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1 expression induced RPE cell apoptosis, which was abrogated by 100 nm docosahexaenoic acid, 10 ng/ml p
3 ic function for a wild-type polyQ tract that is abrogated by a competing longer polyQ mutation in a d
6 naling was found when GLP-1R internalization was abrogated by a dominant-negative version of dynamin
8 mice, secretion of IL5, IL13, IL6 and IL17A was abrogated by a mechanism involving IL33 signaling in
10 st differentiation in vitro, and this effect was abrogated by a physiological BMP-2 inhibitor, noggin
15 neously enhancing muscle regeneration, which is abrogated by adaptive transfer of normal macrophages.
18 ydroethidium fluorescence, an elevation that was abrogated by administration of nitro-l-arginine meth
19 and interleukin 6 responses to infection and was abrogated by alveolar macrophage depletion, using cl
26 Analogue potentiation of the GABA current was abrogated by an alpha(1) subunit Q241L mutation, ind
27 ne receptor agonist U46,619, and this effect was abrogated by an antagonist of the DP1 prostanoid rec
28 the immune activation of cardiac fibroblasts was abrogated by an IL-1R antagonist and an IL-1alpha-bl
29 d expression of M2 genes by TonEBP knockdown was abrogated by antagonism of IL-10 by either neutraliz
30 as associated with ICOS/ICOSL engagement and was abrogated by antagonist anti-ICOS and anti-ICOSL ant
31 s, and that virus infectivity in HT-29 cells is abrogated by anti-A-type antibodies as well as signif
38 eased AHR and higher leukotriene levels that were abrogated by anti-PlGF Ab or the 5-lipoxygenase inh
39 late-phase decrease in body temperature that was abrogated by antibody-mediated depletion of neutroph
42 d activation of the neutrophil NADPH oxidase was abrogated by bacterium-derived proteolysis of galect
43 genic capacity of Th17 cells to transfer EAU was abrogated by BET inhibitors in an adoptive transfer
44 une cytokine elicitation by all Ad serotypes was abrogated by blockade of endosomal acidification, ca
45 wling behavior in CD14(dim)CD16(+) monocytes was abrogated by blockade of ICAM1, VCAM1, or CX3CL1, in
47 A component of FIV that is Kir independent is abrogated by blocking Ca(2+) -sensitive K(+) channels
49 increased sperm intracellular Ca(2+), which was abrogated by blocking the sperm-specific Ca(2+) chan
52 that MtRS also induces p53 expression, which was abrogated by Ca(2+) chelators and short hairpin RNA-
54 ion of beta-catenin critical to osteogenesis were abrogated by calreticulin deficiency or NFAT blocka
55 roliferation caused by blue/green could also be abrogated by capsazepine, and by the antioxidant, N-a
57 This chemoreflex anti-inflammatory network was abrogated by carotid chemoreceptor denervation and b
58 prevented by stop codons or activity of D10 was abrogated by catalytic site mutations, without other
60 tional proinflammatory functions in NTN that were abrogated by cell-specific deletion of RORgammat.
61 nhibit translation, and that this activation is abrogated by certain modifications present in cellula
62 man villous trophoblasts, and this induction was abrogated by CH223191, an aryl hydrocarbon receptor
63 gy-initiation proteins Atg3 and Atg5, and it is abrogated by chelating cytoplasmic calcium or inhibit
65 ibitory effects of PRH on cell proliferation are abrogated by CK2 and that CK2 inhibits the binding o
67 ese detrimental effects of diabetes mellitus were abrogated by co-administration of SEP and L-Cit.
