartments.

87 ment therapy, and they also suggest that the basement membrane components at the dermal-epidermal jun

88 for nuclear positioning and for secretion of basement membrane components via retrograde dynein-depen

89 On basement membrane components, these sliding focal adhesi

90 anogaster model to reveal a pivotal role for basement membrane composition in the formation of hemato

91 oodpasture antigen-binding protein (GPBP), a basement membrane constituent, played a role in this tra

92 ](2)alpha2(IV)) that represent a fundamental basement membrane constituent.

93 How a basement membrane continuously surrounds an organ that i

94 editary nephropathy (XLHN) have a glomerular basement membrane defect that leads to progressive juven

95 were characterized by amnion cell puckering, basement membrane degradation, and tunnels that extended

96 P-AscH(-) inhibited invasion, basement membrane degradation, decreased matrix metallop

97 Capillarization was characterized by ectopic basement membrane deposition, formation of a continuous

98 MMP to promote invasive behaviour leading to basement membrane disruption.

99 invasive phenotype such as lumen-filling and basement membrane disruption.

100 pical layer stiffness and confinement by the basement membrane drive fold formation but influence pos

101 S endothelium and secreted into the vascular basement membrane during BBB formation.

102 ding dry eye disease, anterior or epithelial basement membrane dystrophy, Salzmann nodular degenerati

103 hat the posterior hyaloid membrane is a true basement membrane enveloping the posterior hyaloid surfa

104 ctin signalling depends on a cross-talk with basement membrane extracellular matrix (ECM) via beta1 i

105 ling law for linear elastic matrices such as basement membrane extract hydrogels (Matrigel) that allo

106 utrophils need to penetrate the perivascular basement membrane for successful extravasation into infl

107 Ultrastructural analysis reveals that basement membrane formation around the developing eye is

108 trigger GN, we used low-dose antiglomerular basement membrane globulin, which transiently recruits n

109 ore blisters at two or more sites and linear basement membrane IgG or C3).

110 onstrate that microglia respond to the mural basement membrane in an isoform-specific manner.

111 yte protrusions invading into the glomerular basement membrane in disease and these occurred frequent

112 However, the mechanical role of the basement membrane in post-implantation embryogenesis rem

113 ns anchor cell uses physical force to breach basement membrane in the absence of matrix metalloprotea

114 ain, a structural constituent protein at the basement membrane in the rat testis, likely via proteoly

115 In vivo, mechanical disruption of the basement membrane in wounded corneas prompted an increas

116 e collagen IV network, an event essential to basement membrane integrity.

117 The basement membrane is a specialized sheet-like form of th

118 tion, collagen IV deposition in the vascular basement membrane is reduced in mutant mice, leading to

119 astructural studies show that the glomerular basement membrane is thickened, podocyte slit width is i

120 are grown in substrata that have elements of basement membrane leading to the formation of tissue-lik

121 Furthermore, reconstitution of the basement membrane leads to characteristic cortical tissu

122 munohistochemically staining for collagen IV basement membrane markers, in addition to extracellular

123 ised its surface, enabling the attachment of basement membrane matrix (Geltrex).

124 whole biopsy samples without the addition of basement membrane matrix favors the formation of PDX tum

125 Basement membrane matrix proteins, such as matrigel, are

126 twork formation on Matrigel, a reconstituted basement membrane matrix regularly used to promote EC ne

127 of the laminin-gamma2 chain is a hallmark of basement membrane maturation in the skin.

128 onducted a deeper investigation into how the basement membrane might further regulate the expression,

129 We observed that cells adjacent to the basement membrane mimetic Matrigel survived MEK inhibiti

130 umor 3D clusters that utilized Matrigel as a basement membrane mimetic.

131 uitment of ECs in vivo in a murine synthetic basement membrane model.

132 Impaired podocyte adhesion to the glomerular basement membrane most likely contributed to disease dev

133 tes are vascular mural cells embedded in the basement membrane of blood microvessels.

134 biopsies of patients with SS reveal that the basement membrane of dermal postcapillary venules underg

135 and >4 mononuclear cells within the tubular basement membrane of nonatrophic tubules.

136 ost universally deposited linearly along the basement membrane of NP tissue.

