ライフサイエンスコーパス: bases

1 ntion, especially for shorter introns (<=100 bases).

2 tween reads are relatively short (e.g. <2000 bases).

3 Lewis basicities LB(I) and s(I) for 10 Lewis bases.

4 e enabled high-resolution mapping of damaged bases.

5 lues were almost independent of the flanking bases.

6 t tiling windows of 100 continual nucleotide bases.

7 ches to understanding their detailed genetic bases.

8 siological changes including its mechanistic bases.

9 navigate through ribonucleotides and damaged bases.

10 eactivity using commercially available Lewis bases.

11 CNEP (CSS-CNEP) that is predictive of those bases.

12 es ipsilateral, forming a pair of orthogonal bases.

13 ith an 8-atom linker between the crosslinked bases.

14 l groups with neutral phosphine and pyridine bases.

15 in dsDNA that result from removal of damaged bases.

16 n interactions between Lewis acids and Lewis bases.

17 rcrowded tertiary amines was not promoted by bases.

18 oximately the same total number of sequenced bases.

19 the concurrent formation of all Watson-Crick bases.

20 eferential base partner of methylated purine bases.

21 cofactors that hasten repair of damaged DNA bases.

22 function to search for motifs with modified bases.

23 ally bind to 5hmC and the other oxidized 5mC bases.

24 arboxamide linker to the 5-position of their bases.

25 proteins that may interact with oxidized 5mC bases.

26 to efficiently protonate physiological-like bases.

27 osine (dG) residues are replaced by modified bases.

28 with other software platforms and knowledge bases.

29 , allow them to scale to support larger user bases.

30 nd the strength of its interactions with the bases.

31 nce of myosin IIA filaments at the filopodia bases.

32 ficient as direct N-demethylases of cytosine bases.

33 of simultaneously interacting with two Lewis bases.

34 -adjacent motif (PAM) sequences containing G bases.

35 ble duplexes via recognition through natural bases.

36 indices, as well as its neural reward system bases.

37 le-hydrogen-bonded, distorted Hoogsteen-like bases.

38 predominantly at low elevations and mountain bases.

39 itional substrates with favorably positioned bases.

40 peech sound representations and their neural bases.

41 The strong increase of oxidized cytosine bases (5hmC, 5fC, and 5caC) was accompanied by a drop in

42 DRAIC mapped to the same fragment containing bases 701-905.

43 ept, deprotonation of propanal by the chiral bases 9-11 is predicted to have ee's ranging from 58% (w

44 are computational species-specific knowledge bases able to compute systemic metabolic properties.

45 ome instability and accumulation of aberrant bases accompany multiple diseases, including cancer and

46 Cytotoxic sphingoid long-chain bases accumulated in embryonic fibroblasts and spinal co

47 has been documented at hundreds of military bases, airports, and firefighter training facilities.

48 we connect these two reaction pathways using bases and a simple Pd-based catalyst system to promote a

49 y unravels a role of endogenous oxidized DNA bases and APE1 in controlling the formation of higher-or

50 trogen atoms are typically regarded as Lewis bases and are extensively employed as donor ligands in c

51 DNA at the level of individual nucleic acid bases and base pairs is important for elucidating molecu

52 ing to one helical turn of DNA, spanning ~40 bases and centered ~80 bases upstream of the TSS.

53 ut genes, aggregated from numerous knowledge bases and encoded in a massive "Knowledge Network." Know

54 However, the genetic bases and evolutionary processes underlying this 'molecu

55 rallel, our understanding of its mechanistic bases and its consequences for host and pathogen interac

56 systematic improvement of E. coli knowledge bases and its extension to other organisms.

57 -substituted azulenes based on the nature of bases and nucleophiles employed.

58 d many efforts to understand their molecular bases and physiological consequences(5-14).

59 Here, we show induction of oxidized bases and single-strand breaks (SSBs), but not direct do

60 sites opposite all four canonical undamaged bases and stimulated apurinic/apyrimidinic endonuclease

61 The stability of the observed anionic bases and their supramolecular formations and hydrates h

62 7) which form stacking interactions with RNA bases and thereby bend the RNA backbone.

