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1 represents any aromatic amino acid and B any basic amino acid.
2 )P2-(Ser)P1(Arg) P1'(Ala)), where X is a non-basic amino acid.
3 amino acid types, with ornithine as the only basic amino acid.
4 interaction motif (PIP box) and an adjacent basic amino acid.
5 phobic phenylalanine residues and flanked by basic amino acids.
6 ((273)GSIIRKWN(280)) that contains only two basic amino acids.
7 uires a region with an overrepresentation of basic amino acids.
8 Integrin beta TMDs have such conserved basic amino acids.
9 logues, including structures with acidic and basic amino acids.
10 ard mixtures containing acidic, neutral, and basic amino acids.
11 ne-oriented sequences that contain clustered basic amino acids.
12 of such singly charged complexes except for basic amino acids.
13 es with substrate specificity for a range of basic amino acids.
14 rate polypeptides primarily between pairs of basic amino acids.
15 ts and was abrogated by prior methylation of basic amino acids.
16 n signal of TBX5, we searched for cluster of basic amino acids.
17 and a broadened activity for cleavage after basic amino acids.
18 racellular, juxtamembrane region composed of basic amino acids.
19 hat they all possess a subdomain composed of basic amino acids.
20 n can also accept Gln and Asn in addition to basic amino acids.
21 polyprotein precursor at sites following two basic amino acids.
22 signal (NLS), composed of short stretches of basic amino acids.
23 sic residues followed by a tail of scattered basic amino acids.
24 acterium glutamicum, which detects all three basic amino acids.
25 to the N terminus released peptides rich in basic amino acids.
26 on to arginine, could have been the earliest basic amino acids.
27 erse mixture of polar, nonpolar, acidic, and basic amino acids.
28 educed by mutation of additional clusters of basic amino acids.
29 recognition motif consisting of a cluster of basic amino acids.
31 ion of CobB(L) is amphipathic, containing 18 basic amino acids (12 of which are Arg) and 13 hydrophob
32 s exceptionally efficient PCNA binding and a basic amino acid 4 residues downstream of the PIP box, w
33 rected mutagenesis, SET binding sites to the basic amino acids (66)KRKK(69) and (246)RK(247), located
34 e-rich region, a region (BR) that is rich in basic amino acids, a longer serine-rich region and a C-t
35 domain revealed that a conserved block of 22 basic amino acids (aa 365-386; exons 5-6) is sufficient
36 P are mediated in general by acidic and some basic amino acids, although the specific amino acids inv
37 to heparin, and each contained a cluster of basic amino acids; among them, an intact R(282)VSR(285)S
38 the fusion cleavage site identified multiple basic amino acids and a phenylalanine at position 117, i
39 e protein are novel, with a small stretch of basic amino acids and a putative leucine zipper motif.
41 ol gradients, showed a high concentration of basic amino acids and inorganic phosphate, and were able
43 I prefers to cleave on the C-terminal end of basic amino acids and produced the highest number of fra
44 alpha-helical hydrophobic domain followed by basic amino acids and proline in the same relative genom
46 ies adjacent to the three-residue cluster of basic amino acids and thus may moderate the combined loc
48 ubstrates occurred on the C-terminal side of basic amino acids, and Km for this reaction was approxim
51 ion signals; one is composed of a stretch of basic amino acids, and the other is a bipartite signal l
52 ess, the C- and N-terminal parts are rich in basic amino acids, and these are interspersed with other
54 anhydride, peptides that contain C-terminal basic amino acids are isolated by affinity chromatograph
58 and by the electrostatic interactions of two basic amino acids, Arg(62) and Lys(64), with the phospho
59 n-binding activity of FNIII1 to a cluster of basic amino acids, Arg613, Trp614, Arg615, and Lys617.
