ライフサイエンスコーパス: be accessible to

1 ts that in alpha3betaGlyRs, the binding site is accessible to 2,6-DTBP only after PKA-dependent phosp

2 Cys43 and Cys47 were accessible to 2-aminoethyl methanethiosulphonate (M

3 tly after hatching, at a time when zebrafish are accessible to a battery of techniques to test neuron

4 lter Mg2+ sensitivity and those that do not, are accessible to a modifying reagent [sodium (2-sulfona

5 these exposed and unstructured histone tails are accessible to a repertoire of regulatory factors tha

6 Ergatis was designed to be accessible to a broad class of users and provides a u

7 llel, high-throughput screening of SNPs will be accessible to a large number of laboratories.

8 DOM processing at the molecular level should be accessible to a much wider group of scientists than b

9 ndirect acute lung injury and that it should be accessible to a siRNA-based therapeutic intervention

10 Such computational methods must be accessible to a variety of users beyond computational

11 ive documentation, this tool was designed to be accessible to a wide public, from high school student

12 The dNLP-ISWI system should be accessible to a wide range of researchers and enable

13 s strongly suggest that the BTV dsRNA genome is accessible to a Dicer-type nuclease.

14 The matrix copper pool is accessible to a heterologous cuproenzyme.

15 Furthermore, this compartment is accessible to a membrane-bound marker (dimeric immuno

16 nlinear subunits and show that this capacity is accessible to a structural learning rule that combine

17 low more accurate diagnosis in a format that is accessible to a wider variety of laboratories, we dev

18 IcsA is, therefore, unlikely to be accessible to actin-nucleating proteins within the eu

19 n the presence of glucose, the ADH2 promoter is accessible to Adr1 but that other interactions that o

20 These data demonstrate that chromosomal DNA is accessible to agPNA-peptide conjugates and that chemi

21 d may find broad applicability to crops that are accessible to Agrobacterium T-DNA transfer.

22 icate that Watson-Crick faces of nucleobases are accessible to alkylating agents in canonical dsDNA a

23 king these implicated beta-sandwich regions, are accessible to alkylation in the fibril indicating a

24 hile others (such as pyrosequencing) may not be accessible to all laboratories.

25 although it is possible for all this data to be accessible to all through the internet, the more orga

26 s an integral part of health care and should be accessible to all, no matter the setting.

27 Efforts to ensure that an aggressive regimen is accessible to all patients with MDR tuberculosis, suc

28 is much lower than that of the tyrosines and is accessible to an external fluorescence quencher.

29 ce of the spore's inner membrane, as SpoVAEa was accessible to an external biotinylation agent in spo

30 The combined model is accessible to analysis by reduction to a set of ordin

31 ng for nutritional improvement of foods that are accessible to and eaten by many.

32 scape governs the conformational states that are accessible to and sampled by the translating ribosom

33 onvert inputs into functioning services that are accessible to and used by all segments of the popula

34 oxidized at electrochemical potentials that are accessible to anoxygenic phototrophs and thus the mo

35 ts that had emerged from the plasma membrane were accessible to anti-isotype-reactive microparticles.

36 actions and suggest that viral glycoproteins are accessible to antibodies on infected nerve fibers an

37 hough only two regions of the capsid surface are accessible to antibodies, local clustering of the li

38 of p64 is exposed at the virion surface and is accessible to antibodies and mild trypsin digestion.

39 of gp41 in the prehairpin intermediate state is accessible to antibodies and that access is not restr

40 tells us what is actually expressed and what is accessible to antibodies.

41 positions define the molecular surface that is accessible to antibodies.

42 A, the recombinant OspA decorating the cells was accessible to antibodies and proteases and could be

43 , full-length human, rabbit, and mouse MATE1 were accessible to antibodies from the extracellular fac

44 ding of subunit delta, whereas the other one is accessible to antibody binding without impact on the

45 MalE was accessible to antibody binding, indicating that it i

46 lling results indicated that none of the IRs were accessible to antibody at the spirochetal surface i

47 , 70.0% (+/- 5.5%) of intracellular bacteria were accessible to antibody delivered to the cytoplasm,

48 Furthermore, some Bdr paralogs were accessible to antibody in the IP experiments only i

49 periodically on the cell surface where they were accessible to antigen-specific B cells.

