ライフサイエンスコーパス: basolaterally

1 ndomly delivered but preferentially retained basolaterally.

2 istance of the cells or when STb was applied basolaterally.

3 esicles, whereas alpha(v)beta3 was expressed basolaterally.

4 red to both domains but selectively retained basolaterally.

5 released apically, and 94 uniquely released basolaterally.

6 main deletion mutant, was stably distributed basolaterally.

7 ically, whereas classical N-cadherin resided basolaterally.

8 cle-secreting epithelia sorted both proteins basolaterally.

9 towards the retina apically and the choroid basolaterally.

10 epithelial cells express IL-17RA and IL-17RC basolaterally.

11 were secreted in a polarized manner, mostly basolaterally.

12 whereas no functional BK channels were found basolaterally.

13 localizes the H(+)v-ATPase cytosolically or basolaterally.

14 taR-I and integrin alphaVbeta3 are localized basolaterally.

15 the apical surface after a prior appearance basolaterally.

16 use LLC-PK1 cells lacking AP1B, target CD147 basolaterally.

17 ecreased earlier than that of cells infected basolaterally.

18 is sorted apically, whereas M(3) is targeted basolaterally.

19 independent rotaviruses occurred apically or basolaterally.

20 BEK) resulted in secretion both apically and basolaterally.

21 etectable in the uterine epithelium, appears basolaterally and as prominent apical patches on the epi

22 Notably, interleukin-8 (IL-8) is secreted basolaterally and directs PMN through the lamina propria

23 large, and Lethal giant larvae localize Cdep basolaterally and share phenotypes with Cdep.

24 signaling via Rac activates WAVE and Arp2/3 basolaterally and that basolateral Arp2/3 makes an impor

25 in the colon, is released both apically and basolaterally, and is hence found in both the intestinal

26 cular stomatitis virus has been shown to bud basolaterally, and the matrix protein, but not glycoprot

27 In Ussing chambers, basolaterally applied AVP reduced colonic anion secretio

28 uid interface (ALI) responded to apically or basolaterally applied PAR-2 agonists.

29 Basolaterally applied SMase induced the phosphorylation

30 E virus (HEV) progeny particles are secreted basolaterally as quasi-enveloped particles and apically

31 ing FAs, CD36 and ceramide that are secreted basolaterally as small (80-100 nm) exosome-like extracel

32 T84 cells exposed basolaterally bound at least 30-fold-more PA than did T8

33 mbrane (TM) regions 1-5, was first delivered basolaterally, but within minutes appeared apically, and

34 all three neurotrophins were secreted 65-75% basolaterally by polarized Madin-Darby canine kidney epi

35 compromises the inflammatory cascade induced basolaterally by several other Toll-like receptor ligand

36 Previous work suggested that CLC-2 is sorted basolaterally by TIFS(812)LL, a dileucine motif in CLC-2

37 Conversely, MRP localizes basolaterally, conferring an opposing basal-to-apical dr

38 al vectors, with secretion of enzyme product basolaterally, could allow for widespread enzyme dissemi

39 tein influenza hemagglutinin, but not of the basolaterally delivered polymeric immunoglobulin recepto

40 While the targeting signals of basolaterally destined proteins are generally cytoplasmi

41 affects the surface delivery of apically and basolaterally destined proteins in polarized cells.

42 ons as a second sorting site for a subset of basolaterally endocytosed membrane proteins reaching thi

43 olymeric IgA receptor caused accumulation of basolaterally endocytosed polymeric IgA and the polymeri

44 o incorporated into triacylglycerol, but the basolaterally entering lipid is much more likely to ente

45 In contrast, Vero C1008 cells infected basolaterally exhibited a barely detectable level of BCC

46 a; the virus preferentially enters the cells basolaterally, exits apically, and maintains epithelial

47 Although other, mainly basolaterally expressed K(+) channels are recognized as

48 sed epithelial sodium channel (ENaC) and the basolaterally expressed Na(+)/K(+)-ATPase in type II alv

49 In kidney, CNNM2 is a basolaterally expressed protein with predominant express

50 thmatic patients and that BPIFA1 is secreted basolaterally from healthy, but not asthmatic human bron

51 POWVs were nonlytically transmitted basolaterally from infected hBMECs to lower-chamber peri

52 bset of signals from cargoes that are sorted basolaterally in a mu1B-dependent manner.