137 tension during gastrulation by rendering the basement membrane of the prospective primitive streak mo

138 east 1 of either IgM, IgG, IgA, or C3 at the basement membrane of the specimen; nondiagnostic when on

139 aste bud and a foot process extending to the basement membrane often contacting nerve processes along

140 vasive cellular protrusions that expand tiny basement membrane openings.

141 multilamination of the peritubular capillary basement membrane or arteriopathy manifesting as intimal

142 esion to laminin-332, is critical for proper basement membrane organization during skin development a

143 ect on the ability of alpha3beta1 to promote basement membrane organization.

144 he activity of matrix metalloproteinases and basement membrane perforations-to the posterior side of

145 e, softening and enhanced remodelling of the basement membrane promote tumour budding, while stiffeni

146 mote tumour budding, while stiffening of the basement membrane promotes folding.

147 acterized by autoantibodies directed against basement membrane protein BP180.

148 LVV was associated with accumulation of the basement membrane protein, collagen IV, in LVV-forming e

149 ess this question by showing that individual basement membrane proteins are more dynamic than previou

150 Skin-specific basement membrane proteins called laminins play importan

151 By day 28, basement membrane proteins were reduced in drug-eluting

152 sion of genes encoding extracellular matrix, basement membrane proteins, and members of ERK, FGF and

153 er to new collagen I surfaces, and away from basement membrane proteins.

154 ion in a macrophage-mediated anti-glomerular basement membrane reactive serum-induced immune nephriti

155 Laminin and the basement membrane receptor dystroglycan function to main

156 onfirmed the presence of COL6 throughout the basement membrane region of mouse lung tissue.

157 ntact pObs only where an otherwise occluding basement membrane remains incompletely assembled.

158 links luminal hormone receptor signaling to basement membrane remodeling and stem cell activation.

159 This shows that interstitial matrix and basement membrane remodeling in RC may be distinguishabl

160 F-alpha and IL-17A were conducted to dissect basement membrane remodeling.

161 terior-posterior axis(8,9) further regulates basement membrane remodelling by localizing Nodal signal

162 Thus spatiotemporally regulated basement membrane remodelling contributes to the coordin

163 the importance of spatiotemporally regulated basement membrane remodelling during early embryonic dev

164 This basement membrane remodelling facilitates embryo growth

165 However, recent work has revealed roles for basement membrane remodelling in global tissue morphogen

166 und cells, while others provide a sheet-like basement membrane scaffold beneath epithelial cells.

167 llular polymerization of laminin trimers and basement membrane scaffolding.

168 Biomaterial-based presentation of regulatory basement membrane signals directly addresses limitations

169 Drosophila follicle, a model system in which basement membrane stiffness instructs three-dimensional

170 Basement membrane structures on the serous side stimulat

171 ic vesicles, covered by a smooth and uniform basement membrane surrounded by pericyte processes.

172 etachment and disruption of the perivascular basement membrane surrounding the VECs.

173 ytoskeleton that initiate degradation of the basement membrane that holds a cell in place.

174 Cs) and Bruch's membrane, a highly organized basement membrane that lies between both cell types.

175 The basement membrane that seperates the endothelial cells a

176 QR], 3.5% to 10.1%, P < .001), subepithelial basement membrane thickening (4.4 mum [25th-75th IQR, 4.

177 anges was associated with a higher degree of basement membrane thickening and edematous changes withi

178 Furthermore, DAPT prevented glomerular basement membrane thickening and proteinuria induced by

179 as of foot process effacement and glomerular basement membrane thickening and wrinkling.

180 enlarged glomeruli, mesangial proliferation, basement membrane thickening, albuminuria, podocyte loss

181 pithelial shedding, goblet cell hyperplasia, basement membrane thickening, subepithelial fibrosis, ai

182 ation of fibrocytes/smooth muscle cells, and basement membrane thickening.

183 ard to pulmonary function indices, bronchial basement membrane thickness, and BAL fluid neutrophil an

184 th regard to epithelial integrity, reticular basement membrane thickness, glandular area, expression

185 rway smooth muscle (ASM) area, subepithelial basement membrane thickness, nerve fibers, and epithelia

186 After branch initiation, however, the basement membrane thins at branch tips; this remodeling

187 w and whether cells remodel their cortex and basement membrane to adapt to their microenvironment.

188 ave been proposed to require adhesion to the basement membrane to polarise.