50 techniques described in this protocol should be accessible to any general molecular biology laborator

51 Our approach is accessible to any investigator who wishes to assimila

52 The technology is accessible to any researcher who can operate an AFM i

53 ook and how to see, advances in neuroscience are accessible to anyone and require minimal resources.

54 a web-based python notebook (Jupyter), OMAAT is accessible to anyone without programming experience y

55 s in tissues and cells expressing SR-BI that are accessible to apoE-containing lipoproteins.

56 all molecule inhibitor demonstrates that JH2 is accessible to ATP-competitive compounds, which offers

57 Certain elements of this sequence that would be accessible to Atp11p in the free beta-subunit make co

58 lpha-form are exposed on the [100] faces and are accessible to attack by ammonia gas.

59 ed of monomer subunits in which the epitopes are accessible to autoantibodies, and the D-isoform comp

60 In contrast, this site was accessible to avidin when the identical construct wa

61 o declarative memory is that what is learned is accessible to awareness.

62 DNA must be accessible to B cells for both the production of high

63 e pool of cholesterol in the plasma membrane is "accessible" to binding by a modified version of the

64 ein is oriented such that the fusion partner is accessible to binding of its target from solution.

65 None of these results are accessible to bioinformatic methods hitherto availab

66 NetworkAnalyst is designed to be accessible to biologists rather than to specialist bi

67 t of the HER2 status of lesions that may not be accessible to biopsy and assessment of HER2 heterogen

68 unusual all-oxygen trigonal ligand field and are accessible to both inner- and outer-sphere oxidants:

69 ropriate, similar, environmental spaces that are accessible to both species or populations being comp

70 nd that only two mutants, F1579C and V1583C, were accessible to both outside and inside 2-(aminoethyl

71 HA stem regions on the surface of the virus are accessible to broadly neutralizing antibodies.

72 mutant complexes, interfacial pockets, which are accessible to bulk solvent are formed, whereas inter

73 Certain environmental parameters are accessible to cells only indirectly and require an e

74 These results show that the LGST is accessible to cellular cytosine deaminating agents, e

75 membrane nephritis in which immune complexes are accessible to circulating neutrophils, Fc gamma RIII

76 hat would favor tumor-homing to targets that are accessible to circulating phage, but are not blood v

77 eveal that the activation loop in the kinase is accessible to cleavage and unstructured.

78 directly tested whether the TCR-gamma locus is accessible to cleavage by recombinant Rag proteins in

79 In this way, part of the Umwelt can be accessible to companions, facilitating the communicat

80 ach are that the time and length scales that are accessible to computer simulations often do not reac

81 nguishes true from false recognition may not be accessible to conscious awareness.

82 ons without evoking a perceptual outcome nor being accessible to conscious scrutiny.

83 nt fraction of the surface functional groups is accessible to covalent surface derivatization indepen

84 riments first defined locations in FepA that were accessible to covalent modification with fluorescei

85 In addition, a Cys residue in DBMsignal/PHMs was accessible to Cys-directed biotinylation.

86 strate peptide delivered by either conjugate was accessible to cytosolic kinase as demonstrated by th

87 PG lipids in the outer leaflets of membranes are accessible to daptomycin.

88 ements of such charge distributions have not been accessible to date.

89 V93C, D95C, Y97C, and L99C are accessible to derivatization.

90 ing that each Glu-14 residue in the oligomer is accessible to DiPC.

91 ite should be located in chromatin, where it is accessible to DNA-binding proteins, and it should be

92 tinct classes of open chromatin that may not be accessible to DNase I or Tn5.

93 Target molecules and binding epitopes must be accessible to drug carriers, carriers must be free of

94 the numbers of low-lying excited states that are accessible to each of the disease mutants can vary s

95 om the interference produced when both slits were accessible to each photon.

96 ysteine ligand: the cysteine is reactive and is accessible to electrophilic attack; cysteine S-thiosu

97 ns, indicating that the recombining DNA ends are accessible to end-processing enzyme activities.

98 C-terminal extracellular domain of SpoIIIAH is accessible to enzymatic modification from the forespo

99 that the pyroglutamate at the amino terminal was accessible to enzymatic removal using the thermostab

100 ey to estimating the fraction of soil C that is accessible to enzymes.