63 hat it serves both to protect vulnerable DNA bases and to facilitate DNA replication and compaction.

64 the formation of sheathing/nonsheathing leaf bases and vasculature patterning.

65 produced not as acids but as their conjugate bases, and acetone is neither an acid nor a base.

66 eatment of alpha-silylaryl triflates, Schiff bases, and alkynes generated polysubstituted pyrroles in

67 detailed models of their operations, neural bases, and connections with perceptual and behavioral sy

68 g read lengths, ability to detect methylated bases, and its real-time sequencing methodology.

69 fluorobenzene, using 1 atm of H(2), alkoxide bases, and moderate temperatures (70-90 degrees C).

70 ts including boiling water, strong acids and bases, and oxidation and reduction conditions.

71 utrients may include amino acids, nucleotide bases, and transition metals, the essentiality of which

72 The c.1379 G > A base change and neighboring bases are consistent with a mutation caused by ultraviol

73 Although these bases are known to contribute to distinct demethylation

74 We find single-stranded RNA bases are more chromatin-associated, and we discover hun

75 Chains of rU bases are relatively unstructured under all conditions,

76 on of idiopathic cases, the actual molecular bases are usually undetermined.

77 cross-coupling approaches cannot yet employ bases as weak and economical as trialkylamines.

78 stability against strong oxidants, acids and bases, as well as polar solvents.

79 We find that DNA bases at two sites within Hel308 control sequence-specif

80 HuR binding to RNA transcripts from tens of bases away.

81 on regarding the biophysical and biochemical bases behind observed cellular phenotypes.

82 complex genetic trait with shared biological bases between the sexes.

83 the ZFN dimer, as well as the option to skip bases between the target triplets of otherwise adjacent

84 multiple modes that differ by the number of bases bound per tetramer and the magnitude of the bindin

85 ilable in a semantic language from knowledge bases, but these are often not interoperable.

86 as the iodonium-specific affinities of Lewis bases by the Lewis basicity parameter LB(I) and the susc

87 DNA bases can adopt energetically unfavorable tautomeric for

88 over, the conversion of adenine and cytosine bases can be achieved by fusing SauriCas9 to the cytidin

89 Cytosine DNA bases can be methylated by DNA methyltransferases and su

90 e of RNA backbone constituents and different bases can be predicted from local physicochemical charac

91 c and main-group compounds, usually acids or bases, can accelerate chemical reactions when used in su

92 seen in proteins, namely, (1) the top-ranked bases clustered in secondary and tertiary structures.

93 Our strategy centres on the use of solid bases composed of an alkali carbonate (M(2)CO(3), where

94 ws that both mono- or di-methylated cytosine bases could specify the C:T pair and induce the G to T m

95 tion of an aziridine intermediate in Mannich bases derived from imidazo[1,2-a]pyridines, 2-pyridylami

96 performance cross different DNA methylation bases, different DNA methylation motifs and both singlet

97 red under all conditions, while chains of rA bases display distinct ordering through stacking or clus

98 ed organocatalysts, these new ion pair Lewis bases display superior catalytic reactivity in the react

99 , suggesting that PPR65 cannot bind modified bases due to differences in the structure of the active

100 ve processes and their underlying neurologic bases during development.SIGNIFICANCE STATEMENT Cross-se

101 analogs along with the natural A, T, G and C bases during DNA synthesis, which allows for labeling of

102 ests that the phage phi29 motor contacts DNA bases during translocation; and (iii) one theoretical mo

103 Brilliant bases (e.g., deprotonating C-H bonds), nucleophiles (e.g

104 uickly and accurately copies billions of DNA bases each cell division cycle.

105 elated sulfonated phosphine ligands and five bases, each possessing varying cation size, to the chall

106 by assembling annotations from the knowledge bases EcoCyc, EcoGene, UniProt and RegulonDB.

