ライフサイエンスコーパス: basicity

1 Co(+) has substantially higher stability and basicity.

2 as arginine-mimicking groups with modulated basicity.

3 was improved on decreasing the central amine basicity.

4 lity to hydrolysis was found to correlate to basicity.

5 , we noted a similar light-induced change in basicity.

6 on constants decrease with decrease of anion basicity.

7 a previously undetected isomer with enhanced basicity.

8 r Friedel-Craft reactions, due to their high basicity.

9 d removal of functional groups that mitigate basicity.

10 its energy, which is a measure of the sigma-basicity.

11 bulky base is of sufficiently high Bronsted basicity.

12 shes the rate of hydrolysis by lowering N(7) basicity.

13 gnificantly changes these groups' acidity or basicity.

14 ux was fine-tuning of hydrogen bond acceptor basicity.

15 ion of imidazole to pyrimidine decreases its basicity.

16 and substrate binding to reach the required basicity.

17 idic sites, while simultaneously introducing basicity.

18 city with respect to a thiolate with similar basicity.

19 rather than inhibited by increasing solvent basicity.

20 which are known to potently affect the TAML basicity.

21 onses for H2Pc correlated with hydrogen-bond basicity.

22 ectively, displaying both Bronsted and Lewis basicity.

23 ms were investigated with respect to analyte basicity.

24 on of electron-withdrawing groups lowers the basicity.

25 complexes containing N-donor ligands of low basicity.

26 bI3) crystals as a response to environmental basicity.

27 high nucleophilicity despite relatively low basicity.

28 push-pull nitrogen bases exhibit a very high basicity.

29 is CH or N, display an exceptionally strong basicity.

30 sts confirm trends consistent with predicted basicities.

31 he presence of two amino groups of different basicities.

32 ds correlate only poorly with their Bronsted basicities.

33 viding experimental values for diarylcarbene basicities.

34 gma-donating ability, and Bronsted and Lewis basicities.

35 that is supported by experimental gas-phase basicities.

36 obicity and medium hydrogen bond acidity and basicity (a), and the cluster IV micellar systems are ch

37 rt quantitatively correlates to polarity and basicity, a relationship we formalize as the lipid perme

38 s used to link the observed results with the basicity/acidity of the reactants.

39 amate with several amines possessing varying basicities and nucleophilicities: n-butylamine, diethyla

40 tional design, oxazinoindolines with varying basicities and tunable absorption bands that extend to t

41 l properties such as hydrophobicity, acidity/basicity and conformation of the specific side chains an

42 ction in vivo with low permeability and high basicity and demonstrate that nonspecific binding to lun

43 TU is used to vary the strength of the Lewis basicity and demonstrate that the strength of the TU-met

44 "...no correlation between the thermodynamic basicity and E2 rate should be expected." Our analyses,

45 ttention paid to maintaining the appropriate basicity and limiting the number of H-bonding donors of

46 ysicochemical properties of these compounds (basicity and lipophilicity) and analyzed their ability t

47 heir preparation is often complicated by the basicity and nucleophilicity of nitrogen, its susceptibi

48 nyl oxygen, in spite of the reverse order of basicity and nucleophilicity of the carbonyl group and t

49 n low dielectric solvents due to the reduced basicity and nucleophilicity of the negatively charged c

50 y of TBD is a consequence of both its higher basicity and nucleophilicity than TBO as well as the hig

51 and molecular modeling show that increasing basicity and optimal alkyl chain length enhance use-depe

52 The basicity and other properties of quinolinoquinolines can

53 y of the 8-phenoxy substituent to lower N(7) basicity and predict a preference for N(3)-protonation f

54 nships were identified based on the Bronsted basicity and redox potential of the active site, explain

55 using two approaches: increasing the overall basicity and reducing molecular weight of the lead.

56 The high Lewis basicity and small ionic radius of fluoride promote the

57 es and found a strong correlation between N5 basicity and the conformation of the Met(20) loop.