101 E6gamma binding sites of PDE6 alpha and beta are accessible to excess (presumably cytoplasmic) PDE6ga

102 turating flash suggested that the donor Y(Z) was accessible to exogenous Mn(2+) ions.

103 olated microsomes from CaCo2 and HepG2 cells were accessible to exogenously added trypsin, indicating

104 The basic elements are accessible to experimental investigation with curren

105 pulmonary exacerbations; nevertheless, they are accessible to experimental replication within labora

106 hly stereotypic manner, during which time it is accessible to experimental manipulation.

107 er a century, but they have not historically been accessible to extensive genetic manipulation.

108 uggested that an extended length of TM11 may be accessible to external substrates and probes.

109 th that of pre-ComGC, the major pilin, which is accessible to externally added protease and requires

110 ne may be required for these glycosidases to be accessible to extracellular chitooligosaccharides, (G

111 spike trains from pairs of units that would be accessible to extracellular recording.

112 Additionally, cell wall-localized Ply is accessible to extracellular protease and is detergent

113 were mapped to its transmembrane domain that is accessible to extracellular ZnT8 antibody (ZnT8A).

114 flaps oriented toward the nucleosome surface are accessible to FEN1 cleavage in nucleosomes containin

115 ccurs in some cases where benzylic hydrogens are accessible to form benzylic urazole products.

116 wavelengths beyond the optical range(8) that are accessible to frequency combs(9).

117 s and other forms of synaptic plasticity may be accessible to further investigations, exploiting adva

118 cords of geologically recent climate changes are accessible to future automated and human surface exp

119 tively in simple experimental organisms that are accessible to genetic manipulation, such as snails,

120 hat can be imaged at cellular resolution and is accessible to genetic manipulation.

121 s inherent differences in the Akt pools that are accessible to growth factors as compared with the po

122 (13)CO2, showing that both types of cavities are accessible to guest molecules from the gas phase.

123 Prior studies suggested mouse brain is accessible to GUS in the first 2 weeks of life but no

124 d 2 (ACC1 and ACC2) fragments, both of which are accessible to HCS in the cytoplasm, is slow and disp

125 Unlike the brain, the retina is accessible to high-resolution, non-invasive imaging.

126 The signal peptide of Midkine is accessible to HLA class II pathway for CD4 T cell pre

127 Because only fragments of its habitat are accessible to humans, this endangered salamander's e

128 renewable nitrogenous material on earth and is accessible to humans in the form of crustacean shell

129 tested whether cysteine substitutions in TM7 were accessible to hydrophilic, membrane-impermeant meth

130 STRs (Y-STRs) with 2-6 bp repeat units that are accessible to Illumina sequencing.

131 oth, neuroinflammation and neurodegeneration were accessible to (immuno-) histochemical methods as we

132 n studied only in living animals and has not been accessible to in vitro analysis.

133 The protocol is accessible to individuals with basic skills in (i) mo

134 The protocol is accessible to individuals with experience in microsco

135 ct of MET signaling in cancer that would not be accessible to inhibition by therapeutic antibodies.

136 a conserved, sulfate-binding region of gp120 is accessible to inhibitors in the absence of CD4, and s

137 ASIMOV is accessible to inspection, modification, and experimen

138 dependent from the rest of the structure and is accessible to interactions.

139 critical for the S-glutathionylation, which was accessible to intracellular but not extracellular ox

140 ; however, until recently the method has not been accessible to investigators.

141 ling in these systems, the nitrite pool must be accessible to isotopic analysis.

142 f CMs are surface-exposed and are thought to be accessible to kinases for phosphorylation.

143 and Cys-209 of SERT in ERp44-silenced cells are accessible to labeling by MTSEA-biotin.

144 All but one mutation (K578C) was accessible to labeling with [(3)H]-NEM.

145 y, none of the membrane-processed constructs was accessible to labeling with BM and MTS-TAMRA, nor we

146 n of the extravascular volume in tumors that is accessible to large therapeutic agents is heterogeneo

147 eric pathway via the bicyclic peroxy radical is accessible to lead to ring cleavage.