107 dictions enrich for evolutionarily conserved bases, eQTLs and CTCF motifs, supporting their biologica

108 on recording studies and both classification bases evinced distinct stimulus-evoked phases of populat

109 amer tagged at the 3' end with 40 nucleotide bases exhibited the maximum affinity towards Patulin and

110 OH groups on node vacancies act as Bronsted bases, facilitating TBA dehydration via a carbocation in

111 ure applications, 20 DNA duplexes, where the bases facing and neighboring (th)G were systematically v

112 -stage and arousal transitions that lays the bases for a novel, non-homeostatic paradigm of sleep reg

113 ad use of strong or poorly soluble inorganic bases for amine activation nevertheless complicates the

114 etoclax in BCR-dependent DLBCLs with genetic bases for BCL-2 dysregulation in vitro and confirmed the

115 Together, my work provides structural bases for DUOX1-DUOXA1 activation and regulation.

116 ed choice can be made, and provides a robust bases for expedited risk/benefit.

117 cal systems, and also that the neurochemical bases for food and touch rewards are not identical.

118 based on the current knowledge becoming the bases for future perspectives.

119 Possible mechanical bases for generation of axis stress and resultant deform

120 Studies characterizing the molecular bases for individual differences in AT in the dorsal amy

121 Yet, the cellular bases for its origin, development and subsequent mainten

122 he signaling activity of PEA; the structural bases for NAAA function and inhibition by covalent and n

123 n metastatic recurrence, and provide genomic bases for the efficacy of mTORC1, CDK4/6, and PARP inhib

124 espite the greater total number of sequenced bases for the latter.

125 me profiling to probe the underlying genetic bases for the rapid adaptation of this species to new en

126 -making but the neural circuit and molecular bases for these functions are little known.

127 Here, I describe the bases for these shifts in paradigms.

128 We evaluate candidate brain bases for this relationship.

129 of recently deployed soldiers from 2 US Army bases, Fort Carson and Fort Bragg (2009 to 2015).

130 rity during replication by excising oxidized bases from single-stranded DNA (ssDNA) and unhooking int

131 icting evolutionarily constrained non-exonic bases from such data.

132 ain of the synthesized quasi-random sampling bases from the frequency-diverse cavity.

133 by depurination, i.e. the cleavage of purine bases from the oligomer.

134 nd the best at mapping reads longer than 250 bases, from any platform.

135 Modified DNA bases functionally distinguish the taxonomic forms of li

136 Here, using as model Schiff bases generated from salicylaldehydes and TRIS in a set

137 salts Ar(2)I(+)X(-) with 11 different Lewis bases (halide ions, carboxylates, p-nitrophenolate, amin

138 ed amination reactions using soluble organic bases have provided a solution to the many issues associ

139 nt discoveries of a number of other modified bases have stimulated research to understand their origi

140 ividual variability; the underlying neuronal bases, however, remain unclear.

141 esence of specific range of noncanonical DNA bases in conifer genomes implying potential roles for th

142 es of copper sources, ancillary ligands, and bases in different solvents followed by two deconvolutio

143 les to directly detect methylation states of bases in DNA from reads without extra laboratory techniq

144 Alkylation of guanine bases in DNA is detrimental to cells due to its high mut

145 rated by T(m), incorporation of the modified bases in DNA resulted, with few exceptions, in low stabi

146 on fluorescence quenching to detect unpaired bases in double-stranded DNA.

147 demonstrate that endogenous oxidized guanine bases in G4 sequences and the subsequent activation of t

148 prime editing guide RNAs (pegRNAs), can edit bases in mammalian cells without donor DNA or double-str

149 g parenchyma shrinkage of the posterior lung bases in patients found to have worsened ILD at visual a

150 by studying the contributions of individual bases in the anticodon loop of hmtRNAThr to t6A modifica

151 t poly-G RNA bases synthesized using three C bases in the DNA as a template and extends RNA without d

152 ation, ensuring that the unpaired templating bases in the gap are ushered into the active site in an

153 ng human brain affect a comparable number of bases in the genome (~6200 vs. ~4000 bp), implying that

154 sources for analyzing constrained non-exonic bases in the genome.