58 g occurs via a synergistic action of amines' basicity and the progressively more curved backbone of t

59 inclusions can be reduced by increasing the basicity and the ratio of CaO to Al(2)O(3) in the initia

60 The basicity and, to a lesser extent, ionization potential o

61 ged hydrotalcite support provides sufficient basicity (and buffer) for the catalytic reactions; thus,

62 tical evaluation of the electron affinities, basicities, and H-atom transfer kinetics and thermodynam

63 ice responses for CoPc correlated with Lewis basicity, and device responses for H2Pc correlated with

64 cluding the anions' charge, size, hydration, basicity, and hydrogen-bond acceptor abilities.

65 ent catalysts, including surface properties, basicity, and microstructure.

66 ctrostatic interactions, sequence, gas-phase basicity, and molecular geometry in determining the stru

67 nts with solvent parameters such as acidity, basicity, and polarity/polarizability from Catalan's sca

68 Basicities are enhanced by the lone-pair possessing atom

69 dary beta-deuterium isotope effects on amine basicities are measured using a remarkably precise NMR t

70 rface Bronsted and Lewis acidity and surface basicity are treated in detail.

71 population, as well as the pi-acidity and pi-basicity, are related to the pi-MOs.

72 ganolithium reagent possesses relatively low basicity at low temperature, and is compatible with a va

73 reducing agent while moderate Lewis acidity/basicity at the active centers promotes catalysis by rel

74 pyrazolate > triazolate), metal (relative pi-basicity Au > Cu > Ag), and ligand substituents.

75 sulting in sites with the greatest gas phase basicities being, in large part, unreactive.

76 r b and y ions reveal that the difference in basicity between Arg and Lys results in different dissoc

77 By taking the advantage of difference in basicity, both products can be obtained in good purity.

78 Outside of the range of solvent basicity bounded at the lower end by dichloromethane and

79 ines for a more rational design regarding PA/basicity but also suggesting that NHOs could be specific

80 obicity and medium hydrogen bond acidity and basicity but rather weak dipolarity.

81 on at any position of pyridine increases the basicity, but the IE per deuterium is largest for substi

82 Deuteration definitely increases the basicity, by approximately 0.021 in the Delta pK per D.

83 These changes in acidity or basicity can lead to carboxylate salts forming carboxyli

84 Loss of basicity can result in catalytically impaired enzymes.

85 rge zeolites because of their unusually high basicity combined with their large size and rigidity.

86 side the typical range for pyrrolidines with basicities comparable to those of imidazolidinones.

87 macromolecules show superior pi-acidity and -basicity compared to their organic counterparts.

88 n of the equilibrium was sensitive to ligand basicity, conjugate acid strength, solvent polarity, and

89 When the solvents and anions have comparable basicity, contact ion pairs of the type [H(3)O(+).nSolv.

90 cleave alkane C-H bonds is due to its strong basicity coupled with large reduction potentials of near

91 li metal), the experimentally measured local basicity decreased in the order Li(+) > Na(+) > K(+) > C

92 itrophenylhydrazine based on their gas-phase basicities (DeltaG(deprotonation)).

93 izability descriptor S and the hydrogen bond basicity descriptor B.

94 The paradoxically low basicity (despite high anionicity) of oxygen in the char

95 rg, indicating that differences in intrinsic basicity do not play a role in the relative SB stabiliza

96 The acidity/basicity effects of the electrolytes arise in part from

97 The decrease in basicity enhanced the binding of carbamylated sulfopepti

98 and 2, compounds 6 and 7 display rather high basicity, forming chelated monocations.

99 theoretically determine intrinsic gas-phase basicities (GB, DeltaG for deprotonation of the protonat

100 d thermochemistry parameters, like gas-phase basicity (GB) and proton affinity (PA).

101 to a significant reduction in the gas-phase basicity (GB) of the phosphate group when bound to {LGa2

102 ry and secondary amines of varying gas-phase basicity (GB) were investigated using infrared multiple

103 cid)) and proton affinity (PA, and gas phase basicity (GB)) of adenine, guanine, and O(6)-methylguani

104 sorption of the anions, while solute H-bond basicity has a negative effect.

