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2 sensitivity to ruthenium red inhibition, can be abolished by a point mutation in the putative pore do
9 n embryonic kidney 293 (HEK293) cells, which was abolished by a point mutation at the C terminal of A
10 excess of purified trehalose dimycolate and was abolished by a S124A mutation affecting the catalyti
11 the antiviral activity of both ALA1 and ALA2 was abolished by a single amino acid substitution known
13 responses were purely glutamatergic, as they were abolished by a combination of AMPA and NMDA glutama
15 rostatic epithelial proliferation, which can be abolished by ablating IL-1 signaling or depleting its
17 odeling and heart failure, and these effects were abolished by ablation of tumor necrosis factor rece
18 of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the
19 antly, tumor promotion by p53-deficient MSCs was abolished by administration of S-methylisothiourea,
22 hrough ERK1/2 and PKA pathway; these effects were abolished by an alpha2A-adrenoreceptor antagonist.
25 ammatory monocytes was plasmin dependent and was abolished by anti-Plg-R(KT) monoclonal antibody, eps
30 re produces locomotor sensitization that can be abolished by blocking calcium (Ca(2+))-permeable alph
33 ted potassium channels with iberiotoxin, and is abolished by blocking small conductance calcium-activ
43 DNA damage-induced TMPRSS2-ERG degradation was abolished by cancer-associated PTEN deletion or GSK3
45 mouse partially ligated left carotid artery were abolished by caspase-1 inhibition, local delivery o
50 sed spike activity during the trace interval were abolished by cerebellar inactivation, persistent re
54 freezing cessation; these neural correlates were abolished by chemogenetic mPFC->BNST inhibition.
56 aine seeking in GTs than STs and this effect was abolished by cholinergic losses despite the fact tha
57 ts of heightened autophagy from Becn1(F121A) was abolished by chronic high-Pi diet which also shorten
59 ped astrocytes, the GABA transporter current was abolished by combined application of the selective G
64 early checkpoint in ILC2 development, which was abolished by deficiency in the zinc-finger protein B
66 ause both RNA binding and enzymatic activity are abolished by deletion of the SAS-specific C-terminal
67 Vigilance-dependent astroglial activation is abolished by deletion of alpha(1A)-adrenergic recepto
69 ocytes, required chemokine receptor CCR2 and was abolished by deletion of IL-1beta in CCR2(+) blood m
72 reases in secreted and intracellular Abeta40 were abolished by depletion of presenilin 2 (PSEN2), rec
73 slower diffusion of ErbB2 compared to ErbB3 was abolished by depolymerizing actin filaments, whereas
74 tion by 10-fold (P<0.0001); this natriuresis was abolished by direct renal interstitial infusion of s
75 ons are enhanced when host circadian rhythms are abolished by disrupting the key clock gene transcrip
76 the activity of AKAP95 in splice regulation is abolished by disruption of condensation, significantl
77 essed psychomotor response to cocaine, which was abolished by disruption of the DC pathway, but not t
78 tabilization of inner-membrane-protein mRNAs is abolished by dissociating the RNA degradosome from th
79 rate mouse causes a rise in MAP and HR which is abolished by dorsal rhizotomy or by neuromuscular blo
82 cumulation induced by mechanical stimulation are abolished by either pharmacologic inhibition of ERKs
85 stemic circulating IL-13 and TGF-beta1; this was abolished by endothelial-specific deletion of IL33 b
88 ly, these protective effects produced by XMJ were abolished by eNOS inhibitor L-NAME or specific eNOS
90 n vitro and in vivo, and the internalization was abolished by excess free cRGDyK or knockdown of alph
91 han in Atg5(flox/flox) Lyz-Cre BMMs in vitro was abolished by exogenous treatment with recombinant IL
92 re unaffected by acyclovir pre-treatment but were abolished by exposure to Tetrodotoxin (TTX) which b
93 tion through degradation of cyclin D3, which is abolished by expression of cyclin D3T283A, a non-phos
95 oliferation between NG2KO and control islets was abolished by ganglionic blockade or by weaning the m
99 PA1 by the electrophile allyl isothiocyanate was abolished by glutathione, but was ostensibly unaffec
100 ity of neurons, and the remaining inhibition was abolished by group II/III metabotropic glutamate rec
105 oxygen-glucose deprivation, and this effect was abolished by histamine receptor type I antagonist.
106 agellin receptor FLS2, whose gene expression was abolished by HopQ1 in a promoter-dependent manner.
111 Importantly, this effect of XPLN depletion is abolished by inhibition of Akt or mTOR kinase activit
112 fect of TOR inactivation on BZR1 degradation is abolished by inhibition of autophagy and by the bzr1-
113 potentiating effect of PNU-282987 on eEPSCs was abolished by inhibition of protein kinase A (PKA).