189 h production and maintenance of the vascular basement membrane to prevent abnormal aortic expansion a

190 ells proliferate and spread onto the denuded basement membrane to reseal the barrier.

191 ells divide parallel or perpendicular to the basement membrane to self-renew or produce differentiate

192 Basement membrane transmigration during embryonal develo

193 s schlosseri, in which the disruption of the basement membrane triggers rapid, massive vascular retra

194 nd V collagen formation (PRO-C3 and PRO-C5), basement membrane type IV collagen formation (PRO-C4) an

195 Alport syndrome (AS), a rare disease of basement membrane type IV collagen, impacts the kidneys,

196 Defining the effect of ECM niche (e.g., basement membrane vs. non-basement membrane) on repopula

197 nd are separated from AT1 cells by a limited basement membrane without intervening pericytes.

198 Before branching, the basement membrane wraps the airway epithelium as a spati

199 en, an extracellular matrix component of the basement membrane zone forming the anchoring fibrils.

200 of human type VII collagen restricted to the basement membrane zone.

201 basement membrane) versus fibrous (i.e., non-basement membrane) ECM niche of antigen-removed bovine p

202 f ECM niche (e.g., basement membrane vs. non-basement membrane) on repopulating cell phenotype and fu

203 We aim to understand how serous (i.e., basement membrane) versus fibrous (i.e., non-basement me

204 xpression of secreted proteases that degrade basement membrane, an ECM barrier surrounding all epithe

205 in which surgical removal of the epithelium, basement membrane, and anterior stroma was performed.

206 r, carry erythrocytes, are enclosed within a basement membrane, and can always be traced back to the

207 IgG-positive immune deposits in the tubular basement membrane, and circulating antibodies reactive w

208 ne of the major constituents of the vascular basement membrane, and facilitates spirochete transmigra

209 animals featured endothelial gaps, thickened basement membrane, and fibrin-like intraluminal deposits

210 athway: ECs secrete factors that remodel RPE basement membrane, and integrin receptors sense these ch

211 e-dimensional (3D) spheroids are cultured in basement membrane, and one such state is associated with

212 rastructure of collagen fibers in the vessel basement membrane, and the kinetics of regression were d

213 y contrast, hair cells lose contact with the basement membrane, but contribute to continued outgrowth

214 tion of NOTCH3 fragmentation products in the basement membrane, collagen fibers, and granular osmioph

215 porting cells, which retain contact with the basement membrane, exhibit biased protrusive activity an

216 ies with intercellular gaps and a fragmented basement membrane, facilitate delivery of macromolecules

217 development: solid-cell cords form their own basement membrane, grow on the surface of initially homo

218 ucleus through adjacent tissue, penetrates a basement membrane, or enters a small blood capillary, ch

219 e breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis.

220 chains, a major constituent component of the basement membrane, release the non-collagenous (NC) 1 do

221 Independent of basement membrane, SGP wrapping performs a second, cruci

222 cells to a shared point of fibronectin-rich basement membrane, where the neural folds first contact

223 ion is regulated by mechanical cues from the basement membrane, which are transduced by the Src tyros

224 pdgfr signaling leads to a reduced vascular basement membrane, which in turn results in enhanced dor

225 a1, -gamma2 and -gamma3 chains in the limbal basement membrane, with LN-alpha5 representing a signatu

226 s (co-isolated with the islets) and restored basement membrane-associated type VI collagen, which wer

227 l functional axis in the testis: role of the basement membrane-derived noncollagenous 1 domain peptid

228 l accumulation and damage in anti-glomerular basement membrane-induced (anti-GBM-induced) glomerulone

229 Similarly, both anti-glomerular basement membrane-induced glomerulonephritis and experim

230 glomerulonephritis (GN) and anti-glomerular basement membrane-induced nephritis.

231 thelial cells within the islets and restored basement membrane-related proteins (eg, fibronectin and

232 Agrin is a basement membrane-specific proteoglycan that can regulat

233 CD was measured as number of goblet cells/mm basement membrane.

234 to collagen IV (Col4) in the subendothelial basement membrane.

235 by ultrastructural lesions of the glomerular basement membrane.

236 ix metalloproteinases and degradation of the basement membrane.

237 l shedding, leaving small patches of denuded basement membrane.

238 ng amnion mesenchymal cells (AMCs) through a basement membrane.

239 n IV, a main component of the breast lobular basement membrane.