148 already known binding pocket of 2GBI, which is accessible to ligands from the intracellular side; th

149 However, not all plant tissues are accessible to live imaging using confocal microscopy

150 P27-independent nuclear export pathways that are accessible to many viral transcripts during infectio

151 poxvirus infections, and the technology used is accessible to many laboratories worldwide.

152 e sulfur-rich core of the trimeric BACE1 TMS is accessible to metal ions, but copper ions did not tri

153 and 11 residues, respectively, were found to be accessible to methanethiosulfonate ethylammonium (MTS

154 ral consecutive mutants of motifs II and III are accessible to methanethiosulfonates, suggesting that

155 The oral cavity is accessible to microorganisms, and biofilms are presen

156 tor indicate that H4 and other core histones are accessible to modification throughout the chromatin,

157 an adjoining segment (residues B23-B29) that is accessible to modification in insulin but not proinsu

158 Y102C was accessible to modification by methanethiosulfonate,

159 eric POT1; moreover, telomeres were found to be accessible to modifying enzymes at this time in the c

160 t on shallow external-surface pockets, which are accessible to molecules that are too bulky to benefi

161 show that A. gambiae salivary gland proteins are accessible to monoclonal antibodies that inhibit spo

162 hout storing images of shapes in memory that are accessible to more than one sensory modality.

163 gical assessment and conventional tests that are accessible to most clinicians.

164 oughout the muscle plasma membrane, where it is accessible to MSPd within the pseudocoelomic fluid.

165 Only three of eight M2M3 loop residues were accessible to MTSEA in both the presence and absenc

166 at most of the positions that react with NEM are accessible to MTSES; however, the two NEM-reactive m

167 Conversely, immobilized bees are accessible to neurobiological investigation but disp

168 on of gp41 close to the transmembrane domain is accessible to neutralizing Abs and could form a usefu

169 At +20 mV, N-terminal H6 and biotin tags were accessible to Ni2+ and streptavidin, respectively,

170 CanPIE's web-based interface was designed to be accessible to non-bioinformaticians, its back-end pip

171 a need for a real-time web application that is accessible to non-expert users.

172 rogram, HIV Therapy Simulator (HIVSIM), that is accessible to non-technical users.

173 ive CREs are imbedded in open chromatin that are accessible to nucleases.

174 that has normal nucleosome organization and is accessible to nucleases but excludes hSWI/SNF.

175 ow 500 km) of flares are rarely observed and are accessible to only a few instruments world-wide.

176 ins the only potentially curative option and is accessible to only a small number of fit patients.

177 c innervation at early stages, when the fish are accessible to optical, genetic, and electrophysiolog

178 n expression results and 250,000 images that are accessible to our search tools.

179 Efforts must be made to ensure that assays are accessible to patients most likely to be enrolled on

180 threonine 310, serine 313, and glycine 314, were accessible to pCMBS as judged by the inhibition of

181 ed that this is the main reason why ebulin f is accessible to pepsin action and more sensitive to deg

182 ve of newly synthesized MHC II molecules may be accessible to peptides, allowing newly synthesized MH

183 wever, the range of possible structures that are accessible to peptoids and other biological mimetics

184 on NPY neurons in the arcuate nucleus, which is accessible to peripheral hormones.

185 Subsequently, the RNA must be accessible to permit reverse transcriptase to create

186 As it is accessible to pharmacological modulation, it provides

187 em, we focused on the auditory system, which is accessible to physiological analysis.

188 (317) is near the surface of the protein and is accessible to plasmin.

189 show that beta-glucan in C. albicans hyphae is accessible to PMNs and sufficient to support an innat

190 he range of sequences within duplex DNA that are accessible to PNAs and suggest that TC-PNA-peptide c

191 no-terminal analogs (AbetaF4W and AbetaY10W) are accessible to polar quenchers, and the more carboxyl

192 of certain FliP trans-membrane (TM) segments are accessible to polar reagents.

193 lar end of TM2 (R287C, V289C, P290C, A291C), were accessible to positively charged reagents, whereas

194 The Pd-Cl groups inside the pores are accessible to post-synthetic modifications that faci

195 se results suggest that neuromotor noise may be accessible to practice interventions.