105 capability was found to increase with their basicity (i.e., pKa of their conjugated acids, BH(+)), c

106 ariation of the bridging ligand (relative pi-basicity imidazolate > pyridiniate > carbeniate > pyrazo

107 xperimentally supported very high (pKa > 40) basicities in acetonitrile, which cannot be directly mea

108 Most investigated pyrrolidines have basicities in the range 16 < pK(aH) < 20, while imidazol

109 A good correlation between basicities in THF and acetonitrile spanning 25 orders of

110 ion center, thereby increasing the intrinsic basicity in the gas phase, while the bulk prevents effic

111 x stability was mainly affected by the anion basicity in the presence of monocarboxylates, whereas th

112 hibition were dependent on lipophilicity and basicity in this series.

113 The photoswitching of Sp induces a large basicity increase in the polymeric phase, which triggers

114 numbers of aminophenyl groups, the relative basicity increased and the hyperporphyrin effect increas

115 by metal ion Lewis acidity and solvent Lewis basicity, indicating that C-H deactivation can be modula

116 e trend in redox potentials, indicating that basicity is a key factor in determining the striking dif

117 lattice oxygen species with strong Bronsted basicity is a significant feature in such heterostructur

118 fies amines without sacrificing their native basicity is developed.

119 Amine basicity is the primary controller of detection.

120 ates that the dominant term causing the high basicity is the relaxation energy.

121 rd the active site to increase the residue's basicity) is positioned to act as a general base, abstra

122 ide toward VX, in contrast to their relative basicity, is discussed.

123 k of a general correlation between the Lewis basicities LB(I) (with respect to Ar(2)I(+)) and LB (wit

124 idities LA(I) for 17 iodonium ions and Lewis basicities LB(I) and s(I) for 10 Lewis bases.

125 The Lewis basicity (LB) and nucleophilicity (N, s(N)) parameters o

126 (LA) of the benzhydrylium ions and the Lewis basicity (LB) of the phosphines, pyridines, etc.

127 The importance of ferryl basicity lies in its connection to our fundamental under

128 nd phosphate salts are milder, but their low basicity limits the scope of their reactions.

129 not meet the stringent requirements of weak basicity, low polarizability of high chemical stability,

130 roperties of a suitable counterion: very low basicity, low polarizability, and high chemical stabilit

131 Solvent basicity measures such as Donor numbers and beta values

132 nts an analysis of the exceptional gas-phase basicity, mostly in terms of experimental data, in relat

133 ed by the ultrasmall PtNCs and Lewis acidity/basicity/nanoconfinement endowed by UiO-66-NH2 , Pt@UiO-

134 atic amines (characterized by very different basicities/nucleophilicities) and three anilines have be

135 cidity (electrophilicity), and hydrogen-bond basicity (nucleophilicity).

136 yridine 14a (pKa = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of

137 Basicities of 47 compounds (around half of which are new

138 values are in good agreement with the sigma basicities of all of the rNHCs.

139 ate for substitution reactions; however, the basicities of bromide and trifluoroacetate are reversed

140 Secondary deuterium isotope effects (IEs) on basicities of isotopologues of trimethylamine have been

141 Experimental basicities of some of the strongest superbases ever meas

142 boranes > oxyanions, reflecting the relative basicities of the anions.

143 The basicities of the compounds were evaluated by potentiome

144 nature of the guest, shifts in the effective basicities of the encapsulated amines of up to 4.5 pK(a)

145 Basicities of the pyridinols approached physiological pH

146 Basicities of the two amines determine the threshold pH

147 Secondary isotope effects (IEs) on basicities of various deuterated pyridine isotopologues

148 In addition, the basicity of a 2,3-bis(dialkylamino)cyclopropenimine is m

149 reducibility of H(+), and the high gas-phase basicity of Ac(-) and (ii) a reproducible LC separation

150 (H0) is not realized in practice because the basicity of an added base is suppressed by Lewis acid/ba

151 [reaction: see text] The basicity of an amine has a great impact on physicochemic

152 The strong basicity of biomolecules containing a push-pull nitrogen

153 ation of the cation scales linearly with the basicity of carborane anions on the nuNH scale.

154 ry, yet little has been done to modulate the basicity of compounds.

155 s a host to dramatically shift the effective basicity of encapsulated protonated amine guests.

156 Predictions are made for hydrogen bond basicity of fluorine in situations where relevant experi

157 roxyethyl flip results in both the decreased basicity of Glu166 and a significant increase in the dis

158 ygen-reduction turnover number and the Lewis basicity of graphitic carbon support (accessed via C 1s

159 kely facilitates catalysis by increasing the basicity of H154.

