ライフサイエンスコーパス: be accomplished through

1 This grouping was accomplished through 3-D plotting and an atomic popu

2 Cell adhesion and motility are accomplished through a functional linkage of the ext

3 ty of cambinol in Burkitt lymphoma cells may be accomplished through a combined effect of BCL6 inacti

4 Deployment of the Trivascular graft may be accomplished through a delivery system that is consid

5 evention of cardiovascular complications may be accomplished through a sound understanding of the hem

6 epi-senepodine G and C5-epi-cermizine C have been accomplished through a novel diastereoselective, in

7 atural stilbene (+)-schweinfurthin G (8) has been accomplished through a sequence based on an efficie

8 is of nonracemic 3-deoxyschweinfurthin B has been accomplished through a synthetic sequence including

9 discrimination of one tag versus all others is accomplished through a "phase-nulling" technique.

10 Ascospore formation in yeast is accomplished through a cell division in which daughte

11 ery of critical cargos to specific locations is accomplished through a combination of passive diffusi

12 Their transmission is accomplished through a complex life cycle with two ob

13 The synthesis is accomplished through a convergent strategy that proce

14 tly located domains of a multidomain protein is accomplished through a coordinated movement of struct

15 This is accomplished through a covalent interaction between a

16 f ON-bipolar cells in which its localization is accomplished through a direct association with mGluR6

17 This stimulation of MDM2 sumoylation is accomplished through a direct interaction of SKI with

18 We show that this is accomplished through a functional compartmentalizatio

19 Plastid transformation in higher plants is accomplished through a gradual process, during which

20 ibutes to Ras-mediated radioresistance, this is accomplished through a MEK-independent pathway.

21 ate rather than glucose utilization and this is accomplished through a number of regulatory steps.

22 in, syn-selective alpha-borylation-arylation is accomplished through a one-pot Ni-catalyzed carbomagn

23 itional diminution of VEGF activity by SPARC is accomplished through a reduction in the tyrosine phos

24 s." These data demonstrate that scaling down is accomplished through a regulated increase in Koff, wh

25 This dynamic fine-tuning is accomplished through a rich array of cellular homeost

26 ential for preventing circuit disorders, and is accomplished through a set of negative feedback mecha

27 Synthesis of the precatalyst is accomplished through a straightforward procedure that

28 This is accomplished through a surface morphology-induced, po

29 s suggest that the phages, biological impact is accomplished through a surprisingly limited topologic

30 Mechanistically, this is accomplished through a tailored release of chemoattra

31 Chemoselective disulfide formation is accomplished through a thiol-disulfide interchange ap

32 Linking the PV to the AC-DEG is accomplished through a three-level multifunctional vo

33 Transformation of 10 to 1 is accomplished through a three-step reaction sequence.

34 SNP effect viewing and graphing is accomplished through a user friendly graphical user i

35 r virus and murine gammaherpesvirus 68, this is accomplished through a viral gene-expression program

36 In mammals, tissue regeneration is accomplished through a well-regulated, complex cascad

37 fer via the immobilized AQDS/AH(2)QDS couple was accomplished through a combination of diffusion and

38 This result was accomplished through a differentiation stage-specifi

39 This recovery was accomplished through a form of respiratory plasticit

40 This was accomplished through a genetic and molecular analysi

41 purity hPTH as well as more stable analogues was accomplished through a menu of extended NCL followed

42 The macrocyclization of 2 was accomplished through a Mitsunobu reaction using trip

43 Ring construction was accomplished through a nitro-Mannich reaction linkin

44 c construction of the E- and Z- Ile residues was accomplished through a one-pot reaction featuring an

45 The reengineering was accomplished through a series of choreographed manip

46 fficient formal synthesis of (+)-brefeldin A was accomplished through a synthetic approach that relie

47 thropoietin receptor (EpoR) has historically been accomplished through administration of erythropoiet

48 al amyloid formation in higher organisms can be accomplished through alternative splicing.