196 at at neutral pH the E1 protein regions that are accessible to proteases include domains 1-21 (region

197 ws that the C-terminal domain of N-218 MLN64 is accessible to proteolysis whereas the 244-414 domain

198 ever, enolase in the outer membrane vesicles is accessible to proteolytic degradation by proteinase K

199 e bronchial airway lymphoid tissues prove to be accessible to QSSM.

200 51 are relatively inaccessible, whereas W240 is accessible to quenching agents.

201 In addition, NBD was accessible to quenching agents in both the absence a

202 hopoiesis requires that immunoglobulin genes be accessible to RAG1-RAG2 recombinase.

203 es the fraction of unbound ligand sites that are accessible to receptors, and thus available for bind

204 l epitopes present in the signal peptide can be accessible to recognition by CD4(+) T cells and may t

205 s, the history of kinematic evolution should be accessible to reconstruction through analysis of limb

206 strates that the underlying electrode system is accessible to redox-active molecules through the hydr

207 l, and they demonstrate that heterochromatin is accessible to regulatory factors.

208 Because psoriasis plaques are accessible to repeat biopsy, the effect of TNF/lymph

209 nexpensive, customized cDNA microarrays that are accessible to researchers in a broad range of fields

210 Data sets are accessible to researchers through a community driven

211 e fraction of the Alus within K562 chromatin is accessible to restriction enzyme cleavage and cell st

212 1, is restricted to pro-B cell lines and HS1 is accessible to restriction enzyme digestion exclusivel

213 The aggregate was accessible to RT as pre-formed aggregates synthesize

214 S267C was accessible to short chain (C3-C8) MTS in both open a

215 This subpopulation was accessible to signal peptidase on ribosome-associate

216 behaviors expected for these proteins might be accessible to single-molecule measurements.

217 Significantly, these structures are accessible to small tracers (horseradish peroxidase

218 1) A matrix (collagen fibrils) that is accessible to small apatite crystals but not large mo

219 ed and disease specific manner and one which is accessible to small molecule approaches.

220 at the heme active site in both morphologies is accessible to small molecules for catalysis.

221 ithin the presumably compact A+T-rich region were accessible to small chemicals and oligonucleotide h

222 quenching studies reveal that the open state is accessible to solute quenching by potassium iodide, b

223 and XI, which line the inward-facing cavity, are accessible to solvent from the periplasmic surface o

224 and only, while positions 46, 49, 67, and 70 are accessible to solvent in the absence or presence of

225 fonate (MTSES) show that positions 45 and 53 are accessible to solvent in the presence of ligand only

226 inimal interactions with the protein, and it is accessible to solvent and away from the site of hydro

227 The channel is accessible to solvent at the base of a cleft adjoinin

228 have focused on backbone substitutions that were accessible to solvent.

229 s extinction occurred when no suitable sites were accessible to species.

230 linated axons of retinal ganglion cells, and is accessible to study with optical coherence tomography

231 nly logical states and processes in the mind are accessible to subjective consciousness.

232 CA3 region, where both sides of the synapses are accessible to substances injected into the cell bodi

233 Here, the kinase active site is accessible to substrate, yet the conformation of the

234 Twelve lysine residues were accessible to sulfo-NHS-LC-biotin.

235 rom achiral to chiral in a single step--that are accessible to synthetic chemists.

236 the reactive groups in the subsequent layer are accessible to the ammonia gas.

237 ell as two residues in the intervening loop, are accessible to the aqueous phase from the periplasmic

238 6, 329, 330, and 331 in the cytoplasmic half are accessible to the aqueous phase from the periplasmic

239 PEG coil a smaller fraction of the monomers are accessible to the DNA.

240 surface exposure of STIM1, short His(6) tags are accessible to the dye or antibodies, demonstrating e

241 es based on their ability to find sites that are accessible to the EGS oligonucleotides.

242 ls is mediated by neurons bearing cilia that are accessible to the environment.

243 that maternally administered antidepressants are accessible to the fetus in a manner not previously a

244 expression, indicating that blood stimulants are accessible to the macrophages and that these macroph

245 owed that the N and C termini of the peptide are accessible to the solvent in the fibril state and th

246 f chemical defects, where hydrocarbon chains are accessible to the solvent, and geometrical defects,

247 pitopes mapped to the surface of the protein are accessible to the solvent.

248 ound pmAAT or mAAT-pp, both Arg-8 and Arg-28 are accessible to the solvent.