114 by aberrant Ca(2+) releases and EADs, which were abolished by inhibition of Ca(2+)/calmodulin-depend
115 o insulin in HFD male rats and these actions were abolished by inhibition of either AMPK or nitric ox
116 iR-126 level and SMC turnover; these effects were abolished by inhibition of endothelial miR-126 and
118 platelet activation and Syk phosphorylation were abolished by inhibition of PI3K, which demonstrates
120 ediated by glutamate and not 5-HT because it was abolished by ionotropic glutamate receptor antagonis
123 TSH effects on MTCO1, TFAM, and porin could be abolished by K1-70, a TSH-receptor antagonist, sugges
124 manner, because its junctional localization is abolished by knock-out of PLEKHA7, and is rescued by
125 lial cells on the promotion of wound healing was abolished by knockdown of CTCF with CTCF-specific sh
126 g events in human vascular endothelial cells were abolished by knockdown of AT1 and inhibited by AT1
127 ted in the absence of extracellular Ca(2+) , was abolished by LaCl3 and was attenuated approximately
129 dance behaviors in a runway operant paradigm were abolished by lesions of LHb efferents, lesions of t
130 timulation, and Delay cell persistent firing was abolished by local NR2B NMDAR blockade or by systemi
131 nsity- and frequency-dependent manner, which were abolished by local anesthetic and selective A-fiber
132 t-like effects were sustained for 7 days and were abolished by local Bdnf gene ablation, or pretreatm
133 ong-term recognition memory, and this effect was abolished by loss of the photopigment melanopsin.
135 hosphorylation and intercellular gaps, which were abolished by lysophosphatidic acid receptor 1/2 inh
138 erived EVs could trigger EC migration, which was abolished by miR-150 knockdown in SMCs, suggesting m
141 chronic treatment with the SSRI, fluoxetine, are abolished by mossy cell-specific knockout of p11 or
144 liferation in HepG2 cells; and these effects were abolished by mTORC1 inhibition, demonstrating an es
146 ogenous peptide substrate, and this activity is abolished by mutagenesis of lysine 723 in the catalyt
147 athicity within the TMDs as the interactions were abolished by mutating residues on the polar faces t
149 s not required, but phosphorylation in trans is abolished by mutation of the transmembrane domain.
150 hibited partial apical-lateral polarity that was abolished by mutation of its ankyrin-binding site bu
154 d vessel formation in matrigel plugs in mice was abolished by Ned-19 and, most notably, failed to occ
155 ltures, the growth-promoting effect of ALCAM was abolished by neutralizing antibodies for components
164 ity of pro-inflammatory cytokines/chemokines are abolished by PARP1 ablation or inhibition, or blocke
167 sults in oncogenic toxicity; this effect can be abolished by pharmacological inhibition of Mek to res
168 tive effects of EC preconditioning at low CS were abolished by pharmacological or molecular inhibitio
171 analogous effects of FXYD1 on K0.5Na, which are abolished by phosphomimetic mutants and also by incr
173 induced reduction in LV filling and ejection was abolished by plasma volume expansion but to a lesser
177 in ATP concentration in culture medium that was abolished by preincubation with TRP channel antagoni
178 strongly reduced when speech intelligibility is abolished by presenting speech/noise stimuli in rever
179 dependent on GPR55 activation, because they are abolished by pretreatment with ML-193 [N-(4-(N-(3,4-
181 bition of TNF-alpha secretion by macrophages was abolished by pretreatment with 1-methyl-D-tryptophan
182 al neurons of nucleus ambiguus; the response was abolished by pretreatment with the GPER antagonist G
184 duced pressor and sympathoexcitatory effects were abolished by pretreatment of the RVLM with the vaso
185 increase in ventilation and CO2 sensitivity is abolished by preventing adrenaline release or blockin
186 cell surface synaptic GABA(A) receptors and is abolished by preventing CaMKII phosphorylation of GAB
193 s evoked by laryngeal citric acid challenges were abolished by recurrent laryngeal nerve (RLN) transe
194 tihyperalgesic effects of sigma-1 antagonism were abolished by reducing the neutrophil load with in v
196 asurements, we show that conductance by Bot1 is abolished by removal of the Na(+) ion binding site.
198 rosis predominantly in stellate cells, which was abolished by removal of extracellular Ca(2+) and sig
199 sodium excretion and renal interstitial cGMP were abolished by renal interstitial nitric oxide syntha
200 sion of pohr driven GFP in this strain could be abolished by replacing the intact ohrR gene with a mu
201 ts show escalation of ethanol seeking, which was abolished by restoring mGluR(2) expression in the in
202 ostate cancer cells in which PTEN expression was abolished by RNA interference-mediated attenuation.
