ライフサイエンスコーパス: basic science

1 ignition and producing warm dense matter for basic science.

2 lanar superconducting tunnelling studies for basic science.

3 relevance to biomedicine, biotechnology and basic science.

4 cy to fund edge science is mostly limited to basic science.

5 avigation, communication, remote sensing and basic science.

6 cit is a key challenge for both clinical and basic science.

7 re less likely to be published compared with basic science.

8 uantitative and qualitative cell analysis in basic science.

9 k is needed for translational as well as for basic science.

10 n spectroscopy, communication, metrology and basic science.

11 n from those direct clinical translations of basic science.

12 for improving biostatistics education in the basic sciences.

13 being used by the institutions to teach the basic sciences.

14 ation through its use in the teaching of the basic sciences.

15 experimental approaches in the clinical and basic sciences.

16 o generate a convergence between applied and basic sciences.

17 llaboration patterns between the applied and basic sciences.

18 rofessional stakeholder groups, and clinical/basic science academicians, recommendations were made on

19 goals are to build a contiguous bridge from basic science, accelerate the advancement of promising p

20 These basic science advances have taken the field to its first

21 mportant recent clinical, epidemiologic, and basic science advances within this area of rheumatology.

22 y of PBC in the 2000s has been buoyed by two basic science advances: rapid sequencing technologies th

23 Discoveries in the basic sciences allow us to better understand tumor biolo

24 w strategy for plant genetic manipulation in basic science and agricultural applications.

25 road range of applications in biotechnology, basic science and biosensing.

26 olecule level holds great potential for both basic science and biotechnology applications.

27 otein degradation has many potential uses in basic science and biotechnology.

28 holding great potential for applications in basic science and biotechnology.

29 made for future research priorities for both basic science and clinical application of emerging thera

30 indings, and discuss the challenges for both basic science and clinical applications in the continued

31 Exciting new advances in both the basic science and clinical applications of new therapies

32 tterns in B cell Ig sequences have important basic science and clinical applications, but they are of

33 pathologies would be greatly beneficial for basic science and clinical applications.

34 vestigate luminance vision intended for both basic science and clinical applications.

35 in the field of Alzheimer's disease (AD) for basic science and clinical applications; however, the bi

36 ring of ideas among participating experts in basic science and clinical aspects of allergic diseases

37 ytes (TIL) is increasingly important in both basic science and clinical aspects of breast cancer rese

38 Findings were similar across basic science and clinical departments.

39 Here, we review the basic science and clinical development of these and othe

40 Here, we describe basic science and clinical discoveries that converge mai

41 may provide data complementary to that from basic science and clinical intervention studies, all of

42 ing of disease progression and regression in basic science and clinical investigations.

43 n mammalian samples is of great interest for basic science and clinical lipidomics.

44 technology would enable a whole new class of basic science and clinical MRI experiments that simultan

45 This minireview examines both the basic science and clinical observations over the past 20

46 ings in humans has broad applications within basic science and clinical practice beyond DBS, offering

47 the past 3 years, numerous breakthroughs in basic science and clinical research have been made, augm

48 respect to their contributory roles in both basic science and clinical research investigations.

49 Ongoing basic science and clinical research is critical to impro

50 ute to the field with their participation in basic science and clinical research.

51 s that have aimed to accomplish this in both basic science and clinical settings and follow the gener

52 Basic science and clinical studies were included; non-En

53 y requiring more careful scrutiny in ongoing basic science and clinical studies.

54 rapidly advancing field with applications in basic science and clinical translation.

55 The basic science and clinical use of morphine and other "op

56 eview summarizes the past year's literature, basic science and clinical, regarding the neural, paracr

57 stric exocrine and endocrine secretion, both basic science and clinical.

58 ogy and provide a rich body of knowledge for basic science and disease control.

59 the potential for empowering applications in basic science and enhancing our understanding of the act

60 ratory mice are used to address questions in basic science and experimental medicine.

61 review, we discuss the implications both for basic science and for targeting glutamine metabolism in

62 Research in this area has both advanced basic science and generated broader lessons for studying

63 al for developing models that can be used in basic science and medicine, to aid in predicting cells f

64 in which monkeys provide unique leverage for basic science and medicine.

