ライフサイエンスコーパス: basophilic

1 nclusions, which ranged from eosinophilic to basophilic.

2 dergoes 3 mitosis to generate sequentially 2 basophilic, 4 polychromatic, and 8 orthochromatic erythr

3 3+)-IMAC (72%), while Pro-directed (85%) and basophilic (79%) phosphorylation sites were enriched in

4 In contrast, basophilic and clear-cell foci, as well as pseudo-glandu

5 94/NKG2A molecules in the HLA-E negative rat basophilic cell line RBL-2H3, we demonstrate that CD94/N

6 it allergen binding to specific IgE on a rat basophilic cell line stably expressing human FcepsilonRI

7 IgEs from those hybridomas could activate a basophilic cell line to undergo degranulation upon the s

8 2+ current, in a model system, the RBL-1 rat basophilic cell line.

9 y measuring mediator release from engineered basophilic cell lines.

10 anucleated cells in the center surrounded by basophilic cells and partial calcification.

11 Similar to the human C3aR, RBL-2H3 rat basophilic cells stably expressing this receptor respond

12 lls (MZL), ii) distinct enlargement of MZ by basophilic centroblast-like cells (MZL+), and iii) exten

13 population of large immunoblastic cells with basophilic cytoplasm, centrally placed nuclei, and disti

14 2(int) large mononuclear cells with abundant basophilic cytoplasm.

15 ononuclear infiltrate, with eosinophilic and basophilic degranulation.

16 mitogenesis, enhanced survival, and enhanced basophilic differentiation.

17 the cells in the midgut, do not stain with a basophilic dye (toluidine blue) and are less osmiophilic

18 cy with inhibition of differentiation at the basophilic erythroblast stage.

19 late burst forming unit-erythroid (BFU-E) to basophilic erythroblast stages.

20 st at the transition from proerythroblast to basophilic erythroblast.

21 ciated glycoprotein (RhAG) were found in the basophilic erythroblast.

22 late terminal erythroid maturation with the basophilic erythroblasts expressing predominantly Hb Gow

23 e cells are proerythroblasts with some early basophilic erythroblasts, with no change in morphology o

24 In later (basophilic) erythroblasts, Epo stimulation triggers a lo

25 strate that the development of dysplasia and basophilic foci in the liver is correlated with aneuploi

26 t Mgat3-/- livers had significant numbers of basophilic foci, and by 10-12 months after diethylnitros

27 ells (e.g., oval cells, early hepatocytes in basophilic foci, and intestinal type of cells) are most

28 The lesions were putatively preneoplastic basophilic foci, hepatocellular karyomegaly, megalocytic

29 c/TGF-alpha liver is dysplastic and contains basophilic foci.

30 eosinophilic myelocytes that showed abnormal basophilic granulation.

31 The cytokine was localized to basophilic granules by electron microscopic examination

32 The dose-dependent presence of basophilic granules in multiple tissues in ISIS 416858-t

33 Basophilic granules reflect cellular drug uptake and sub

34 dies revealed that IgE specifically bound to basophilic granulocytes and mast cells through the Fc po

35 Mediator release from basophilic granulocytes correlated better with allergen

36 proportion of memory (and naive) B cells and basophilic granulocytes, suggesting the potential for li

37 titial collections of collagenous tissue and basophilic ground substance.

38 approximately twice as many focal lesions of basophilic hepatocytes as treated wild-type littermates.

39 ogen that infects platelets of dogs, forming basophilic intracellular morulae.

40 site at serine 14 of TRPC6 is embedded in a basophilic kinase motif that is highly conserved across

41 lated phosphopeptides was highly enriched in basophilic kinase substrate motifs (AGC or calmodulin-se

42 ecificity for moesin compared to traditional basophilic kinase substrates.