53 the sorting motif, which targets syntaxin 4 basolaterally in a munc18c-independent manner and second

54 rous human diet, kidney AE1 is mainly active basolaterally in alpha-intercalated cells of the collect

55 riched apically in one epithelial tissue and basolaterally in another.

56 PAR-2 is normally expressed basolaterally in differentiated nasal ciliated cells.

57 emonstrate that the Na pump is not localized basolaterally in epithelial cells, but instead is concen

58 monstrate that JAM-C is abundantly expressed basolaterally in intestinal epithelia and localizes to d

59 pha precursor (proTGFalpha), which is sorted basolaterally in Madin-Darby canine kidney (MDCK) cells,

60 Whereas receptors concentrate basolaterally in regions of direct cell-cell contact in

61 It preferentially accumulates basally or basolaterally in several tissues, but does not preferent

62 apically in human bronchiolar epithelia and basolaterally in the reabsorptive duct of human sweat gl

63 eloping ureteric tree and CD44 was expressed basolaterally in UB-derived structures.

64 ly to epithelial cells, TFV/TAF was released basolaterally, in part through Multidrug Resistant Prote

65 es the same set of apical membrane molecules basolaterally, including the polarity regulator PAR-6, a

66 Degradation of basolaterally internalized epidermal growth factor was s

67 in cells expressing RhoAV14, transcytosis of basolaterally internalized IgA was severely impaired.

68 In this compartment, apically and basolaterally internalized membrane constituents are tho

69 ests that significant mixing of apically and basolaterally internalized membrane proteins occurs in s

70 ssing and nuclear trafficking of apically or basolaterally internalized virions.

71 osing (apically internalized) and recycling (basolaterally internalized) TRs are delivered to the bas

72 articles (SLP) are secreted from enterocytes basolaterally into the lamina propria, and reach the api

73 secreted both apically (into the lumen) and basolaterally (into the circulation).

74 ey guide new and recycling membrane proteins basolaterally is unknown.

75 e conserved polarity protein PAR-1, which is basolaterally localised in epithelia, promotes and is re

76 at in 2D cultures, the prolactin receptor is basolaterally localized and physically segregated from i

77 ocalized growth factors segregate from their basolaterally localized erbB receptors.

78 elsewhere because it has stated that OCT1 is basolaterally localized in enterocytes.

79 Here we demonstrate that TbetaRIII is basolaterally localized in polarized breast epithelial c

80 pressed epithelial sodium channel (ENaC) and basolaterally localized Na(+)-K(+)-ATPase in type II alv

81 ese leucines to alanines in the context of a basolaterally localized NET/DAT chimera restored transpo

82 and Crumbs groups (Crb3-PALS1-PATJ) and the basolaterally localized proteins of the Dlg group (Dlg1-

83 An important conductor of this Ca(2+) is the basolaterally localized, intracellular Ca(2+) channel ry

84 and is pumped into the lung interstitium by basolaterally located Na/K-ATPase, thus creating a local

85 In addition, by targeting a basolaterally located receptor in the respiratory epithe

86 led with amino acid precursors compared with basolaterally located subunit.

87 EA (applied apically, logEC50 -5.4) and PEA (basolaterally, logEC50 -4.9; apically logEC50 -5.3) incr

88 To activate actin/myosin basolaterally, microtubules in neighboring cells reorien

89 is activated by TLR9 ligand both apically or basolaterally, NF-kappaB is activated only via basolater

90 vity that induced IL-8 secretion when placed basolaterally on model epithelia).

