ライフサイエンスコーパス: basilar membrane

1 ts along the cochlea, similar to that of the basilar membrane.

2 traveling wave to amplify the motion of the basilar membrane.

3 nd that the stapes vibrates earlier than the basilar membrane.

4 lieved to provide mechanical feedback to the basilar membrane.

5 orce acting between the reticular lamina and basilar membrane.

6 through waves that propagate on the elastic basilar membrane.

7 thus has an equivalent role to the mammalian basilar membrane.

8 amina, but only a slow tuned response of the basilar membrane.

9 ously measured close to the sensory tissue's basilar membrane.

10 increases the sound-evoked vibrations of the basilar membrane.

11 line in motion amplitude occurred across the basilar membrane.

12 ular lamina, to the transverse motion of the basilar membrane.

13 fer of electrical to mechanical power at the basilar membrane.

14 on caused motion of a minimal portion of the basilar membrane.

15 seen when the beam was directed towards the basilar membrane.

16 interferometry to measure vibrations of the basilar membrane.

17 and were enhanced compared with those at the basilar membrane.

18 f sensory and supporting cells riding on the basilar membrane.

19 ng the organ of Corti than in displacing the basilar membrane.

20 nge well below the resonant frequency of the basilar membrane.

21 decouples active hair-bundle forces from the basilar membrane.

22 ar to be related in part to the width of the basilar membrane.

23 rvating different loci on the left and right basilar membranes.

24 rwise damped sound-induced vibrations of the basilar membrane [2-4], a mechanism known as negative da

25 erilymphatic chloride level manipulations of basilar membrane amplification in the living guinea pig.

26 by the passive mechanical properties of the basilar membrane and active feedback from the outer hair

27 ound stimuli from hair cell receptors in the basilar membrane and are arranged tonotopically.

28 ncy ratio, and measured as vibrations at the basilar membrane and at the stapes, and as sound pressur

29 of OHC electrical activity, pressure at the basilar membrane and basilar membrane displacement gave

30 , likely by the mechanical properties of the basilar membrane and organ of Corti.

31 is fully expressed in the vibrations of the basilar membrane and renders unnecessary additional ("se

32 ed by measuring the phase difference between basilar membrane and stapes vibrations.

33 ugh the fluid-tissue interaction between the basilar membrane and the fluid in scala tympani (ST) has

34 pled fluid-structure interaction between the basilar membrane and the scala fluids.

35 hese mice have a low-frequency hearing loss, basilar-membrane and neural tuning are both significantl

36 al coupling between adjacent sections of the basilar membrane, and such coupling may be critical for

37 o Deiters' cells, the sulcus epithelium, the basilar membrane, and the surface of the spiral limbus.

38 partition and active frequency tuning of the basilar membrane are enhanced in the cochleae of CD-1Cx3

39 ratchet: Sound-evoked forces, acting on the basilar membrane, are transmitted to the hair bundles, w

40 ibited considerable re-growth of PAFs in the basilar membrane area.

41 s as compression waves rather than along the basilar membrane as backward-traveling waves.

42 timulation of the cochlear bone vibrates the basilar membrane as well.

43 to a constant suppressor displacement on the basilar membrane (as in experiments with wild-type anima

44 the extracellular voltage referenced to the basilar membrane at a frequency approximately one-half o

45 isplacements of the reticular lamina and the basilar membrane at the 19 kHz characteristic place in g

46 body vibrations normal to the surface of the basilar membrane (BM) at 0.8 (d(1)), 5.8 (d(2)), 15.6 (d

47 The mammalian basilar membrane (BM) consists of two collagen-fiber lay

48 Sound-evoked vibrations of the basilar membrane (BM) in anaesthetised guinea-pigs are s

49 Within the cochlea, the basilar membrane (BM) is coupled to the reticular lamina

50 The basilar membrane (BM) of the mammalian cochlea constitut

51 changing the timing of its feedback, altered basilar membrane (BM) responses to tones at all measured

52 Using a laser velocimeter, basilar membrane (BM) responses to tones were measured i

53 -otoacoustic-emissions (DPOAEs), and passive basilar membrane (BM) responses.

54 ounts of energy as passive, pressure-driven, basilar membrane (BM) traveling waves.

55 served to propagate longitudinally along the basilar membrane (BM) ultimately stimulate the mechano-s

56 h in vivo physiological measurements for the basilar membrane (BM) velocity, V(BM), frequency tuning

57 IHCs respond to basilar membrane (BM) vibration by producing a transduce

58 rimentally tested in this study by measuring basilar membrane (BM) vibrations at the cubic distortion

59 ween internal structures such as hair cells, basilar membrane (BM), and modiolus with external surfac

60 ty, harmonic distortion, and DC shift on the basilar membrane (BM), tectorial membrane (TM), and OHC

61 situated within the organ of Corti atop the basilar membrane (BM), which supports sound-evoked trave

62 m to be observed in vivo at the level of the basilar membrane (BM).