43 e specificity analyses characterize LOK as a basophilic kinase whose optimal substrate sequence resem

44 trategy that assures distinct substrates for basophilic kinases (PKA, PKG and PKC (AGC) and calmoduli

45 this by designing families of kinase such as basophilic kinases and proline-directed kinase with dist

46 Thus, H89 appears to inhibit basophilic kinases even in the absence of PKA.

47 Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 1

48 s immediately active upon the infection, and basophilic kinases, ATM, and ATR engaging later.

49 h forms a consensus phosphorylation site for basophilic kinases, markedly reduced the endocytosis, wh

50 alysis of reported substrates of two typical basophilic kinases, protein kinase C and protein kinase

51 of which many represent putative targets of basophilic kinases.

52 strategy that should be generalizable to all basophilic kinases.

53 matches the consensus for the AGC family of basophilic kinases.

54 terized both in ELISA and in a humanized rat basophilic leukaemia (RBL) cell model.

55 human T cells, DT40 chicken B cells and rat basophilic leukaemia (RBL) cells were examined.

56 elease-activated Ca2+ current (ICRAC) in rat basophilic leukaemia (RBL) cells.

57 In rat basophilic leukaemia (RBL-1) cells dialysed with high in

58 elease-activated Ca2+ current (ICRAC) in rat basophilic leukaemia (RBL-1) cells under conditions of w

59 release-activated Ca2+ current ICRAC in rat basophilic leukaemia (RBL-1) cells.

60 l Mast Cells (PMCs) from BALB/c mice and Rat Basophilic Leukaemia (RBL-2H3) MCs led to significant ki

61 f store-operated Ca2+ entry in the RBL-1 rat basophilic leukaemia cell-line.

62 Rat basophilic leukaemia cells (RBL-2H3-M1) were used to stu

63 asuring beta-hexosaminidase release from rat basophilic leukaemia cells passively sensitized and stim

64 Coimmunoprecipitation experiments in rat basophilic leukemia (RBL 2H3) cells show that SHIP-2 int

65 pressed CD94/NKG2A-EGFP receptors in the rat basophilic leukemia (RBL) cell line.

66 In studies using transfected rat basophilic leukemia (RBL) cell lines expressing either f

67 itro with human and mouse mast cells and rat basophilic leukemia (RBL) cells and in vivo in mice.

68 ocessed appropriately, and functional in rat basophilic leukemia (RBL) cells following retroviral tra

69 Cross-linking of FcepsilonRI on rat basophilic leukemia (RBL) cells initiates a signaling ca

70 parallel studies of FcepsilonRI-bearing rat basophilic leukemia (RBL) cells transfected with constru

71 ion channel, in human and rat platelets, rat basophilic leukemia (RBL) cells, and phorbol myristate a

72 and capacitative Ca(2+) influx, we used rat basophilic leukemia (RBL) cells, vascular smooth muscle

73 gE-Fc epsilonRI) and the cytoskeleton in rat basophilic leukemia (RBL) mast cells.

74 ysteinyl leukotriene type I receptors in rat basophilic leukemia (RBL)-1 cells, large amplitude Ca(2+

75 to analyze published experiments on the rat basophilic leukemia (RBL)-2H3 cell line that seem to con

76 d, disassembled, and soluble vimentin in rat basophilic leukemia (RBL)-2H3 cells expressing human CCR

77 ist of (125)I-C3a radioligand binding to rat basophilic leukemia (RBL)-2H3 cells expressing the human

78 Surprisingly, overexpression of SphK1 in rat basophilic leukemia (RBL)-2H3 mast cells impaired degran

79 Here we show that stimulation of rat basophilic leukemia (RBL)-2H3 mast-like cells with the A

80 Rat basophilic leukemia (RBL)-SX38 cells that express human

81 and intracellular Ca2+ concentrations in rat basophilic leukemia (RBL-2H3 m1) cells.

82 lation of the CCR1 chemokine receptor, a rat basophilic leukemia (RBL-2H3) cell line was modified to

83 n-8 (CXCR1) were stably coexpressed in a rat basophilic leukemia (RBL-2H3) cell line.