69 naling and stroma-mediated resistance, which is abrogated by combination therapy with gamma secretase
70 y responses against pathogenic organisms can be abrogated by commensals; however, the molecular mecha
73 ortantly, the antimicrobial effect of MSC EV was abrogated by cotreatment with a LTB(4) BLT1 antagoni
74 mide- and IMiD-induced SALL4 degradation can be abrogated by CRBN V388I mutation or SALL4 G416A mutat
75 te growth promotion and myelin disinhibition were abrogated by CRMP2 inhibition and largely mimicked
76 rophic-like disease in STIM1 transgenic mice was abrogated by crossing in a transgene expressing a do
77 -3) The rescue of N57A by G94D in HIV-1(LAI) is abrogated by CsA treatment in some cell types, demons
86 ibitor aphidicolin, and active demethylation was abrogated by deletion of Tet3 in both pronuclei.
88 ggesting a role in tumor growth; this effect was abrogated by deletion of two hydrophilic domains.
89 APP, reducing amyloid-beta production, which are abrogated by delta-secretase cleavage of TrkB in AD.
92 The antitumor activity from Mertk inhibition was abrogated by depletion of cytotoxic CD8alpha T cells
94 responsive, whereas their enduring activity is abrogated by different microenvironmental immunosuppr
95 imicrobial peptide human beta-defensin 2 and is abrogated by digestion of milk HA with a specific hya
96 urable endothelial cell NO production, which was abrogated by dihydrotestosterone in an androgen rece
98 n be opposed by HDAC1, but not by HDAC3, and is abrogated by disrupting HIF1alpha-p300 interaction.
99 the in vivo pro-tumorigenic effect of CA-MSC is abrogated by dual blockade with the JAK2 inhibitor ru
100 ER stress observed in hLrp1(-/-) hepatocytes were abrogated by E64D treatment, whereas inhibiting ER
102 ctivated T cells (NFAT) nuclear accumulation was abrogated by either antioxidant supplementation or C
105 lls was mediated by complex-type glycans and was abrogated by enzymatic inhibition of N-linked glycos
110 This effect of Asef2 on spines and synapses is abrogated by expression of GEF activity-deficient Ase
111 er was activated by E2F1, and the activation was abrogated by expression of SHP and its co-repressor
113 wal defect in transplanted recipients, which was abrogated by genetic ablation or pharmacologic inhib
114 lencing-induced increase in LR-MSC migration was abrogated by genetic and pharmacologic targeting of
116 ariation in microglial synaptic phagocytosis was abrogated by global REV-ERBalpha deletion, which cau
117 ans and mice, and the effect of AKI on FGF23 was abrogated by GPAT inhibition or Lpar1 deletion.
120 (PAF) causes wheal and flare responses which are abrogated by H1-antihistamines giving rise to the hy
122 ol induced S-phase accumulation; this effect was abrogated by HDACI coadministration, which suggests
123 eta mRNA upregulation in chicken macrophages was abrogated by heat inactivation or pre-exposure of th
125 d insulin sensitivity in obese M4K4 iKO mice was abrogated by high exogenous insulin over the course
128 gressive 4T1 breast cancer cells in mice can be abrogated by inactivation of tumor-evoked regulatory
129 restricts virus replication, and infectivity is abrogated by inactivation (e.g., irradiation, heating
130 e of binding ligands at the active site, and is abrogated by inactivation of the catalytic residue Se
132 inhibition of B6.K(d) heart graft rejection was abrogated by increasing T cell help through transfer
134 clusively within RV-infected cells and could be abrogated by inhibiting the lysosomal-endosomal degra
136 s and that the efficacy of this strategy can be abrogated by inhibition of TGFbetaR on BM-hMSCs.
137 njury induced sickness behavior, which could be abrogated by inhibition of the HMGB1-RAGE pathway or
138 or HSF1-mediated neuroprotection, protection is abrogated by inhibition of classical histone deacetyl
139 y controlled by hypoxia and how this control is abrogated by inhibition of insulin-like growth factor
141 that this co-culture-induced chemoresistance is abrogated by inhibition of the CXCR4 and hedgehog pat
142 ty in mesenchymal progenitor cells, and this was abrogated by inhibition of ataxia-telangiectasia-mut
145 When the Grp94-mutant myocilin interaction is abrogated by inhibitors or siRNA, mutant myocilin is
147 Increases in VEGF and NADPH oxidase levels were abrogated by inhibitors of NADPH oxidase and MAPK,
148 ed with expression of TNF receptor TNFR1 and was abrogated by interfering with the TNFalpha/TNFR1 int
155 ive oxygen species generation and cell death were abrogated by knock down of uncoupling protein 3.