49 This is accomplished through alternative translation initiati

50 rior spinal levels suggest that these events are accomplished through an integration of Hensen's node

51 This will best be accomplished through an international academic and ph

52 Estimating passive myocardial stiffness can be accomplished through an MRI-based approach that requi

53 ine, lycoflexine, and lycoposerramine B have been accomplished through an efficient, unified, and ste

54 t of the epimer at C4 of its enantiomer have been accomplished through an enantioselective approach f

55 damycins A (2c) and B methyl ester (2a) have been accomplished through an enantioselective divergent

56 ntheses of senepodine G and cermizine C have been accomplished through an intramolecular cyclization

57 C(26) subunit of amphidinolide B(3) has also been accomplished through an unexpected anti aldol react

58 This is accomplished through an array of pattern recognition

59 This is accomplished through an assortment of isotopic labeli

60 tachment of ubiquitin to a protein substrate is accomplished through an enzymatic cascade involving t

61 tabilization of mature dendritic spines, and is accomplished through an EphB receptor-focal adhesion

62 Fitting is accomplished through an expectation-maximization appr

63 nutrient homeostasis during food deprivation is accomplished through an increase in mitochondrial fat

64 This is accomplished through an interaction between NC and a

65 This is accomplished through an optimization algorithm that h

66 This was accomplished through an unprecedented increase in pl

67 Assignment of the two pathways was accomplished through analysis of femtosecond time-re

68 generation of substituted gamma-lactones can be accomplished through application of a tandem chain ex

69 Oxidation of the C2-position can be accomplished through application of an operationally

70 n the ICR cell of a FT-ICR mass spectrometer are accomplished through appropriate modulation of laser

71 clei, indicating that commissural inhibition is accomplished through at least two processing streams

72 Regulation of the F3 lobe is accomplished through autoinhibition via anti-parallel

73 We suggest that silencing of the PCNA gene is accomplished through base pairing between sense pre-m

74 In the spindle checkpoint pathway, this is accomplished through Bfa1/Bub2, a heteromeric GTPase-

75 ypic, structural and mapping information has been accomplished through bi-directional links between H

76 Proper chromosome organization is accomplished through binding of proteins such as cond

77 The latter function is accomplished through binding of the C-terminal cytopl

78 Regulation of biotin biosynthesis is accomplished through binding of the repressor to the

79 major groove of the core KBS and mCpG sites is accomplished through both classical and methyl CH...O

80 tate cancer incidence (n = 385 through 2000) was accomplished through cancer registry and hospital li

81 Neuronal differentiation is accomplished through cascades of intrinsic genetic fa

82 dition, a synthesis of 1,1,1-triborylalkanes was accomplished through cobalt-catalyzed hydroboration

83 uum in the region is urgently needed and can be accomplished through collaborative efforts and increa

84 hesis that H3 modification is essential, but is accomplished through combined activities of two enzym

85 Route determination of sulfur mustard was accomplished through comprehensive nontargeted scree

86 pyrazolopyrazinyl series of TYK2 inhibitors was accomplished through computational and structurally

87 This was accomplished through conditional inactivation using

88 Cytokinesis in animal cells is accomplished through constriction of an actomyosin ri

89 Their multiple regulatory functions are accomplished through context-dependent inputs of tar

90 interfaces, this optimization has previously been accomplished through control of the distance betwee

91 These functional properties are accomplished through coordinated promotion of cell m

92 An important regulated step in this process is accomplished through covalent chemical modifications

93 isms from breaching the mucosal layer, which is accomplished through crosstalk with enterocytes and o

94 antiomerically pure 3,3'-bis-arylated BINOLs is accomplished through decarboxylative iodination of th

95 the mammary epithelial (ME) cell compartment is accomplished through decreased apoptosis during pregn

96 Focusing of the extracted amino acids was accomplished through desorption of the extracted ami

97 ntracellular parasite Toxoplasma gondii this is accomplished through differentiation into dedicated c

98 pression of CTF-1-directed transcription may be accomplished through direct physical interaction betw