84 IV-1 infection, monocytes and MAGIC5 and rat basophilic leukemia (RBL-2H3) cell lines co-expressing t

85 Rat basophilic leukemia (RBL-2H3) cells predominantly expres

86 hannels and store-operated Ca2+ entry in rat basophilic leukemia (RBL-2H3) cells.

87 of 60 phosphate units was identified in rat basophilic leukemia (RBL-2H3) mast cells using specific

88 are expressed either in the cytoplasm of rat basophilic leukemia (RBL-2H3) mucosal mast cells or anch

89 e phosphatase-inactive forms of SHP-1 in rat basophilic leukemia 2H3 (RBL-2H3) mast cell line.

90 Overexpression of Gab2 in rat basophilic leukemia 2H3 cell line cells inhibited the Fc

91 investigated the role of Gab2 using the rat basophilic leukemia 2H3 cell line mast cells.

92 The receptors were stably expressed in rat basophilic leukemia 2H3 cells and characterized for rece

93 lize the level of LAT phosphorylation in rat basophilic leukemia 2H3 cells show that Erk2 phosphoryla

94 duces an increase in 5-HT uptake Vmax in rat basophilic leukemia 2H3 cells that is enhanced by pretre

95 A were then cotransfected with CD94 into rat basophilic leukemia 2H3 cells.

96 ing events that lead to degranulation in rat basophilic leukemia 2H3 cells.

97 ctions enriched in plasma membranes from rat basophilic leukemia 2H3 mast cells.

98 n a Syk-negative variant of the RBL-2H3 (rat basophilic leukemia 2H3) mast cell line.

99 or genetically encoded Ca(2+) sensors in rat basophilic leukemia and bone marrow-derived rat mast cel

100 release-activated Ca2+ (CRAC) channel in rat basophilic leukemia and other hematopoietic cells to rel

101 Significantly, the most prominent rat basophilic leukemia cell integrin (alpha5) avoids the pa

102 Rat basophilic leukemia cell line (RBL-2H3) stably expressin

103 In mast cells of the rat basophilic leukemia cell line (RBL-2H3), cholera toxin (

104 in a similar manner, we studied a stable rat basophilic leukemia cell line (RBL-CR1) transfected with

105 ere therefore examined using transfected rat basophilic leukemia cell lines (RBL-2H3) that expressed

106 blasts (as a model of adherent cell) and rat basophilic leukemia cells (as a model of nonadherent cel

107 In fact, CaG chemoattracts rat basophilic leukemia cells (RBL cells) expressing the hig

108 ctive channels in the plasma membrane of rat basophilic leukemia cells (RBL-2H3 m1), an immortalized

109 donoyl ethanolamide (anandamide, AEA) in rat basophilic leukemia cells (RBL-2H3) has been proposed to

110 investigated the regulation of CXCR4 in rat basophilic leukemia cells (RBL-2H3) stably transfected w

111 alcium mobilization and degranulation in rat basophilic leukemia cells and cytokine production (IL-6

112 gated through patch-clamp experiments on rat basophilic leukemia cells and fluorometric imaging plate

113 , 5-LO is localized to the cytoplasm; in rat basophilic leukemia cells and human alveolar macrophages

114 o image Annexin 2-GFP in live, secreting rat basophilic leukemia cells and in cells performing pinocy

115 s across intact cell-attached patches in rat basophilic leukemia cells and rat megakaryocytes reveale

116 on-dependently inhibited CRAC current in rat basophilic leukemia cells and thapsigargin-induced Ca(2+

117 cts more effectively with FcepsilonRI(+)-rat basophilic leukemia cells at 37 degrees C compared with

118 Examination of rat basophilic leukemia cells by both immunocytochemistry an

119 mouse bone marrow-derived mast cells or rat basophilic leukemia cells expressing Siglec-8.