156 ased production of superoxide, both of which were abrogated by knockdown or antibody blockade of SIRP
157 inflammatory actions by activated platelets were abrogated by lack of CD40 on injected platelets.
158 (mepS) were synthetic sick, and the defects were abrogated by lack of l,d-transpeptidases, enzymes c
162 ral endothelial alterations induced by Abeta were abrogated by lovastatin, consistent with its anti-i
164 sed endothelial cell apoptosis, all of which were abrogated by maternal administration of intravenous
171 that LpSpl possesses S1P lyase activity that was abrogated by mutation of the catalytic site residues
172 using wild type AChE 3'-UTR RNA segment that was abrogated by mutation of the consensus recognition s
173 ct did not depend on enzymatic activity, but was abrogated by mutations disrupting the hexameric stru
174 tion of high glucose-induced NOX4 expression was abrogated by N(omega)-nitro-l-arginine methyl ester,
179 n of metabolic disorders via brain ER stress was abrogated by NF-kappaB inhibition in the hypothalamu
182 igation induced STAT5 phosphorylation, which was abrogated by nontoxic concentrations of the JAK1/2 i
186 HNE-induced increases in GSH and NQO1 levels were abrogated by Nrf2 small interfering RNA in normal c
188 persensitive to amino acid feeding, and this is abrogated by oral administration of EGCG prior to cha
189 while in the remaining cases, TP53 activity is abrogated by other oncogenic events, such as hyperact
192 giotensin-II-promoted MARCKS phosphorylation is abrogated by PEG-catalase, implicating endogenous H(2
193 l of organ transplantation with CD40Ig could be abrogated by permanent depletion of CD8(+) cells that
195 lysosomal damage and cytotoxicity of Dp44mT were abrogated by Pgp inhibitors, Pgp silencing, or incr
197 thelial de-differentiation observed in vitro was abrogated by pharmacological blockade of the ALK-5 c
198 ingly, ABHD5-dependent suppression of mTORC1 was abrogated by pharmacological inhibition of DGAT1 or
200 spiration and ATP production, an effect that was abrogated by phosphocreatine-mediated reactivation o
201 line expressing endogenous mutated p53, can be abrogated by pre-miR-205 or silencing of mutated p53.
203 lter responses to AMPA receptor agonists and was abrogated by preabsorption of CSF with HEK cells exp
204 en-induced acute liver failure plasma, which was abrogated by preincubation with deoxyribonuclease-I.
205 e oxygen species (ROS) generation because it is abrogated by pretreatment of PC cells with the free r
206 r, FXIIa stimulated IPF HLF migration, which was abrogated by pretreatment of cells with heparinase I
207 MOG-induced models of EAE, respectively, and was abrogated by pretreatment with a depleting anti-CD25
208 induced BBB disruption and neuroinflammation were abrogated by pretreatment with the rho kinase inhib
210 onversion was reversible by antioxidants and was abrogated by prior methylation of basic amino acids.