99 This is accomplished through direct interaction between the b

100 This is accomplished through direct interaction with the comp

101 Introduction of the key substituent was accomplished through directed metalation of the seco

102 HBV DNA chain termination by ETV was accomplished through disfavored energy requirements

103 t but nontoxic pools of metal micronutrients is accomplished through diverse homeostasis mechanisms i

104 Protection is accomplished through DNA sequence polymorphisms, as i

105 direct evidence that categorizing such faces is accomplished through dynamic competition between para

106 ternal stress-induced subcellular adaptation is accomplished through dynamic cytoskeletal reorganizat

107 led to a level of water demand that can only be accomplished through efficient reservoir networks.

108 Non-sequence-specific DNA recognition is accomplished through electrostatic attraction between

109 Proper staging can be accomplished through endoscopic ultrasound and multid

110 This large activation is accomplished through enhanced action of GCAPs as show

111 ally blocks scaling down, suggesting that it is accomplished through enhanced dissociation of AMPAR f

112 tic information from bidirectional reactions is accomplished through equation-based formalisms (e.g.,

113 This is accomplished through exchanges between the full chain

114 This reduction may also be accomplished through exogenous phosphine additives, t

115 It was proposed that this type of LP-BER is accomplished through FEN1 removal of a 2- to 11-nucle

116 osure and the dimer-dimer ring concatenation were accomplished through formation of disulfide bonds,

117 This regulation is accomplished through four GATA-family transcription f

118 In eukaryotes, this regulation is accomplished through glucose-6-phosphate levels and p

119 ntegration of GrassTFDB and GrassPROMDB will be accomplished through GrassRegNet as a first step in r

120 fication in both prokaryotes and eukaryotes, is accomplished through highly coordinated cell-fate seg

121 chromosomal double-strand breaks (DSBs) can be accomplished through homologous recombination in most

122 High-resolution epitope mapping was accomplished through hydrogen deuterium exchange-mas

123 Its depolymerization can be accomplished through hydrogenolysis, although the dev

124 Target specificity is accomplished through immobilization of the enzyme, li

125 up in response to action-potential blockade is accomplished through increased synaptic accumulation

126 subsequent damaging insult and is thought to be accomplished through induced expression of protective

127 of matter in these 'hotspots' has previously been accomplished through inefficient 'top-down' methods

128 Expression of CYP8b1 and CYP7a1 was accomplished through infection of primary rat hepato

129 required; and (2) generalization of CCD can be accomplished through integration mechanisms that link

130 rocurement and Transplantation Network could be accomplished through interpretation of the vascular c

131 embrane integrity under different conditions are accomplished through intracellular tethering to an e

132 egrity and organization in the metazoan cell is accomplished through intracellular tethering of membr

133 ernization of the two alpha-carbon atoms has been accomplished through iteration of completely regio-

134 This is accomplished through its surface fimbriae, which indu

135 heir activity inferring that this regulation is accomplished through its transmembrane and extramembr

136 C. pneumoniae in Red Blood Cell (RBC) units was accomplished through leukoreduction by filtration.

137 han-dependent control of RNA binding by TRAP is accomplished through ligand-induced changes in protei

138 Vertebrate vision is accomplished through light-sensitive photopigments co

139 ation rates in Caenorhabditis elegans adults is accomplished through localized neutralization of insu

140 Helicobacter pylori virulence is accomplished through many mechanisms, including vacuo

141 The protein detection is accomplished through measuring changes in the electri

142 d disks into micrometer-sized hollow spheres was accomplished through metal-ligand interactions betwe

143 on of the rat brain CB1 cannabinoid receptor was accomplished through microinjection of in vitro tran

144 luoromethylation of C(sp(2))-H bond has also been accomplished through Minisci-type radical chemistry