61 5 and H7 subtypes typically possess multiple basic amino acids around the cleavage site (MBS) of thei
62 ntrol peptides containing the same number of basic amino acids as TP but lacking disulfide constraint
63 amino acid repeats with a high percentage of basic amino acids, as well as an amino-terminal extensio
65 nd in vivo by the insertion of an additional basic amino acid at the HA cleavage site and not by the
66 owever, the TX/04 isolate had one additional basic amino acid at the HA cleavage site, which could be
67 hydrophobic and bulky amino acids at P2 and basic amino acids at P3 display better binding activity
69 hogenicity (i.e., their HA contains multiple basic amino acids at the cleavage site and has glycosyla
70 downward arrowFA) (underlining indicates the basic amino acids at the F protein cleavage site, and th
72 ntify an extended structural loop containing basic amino acids at the interface of the receptor bindi
74 olume and a severe growth defect specific to basic amino acid availability for btn1-Delta, but not wi
76 cterization of two Arabidopsis mitochondrial basic amino acid carriers (BAC), AtmBAC1 and AtmBAC2, wh
77 current study, a mutant trypsinogen (paired basic amino acid cleaving enzyme (PACE)-trypsinogen), wh
78 Several PCs, including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7, are able to
79 folded structure together with three or more basic amino acids closely packed in a charged region in
80 e C-terminal region of NSm, which contains a basic amino acid cluster and a putative transmembrane do
82 ino acids 208 to 236, containing a bipartite basic amino acid cluster, is able to mediate nuclear loc
83 demonstrated that mutating one of the three basic amino acid clusters (R or K --> A) leads to signif
88 oylated cysteines and the presence of nearby basic amino acids determine polarized targeting by these
91 hat they are selectively used as a source of basic amino acids during nutrient stress through autopha
93 at replacement of a hydrophobic residue by a basic amino acid enabled the meprin alpha protease to cl
95 d MAPK includes residues 128-133 (KGFFRR), a basic amino acid-enriched motif novel for MAPK substrate
96 a heart-shaped homodimer with a ridge of six basic amino acids extending diagonally across the apolar
97 ormation of salt bridges between SRP RNA and basic amino acids facilitates the binding of a distinct
98 and builds upon previous studies implicating basic amino acids flanking the zinc finger as important
99 s pinpointed the association to a histidine (basic amino acid) for aspartic acid (acidic amino acid)
100 ween negatively charged PM phospholipids and basic amino acids found in K-Ras4B (K-Ras) but not in H-
104 )Q sequence have a positive influence, while basic amino acids have a negative influence on substrate
105 utamate residues at positions 9 and 13 and a basic amino acid (HKH) motif at positions 15-17 on the a
106 r basis for block, we mutated a portion of a basic amino acid (HKH) motif on the Cx40 amino-terminal
108 phase basicities than the side chains of the basic amino acids (i.e., those of histidine, lysine, or
109 minal amino group and the side chains of the basic amino acids, i.e., the favorable sites for binding
110 glutamic acid, but not to several neutral or basic amino acids, impedes protease autoprocessing in ba
112 irected mutagenesis targeting each conserved basic amino acid in RAG2 revealed several separation-of-
113 the R174W mutation neutralizes the innermost basic amino acid in the voltage-sensing S4 helix of the
114 hes and mutagenesis, we identify a conserved basic amino acid in TM6 in Class F receptors that acts a
115 itionally, statistics on the distribution of basic amino acids in a data set of membrane-binding doma
116 possibility we examined the degree to which basic amino acids in a signal peptide influence the targ
117 trahymena 40 S.eIF1 complex revealed several basic amino acids in eIF1 contacting 18 S rRNA, and we t
121 5, it appears that the C-terminal stretch of basic amino acids in Rac is required for a high affinity
124 lity that electrostatic interactions between basic amino acids in signal peptides and the phosphate b
125 Cumulatively, the results demonstrate that basic amino acids in the autolysis loop of fXIa are impo
129 s dependent on the integrity of a stretch of basic amino acids in the carboxy terminus of Chp and tha
133 rat neuroendocrine cells, we find that a few basic amino acids in the cysteine-rich region of SNAP25
134 front-to-back arrangement, with a cluster of basic amino acids in the front of the MEKK2 PB1 domain b
135 ructure of 12 amino acid residues flanked by basic amino acids in the HIV-1 MSD that function to anch
141 predicted by identifying groupings of nearby basic amino acids in the positive mode or acidic amino a
142 in nature, and is facilitated by a region of basic amino acids in the tail and the acidic E-hook at t
143 apoE to its receptor binding domain and the basic amino acids in this domain are important for its a
146 N-terminal 15 amino acids, particularly six basic amino acids, in the C-terminal PA-X-specific regio
147 yzed peptide bonds on the C-terminal side of basic amino acids, including a bond located within the C
148 resented results further our knowledge about basic amino-acid insertion into bilayers, and may lead t
149 physiological role of SLC25A29 is to import basic amino acids into mitochondria for mitochondrial pr
150 sport of, or regulation of the transport of, basic amino acids into the vacuole or lysosome for yeast
151 ly, our results suggest that cleavage at all basic amino acids is suppressed when a mobile proton is
152 utant Gap1p(A297V), which does not transport basic amino acids, is also not regulated by these amino
155 of gentamicin and the clinically compatible basic amino acid L-arginine against planktonic and biofi
156 of gentamicin and the clinically compatible basic amino acid L-arginine increases in vitro planktoni
157 We determined that the incorporation of basic amino acids led to analogues with improved inhibit
158 rges, particularly those with three or fewer basic amino acids, led to a significant decrease in pote
161 cation designed to predict cleavage sites at basic amino acid locations in neuropeptide precursor seq
163 e sequences that contain a single cluster of basic amino acids (Lys/Arg) or bipartite sequences that
165 tidylserine are found to be similar in GB to basic amino acids lysine and histidine, and phosphatidic
166 ncentrations of Zn2+, high concentrations of basic amino acids (lysine and arginine), and heparin.