160 4 and 9.3, respectively, indicating that the basicity of His-464' in TrxR in complex with its substra

161 enhance the substrate binding, increase the basicity of His143, strengthen the catalytic role of zin

162 her Nudix enzymes, is not due to the greater basicity of histidine, since the pK(a) of E124 in the ac

163 19g on STK17B was attributed to the reduced basicity of its pyrimidine N1.

164 Under pyrolytic conditions the acidity/basicity of Maillard reaction mixtures can be controlled

165 as been used to assess the pi-acidity and pi-basicity of metal-organic trimetallic macromolecular com

166 Deuteration is found to increase the basicity of methylamine, dimethylamine, benzylamine, N,N

167 To attenuate the basicity of morpholine, a bicyclic amine was designed an

168 th the Lewis acidity of the aluminum and the basicity of nearby oxygens, hence the high reactivity of

169 licate its chemical synthesis because of the basicity of nitrogen atoms and their susceptibility to o

170 ks our study with Laurence's scale of H-bond basicity of organic molecules.

171 o lower C-H activation barriers, because the basicity of oxygen adatoms increases with coverage and t

172 face is most likely due to the high Bronsted basicity of oxygen, our model could be a more general pi

173 e important factor than the higher gas-phase basicity of PABAOMeH(+) in stabilizing protonation at th

174 However, owing to the basicity of the -amino group in lysine, this strategy ge

175 e catalyst resting state(s) depending on the basicity of the alkyl ether.

176 factor could be traced back to the relative basicity of the alternative products (migrated vs nonmig

177 that K218A activity rescue depended upon the basicity of the amine.

178 etonitrile and decreased with the decreasing basicity of the anion (CH(3)COO(-) > C(6)H(5)COO(-) > H(

179 luene coordination increases with decreasing basicity of the anion (i.e., decreasing pK(a) of the cor

180 luorogenic substituent, the solvent, and the basicity of the anion.

181 strate coordination step correlates with the basicity of the anionic ligands coordinated to Pd(II), a

182 hydridotris(pyrazolyl)-borate) enhances the basicity of the arene ligand to the point that it can be

183 uents in the aromatic ring that increase the basicity of the aromatic amine.

184 is observed and taken as evidence for a high basicity of the aryl anion.

185 fine tune this reactivity by considering the basicity of the attached functionality.

186 CO2 hydrogenations: the steric bulk and the basicity of the base.

187 ing force for proton transfer, enhancing the basicity of the carboxylate also decreases the equilibri

188 at pH < 6 and an ~2 pK unit decrease in the basicity of the carboxylate side chain of Glu-167 at the

189 pieces are consistent with a decrease in the basicity of the carboxylate side chain of Glu-167 for th

190 there is a large ~6 pK unit increase in the basicity of the carboxylate side chain of Glu-167 upon b

191 This reflects the large increase in the basicity of the carboxylate side chain of Glu-167 upon b

192 transfer driving force depends mainly on the basicity of the carboxylate, which is influenced by the

193 role in effecting the large increase in the basicity of the catalytic base upon the binding of subst

194 esence of Glu(78) and Glu(122) modulates the basicity of the catalytic groups.

195 By reducing the basicity of the core heterocycle in a series of HCV NS5B

196 w the unique directional bonding and varying basicity of the decaniobate ([Nb(10) ]) oxo-caps can be

197 of proton transfer mechanisms shows that the basicity of the dioxo dianion and the hydroperoxo-iron (

198 acilitates this reactivity by increasing the basicity of the distal oxygen.

199 nes are then used to calculate the effective basicity of the encapsulated amines.

200 xidation potential has a compensating higher basicity of the ferryl oxygen.

201 system and induces a strong decrease in the basicity of the guanidine moiety.

202 correlate with the size rather than with the basicity of the guests.

203 he adjacent carbonyl group and decreased the basicity of the hydroxyl group of the CF3 amino alcohol

204 The strong Bronsted basicity of the iminophosphorane moiety of the catalyst

205 The basicity of the ipso-carbon atom of the pincer ligand wa

206 ous adducts are discussed in relation to the basicity of the Me(n)H(3-n)N fragment.