120 that the mitotic clock of unsynchronized rat basophilic leukemia cells has a marked precision with 80

121 inity receptor for IgE (Fc epsilonRI) on rat basophilic leukemia cells is regulated by its initiating

122 sured the extent and rate of adhesion of rat basophilic leukemia cells preincubated with anti-dinitro

123 Recent studies in Jurkat T cells and in rat basophilic leukemia cells revealed an Mg(2+)-inhibited c

124 ster ovary cells and alpha4 integrins on rat basophilic leukemia cells showed little or no associatio

125 iating Ca(2+) waves are observed in most rat basophilic leukemia cells stimulated with soluble Ag and

126 Using rat basophilic leukemia cells transfected with the human hig

127 gh affinity receptors (Fc epsilon RI) on rat basophilic leukemia cells using both single particle tra

128 we describe a study in which we incubate rat basophilic leukemia cells with a fluorescently labeled c

129 cepsilonRI-mediated calcium signaling in rat basophilic leukemia cells, a property dependent on the S

130 rent (I(crac)) in lacrimal acinar cells, rat basophilic leukemia cells, and DT40 B-lymphocytes.

131 In rat basophilic leukemia cells, emptying of the stores activa

132 ar characteristics to that recorded from rat basophilic leukemia cells, namely a similar time course

133 Here we show, in intact rat basophilic leukemia cells, that calcium responses induce

134 degranulation assay in C3aR-transfected rat basophilic leukemia cells, two were prominent agonists (

135 Using mFPR-transfected rat basophilic leukemia cells, we found that a recently iden

136 om HeLa cells expressing SERT and intact rat basophilic leukemia cells, we show that agents such as N

137 lently cross-linked IgE dimers stimulate rat basophilic leukemia cells.

138 activation of whole-cell CRAC current in rat basophilic leukemia cells.

139 usly measured in thousands of individual rat basophilic leukemia cells.

140 itutions on FPR functions in transfected rat basophilic leukemia cells.

141 um compounds in Jurkat T lymphocytes and rat basophilic leukemia cells.

142 e-labeled anti-DNP IgE on the surface of rat basophilic leukemia cells.

143 ase-activated calcium current (Icrac) in rat basophilic leukemia cells.

144 ays and degranulation tests of humanized rat basophilic leukemia cells.

145 lung epithelial cells, Jurkat cells, and rat basophilic leukemia cells.

146 roliferation in human Jurkat T-cells and rat basophilic leukemia cells.

147 sequent release of chemical mediators on rat basophilic leukemia cells.

148 I(CRAC) to a size comparable to that in rat basophilic leukemia cells.

149 se-activated Ca(2+) current (I(CRAC)) in rat basophilic leukemia cells.

150 a large gain in CRAC channel function in rat basophilic leukemia cells.

151 ibitor of mast cell degranulation in the rat basophilic leukemia mast cell model, in the passive cuta

152 ng enlargement of these vesicles in both rat basophilic leukemia mast cells and Jurkat T leukemia cel

153 find that SNAP-23 is phosphorylated when rat basophilic leukemia mast cells are triggered to degranul

154 Rat basophilic leukemia mast cells primed with fluorescent a

155 lation mutants inhibited exocytosis from rat basophilic leukemia mast cells, demonstrating that phosp

156 tion of Ag-crosslinked IgE-FceRI in live rat basophilic leukemia mast cells.

157 ) responses to antigen in IgE-sensitized rat basophilic leukemia mast cells.

158 C3a stimulated degranulation in a basophilic leukemia RBL-2H3 cell expressing wild-type C3

159 Using a basophilic leukemia RBL-2H3 cell line expressing wild-ty

160 These mutants expressed in rat basophilic leukemia RBL-2H3 cells bound LTB4 with simila

161 ion of the IgE high affinity receptor on rat basophilic leukemia RBL-2H3 cells results in activation

162 a monoclonal antibody raised against the rat basophilic leukemia RBL-2H3 cells, we identified that pl

163 man chemoattractant receptor regulation, rat basophilic leukemia RBL-2H3 cells, which are thrombin-re

164 (CD31), after FcepsilonRI stimulation in rat basophilic leukemia RBL-2H3 cells.