145 N-containing heterocycles is reported; this is accomplished through Mo-catalyzed kinetic resolution

146 Validation of the model was accomplished through modeling of LVD resistance subs

147 The regulation was accomplished through modulation of the p53 and repli

148 More stable rectification can be accomplished through molecular asymmetry of the synap

149 heterocyclic and spiroheterocyclic compounds was accomplished through mono- and bis[3 + 2]-cycloaddit

150 This can be accomplished through multiple exposures to nutrition

151 hat the same perceptual decision-making task is accomplished through multiple brain activation patter

152 at (1) TGF beta 1-mediated growth inhibition is accomplished through multiple pathways and (2) p27(ki

153 This success is accomplished through necessary but non-unique choices

154 tively direct and organize services, and may be accomplished through novel, densely sampled and pheno

155 Ileal ischemia was accomplished through obstruction of the distal branc

156 t signal transduction and amplification must be accomplished through only small, nanoscale conformati

157 and we present a model as to how this could be accomplished through overlapping BMP and FGF signals.

158 Validation of this HPLC method was accomplished through parallel evaluation of three gl

159 This encoding is accomplished through phase precession, a phenomenon w

160 of this protein's pleiotropic functions may be accomplished through phosphorylation of specific amin

161 s culminating with the detection of coronene is accomplished through photoionization and is based upo

162 e diverse functions of RBTN2 are presumed to be accomplished through physical interaction with differ

163 This is accomplished through postexcitation modulation of the

164 ercoming this patient heterogeneity has also been accomplished through precision therapeutics, in whi

165 This has been accomplished through progressive improvements in ac

166 olution of species-specific innate behaviors is accomplished through progressive modifications of pre

167 ation by G-protein coupled receptors (GPCRs) is accomplished through proper interaction with the cyto

168 It is hypothesized that this is accomplished through prophylactic and inducible defen

169 the epidermal growth factor receptor (EGFR) was accomplished through random mutagenesis and yeast su

170 actin-based transport, polarization of Cdc42 is accomplished through Rdi1, the Cdc42 guanine nucleoti

171 at both normal and neoplastic stratification are accomplished through receptor tyrosine kinase signal

172 Functions of Alk3 are accomplished through regulating expression/activatio

173 Model parameterization is accomplished through replica exchange molecular dynam

174 This growth pattern is accomplished through restriction of secretion to the

175 f diarylacetate, a diarylmethine derivative, was accomplished through rhodium catalyzed direct arylat

176 port into this organelle, the glycosome, can be accomplished through RNA interference (RNAi)-mediated

177 r adults at risk for mobility limitation can be accomplished through routine screening in the ambulat

178 igand discovery of nonenzymatic proteins can be accomplished through screening methods utilizing libr

179 Achieving such a balance can only be accomplished through several iterations involving bio

180 , we discovered that speed-accuracy tradeoff is accomplished through several distinct adjustments.

181 In each case, recognition is accomplished through shape complementarity between th

182 The high-speed GC x GC analysis of naphtha is accomplished through short GC columns, high carrier g

183 The high-speed GC x GC analysis of jet fuel is accomplished through short GC columns, high gas veloc

184 e, regulation of the degradative enzymes can be accomplished through soluble sugars generated by the

185 d cotton plastid transformation has recently been accomplished through somatic embryogenesis using sp

186 iffuse and overlapping cortical innervation, is accomplished through sparse yet complementary connect

187 Surface display of the target protein is accomplished through specific heterodimerization of G

188 Structure elucidation was accomplished through spectroscopic methods, mass spe

189 For most proteins, this is accomplished through spontaneous folding to a thermod

190 This is accomplished through stabilizing the conserved chloro

191 The preparation of such analogues was accomplished through standard phosphoramidite chemis

192 o-2-deoxy-l-idopyranosyl benzene derivatives was accomplished through stereospecific addition of trib

193 This can be accomplished through stochastic mechanisms, where ind

194 The inversions were accomplished through strategic employment of La Ros

195 The extent to which this is accomplished through stress tolerance vs stress avoid

196 novobiocin, into a selective Hsp90 inhibitor was accomplished through structural modifications to the

197 This is accomplished through supervised machine learning afte

198 ol, Negin, Pushal, Bunch, Style, and Powder, was accomplished through suspect and non-target screenin

199 The total synthesis of antroquinonol has been accomplished through Suzuki-Miyaura cross-coupling

200 This is accomplished through systematic variation of the PLA

201 thyl BODIPY photoremovable protecting groups was accomplished through systematic variation of the lea

202 analysis of the limiting factors of the IQE are accomplished through the CIE model.