155 repeats have an even(odd) number of hanging bases in the hairpin stem.

156 saged viruses which have acquired an extra 6 bases in the long untranslated region between the M and

157 ent of a novel molecular tool to edit single bases in the mtDNA (Mok et al., 2020).

158 ional analyses, we identified the nucleotide bases in the occluding mRNA 3'UTR that interact with MIR

159 gh-resolution genomic interaction maps (~750 bases) in aortic endothelial, smooth muscle cells and TH

160 These bases include a common pathology affecting the ascending

161 of degenerate codons (DCs), mixtures of DNA bases incorporated at specific positions during DNA synt

162 dsDNA, loop or bulge regions, with flanking bases influencing the degree of preference.

163 e modifications in DNA to recognize all four bases involved in demethylation.

164 ociation studies to determining such genetic bases is an evolutionary framework.

165 th a model where altered risk at neighboring bases is linked to lesion formation at the focal CpG and

166 ycosylase that specifically removes oxidized bases, is one mechanism through which H. pylori infectio

167 chains as well as nucleic acids termini and bases, it can adopt.

168 hat measurements are related to operators or bases, it does not rely on the universality of quantum m

169 Lysine derivatives bearing two melamine bases (K(2M)) can be prepared on multigram scale by doub

170 e expected to be among the strongest organic bases known, assessing the energetics of protonation of

171 phenes with various reagents (Knochel-Hauser bases, LDA) as an efficient synthetic tool.

172 We conclude that weak bases like ammonia, potentially generated during H. pylo

173 eriment, we observe particular apical loop U bases, likely recognized by DGCR8, are important for eff

174 apture efficiency and stability of hydroxide bases make them superior to existing amine-based routes

175 sometimes being separated by tens of million bases (Mb) along genomic sequence show a significantly h

176 e achieve a N50 contig length of 7.7 million bases (Mb) directly from long-read assembly, compared to

177 ein, naproxen, torasemide, and warfarin) and bases (metoprolol and propranolol).

178 dy reports the clinical features and genetic bases of 3 previously unreported families with punctifor

179 , and bilingualism and touch upon the neural bases of a processing approach.

180 In contrast, the molecular bases of acinar dysplasia and congenital alveolar dyspla

181 e investigated the structural and behavioral bases of an ASD-associated in-frame deletion in hDAT at

182 a pair of polar residues and the nitrogenous bases of an RNA target.

183 crucial window into the cognitive and neural bases of awareness.

184 eezes, and crackles heard at auscultation of bases of both lungs.

185 We describe the structural bases of both.

186 play a vital role in revealing the molecular bases of cancer development and progression.

187 es to uncover novel mechanisms and molecular bases of cardiovascular pathophysiological manifestation

188 to modern society, the cognitive and neural bases of code comprehension are largely unknown.

189 recise identification of the neurobiological bases of cognitive decline in aging populations may prov

190 e ABA model for understanding the biological bases of cognitive deficits in AN and provides context f

191 Our findings reveal the reward bases of color, demonstrating color is a potent regulato

192 Although the neural bases of conscious experience have been extensively inve

193 sent a powerful tool to study the functional bases of consciousness in physiological and pathological

194 To investigate the molecular bases of dental fluorosis, we analyzed the effects of fl

195 d intracellular environment packed with mega bases of distracting non-target DNA?

196 The adenine, cytosine, and guanine bases of DNA are susceptible to alkylation by the aldehy

197 susceptibility genes and clarify the genetic bases of dyslexia.

198 Understanding the biological bases of erosion points to novel therapies for acute cor

199 surements made at depths deeper than defined bases of fresh water pump fresh groundwater (TDS < 2,000

200 d salinity distributions and compare defined bases of fresh water with salinity distributions and gro

201 existing groundwater wells penetrate defined bases of fresh water, and nearly 16% of wells overlie it

202 derlying yield is critical for understanding bases of genetic gain in species of agronomic importance

203 nd substrate specificity as the evolutionary bases of glucosinolate diversity.