240 in vitro induces thickening of the vascular basement membrane.

241 migrate from all sides to cover the denuded basement membrane.

242 o capillary networks that are enveloped by a basement membrane.

243 was, in part, attributable to damage of the basement membrane.

244 ition occurred linearly along the epithelial basement membrane.

245 rved that basal cells flattened to cover the basement membrane.

246 pport and cues to the cells as an engineered basement membrane.

247 ced using an antibody against the glomerular basement membrane.

248 lial cell junction proteins and a continuous basement membrane.

249 ing are modulated by components of the mural basement membrane.

250 in the testis: role of laminin alpha2 in the basement membrane.

251 d collagen IV immunoreactivity at the muscle basement membrane.

252 that stabilizes collagen IV scaffolds in the basement membrane.

253 e occurred frequently in expanded regions of basement membrane.

254 resulting in mosaic vessels with gaps in the basement membrane.

255 by ultrastructural lesions of the glomerular basement membrane.

256 rm of the mouse embryo become enveloped by a basement membrane.

257 along the subepithelial region of glomerular basement membrane.

258 ia transmission electron microscopy near the basement membrane.

259 will alter extensile tensions on the tumour basement membrane.

260 bly of vasculature and the deposition of new basement membrane.

261 h acute edema due to spontaneous Descemet s (basement) membrane rupture in keratoconus, mimicking thi

262 Basement-membrane protein loss is a prominent feature of

263 with plaque rupture, including inflammation, basement-membrane protein loss, and apoptosis.

264 d human plaques, suggesting a major role for basement-membrane proteins in maintaining plaque stabili

265 and ruptured human plaques; however, several basement-membrane proteins were reduced in both SR-uPA(+

266 M (Extracellular matrix) proteins, including basement-membrane proteins, were decreased.

267 This basement-membrane-triggered mechanism produces rapid fib

268 Basement membranes (BMs) are cell-associated extracellul

269 Basement membranes (BMs) are planar protein networks tha

270 Basement membranes (BMs) are supramolecular matrices bui

271 Basement membranes (BMs) are thin, dense sheets of speci

272 Cancer cells typically invade through basement membranes (BMs) at key points during metastasis

273 pithelial cancers, cells must invade through basement membranes (BMs) to metastasize.

274 XV/XVIII ortholog Multiplexin in the tissue-basement membranes and the phagocytosis receptor Eater o

275 Basement membranes are often remodeled in chronic AMR.

276 ustrated matrix proteins that constitute the basement membranes in the renal cortex are constantly re

277 Genetically decreasing the stiffness of basement membranes increases membrane tensions in silico

278 to the perivascular spaces and tunica media basement membranes of leptomeningeal arteries.

279 iency, or the presence of mutant proteins in basement membranes represents an important gap in knowle

280 ic proteins that are major components of the basement membranes that separate endothelia and epitheli

281 sues live in the interstitial spaces between basement membranes that spatially delimit complex organ

282 c conditions affecting the competency of the basement membranes to which they contribute.

283 erineuronal nets, interstitial matrices, and basement membranes, each composed of a set of collagens,

284 llagen IV from EC and deposition in vascular basement membranes.

285 the sulfilimine crosslink in collagen IV in basement membranes.

286 a structural protein of epidermal/epithelial basement membranes.

287 l. (2017) identify a mechanism for breaching basement membranes.

288 ized by weak interactions between muscle and basement membranes.

289 ulfilimine bonds to reinforce collagen IV in basement membranes.

290 olymerise to form a central component of all basement membranes.

291 essels or nerve bundles and their associated basement membranes.

292 ad accumulation of fibronectin at many organ basement membranes.

293 ity to study the composition and assembly of basement membranes.

294 epths, our results support an exhumed mantle basement rather than an oceanic basement below the Vavil

295 spatially localized above the Munger-Saharsa basement ridge.

296 ical development of west Scandinavia coastal basement rocks during the Mesozoic and later, long-lasti

297 cean oligotrophic sediments from seafloor to basement, spanning approximately 8 million years.

298 ve in marine subsurface sediments or igneous basement to obtain sufficient carbon resources and energ

299 arshore biofacies (<20 m water depth) to the basement topography undoubtedly shaped by subaerial weat

300 The image clearly shows that the crystalline basement was uplifted within the LMS orogenic belt, and