65 Results from basic science and narrative reviews suggest a potential

66 statin protection against OAG including both basic science and observational clinical studies, an int

67 Basic science and patients are the immediate beneficiari

68 s from radiology, hepatology, pathology, and basic science and physics to arrive at a consensus regar

69 be used to manipulate cytokine signaling for basic science and possibly for therapeutic applications.

70 cant to the generation of gametes for future basic science and potential clinical applications.

71 ertook a detailed review of data from recent basic science and preclinical studies to investigate the

72 too difficult to tackle have benefited from basic science and technological advances over the past d

73 This review highlights developing basic science and technologies for potential application

74 ries, the wisdom of the West of investing in basic science and technology led to its dominance in wor

75 easons: first, the intellectual curiosity of basic science and the desire to understand fundamental p

76 me suggest significant implications for both basic science and the development of novel biomarkers/di

77 active motifs because of their importance in basic science and their broad utility in medicine and bi

78 by oxygen are of considerable interest from basic science and therapeutic perspectives.

79 a powerful tool in developing antibodies for basic science and therapy.

80 the isolation of cellular subpopulations in basic science and translational applications.

81 iated virus (rAAV) is an attractive tool for basic science and translational medicine including gene

82 oding DNA can have enormous benefit for both basic science and translational research because over 98

83 Here, we review the most current basic science and translational research findings on sev

84 g is an independent review that analyzes the basic science and translational strategies supporting th

85 Time- and dose-to-event phenotypes used in basic science and translational studies are commonly mea

86 ss time than FACS may prove valuable in both basic science and translational, cell-based applications

87 indings that help bridge the gap between the basic sciences and clinical application.

88 d have wide applications to glycoproteins in basic sciences and industry because no apparent bias for

89 clinical findings, pathology, epidemiology, basic science, and risk-management issues associated wit

90 A variety of basic science, animal, and human data suggests that cont

91 apacity in living cells is valuable for both basic science applications and epidemiological studies,

92 and pathways for therapeutic, diagnostic and basic science applications.

93 roteases and should have clinical as well as basic science applications.

94 early apoptotic events for both clinical and basic science applications.

95 king functional predictions for clinical and basic science applications.

96 There is an urgent need to expand basic science approaches for neglected diseases, especia

97 e disorders in recent years, and advances in basic science are being translated into increasing numbe

98 ponential increase was seen in the number of basic science articles (P < .001), review articles (P <

99 computer science, new imaging technique, and basic science articles were considered "preclinical." Us

100 Thus, HistoMosaic has wide applicability in basic science as a tool to map genetic heterogeneity.

101 oung researchers are crucially important for basic science as they make unexpected, fundamental disco

102 antification of FC and CE in samples used in basic science as well as clinical studies such as cultur

103 Psychiatry has similarly emphasized the basic sciences as the starting point of translational re

104 Here, we will review the basic science aspects of chromatin modifications and the

105 anticipate that these results, besides most basic science aspects, hold the potential for numerous a

106 Despite a need for basic science backgrounds within these fields, finding e

107 The basic science behind cognition, emotion, behavior, and s

108 epeat) systems have been broadly adopted for basic science, biotechnology, and gene and cell therapy.

109 of research has been primarily practiced in basic science but has recently been extended to clinical

110 ADME processes in humans and is relevant to basic science, clinical medicine and pharmaceutical rese

111 omposed of researchers with expertise in the basic science, clinical science, and epidemiological asp

112 tutes, the workshop addressed epidemiologic, basic science, clinical, and translational issues in can

113 published literature and expert opinion, the Basic Science Committee of the Society of University of

114 l sciences, which are largely unknown to the basic sciences community.

115 n is thought to improve the understanding of basic science conceptual knowledge and to better prepare

116 Basic sciences constitute the most abundant sources of c

117 Both the basic science data and the clinical experience with PPAR

118 Recent basic science data indicate that in healthy individuals,

119 Clinical and basic science data suggest a role for reduced gamma-amin

120 Clinical and basic science data support an integral role of calcitoni

121 clinical trials, translational research, and basic science demands that investigators in the field us

122 cy, and medicine and have worked in multiple basic science departments and one clinical department.