207 Control of the basicity of the media allows further discrimination of t

208 becomes more stable with an increase in the basicity of the medium.

209 enerally increases with increasing gas-phase basicity of the N-terminal amino acid, but only ArgArg x

210 the side chain of N-terminal Asp reduces the basicity of the N-terminal amino group and, as hence, it

211 Calculated basicity of the N-terminus of tubulysins was shown to be

212 th a concomitant substantial decrease in the basicity of the N1H sites (pKa approximately 7.0 in CD3C

213 e extra carbonyl group, which diminishes the basicity of the nitrogen atom, thereby retarding the rin

214 Quantitative estimates of the basicity of the nitrogen atoms were obtained using conce

215 ivity of these amides; it also increases the basicity of the nitrogen so that it often behaves more l

216 t the process, it appeared that the moderate basicity of the nitroso compound plays a crucial role to

217 The basicity of the nucleophile as well as solvent effects c

218 x potiental of the complexes, suggesting the basicity of the oxo ligand is a major contributor to the

219 avior can be explained in the context of the basicity of the oxo ligands that leads to different mech

220 ination of the aminoisoquinoline reduced the basicity of the P1 group and significantly improved perm

221 Despite the basicity of the parent amido ligand and the typically fa

222 Further SAR on reducing the basicity of the piperidine and introducing polarity led

223 ions here, largely associated with the Lewis basicity of the polar co-monomers.

224 the pushing amino-group(s) and increases the basicity of the pulling cyano, imino, or phosphoimino gr

225 nd pulling groups in such systems lowers the basicity of the pushing amino-group(s) and increases the

226 harge-transfer states leading to an enhanced basicity of the pyridine (pKa* approximately 12) and enh

227 functionalities are observed to increase the basicity of the quinolinoquinoline moiety, while the sub

228 ions also changed according to the intrinsic basicity of the rescuing nucleobase, providing further e

229 Systematic variation of the branching and basicity of the side chain of chloroquine yielded a seri

230 extreme to the other by increasing the Lewis basicity of the solvent, and the equilibrium E/Z ratio g

231 complexes is basic with a pK(a) of 28.3; the basicity of the terminal oxo ligand in the Mn(IV)(O) com

232 f the open-shell radical is derived from the basicity of the tert-butylimino group and the intramolec

233 e carried on the carboxyl group, whereas the basicity of the tropylium ion facilitates cation export.

234 as the hydrogen bond partners to adjust the basicity of the water molecule.

235 The solution basicity of the well-known t-Bu-N horizontal lineP4(dma)

236 relief on protonation largely determines the basicity of these compounds, and the key to the design o

237 ed)piperidin-4-yl ring to exploit the higher basicity of this nucleus and for the the possibility to

238 pose that there is a similar increase in the basicity of this side chain when the physiological subst

239 hould provide reliable information about the basicity of valine and other aliphatic amino acids.

240 ng on the electron-donating abilities (Lewis basicity) of anions and electron-accepting abilities (pi

241 The donor capacity (basicity) of the anionic subunit in these zwitterions is

242 ed have been explained in terms of substrate basicity, of the distance between the two basic centers

243 or enthalpic and entropic stability (and low basicity) on permethylated Si-O-Si linkages.

244 ons observed for analytes of lower gas-phase basicity or higher electron affinity than O2.

245 ities of anions generally follow their Lewis basicity order, whereas pi-acidity of NDIs can be fine-t

246 cific affinities of Lewis bases by the Lewis basicity parameter LB(I) and the susceptibility s(I).

247 It is found that the decrease in basicity, per deuterium, increases with the number of de

248 In contrast, when the low Lewis basicity phosphane containing alkyne (C6F5)2P-C identica

249 The Bronsted basicities pK(aH) (i.e., pK(a) of the conjugate acids) o

250 ng equilibrium constants (log K) or Bronsted basicities (pK(aH)) do not show enhanced nucleophiliciti

251 in vivo activity within a range of measured basicity (pK(a) = 6.0-6.6) and lipophilicity (cLogD = 10

252 The obtained rates have been related to the basicity (pK(aH) in water and K(b) in benzene) or nucleo

253 nalyte adsorption is largely affected by the basicity (pKb) of surface groups.