91 In monolayers permeabilized basolaterally or apically with nystatin, AP activated ap

92 Studies of basolaterally permeabilised cells revealed a small rise

93 Studies of basolaterally permeabilised cells showed that these horm

94 CBF of basolaterally permeabilized human tracheobronchial cells

95 The current-voltage relationship of basolaterally permeabilized monolayers treated with Epac

96 lateral, not the apical, surface, implying a basolaterally polarized TLR5 response in human colonic m

97 ithelia recapitulated hypoxia and identified basolaterally polarized TNF-alpha receptor types I and I

98 analogues (EC50 = 280 nM) activate the same basolaterally polarized, Ca2+-coupled epithelial recepto

99 t on the apical surface, and 79% of LDLR was basolaterally polarized.

100 recycling transmembrane cargo molecules and basolaterally recycling fluid, consistent with a block i

101 compared it to the endocytic trafficking of basolaterally recycling membrane proteins.

102 early endosomes in rab-10 mutants accumulate basolaterally recycling transmembrane cargo molecules an

103 However, such basolaterally released chemokines, while likely importan

104 Characterization of isolated apically and basolaterally released EVs revealed enrichment in sEVs.

105 RT-PCR; n=5-10), indicating Kcne3 actively, basolaterally rerouted Kcnq1 in Kcne2(-/-) PCs.

106 Here, we discovered that Kcne2 deletion basolaterally reroutes the Kcnq1 alpha subunit in vivo i

107 ighted by apical labeling with antibody to a basolaterally restricted ligand, beta1-integrin.

108 peptidase were reduced with no effect on the basolaterally secreted fraction.

109 e present the first endothelial apically and basolaterally secreted proteomes, demonstrating that ECs

110 unction of epithelia depends on apically and basolaterally situated ion channels as well as tight jun

111 endothelial cells occurred both apically and basolaterally, suggesting an endothelial contribution to

112 se of ARPE-19 cells to VEGF apically but not basolaterally, suggesting polarized expression of the AN

113 t Golgi-recruited GRK2ct-KERE inhibits model basolaterally targeted but not apically targeted cargo d

114 ular loop can confer apical targeting to the basolaterally targeted M4 receptor, Val270-Lys280 and Ly

115 ed proteins, analogous to that described for basolaterally targeted proteins.

116 ntracellular appearance of both apically and basolaterally targeted SVCTs in the absence or presence

117 er the CNS by infecting hBMECs and spreading basolaterally to abluminal pericytes.

118 s, but subsequently re-enters the epithelium basolaterally to elicit an acute inflammatory response.

119 man intestinal epithelial cells were exposed basolaterally to interferon (IFN)-gamma (10(3) U/mL) or

120 n-1beta-stimulated Caco-2 cells were exposed basolaterally to nanomolar concentrations of activated M

121 s (LI9/LI41 and LB) to infect hBMECs, spread basolaterally to pericytes, and enter the CNS.

122 When MV-eGFP was applied apically or basolaterally to primary cultures of airway epithelia, d

123 mes highly polymerized, THP is also released basolaterally, toward the interstitium and circulation,

124 f low-molecular-weight (LMW) VWF is targeted basolaterally, toward the subendothelial matrix, using t

125 ect hBMECs and pericytes and that POWVs were basolaterally transmitted from hBMECs to lower-chamber p

126 -independent rotaviruses applied apically or basolaterally were capable of efficiently infecting both

127 inia virus growth factor, which was released basolaterally, where it activated epidermal growth facto

128 We found that PAR-2 is expressed basolaterally, where it stimulates both intracellular Ca

129 Albumin, urea, and lipoproteins are secreted basolaterally, whereas bile acids are secreted apically.

130 n cytoplasmic domain deletion, was localized basolaterally, whereas N-TGPI, a GPI-anchored N-cadherin

131 In contrast, TRPC1 was localized basolaterally, whereas TRPC6 was detected in both locati

132 ls bearing tight junctions only when applied basolaterally, while the EpR-blind virus did not infect

133 WAVE localized basolaterally with Arp2/3 and controlled F-actin levels

134 0.4-microm pores, were infected apically or basolaterally with SA-independent or SA-dependent rotavi

135 , disruption of polarized T-84 cells treated basolaterally with the TLR5 ligand flagellin was prevent