204 The molecular bases of heteromeric assembly and link between Na(+) sel

205 with Ophn1-dependent XLID, but the cellular bases of hyperexcitability are poorly understood.

206 ritical for gaining insights into structural bases of interactions and their roles in the biomolecula

207 The genetic bases of many complex phenotypes are still largely unkno

208 However, while the genetic bases of many phenotypic differences have been identifie

209 malignancies, but the genetic and molecular bases of many rare cancers remains unclear.

210 EMs) are mathematically structured knowledge bases of metabolism that provide phenotypic predictions

211 r future research, including neurobiological bases of musicality and relationships between human musi

212 model organism for the study of the genetic bases of non-symbolic numerical and spatial cognition, a

213 re synthesized from the corresponding Schiff bases of O-perbenzoylated (gluculopyranosylamine)onamide

214 ts worldwide aiming to understand the neural bases of our psychological functions.

215 links between the genetic and biomechanical bases of plant growth.

216 tionary, biochemical, genetic, and molecular bases of primary metabolic diversity could provide ratio

217 However, the molecular bases of proteotoxicity by soluble LCs have not been cla

218 Here, we investigated the molecular bases of rcd-1-dependent cell death.

219 nt insights into the molecular and metabolic bases of reticulation and its tight association with ski

220 s, knowledge about the genetic and molecular bases of rice seed metabolomes at different developmenta

221 editing, the process that alters individual bases of RNA, may contribute to AD pathogenesis due to i

222 the genetic, physiological, and biochemical bases of salt-tolerance mechanisms.

223 nhanced threefold the depletion width at the bases of silicon pyramids.

224 arvae, to investigate the genetic and neural bases of sleep.

225 ing directed toward investigating the neural bases of social cognition from a systems neuroscience pe

226 system for understanding the neuromolecular bases of social status independent of reproductive state

227 ogy assays to start investigating the neural bases of the ANS in zebrafish.

228 positioned loops accumulate with CARs at the bases of the loops.

229 ndard phylogenetic approaches assume the DNA bases of the progenitor (or "naive") sequence arise inde

230 ecently become possible to study the genetic bases of the traits responsible for diversification and

231 The structural bases of their function are well established, particular

232 To identify the molecular bases of their partnership, we generated recombinant for

233 se 127 survey items to measure six potential bases of these and other antidemocratic sentiments: part

234 to later life stages; however, the molecular bases of these changes remain unknown.

235 The mechanistic bases of these harmful effects remain to be established.

236 However, the cellular and synaptic bases of this hyperexcitability have proved elusive.

237 enetic strategies to elucidate the molecular bases of this organization using Caenorhabditis elegans.

238 HG fluxes were measured from individual stem bases of two common tree species and from soils beneath

239 this paper, first we review the theoretical bases of UWHAM, its stochastic solver RE-SWHAM (replica

240 nded nucleotide contexts (e.g. surrounding 3 bases on either side) explains an additional 4% of share

241 equence on t-amide side and the other to the bases on the Calpha side chain.

242 duct formations from iodonium ions and Lewis bases originating from solvation effects.

243 a linear relationship between the number of bases per molecule and the associated imaging contrast f

244 HMDS had carried out the roles that Bronsted bases play in amide-assisted NP syntheses and were neces

245 bonds between amino acid side chains and DNA bases play major roles in specific protein-DNA interacti

246 PAs) and hydride affinities (HAs) of organic bases possessing an allene moiety and substituted with m

247 zymes pause after transcribing less than 100 bases; precisely how RNAPII pausing is enforced and regu

248 henoxide that, in combination with inorganic bases, provided 3,4-dihydropyran-2-ones in yields of up

249 fewer direct contacts and hydrogen bonds to bases, relying mostly on water-mediated and Van der Waal

250 of autism spectrum disorder (ASD), its brain bases remain uncertain.