63 the cochlear organ of Corti that rest on the basilar membrane (BM).

64 comparisons of the magnitudes and phases of basilar-membrane (BM) vibrations and auditory-nerve fibe

65 nds on not only the passive mechanics of the basilar membrane but also an active amplification of the

66 duced comparable amplitudes of motion of the basilar membrane but differed in the polarity of their f

67 fferences in wave propagation time along the basilar membrane can provide the necessary delays, if th

68 h constrain outer hair cells standing on the basilar membrane, causes a leftward shift in outer hair

69 region is restricted to a 1.25 mm length of basilar membrane centered on the 15 kHz place.

70 resenting ~25% basicranial width, and a long basilar membrane, collectively suggest that the kind of

71 Maturation of the supporting cells and the basilar membrane commenced first in the middle turn.

72 gy is that tuned mechanical vibration of the basilar membrane defines the frequency response of the i

73 As a means to verify the computer model, the basilar membrane deformations because of static and dyna

74 tivity, pressure at the basilar membrane and basilar membrane displacement gave direct evidence for p

75 tory nerve fibers closely paralleled that of basilar membrane displacement modified by high-pass filt

76 as been considered to be proportional to the basilar membrane displacement or velocity.

77 generated extracellular voltage relative the basilar membrane displacement, which was initiated at a

78 ve relations between transducer currents and basilar membrane displacements are lacking, as well as t

79 sured acoustically and electrically elicited basilar membrane displacements from the cochleae of wild

80 Basilar membrane displacements in response to characteri

81 continuous minor adjustments of tone-evoked basilar membrane displacements over their entire dynamic

82 Such faint sounds produce 0.1-nm basilar membrane displacements, a distance smaller than

83 to cochlear filtering that is independent of basilar membrane filtering.

84 hick fibers that coursed radially across the basilar membrane in small fascicles, gave off small bran

85 to pure-tone stimuli were recorded from the basilar membrane in the basal turn of the guinea-pig coc

86 on (reflecting the nonlinear response of the basilar membrane in the cochlea), followed by linear sum

87 At the level of the basilar membrane in the cochlea, a tonotopic arrangement

88 between measured frequency responses of the basilar membrane in the inner ear and the frequency tuni

89 er hair cells, which transduce motion of the basilar membrane induced by sound and generate forces to

90 Acoustic stimulation vibrates the cochlear basilar membrane, initiating a wave of displacement that

91 A hearing sensation arises when the elastic basilar membrane inside the cochlea vibrates.

92 The maturation of the basilar membrane involved the thickening of the central

93 A simple monophasic vibratory mode of the basilar membrane is found at both ends of the cochlea.

94 OHCs at various cochlear locations while the basilar membrane is mechanically stimulated.

95 The basilar membrane is typically set into motion through ai

96 s at the stapes earlier than at the measured basilar membrane location.

97 furosemide injection, the vibrations of the basilar membrane lost the best frequency (BF) peak and s

98 man speech, is not principally determined by basilar membrane mechanics.

99 are characterized here through recordings of basilar membrane motion and hair cell extracellular rece

100 was found by taking the phase difference of basilar membrane motion between two longitudinally space

101 sducer currents (or receptor potentials) and basilar membrane motion in an excised and bisected cochl

102 istortion product otoacoustic emissions, and basilar membrane motion indicate that the TM remains fun

103 The model is fit to in vivo basilar membrane motion with one free parameter for the

104 energy at the appropriate moment to enhance basilar membrane motion.

105 cells that detect and amplify sound-induced basilar membrane motions.

106 he OHCs were reduced by up to 65 dB, and the basilar membrane moved with similar phase across its ent

107 have demonstrated that efference suppresses basilar membrane movement, there is still much unknown a

108 ilar membrane responses to CF tones when the basilar membrane moves at maximum velocity.

109 is for enhanced frequency selectivity in the basilar membrane of mammals.

110 o measure in vivo the distribution along the basilar membrane of nonlinear, saturating vibrations to

111 odel could be tested by measuring TTS on the basilar membrane of the Otoa(EGFP/EGFP) mice to improve

112 ries are very similar to the trajectories of basilar-membrane peak velocity toward scala tympani.

113 The detectable basilar membrane response to a low-level 16-kHz tone occ

114 In a sensitive cochlea, the basilar membrane response to transient excitation of any

115 We suggest OHCs amplify basilar membrane responses to CF tones when the basilar

116 he amplification and frequency tuning of the basilar membrane responses to sounds are almost normal.

117 ation results agree with 2TS measurements of basilar membrane responses.

118 ortion products were observed in many of the basilar membrane responses.

119 10], we show that the nonlinear component of basilar-membrane responses to sound stimulation leads th

120 compared with that at the commonly measured basilar membrane side.