165 gE receptor (FcepsilonRI) aggregation in rat basophilic leukemia RBL-2H3 cells.

166 d phospholipase C-gamma1 from lysates of rat basophilic leukemia RBL-2H3 cells.

167 een identified in T-lymphocytes and RBL (rat basophilic leukemia) cells and named MagNuM (for Mg(2+)-

168 STZ mitigated degranulation of RBL-2H3 (rat basophilic leukemia) mast cells induced by compound 48/8

169 retion from transiently transfected RBL (rat basophilic leukemia)-2H3 mast cells (a tumor analog of m

170 d receptor, Mas-related gene X2 (MrgX2), rat basophilic leukemia, RBL-2H3 cells, and murine BMMCs do

171 IgE-dependent stimulation of either rat basophilic leukemia-2H3 cells (RBL-2H3 cells) or mouse b

172 In rat basophilic leukemia-2H3 cells expressing formyl peptide

173 In rat basophilic leukemia-2H3 cells expressing transfected mou

174 In rat basophilic leukemia-2H3 cells, Lyn thus plays a dual rol

175 ransfected the unique domain of Lyn into rat basophilic leukemia-2H3 mast cells and examined the cons

176 E-loaded receptors (IgE-FcepsilonRI) on rat basophilic leukemia-2H3 mast cells in contact with fluid

177 rgent sensitivity of this association on rat basophilic leukemia-2H3 mast cells, and we compare the c

178 The rat basophilic leukemic (RBL-2H3) cell line was stably trans

179 o demonstrate the utility of the system, rat basophilic leukemic cells loaded with Oregon green and f

180 bilizing activity previously reported in rat basophilic leukemic cells.

181 up were irregular and presented an amorphous basophilic line and bone necrosis that was slowly resorb

182 mbra(-/-) mice develop massive splenomegaly, basophilic macrocytic red blood cells, and anemia as the

183 Some had a clearly defined basophilic margin, while others were granular with a hya

184 by dDAVP showed a predominance of so-called "basophilic" motifs consistent with activation of kinases

185 The transition from proerythroblast to basophilic normoblast occurred later, from days 7 to 9,

186 apex in cell cycling and the proerythroblast-basophilic normoblast transition.

187 utant embryos contain few pronormoblasts and basophilic normoblasts and have drastically reduced numb

188 mplete the transition from pronormoblasts to basophilic normoblasts.

189 of papillary renal cell carcinoma had small basophilic nuclei, and clear cell areas lacked a fine va

190 illary in architecture and showed chromophil basophilic, papillary renal cell carcinoma type 1 histol

191 in vitro cell system that progressed through basophilic, polychromatic, orthochromatic, and reticuloc

192 revealed that the ratio of proerythroblasts:basophilic:polychromatic:orthromatic erythroblasts follo

193 sequential formation of proerythroblasts and basophilic, polychromatophilic and orthochromatic erythr

194 emia-associated peptides containing the KXXS basophilic protein kinase consensus motif.

195 Likely H89 targets include basophilic protein kinases such as AKT, RSK, AMPK and RO

196 rates that we previously defined for related basophilic protein kinases such as protein kinase A, Ser

197 r more members of the AMPK/SNF1-subfamily of basophilic protein kinases.

198 sion system and Syk-negative variants of rat basophilic (RBL-2H3) cells.

199 , eosinophilic inclusions, and vacuoles with basophilic rims were seen in moderately affected muscles

200 Most basophilic serine/threonine kinases preferentially phosp

201 erythroblasts lack UBA1 mutations beyond the basophilic stage of erythroid differentiation.

202 d associated at the plasma membrane from the basophilic stage of erythropoiesis.

203 coagulative necrosis associated with intense basophilic staining of extracellular matrix, including c

204 Unlike tolerant challenged controls, basophilic upregulation of CD203c in response to moxiflo