251 hment sequence data of 1827 exons (> 940 000 bases) representing 63 species, as well as sequenced gen

252 Damaged or mismatched DNA bases result in the formation of physical defects in dou

253 91 mass features from the leaf tips and leaf bases, showed that 90% have multiple significantly assoc

254 death of cells with methylation-damaged DNA bases, so we measured proportions of cells that undergo

255 argue that modified versions of the standard bases, some with features that resemble cofactors, could

256 levels of sphingolipids, including sphingoid bases (sphingosine and dihydrosphingosine) and sphingoid

257 tion site can be accessed by using different bases, steric and electronic effects promoted by the aro

258 Modified bases studied in this report are preferentially recogniz

259 toward the coupling route, whereas carbonate bases such as K(2)CO(3) and Na(2)CO(3) switch toward an

260 By using lipophilic bases such as potassium 2-ethyl hexanoate, the borylatio

261 operates efficiently with even weak terminal bases, such as Et(3)N.

262 rG promoter, which contains eight poly-G RNA bases synthesized using three C bases in the DNA as a te

263 ction, has more than doubled the fraction of bases that are confidently predicted to be under conserv

264 adding additional reagents such as acids or bases that can perturb biological activity.

265 tective benefits including their mechanistic bases that could be further potentiated through HIIT.

266 moieties deliberately staggered between the bases that define the complementary code.

267 ion where residues D567 and E491 are general bases that deprotonate the epsilon-amino group of lysine

268 The vast majority of oxidized bases that form in DNA are subject to base excision repa

269 rks are organized and systematized knowledge bases that have multiple uses, including conversion into

270 d selective base-triple formation with 4 T/U bases; the Fmoc-K(2M) derivative can be used directly in

271 cals have involved the use of Lewis acids or bases, this tutorial review focuses on new avenues to ma

272 of chemical modifications and non-canonical bases; this in turn requires advances in current sequenc

273 1,2-elimination, their alkylation by Schiff bases through 1,2-addition, 1,4-intramolecular proton tr

274 We use biomedical knowledge bases to create a knowledge graph of entities connected

275 orted by undercut stem regions with filleted bases to ensure successful skin penetration and retentio

276 hway that recognises and excises damaged DNA bases to help maintain genome stability.

277 vides critical physiological and mechanistic bases to investigate sarcomeric mutations in the pathoge

278 re more frequent (4684) within 0.14 gb (giga bases) transcriptome than other repeats, of which was tw

279 that certain combinations of Lewis acids and bases undergo single-electron transfer (SET) processes.

280 h an improved understanding of the molecular bases underlying the dysregulation of connexins during c

281 agronomically important traits, but genetic bases underlying these changes and the effects of artifi

282 ing of the molecular mechanisms and cellular bases underlying these fundamental and important biologi

283 of DNA, spanning ~40 bases and centered ~80 bases upstream of the TSS.

284 inal rate inferences, and by considering the bases used in substitution, we find evidence that if tem

285 A transversions, potentially due to oxidized bases, was also observed in non-irradiated XP-V cells, i

286 two isoenzymes that phosphorylate sphingoid bases, was markedly reduced in both NPC1 mutant and NPC1

287 On these bases, we demonstrate a three-neuron brain-silicon netwo

288 by the principle of hard and soft acids and bases, we performed a comprehensive experimental and com

289 he bed positions covering the liver and lung bases were acquired with a duration of 6 min.

290 the pathways taken by the lesion and normal bases when extruded from the DNA helix and their associa

291 bleb initiation was biased toward filopodial bases, where the cytoskeleton exhibited local weaknesses

292 based CBE induces substantial editing of RNA bases, whereas an enhanced APOBEC3A-based CBE(6), human

293 s utilized for the detection of nucleic acid bases with a well resolved oxidation peak for the indivi

294 ity of intact CA to quantitatively protonate bases with biologically-relevant pK(a)s and argue that C

295 protonated mono- and biradicals to reference bases with known proton affinities as a function of time

296 cterize the nature of constrained non-exonic bases with low CNEP scores using additional types of inf

297 because of their ability to alter single DNA bases with precision.

298 leotide target sites, and different flanking bases within diverse DNA secondary structures.

299 ficity is attributable to just three variant bases within the predicted loop.

300 NN predictions involving modified bases without experimental parameters (N6-methyladenosin