123 ed as assistant professors in medical school basic science departments was not related to the number

124 epartments now exceeds the number working in basic science departments.

125 pace in clinical departments but declines in basic science departments; and research is judged more o

126 Basic science derived data seem to only add to the confu

127 Subsequently, my desire to do research in basic science developed.

128 essing the epidemic will require advances in basic science, development of more acceptable and effect

129 In addition, basic science discoveries about neuroinflammation are no

130 late the immune system continue to emerge as basic science discoveries are made, including the use of

131 Basic science discoveries elucidating the molecular and

132 the demand for more effective translation of basic science discoveries into new clinical applications

133 However, even as basic science discoveries remain promising, clinical uti

134 functional specialization; integrating these basic science discoveries with clinical efforts will sup

135 connect in the translational process between basic science discovery, early drug development, and def

136 Controversies from basic science, discrepancies from clinical trials, and d

137 ate that simulation is an effective tool for basic science education and garners high learner satisfa

138 then, continued cross-fertilization between basic science efforts and clinical endeavors has highlig

139 e view from different disciplines, including basic science, epidemiology, bioinformatics, and network

140 microscopy is an essential technique for the basic sciences, especially biomedical research.

141 There is also new basic science evidence for stress as a contributing fact

142 Accumulating basic science evidence has identified chloride as a crit

143 Like other basic sciences, evolutionary biology needs to be taught

144 A basic sciences examination has been added to the process

145 d an explosion in studies--both clinical and basic science--examining the relationship between the mi

146 ns have been described and modeled both as a basic science exercise and for a range of applied goals

147 use as nanotools and reagents in a range of basic science, experimental therapeutic and clinical app

148 steady drop in the number of grant-eligible basic-science faculty [principal investigators (PIs)] yo

149 value to researchers working in clinical and basic science fields.

150 In this review, I discuss the basic science findings that position the TSC1 and TSC2 g

151 Translation of these basic science findings to clinical applications represen

152 on is that evolutionary biology is a crucial basic science for medicine.

153 ing needs, in turn, require mission-oriented basic science, for example about potential signposts and

154 nical insights for the basic scientist and a basic science foundation for the clinician.

155 ovation and the high-profile achievements of basic science generated in academic and biomedical labs.

156 y of the epidermis and, in turn, progress in basic science has informed our understanding of disease.

157 Basic science has provided a better understanding of the

158 assessments of disease for both clinical and basic science imaging research studies.

159 Our finding has basic science implications for understanding network fun

160 We believe basic science in communication and decision making, impl

161 s, and pathology), clinical research, and/or basic science in the areas of PH identified important qu

162 The role of basic science in the development of health care has rece

163 Basic science indicates a complex interplay of genetic,

164 for very diverse analytical applications in basic science, industry, and medicine.

165 nologists play a crucial role in translating basic science into effective response strategies.

166 late the biologic-mechanistic knowledge from basic science into efficacious treatments able to improv

167 ponsible for SCD has emerged from decades of basic science investigation into the normal electrophysi

168 Basic science investigations have consistently shown tha

169 nformation that is valuable for clinical and basic science investigations of cancer but extracting qu

170 r many applications, whether the focus is on basic science investigations or therapeutic efficacy, ac

171 reviews, prospective randomized trials, and basic science investigations, were identified in a PubMe

172 ounter to what might have been expected from basic science investigations.

173 presented here is instructive to clinicians, basic science investigators, and policy makers who deter

174 ed in moving from being Editor-in-Chief of a basic science journal to the same position at Annals of

175 l biomedical engineering journals, and the 5 basic science journals with the highest impact factor, w

176 egenerative therapies that are emerging from basic science laboratories.

177 d tissue, preoperative neuroimaging, and the basic science laboratory suggest that the syndrome is no

178 and later life outcomes at a mechanistic and basic science level, it is important to understand the p

179 We review the current clinical and basic science literature related to postinjury inflammat

180 cripts (0.94 vs. 1.67, p < 0.05), as well as basic science manuscripts (0.21 vs. 0.54, p < 0.05) and

181 sed materials, with numerous applications in basic science, materials engineering, and biotechnology.

182 ic research and a perception that success in basic science may no longer be achievable.