249 conditions to identify regions of SecA that are accessible to the trans side of the membrane in its

250 All alignment parameters are accessible to the user including the ability to spec

251 c-hydrophilic interface and at the same time be accessible to the aqueous phase.

252 any of the targeted antigens may in fact not be accessible to the B-cell immune system in untreated m

253 lk phase of the membrane and not expected to be accessible to the cytosolic glutathione.

254 13 of the 26 residues tested were found to be accessible to the reaction with 3-(N-maleimidylpropio

255 This location would be accessible to the stroma, thereby promoting efficient

256 conformation of loop 3 in the binary complex is accessible to the apo-enzyme and is the favored confo

257 Remarkably, this membrane-spanning face is accessible to the aqueous phase from the periplasmic

258 e that online ophthalmic patient information is accessible to the broadest audience possible.

259 conformation for LeuT in which the substrate is accessible to the cytoplasm and a corresponding mecha

260 uggest that newly synthesized apoB in the ER is accessible to the cytoplasmic ubiquitin-proteasome pa

261 al question concerns the extent to which AID is accessible to the displaced strand of a transcription

262 esponse are similar regardless of whether Ag is accessible to the endogenous MHC class I pathway or c

263 The cavity is accessible to the external milieu by means of gaps be

264 xofacial portion of transmembrane segment 11 is accessible to the external solvent and provide eviden

265 exofacial portion of transmembrane segment 7 is accessible to the external solvent and provide eviden

266 ng that only a very small portion of helix 9 is accessible to the external solvent.

267 be coordinated to create a DNA template that is accessible to the general transcription apparatus.

268 rmeabilization suggests that the autoantigen is accessible to the immune system during apoptosis.

269 have been deposited into a web database that is accessible to the public domain.

270 s to the pectin/pectate lyase reaction site, is accessible to the solvent, but the substrate binding

271 und and Mg(II)-bound states, the active site is accessible to the solvent.

272 s that most of the void space within the MOF is accessible to the solvent.

273 how the volume within the packed column that is accessible to the test molecules, and therefore revea

274 iodoacetamide treatment, suggesting that it is accessible to the TpT radical.

275 ssed chromatin, and into open chromatin that is accessible to the transcription machinery.

276 inding, the sgp140 SOSIP.664 HR1 coiled coil was accessible to the gp41 HR2 peptide even in the absen

277 ags at positions 116, 120, 186, 270, and 284 were accessible to the epitope antibodies in nonpermeabi

278 ganism was also recovered from surfaces that were accessible to the public.

279 These must be accessible to their ligands but must not confer susce

280 d to the surface of malignant cells where it is accessible to therapeutic antibodies.

281 (bLow) T cells, the K(b) gene appears not to be accessible to these factors.

282 but low abundance aggregate morphology, that is accessible to these Abeta analogues, mediates toxicit

283 ecessary to ensure that effective treatments are accessible to this patient population.

284 hat mtDNA within intact mitochondria may not be accessible to this class of alkylating reagent.

285 Problem-solving therapy was modified to be accessible to this population.

286 istic insight that could frequently not have been accessible to this high degree of certainty by util

287 n melting and the amount of PEG surface that is accessible to this DNA, and these effects are complet

288 pump; this method is simple enough it should be accessible to those without expertise in microfluidic

289 wever, these bulky and expensive instruments are accessible to trained personnel in clinical settings

290 es in particular, although highly condensed, are accessible to transcription factors and chromatin pr

291 etermines whether information encoded in DNA is accessible to transcription factors, dynamic chromati

292 ent state, only the distal regulatory region is accessible to transcription factors.

293 trypsin whereas assembled N-terminal fusions were accessible to trypsin, consistent with locations in

294 sine residues and 18 of 19 arginine residues were accessible to trypsin.

295 This protocol is accessible to uninitiated users with little experienc

296 hemical openers indicates that KCNQ channels are accessible to various types and combinations of phar

297 containing alpha2-3-linked sialic acid that are accessible to viral particles only on M cell apical

298 gments of residues that are predicted not to be accessible to water and, therefore, may be 'buried' i

299 hat a large fraction of the helical residues were accessible to water, suggesting the possibility tha

300 It is accessible to young children.