167 was coincident with an arginine (or another basic amino acid, lysine) at a position corresponding to
168 ct primary preference for cleavage after the basic amino acids, lysine and arginine, with only a slig
169 synthesis, fructose and glucose metabolism, basic amino acid metabolism, and bile acid transport.
171 Ins(3)P and that this interaction requires a basic amino acid motif (KKPAKK) within the cytosolic reg
172 minus (NLS-c), which consists of a bipartite basic amino acid motif plus the last 39 residues of ADAR
173 nes of these H5N1 viruses possessed multiple basic amino acid motifs at the cleavage site, were HP fo
176 ediated by one or more specific stretches of basic amino acids-nuclear/nucleolar localization signals
178 signaling, suggesting a role for N-terminal basic amino acids of alpha(q) beyond simple plasma membr
179 ular modelling suggests that interactions of basic amino acids of the enzyme with the carboxyls on th
181 contacts that primarily involve clusters of basic amino acids on actin subdomains 1 and 3 juxtaposed
184 n binders as they do not contain clusters of basic amino acids or other known features associated wit
185 was mutated to contain increased numbers of basic amino acids or to mimic the naturally occurring cl
187 overexpression of Can1p, the plasma membrane basic amino acid permease, results in increased cell vol
188 d residues within the amphipathic helix (the basic amino acid PI(4,5)P2 pincer domain) was required f
190 of the hydrophobic patch or the surrounding basic amino acids prevents PM localization of GRK5-GFP.
191 nd in combination with previously identified basic amino acid probes can be used to examine molecular
192 nkephalin sequence flanked by sets of paired basic amino acid proteolytic cleavage sites and two C-te
193 Using large-scale mutagenesis, acidic and basic amino acids putatively involved in ion transport m
195 al series of amino acids bounded by pairs of basic amino acids, raising the possibility that addition
198 ly protonated glycopeptide ions containing a basic amino acid residue almost exclusively resulted in
200 of its homologs in other bacteria, there are basic amino acid residues (Arg, Lys, and Gln) immediatel
202 ally pronounced with peptide ions containing basic amino acid residues (for example, tryptic peptides
203 ling and mutagenesis identified a cluster of basic amino acid residues (Lys(51), Arg(56), and Arg(80)
204 itively charged clusters, involving up to 11 basic amino acid residues (mostly arginines with their p
205 ion near the C-terminal domain enriched with basic amino acid residues also affected the nuclear impo
206 nism involves protein electrostatics between basic amino acid residues and acidic lipids such as phos
207 sphatase domain and an N-terminal cluster of basic amino acid residues conforming to a nuclear locali
208 peptides HA and BMP2, which contained highly basic amino acid residues either at the N-terminus (BMP2
209 bridge the ribose zipper chain segments with basic amino acid residues hydrogen bonding to the RNA ba
210 hibition of TRPML1 were mediated by distinct basic amino acid residues in a common PIP(2)-interacting
211 R1 from PLDbeta or mutation of the conserved basic amino acid residues in PBR1 (K437G/K440G) abolishe
212 n studies indicate that two highly conserved basic amino acid residues in the C-terminal region, Lys3
213 Conserved in the ErbB family is a cluster of basic amino acid residues in the cytoplasmic juxtamembra
214 de levels in mice and that a substitution of basic amino acid residues in the region 61-66 of the fra
216 occur by interaction of sulfate groups with basic amino acid residues on the surface of the enzyme,
218 amino acid sequence containing two groups of basic amino acid residues separated by eight amino acid
219 r the derivatization step removes C-terminal basic amino acid residues such as arginine and lysine.