183 choice of anti-inflammatory agent given the basic science mechanisms and epidemiologic results that

184 te to human adulthood, with consequences for basic science, medicine, and public policy.

185 Basic sciences, microbiology, infectious diseases, and p

186 r the MA are taking up new challenges in the basic science needed to assess, project, and manage flow

187 The way forward is to invest more in basic science, not less.

188 avenues to advance OPV technologies and the basic science of charge transfer in organic semiconducto

189 r materials could contribute not only to the basic science of fullerene chemistry but would also be u

190 has two major objectives: first, to sketch a basic science of intentional change centered on evolutio

191 "translational nanotechnology" as it bridges basic science of nanomaterials with practical applicatio

192 To begin organizing the basic science of psychiatry in a comprehensive manner, w

193 how that this issue is deeply related to the basic science of soft matter, especially to the viscosit

194 ropathies has in turn driven progress in the basic science of telomere biology.

195 What began as three questions of basic science one half-century ago has now grown into th

196 PubMed databases from inception to 2013 for basic science or clinical studies relating to genetic as

197 f the BPH literature with a special focus on basic science or translational studies concerned with th

198 in use today, research has tended to be more basic-science oriented rather than commercially applicab

199 ed by article type (clinical, population, or basic science; P=0.19), whether an article had an editor

200 Jak/STAT research has not only impacted basic science, particularly in the context of intercellu

201 elucidate these complex circuits both from a basic science perspective and in the context of psychiat

202 hese rich phenomena are fascinating from the basic science perspective and offer possibilities for te

203 Moreover, from a basic science perspective, CRAC channels exhibit a uniqu

204 y relevant and of particular interest from a basic sciences perspective due to the complex nature of

205 aused the steady drop in the number of young basic-science PIs and could reduce future US discoveries

206 this time, the PI success ratio (fraction of basic-science PIs who are R01 grantees) dropped for youn

207 Basic sciences play the role of stem cells, providing ma

208 article explores the latest developments in basic science presented at the Congress which may offer

209 hlights how translation of these advances in basic science promises to change clinical practice.

210 at recent young surgeons published 59% fewer basic science publications (IRR 0.41, 95% CI 0.29-0.57,

211 rating that statistical errors are common in basic science publications have led to calls to improve

212 ng tunnel junctions from these materials for basic science purposes and applications.

213 sional training of cancer researchers in the basic sciences rarely involves interactions with patient

214 summarizing progress in clinical trials and basic science redefining the diagnosis and treatment of

215 prospective randomized clinical trials, and basic science reports, were identified in a PubMed searc

216 decline in the number of surgeons performing basic science research alongside clinical activity - so-

217 e the potential to advance both clinical and basic science research and practice.

218 Basic science research articles, review articles, case r

219 esearch faculty, 33.6% exclusively conducted basic science research as principal investigators compar

220 ts in this field that are paving the way for basic science research discoveries to transition to clin

221 As both clinical and basic science research expands our understanding of TIC,

222 For the greater part of the last century, basic science research has been limited to in vitro stud

223 However, funding for basic science research has not kept up, such that we are

224 Insights from basic science research have helped elucidate the mechani

225 e challenges confronting surgeons performing basic science research in today's academic surgery envir

226 on (MI) are important for the translation of basic science research into bedside medicine.

227 hey had a good understanding for translating basic science research into clinical practice, and 77.2%

228 Despite recent progress, further basic science research into the autoimmune process is ne

229 rgeted agents for therapeutic use, much more basic science research is required before we fully under

230 University basic science research laboratory.

231 The past decade has seen advances in basic science research of neural repair in stroke.

232 Owing to relatively rapid translation of basic science research on a novel regulatory pathway of

233 urope, and Australia engaged in clinical and basic science research on ALPS and related disorders.