203 Telomere protection and maintenance are accomplished through the coordinated actions of telo

204 for high internal quantum efficiencies (IQE) are accomplished through the current injection efficienc

205 th the pyrrolizidine alkaloid retrorsine can be accomplished through the activation, expansion, and d

206 Further improvements will be accomplished through the controlled and/or rationally

207 ctural disorder within the material can also be accomplished through the electrochemical driving forc

208 a face-centered cubic crystal is believed to be accomplished through the formation of twinning partia

209 r high-turnover cell populations in vivo can be accomplished through the incorporation of an isotopic

210 change in the metabolism of an organism can be accomplished through the introduction of a single gen

211 n adduct, which, among other mechanisms, can be accomplished through the proteasomal degradation of T

212 tion in regeneration-competent organisms can be accomplished through the remodeling of gene expressio

213 This endeavor may be accomplished through the study of patients, animal mo

214 iminohydroxylation cyclization reactions has been accomplished through the design of a new class of r

215 lic and acyclic ethers with heteroarenes has been accomplished through the design of a photoredox-med

216 s-3,6-disubstituted dihydro-1,2-oxazines has been accomplished through the one-pot oxidative nitroso-

217 lkyl carboxylic acids with vinyl halides has been accomplished through the synergistic merger of phot

218 generation synthesis of amphidinolide F have been accomplished through the use of a common intermedia

219 idursulfase (iduronate-2-sulfatase, I2S) has been accomplished through the use of hydrogen-deuterium

220 genes that cause human diseases has largely been accomplished through the use of positional cloning,

221 This has been accomplished through the use of satellite radar obs

222 ce submissions and community annotation, are being accomplished through the use of a graphical client

223 of the plasmid R6K gamma origin (gamma ori) is accomplished through the ability of the pi protein to

224 efficient production of viral particles and is accomplished through the action of a leptomycin B (LM

225 diated regulation of the bvg-repressed genes is accomplished through the activation of expression of

226 Tumor escape is accomplished through the activation of one or several

227 This is accomplished through the activation of the master reg

228 d with the pyrrolizidine alkaloid retrorsine is accomplished through the activation, expansion, and d

229 thesis of the AB and CD spiroketal fragments is accomplished through the addition of a metalated gamm

230 This regulation is accomplished through the balance of regulatory elemen

231 supporting the proposal that CatK activation is accomplished through the combined action of the acidi

232 Triacylglycerol synthesis is accomplished through the coordinate action of multipl

233 Chloroplast division in plant cells is accomplished through the coordinated action of the tu

234 Translation initiation in eukaryotes is accomplished through the coordinated and orderly acti

235 Anaerobic growth by P. aeruginosa is accomplished through the denitrification enzyme pathw

236 This is accomplished through the development and application

237 This is accomplished through the development of a method for

238 This is accomplished through the direct competition of tumor

239 This is accomplished through the electrical stimulation of th

240 Cell-cell communication in bacteria is accomplished through the exchange of chemical signal

241 Cell-cell communication in bacteria is accomplished through the exchange of extracellular si

242 and cell-substrate adhesion of motile cells is accomplished through the formation and removal of foc

243 solid-phase peptide synthesis techniques and is accomplished through the formation of two peptide bon

244 ascorbate (DHA) into a variety of cell types is accomplished through the Glut-1 glucose transporter.