254 o be an effective predictor of hydrogen bond basicity (pKBHX), and predictive models are presented fo

255 London dispersion, hydrogen-bond acidity and basicity, polarizability and lone-pair electrons.

256 estimated gas-phase enthalpies of formation, basicities, proton and electron affinities, and adiabati

257 (3 to 106) x 10(-5) s(-1), while the amidine basicity ranged over 5 pK(a) units.

258 amental properties of carbenes, particularly basicity, remain poorly understood.

259 ol addition by providing the strong Bronsted basicity required for rapid aryl enolate formation.

260 ngement of the polycationic amines and their basicity requirements to fulfill outer membrane destabil

261 s molar refraction, and hydrogen acidity and basicity, respectively; and ai is the sorbate's aqueous

262 luorine in the piperidine ring to reduce its basicity, resulting in attractive oral pharmacokinetic (

263 f one of these inhibitors, which reduced its basicity, resulting in compounds with monocationic chara

264 e2 group, contrary to the "aniline-pyridine" basicity rule.

265 een the solvent donor number (DN) or solvent basicity (SB) parameters and the change in the Cotton ef

266 observed is used to provide a relative Lewis basicity scale of nine ionic liquids commonly used as so

267 compounds, the experimental self-consistent basicity scale of superbases in THF, reaching a pKalpha

268 l(-1)) and bridges the gas-phase acidity and basicity scales for the first time.

269 ease in the negative D with increasing Lewis basicity (shortening of the Co-N bond distances) of the

270 factors, including molecular hydrophobicity, basicity, solution composition, and instrumental paramet

271 presence of not just N2 but also much higher-basicity solvents.

272 s representing a continuum of nitrogen Lewis basicity strength suggests how the strength of N-Zn bind

273 nder extreme conditions of super acidity and basicity, strong irradiation field, and high ionic stren

274 compiled scale is a useful tool for further basicity studies in THF as well as in other solvents, in

275 y occurring amino acids have lower gas phase basicities than the side chains of the basic amino acids

276 These halides have less basicity than the common RIs in negative mode (NO(2)(-),

277 vity of the rate constant to the carboxylate basicity than to the redox potential of the oxidant.

278 s are much more sensitive to the carboxylate basicity than to the redox potential of the oxidant.

279 trimers are found to exhibit pi-acidity and -basicity that can be systematically tuned both coarsely

280 in elucidating factors, such as terminal oxo basicity, that may control ferryl reactivity.

281 rogen bond acidity, the solute hydrogen bond basicity, the solute dipolarity/polarizability, the inte

282 gen bond networks can substantially increase basicity through stabilization of the resultant conjugat

283 clization rates by nucleophile proximity and basicity, through detailed analyses of starting material

284 ionic liquid (IL) electrolytes with tailored basicities to solvate SO2 by reversible chemical absorpt

285 rograms it is relatively common to attenuate basicity to circumvent undesired effects such as lack of

286 ted piperidine moieties, thus modulating the basicity to improve the hydrophilic/lipophilic balance.

287 alysts appears to be due to their high Lewis basicities toward neutral electrophiles as quantified th

288 Analysis of structure-basicity trends is presented.

289 However, functional-group Lewis basicity typically depresses catalytic activity and co-m

290 The remeasured basicity values are in close agreement with the values r

291 Previously established gas-phase basicity values were remeasured for LIAD-evaporated orga

292 Linear correlations of ten superbase basicities vs that of their substituents demonstrated th

293 Apparent basicity was verified to be an effective indicator for t

294 Hence, using dopants with appropriate basicity, we could suppress the fragment peaks and obtai

295 eakly basic structural isomers with variable basicity, we illustrate that the magnitude of the pKa va

296 ucturally modified forms of DNR with reduced basicity were synthesized, and their intracellular distr

297 Physicochemical properties (polarity and basicity) were considered to guide the design process.

298 hrinkage of CO2 bubbles occurred with higher basicity, while an increased expansion of CO2 bubbles wa

299 ders of magnitude in CH2Cl2 as well as Lewis basicities (with respect to C-centered Lewis acids) for

300 ly, polar analytes with pronounced gas phase basicities worked best, nonpolar and amphoteric compound