234 This review will first discuss the basic science research performed in healthy monkeys that

235 tiary PAH centers often support clinical and basic science research programs to gain novel insights i

236 Today, more than ever, basic science research provides significant opportunitie

237 RECENT FINDINGS: Basic science research shows us that varicoceles exert d

238 ove their communication skills by explaining basic science research to a general audience, and studen

239 It enhances interest and support of basic science research while providing opportunities for

240 reatment will require a rapid translation of basic science research, and the simultaneous development

241 eated; opportunities for proteomics to drive basic science research, facilitate clinical translation,

242 Basic science research, involving solid-state chemistry

243 espread use in both clinical diagnostics and basic science research, nearly all methods require direc

244 d 9 technology, the impact on cardiovascular basic science research, possible therapeutic application

245 ng to encourage participation of surgeons in basic science research, translational research, clinical

246 food safety, and public security as well as basic science research.

247 mainly for vaccines and microbicides), or to basic science research.

248 or clinical diagnostics, drug discovery, and basic science research.

249 s 1.7 years, with 72% of trainees performing basic science research.

250 aving a substantial effect on cardiovascular basic science research.

251 cation of knowledge generated by advances in basic sciences research translated into new approaches f

252 earchers were significantly more likely than basic science researchers (41.9%) to report a relationsh

253 trainees; pharmacists; and translational and basic science researchers from the Pediatric Acute Lung

254 red, a proportion that ranged from 11.5% for basic science researchers to 46.8% for health services r

255 the field, and propose ways to translate the basic science results as well as the mechanistic underst

256 ory of T1 translational research-translating basic science results into new interventions-and T2 tran

257 ith those suggested by the epidemiologic and basic science results.

258 he increasing use of RNA-seq in clinical and basic science settings provides a powerful opportunity t

259 Basic science studies demonstrating disparate regulation

260 Many clinical and basic science studies have provided important insights i

261 Translation of these basic science studies into clinically valuable biomarker

262 le to translate the discoveries derived from basic science studies into the clinical care of the pati

263 Basic science studies investigating nutritional modulati

264 Our findings, in conjunction with basic science studies on erythropoietin and erythropoiet

265 While basic science studies show repeated and chronic stress e

266 Meanwhile, a variety of basic science studies testing different exercise protoco

267 his timely review will focus on clinical and basic science studies that have greatly advanced our kno

268 We present findings from clinical and basic science studies to help gastroenterologists naviga

269 Clinical trials and basic science studies without statistically significant

270 vides a realistic human cell based model for basic science studies, identification of new treatment t

271 e bulk of research is limited to preclinical basic science studies.

272 measure histologic patterns for clinical and basic science studies.

273 putational reinforcement-learning models and basic-science studies of the dopamine system, we show th

274 ging evidence from epidemiologic studies and basic science suggests an inverse association between me

275 diagnosis of prostate cancer, highlight the basic science supporting this role, and analyze the phas

276 eering and opened countless possibilities to basic science, synthetic biology and gene therapy.

277 in vivo may ultimately have applications in basic science, technology and therapeutics.

278 nd cellular specificity has been greater for basic science than clinical research, it is natural to a

279 S: This review will focus on two advances in basic science that are now translating into clinical tri

280 In basic science, the conditions of an experiment can be se

281 arly-stage translation of the discoveries in basic science, the National Institutes of Health and the

282 Just as in basic science, this approach to research can facilitate

283 amine future opportunities in this area from basic science to applied technology.

284 Cancer models relating basic science to clinical care in oncology may fail to a

285 therapies are rapidly transitioning from the basic science to clinical care.

286 hly desired for applications that range from basic science to healthcare.

287 pplication including hypothesis testing from basic science to precision medicine.

288 eries and innovations move from the realm of basic science to preclinical and clinical applications,

289 ut the translational research continuum from basic science to public health.

290 All aspects of the field of itch, from basic science to quality of life to therapeutics, are mo

291 atter interactions with impacts ranging from basic science to technological applications.

292 Promising advances are being translated from basic science to the clinic, including approaches to dis

293 suggest potential applications ranging from basic science to the clinic.

294 education, specifically, the teaching of the basic sciences to accomplish the goal of improved integr

295 from the bench-to-bedside framework by which basic science transitions to clinical treatment.

296 The importance of continued basic science, translational, and animal studies for pro

297 ortion of academic surgeons who are pursuing basic science/translational research, which represents a

298 Further delineation of the basic science underlying BRCA network function holds pro

299 e discoveries emphasize the critical role of basic science, which often evolves in unpredictable and

300 Ongoing basic science work has provided considerable new insight