204 GLP-1, was as cardioprotective as GLP-1 and was abolished by scrambling its amino acid sequence.
205 All electrophysiological responses to TCWs were abolished by SEA0400 and ORM10103, indicating that
206 dopamine D3 receptors (D3R), as its effects were abolished by selective D3R antagonists and absent i
207 lencing induced greater ADSC survival, which was abolished by short hairpin RNA against hypoxia-induc
209 d ventilated rats, moderate AIH-induced pLTF was abolished by siBDNF and UO126, but not siTrkB or PI8
212 akefulness caused by cholinergic stimulation was abolished by simultaneous reverse microdialysis of c
214 hosphorylation and XBP1 mRNA splicing, which was abolished by siRNA-mediated knockdown of kinase inse
216 teraction with human SLX4 (huSLX4) and could be abolished by small interfering RNA (siRNA) depletion
217 collagen I led to TGF-beta expression, which was abolished by small interfering RNA (siRNA) Hic-5 kno
218 ha-mediated suppression of virus replication was abolished by small interfering RNA (siRNA) knockdown
219 y effects of Ang II on STAT3 phosphorylation were abolished by small-interfering RNA knockdown of TRP
226 nstressed cells, but SET-mediated repression is abolished by stress-induced acetylation of p53 CTD.
227 d to increased T lymphocyte infiltration and are abolished by T cell depletion or interferon-gamma ne
230 ed both behavior and learning, learning that was abolished by temporally specific inhibition of orbit
232 ells fire spontaneous action potentials that are abolished by tetrodotoxin, and all display spontaneo
233 cts of ghrelin on AMPK in peripheral tissues are abolished by the lack of functional CB1 receptor via
234 -apoptosis induced by mechanical stimulation are abolished by the Wnt antagonist Dkk1 and the beta-ca
236 y effects of JAM-A-deficient platelets could be abolished by the inhibition of alphaIIbbeta3 signalin
238 Colocalization of PDI and beta-actin could be abolished by the membrane-permeable sulfhydryl blocke
240 19S bind to the a1 subunit of vATPase, which is abolished by the LRRK2-R1441C mutation, leading to a
241 ystem, and that the ability to cause disease is abolished by the natural absence or experimental dele
243 eotide-binding domain 1 (NBD1) pore loop and is abolished by the Y662A mutation that disrupts substra
245 uction by PAMPs in primary human hepatocytes was abolished by the addition of neutralizing IL-6 antib
247 rnal QX-222 created by mutations of Ile-1575 was abolished by the additional mutation K1237E, support
251 mpairment to recognize the familiar juvenile was abolished by the coinfusion of agonist plus antagoni
253 e maternal defense test, maternal aggression was abolished by the CRF-R2, but not the CRF-R1, agonist
254 Furthermore recombinant GST-theta activity was abolished by the denaturants triton X-100, Gua-HCl,
255 otected mice from S. aureus infection, which was abolished by the depletion of either monocytes/macro
258 nhanced glycerol release, a dual effect that was abolished by the inhibition of cAMP-dependent protei
259 terial EC differentiation, and this increase was abolished by the inhibition of ROS generation or by
260 the effect of TX on GLT-1 promoter activity was abolished by the inhibition of the NF-kappaB pathway
261 n of NAD(+) significantly increased JO2, and was abolished by the inhibitor of mitochondrial pyruvate
262 rrent transient seen with phosphatidylserine was abolished by the mutation E198Q, which blocks dephos
263 Prdx6 for aiPLA2 activity, and this activity was abolished by the mutation of serine 32 to alanine (S
264 bitor trichostatin A, an effect that in turn was abolished by the NF-kappaB inhibitor N(4)-[2-(4-phen
266 on in the presence of fibronectin aggregates was abolished by the PKA inhibitor H89, whereas the effe
268 at Thr(345)-Leu(346) and Asn(347)-Leu(348), was abolished by the presence of Asn(347) glycosylation
271 not depend on the loss of noradrenaline but were abolished by the antiparkinsonian drug, L-DOPA, or
272 he atropine-insensitive tachycardia and PVCs were abolished by the beta(1) -adrenoceptor antagonist a
273 f 32 kDa), most of the behavioral phenotypes were abolished by the D1R antagonist, SCH23390, and the
275 , typical of P2X1 homomeric receptors, which were abolished by the selective P2X1 antagonist NF449 (1
276 lammatory effects of water-induced hemolysis were abolished by the simultaneous administration of DEA
279 1-EBIO enhanced whole cell currents which were abolished by TRAM-34 and reduced by apamin indicati
287 ermeability to FITC-Dextran, and this effect was abolished by treatment with anti-TLR2 blocking antib
300 n and increased beta-catenin activation that was abolished by XAV939, a pharmacological AXIN stabiliz