220 ation of nPKCs (PKCepsilon) and PKD that can be abrogated by selective inhibitors or by expression of
221 The adverse immunostimulatory responses were abrogated by selective B cell-targeted delivery and
222 show that fusion of macropinosomes/endosomes is abrogated by septin immunodepletion and function-bloc
223 S100P elevation under hypoxic conditions was abrogated by silencing of Cav1 or NF-kappaB function
224 ar signal-related kinase 1/2 and Snail1 that was abrogated by silencing of TrkA or CCN2 using small i
225 CCL5 Such infiltration and tumor regression were abrogated by silencing CCL5 in BECN1-defective tumo
227 nvasion, and the enhancement of invasiveness was abrogated by small interfering RNA (siRNA)-mediated
231 levels were maintained, whereas IL-13 levels were abrogated by steroid treatment in neonatal HDM-expo
233 ion of NK1-expressing PC, with these effects being abrogated by systemic administration of the opioid
234 and that the aberrant cellular changes could be abrogated by targeting the cell-mechanosensing machin
235 transcription and protein expression, which were abrogated by Tat heat inactivation, immunodepletion
239 -) dams provoked pregnancy loss, which could be abrogated by the adoptive transfer of IL-10(+/+) NK c
243 tion of AhR is 5-HT(2B) dependent because it is abrogated by the 5-HT(2B)-specific antagonist SB20474
245 prognostic impact of chemotherapy resistance is abrogated by the implementation of early response-bas
247 the angiogenic receptor neuropilin-1 (NRP-1) is abrogated by the liver kinase B1 (LKB1), a serine-thr
249 poI-induced contact between homologous genes is abrogated by the transcriptional inhibitors actinomyc
250 nd to lower concentrations of eotaxin, which was abrogated by the above-mentioned PKCbetaII inhibitor
251 ; and queuine-stimulated in vivo methylation was abrogated by the absence of the enzyme that inserts
254 ssing the couAB promoter region, and binding was abrogated by the addition of nanomolar quantities of
257 f S100A9KO mice, but not wild-type mice, and was abrogated by the administration of anti-CD8 Ab or ad
258 ile recruitment to the oxidative DNA lesions was abrogated by the anti-oxidant N-acetylcysteine, this
259 HRL-4-mediated degradation of E. chaffeensis was abrogated by the autophagy inhibitor 3-methyladenine
260 gmented by dominant-negative RhoA(T19N), but was abrogated by the constitutive-active RhoA(G14V).
261 uclear localization of P. pastoris MS (PpMS) was abrogated by the deletion of 107 C-terminal amino ac
262 e, the suppressive effect of oxo-m on PF-LTP was abrogated by the GDP analog GDP-beta-S (applied intr
268 ulin autoantibodies by TRAV5D-4 alpha-chains was abrogated by the mutation of insulin peptide B:9-23
271 s revealed that TNF-alpha-induced cell death was abrogated by the simultaneous inhibition of caspases
273 Ancestry-related differences in relapse risk were abrogated by the addition of a single extra phase o
274 d STAT3 phosphorylation and astrogliogenesis were abrogated by the addition of neutralizing antibody
275 l of the effects of TNF-alpha on SDC4 and HS were abrogated by the metalloproteinase (MMP) inhibitor
278 Spontaneous and TGF-beta1-stimulated EndoMT were abrogated by the restoration of functional CAV1 dom
282 Thus, TorA-nucleoporin interactions might be abrogated by TorA-DeltaE, suggesting new experimental
283 f colitis, and this increased susceptibility is abrogated by transfusion of HYAL2-competent platelets
284 or high glucose in vitro, and this increase was abrogated by transgenic overexpression of superoxide
285 e single binding sites in vitro, and binding was abrogated by transversions in the binding sites that
286 ta indicate that inflammatory osteolysis can be abrogated by treatment with a molecule composed of th
287 f MAPK inhibitor resistance in melanoma, can be abrogated by treatment with the MDM2 inhibitor Nutlin
288 transcription 5 (STAT5) phosphorylation and is abrogated by treatment with C188-9, a STAT3/5 inhibit
291 mice suppressed melanoma growth; this effect was abrogated by treatment with neutralizing antibodies
292 ce by the ERBB2 extracellular domain mutants was abrogated by treatment with small-molecule inhibitor
295 ng term barrier-promoting effects of HDL-S1P were abrogated by treatment with the recycling blocker,
299 To ascertain if this interference could be abrogated by using a synthetic non-acetylated oligosa