223 rboxyl-terminal domain, whereas a cluster of basic amino acid residues within the N-terminal domain i
226 s, with most of these sites being flanked by basic amino acid residues, and predicted to be solvent e
227 most aspartic proteases from other origins, basic amino acid residues, particularly lysine, were fou
228 oposed to be a consequence of the absence of basic amino acid residues, promoting a mobile proton-lik
229 peptides centers on alternating aromatic and basic amino acid residues, with dimethyltyrosine providi
230 charged peptides, including those harboring basic amino acid residues--a crucial feature in the cont
240 the extent to which a cis-acting CD3epsilon basic amino acid-rich stretch (BRS), with its unique pho
242 no acid positions 148 to 162 and a series of basic amino acids (RKLKR) at amino acid positions 101 to
243 no acid positions 148 to 162 and a series of basic amino acids (RKLKR) at amino acid positions 101 to
244 arbors a putative NLS with three clusters of basic amino acids (RRRHIVRKRTLRR (amino acids 645-657))
245 the TGF-beta propeptide-binding domain and a basic amino acid sequence (hinge domain) with ECM target
246 nts with [(14)C]-labeled neutral, acidic and basic amino acids showed significantly reduced uptake of
247 ally unstructured portion of Scr so that two basic amino acid side chains can insert into the minor g
248 Furthermore, reversible N-chlorination of basic amino acid side chains is the major factor that co
250 the precursor ion as well as the presence of basic amino acid side chains, phosphate transfer reactio
252 rchetype of the entire family, OccD1, from a basic amino acid-specific channel into a channel with a
254 at positions 101 to 105, M1 contains another basic amino acid stretch at positions 76-78 that is high
257 her demonstrated that the positively charged basic amino acid substitution at E367 enhanced the viral
258 r findings provide the first evidence that a basic amino acid substitution at E367 strongly impacts t
260 acids on the opposite face, and a number of basic amino acids surrounding the hydrophobic patch.
261 acid binding, could emerge with ornithine, a basic amino acid that forms abiotically yet is absent in
262 tution mutagenesis demonstrated that R327, a basic amino acid that is highly conserved in CfrA, plays
264 ational data, highlight five acidic and four basic amino acids that are likely to comprise the LEF4 t
265 on factors (bZIPs) contain a segment rich in basic amino acids that can bind DNA, followed by a leuci
266 PTDs usually consist of short stretches of basic amino acids that can cross the plasma membrane and
268 to heparin binding formed a cluster of five basic amino acids that presented toward the icosahedral
269 he structure revealed a cluster of conserved basic amino acids that protrude from the surface of Hha
271 her organisms can synthesize polyamines from basic amino acids, the protozoan parasite Trypanosoma cr
273 natomy of RAG-1, we mutated all 86 conserved basic amino acids to alanine and evaluated the mutant pr
274 transporter system function in the uptake of basic amino acids to support growth of M. catarrhalis.
275 group acts in conjunction with a cluster of basic amino acids to target Nullo to the plasma membrane
278 tron microscopy structure of the neutral and basic amino acid transport complex (b([0,+])AT1-rBAT) wh
279 g glucose transporter 2 (Glut2), neutral and basic amino acid transporter, liver pyruvate kinase (L-P
280 he N terminus of the proteinase containing a basic amino acid triplet (Arg8-Lys9-Lys10) that forms mu
281 terestingly, in the most central position, a basic amino acid triplet of p135H peptide was found to b
284 ergy (BE) of protonated amines, pK values of basic amino acids were calculated by plotting the fracti
285 in the carboxy terminus of Chp and that the basic amino acids were not simply part of a palmitoyl ac
286 is is a new chemical synthesis of one of the basic amino acids which had not been synthesized prebiot
287 P1 N terminus contains a number of groups of basic amino acids which resemble classical nuclear local
288 sites on TG2 mainly comprise two clusters of basic amino acids, which are distant in the linear seque
289 quence near the N terminus comprised of four basic amino acids, which in a peptide can act to transpo
292 E12 and E47 each contain two regions of basic amino acids, which, when mutated, lead to cytoplas
293 the PB1-F2 reveals that replacement of five basic amino acids with Ala abolishes mitochondrial targe
297 his purpose, we substituted alanines for two basic amino acids within NS1 (R38 and K41) that were pre
300 d a 13-residue sequence of basic-hydrophobic-basic amino acids within the putative PH domain that may