245 he colloidal synthesis of SnSe nanoparticles is accomplished through the injection of bis[bis(trimeth

246 This is accomplished through the integration at each gene of

247 longatus is metabolism-dependent and that it is accomplished through the interaction of the circadian

248 Reprogramming is accomplished through the interplay of transcription f

249 The function of most proteins is accomplished through the interplay of two or more pro

250 ed low density lipoprotein (LDL) cholesterol is accomplished through the LDL receptor in the liver.

251 This is accomplished through the localized expression of Grk

252 This localization is accomplished through the matrix (MA) domain of the Ga

253 joint shows high ductility in bending which is accomplished through the operation of multiple shear

254 hepatectomy (PH) in retrorsine-exposed rats is accomplished through the outgrowth and expansion of s

255 lly pure 3,3'-bis-arylated BINOL derivatives is accomplished through the palladium-catalyzed Suzuki-M

256 d that dimerization of the N-terminal region is accomplished through the PAS-B/PAS-C region of the mo

257 This optimization is accomplished through the prediction of peptides that

258 This is accomplished through the quantum mechanical treatment

259 dihydrofunctionalization of terminal alkynes is accomplished through the reductive three-component co

260 This is accomplished through the regulation of the first two

261 QS is accomplished through the secretion and detection of e

262 The synthesis of salicylate WN-8 is accomplished through the union of fragments A-III and

263 This is accomplished through the use of a novel lyso-phosphol

264 This is accomplished through the use of a workflow of lexicog

265 The variable turnover of Nrf2 is accomplished through the use of at least two degrons

266 Recognition of objects is accomplished through the use of cues that depend on i

267 total synthesis of lycoposerramine congeners is accomplished through the use of nitrogen deletion str

268 Detection by SIERRA is accomplished through the use of novel nanoparticle re

269 This system's imaging is accomplished through the use of the Fluorescence Talb

270 This is accomplished through the web interface or programmati

271 Much of this was accomplished through the application of an antibody

272 This study was accomplished through the combination of solid-phase

273 Lysis was accomplished through the delivery of 6 ns, lambda=53

274 tion N-hydroxyurea 5-lipoxygenase inhibitors was accomplished through the development of a broad stru

275 This was accomplished through the development of a software p

276 This was accomplished through the development of a web interf

277 This was accomplished through the development of hybrid urea-

278 ric carbon-functionalized furanoside systems was accomplished through the employment of an oxo-rheniu

279 This effect was accomplished through the formation of a resonant, st

280 This transformation was accomplished through the introduction of a new strat

281 This was accomplished through the production of vitamin A-dep

282 utant analyses indicated that acs regulation was accomplished through the regulator LitR but was inde

283 ,3-dihydrobenzofuran (coumaran) and chromane was accomplished through the ring-opening of donor-accep

284 the fungal metabolite ent-malbrancheamide B was accomplished through the union of a C-prenylated pro

285 selective addition of anilines to azoalkenes was accomplished through the use of a chiral phosphoric

286 This was accomplished through the use of a hydrophobic ion pa

287 This was accomplished through the use of an improved expressi

288 alysis of many crystallographic orientations was accomplished through the use of an in situ fluoresce

289 Biochemical analysis was accomplished through the use of matrix-assisted lase

290 This was accomplished through the use of next-generation sequ

291 le alkaloids (-)-leucoridine A (1) and C (2) were accomplished through the biomimetic dimerization of

292 The synergistic activation is accomplished through their 20E-dependent protein-prot

293 t the functional versatility of Ras proteins is accomplished through their differential compartmental

294 nd donor-specific tolerance, and this effect is accomplished through thymic production of donor-speci

295 f and response to the V.harveyi autoinducers are accomplished through two two-component sensory relay

296 tivar identification and ancestry estimation was accomplished through two complementary clustering me

297 ce to P. s. maculicola ES4326 must therefore be accomplished through unidentified antibacterial gene

298 cilitating PMN infiltration; this appears to be accomplished through upregulation of PECAM-1 expressi

299 +)- and (-)-cyclophellitol from d-xylose has been accomplished through utilization of the latent plan

300 The rise of surgery as a specialty was accomplished through various new initiatives; among