121 Responses to tones of a basilar membrane site and of auditory nerve fibers inner

122 tion result from longitudinal differences in basilar membrane stiffness and numerous individual grada

123 For example, the basilar membrane stiffness changes tonotopically, thus a

124 itude of the crista stiffness was similar to basilar membrane stiffness in mammals, and as in mammals

125 efrom, may not involve the usual wave on the basilar membrane, suggesting that additional cochlear st

126 nt of the biophysical characteristics of the basilar membrane that critically underlies cochlear pass

127 lfrog's amphibian papilla lacks the flexible basilar membrane that effects tuning in mammals, its aff

128 zing their responses to the vibration of the basilar membrane, the radial vibrations of the tectorial

129 In the basilar membrane, the responses were amplified near the

130 ar partition having three subpartitions, the basilar membrane, the reticular lamina, and the tectoria

131 n physical and geometrical properties of the basilar membrane, the sensitivity or gain of the hearing

132 's cells region than in the proximity of the basilar membrane, their frequency selectivity increased

133 ning which OHCs enhance the vibration of the basilar membrane, thereby tuning the gain of cochlear am

134 her than an immediate local vibration of the basilar membrane; this travelling wave vibrates in phase

135 ane in hearing: it enables the motion of the basilar membrane to optimally drive the inner hair cells

136 also found in the response of the mammalian basilar membrane to sound, signals the operation of an a

137 ructures range from a few hundred (e.g., the basilar membrane) to a few micrometers (e.g., the stereo

138 vibration collaboratively interacts with the basilar membrane traveling wave primarily through the co

139 hlear outer hair cells (OHCs) to amplify the basilar membrane traveling wave; however, it is unclear

140 Cochlear amplification of basilar membrane traveling waves is thought to occur bet

141 Compared with basilar membrane traveling waves, tectorial membrane tra

142 lar lamina motion is not directly coupled to basilar membrane traveling waves.

143 sms within outer hair cells that amplify the basilar membrane travelling wave.

144 We now know that basilar membrane tuning can account for neural tuning, a

145 peaked at a higher frequency than transverse basilar membrane tuning in the passive, postmortem condi

146 apical ends of outer hair cells and from the basilar membrane using a custom-built heterodyne low-coh

147 in the cochlea, as shown by measurements of basilar membrane velocity and auditory nerve responses t

148 ived electromotile force near to that of the basilar membrane velocity at frequencies above the shift

149 The basilar membrane velocity was measured through the trans

150 hlear responses are amplified during maximum basilar membrane velocity.

151 sh-pull" forces that drive the motion of the basilar membrane via the spatial feedforward and/or feed

152 n discrepancies between previously published basilar membrane vibration and auditory nerve single uni

153 Data also show that basilar membrane vibration at the emission frequency is

154 The phase relation of reticular lamina to basilar membrane vibration changes with frequency by up

155 difference between the reticular lamina and basilar membrane vibration decreases with frequency by ~

156 ate that outer hair cells do not amplify the basilar membrane vibration directly through a local feed

157 difference between the reticular lamina and basilar membrane vibration has been thought to result fr

158 ear amplifier from available measurements of basilar membrane vibration in sensitive mammalian cochle

159 best to different sound frequencies because basilar membrane vibration is mechanically tuned to diff

160 sions showed no significant change while the basilar membrane vibration nearly disappeared.

161 a vibration is substantially larger than the basilar membrane vibration not only at the best frequenc

162 difference between the reticular lamina and basilar membrane vibration results from the cochlear act

163 The current data indicate that basilar membrane vibration was not involved in the backw

164 that the reticular lamina vibration lags the basilar membrane vibration, and it is physiologically vu

165 ve yielded ever-better descriptions of gross basilar membrane vibration, the internal workings of the

166 ically been limited to point measurements of basilar membrane vibration.

167 Whether measured by basilar-membrane vibration, nerve-fiber activity, or per

168 ase differences between reticular lamina and basilar membrane vibrations are absent in postmortem coc

169 electrically in the second turn and measured basilar membrane vibrations at two longitudinal location

170 oncern, we measured the reticular lamina and basilar membrane vibrations in the transverse direction

171 n longitudinal location, electrically evoked basilar membrane vibrations showed the same tuning and p

172 generate forces for amplifying sound-induced basilar membrane vibrations, yet how cellular forces amp

173 For CF tones, basilar membranes vibrations were largest beneath the OH

174 uter hair cells that generates forces on the basilar membrane, we demonstrate that these forces inter

175 bing amplification in narrow segments of the basilar membrane, we further show that a cochlear travel

176 of Corti, including supporting cells and the basilar membrane, were carried out.

177 echanical filters analogous to the cochlea's basilar membrane, which deconstructs complex sounds into

178 tion, OHCs need to amplify the motion of the basilar membrane, which is much stiffer than themselves.

179 cells that effectively couple energy to the basilar membrane, which reduces sensitivity.

180 erferometer at up to 15 locations across the basilar membrane width in the basal turn of the guinea p

181 on the enhanced mechanical properties of the basilar membrane within the cochlear duct.

182 the transverse motions of the tectorial and basilar membranes within the organ of Corti.