ライフサイエンスコーパス: be achieved by

1 This can best be achieved by 1) the study of rare variants, often chos

2 Endoscopic remission was achieved by 10% (P < .1 vs placebo), 8%, 8% (P < .1

3 The EASI-50 and EASI-75 were achieved by 114 (86%) and 82 (62%) patients after 1

4 Ambulatory status grade 1 or 2 at week 8 was achieved by 115 of 166 (69.3%) patients in the singl

5 20 patients in the study, clinical remission was achieved by 13% of patients receiving 3 mg upadaciti

6 fficacy-evaluable set, an objective response was achieved by 186 (73%, 95% CI 66.8-78.0) patients and

7 dependent reviewer-assessed overall response was achieved by 20 (47%, 95% CI 31-62) of 43 patients.

8 structure and function of marine life could be achieved by 2050, if major pressures-including climat

9 An investigator-assessed overall response was achieved by 22 (51%, 95% CI 36-67) of 43 patients.

10 The viability was achieved by 22 (71%) organs, that were transplanted

11 Recovery was achieved by 30 d of once-daily administration of P7C

12 The primary endpoint was achieved by 31 children (82%) in the proactive group

13 ysis, endoscopic remission (SES-CD score <4) was achieved by 36 patients (33%) and 40 patients (36%)

14 group (P = .127), and bacterial eradication was achieved by 43.3% (94/217) and 46.8% (102/218), resp

15 eye at the day 5 visit, clinical resolution was achieved by 50.5% (111/220) subjects in the PVP-I/DE

16 20% or more mean IOP reduction from baseline was achieved by 67.8% of the study cohort at POM 12.

17 A modified Rankin score of 0-2 at 90 days was achieved by 69 patients (52%; 95% CI 43.8-60.3) in t

18 At week 14, an ACR20 response was achieved by 89 (41%) of 216 patients (95% CI 35-48)

19 SVR12 was achieved by 99.2% (95% CI, 97.9-99.7%) of subjects w

20 Importantly, the presented results are achieved by a simple modification of photonic sensin

21 Improved understanding could be achieved by a method that enables simultaneous screen

22 se findings show that epithelial bending can be achieved by a morphogenetic mechanism of coordinated

23 t significantly longer life expectancy could be achieved by a reduction in the ambient PM2.5 concentr

24 crowded environment of the cell, cannot yet be achieved by a single technology.

25 Periodic Table neighbors Fe and Mn in 3 has been achieved by a combination of investigative techniqu

26 karyophilic DNA aptamers (~100 nucleotides) is achieved by a biosensor strategy that rewards exposur

27 versity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stocha

28 Paste of new recombinant (r)C0C7 domains is achieved by a covalent bond formed between SpyCatcher

29 This is achieved by a framework that consists of three stages

30 Control of HLB growth is achieved by a mechanism integrating nascent mRNAs at

31 nexpectedly, coordination of phosphotyrosine is achieved by a modified binding pocket that appears ea

32 This is achieved by a novel growth process that uses a SiGe s

33 The orientational ordering is achieved by a rapid evaporation of mixed solvents dur

34 half-life of ~20 h in dogs and ~70 h in man is achieved by a strong albumin binding, and by lowering

35 nge motion, whereas bidirectional conduction is achieved by a symmetric scissor motion.

36 The highest accuracy was achieved by a combination of TBR(max) and slope (sen

37 Profiling chloroplast envelope membranes was achieved by a cross comparison of protein intensitie

38 The micronization process was achieved by a jet mill and flours (JF) of particle s

39 This optimality was achieved by a non-linear influence of an opponent's

40 gation of these subunits, and final assembly were achieved by a combination of Michael-type thiol-ene

41 These challenging transformations were achieved by a focused mutagenesis strategy and appl

42 s on aligning metadata, data integration can be achieved by abstracting experimental results into gen

43 h yield strength of nearly 2 gigapascals can be achieved by activating delamination toughening couple

44 Synaptic restoration can be achieved by activation of the cAMP/PKA pathway, by ei

45 Movement is achieved by active cell-on-cell migration: outer cell

46 This improvement is achieved by adapting both microsaccades and ocular dr

47 m sensitivity up to 0.87 (95% CI, 0.76-0.94) was achieved by additionally rating the supine chest rad

48 Control of the dynamics of the IL films can be achieved by adjusting the charge density on substrate

49 Electronic stability was achieved by adjusting the pai-pai orbitals overlap o

50 This could be achieved by administering recombinant soluble ACE-2.

51 Better results in terms of adsorbed quantity were achieved by adopting 12%v/v EtOH/H(2)O solvent and

52 vant influenza types (H1N1, H3N2, and B) can be achieved by airway administration of a single combina

53 This is achieved by an organosilane-mediated ester hydrosilyl

54 Scalability is achieved by an underlying API implemented using Apach

55 vileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based

56 3 hydroxyl group of the terminal alpha-l-Rha is achieved by another virus-encoded protein A061L, whic

57 or treatment strategies but currently cannot be achieved by any clinical method.

58 This modularity is achieved by appending a phenyl ring with different pa

59 High separation power was achieved by application of a 5-layers successive mul

60 xide to RGO and covalent attachment of 4-ABA are achieved by applying alternating cathodic and anodic

61 y good agreement between both techniques can be achieved by applying a newly developed linearity corr

62 rocal sensitivity of the antenna devices has been achieved by applying electromagnetic waves with dif

63 andible and horn in a manner that could only be achieved by articulating their mouthparts in an axial

64 This can be achieved by assigning learning in different contexts

65 ly the effective control of chemical hazards is achieved by assuring that they either are minimized o

66 This dual function is achieved by basic residues that alternately face eith

67 This was achieved by bis-carbonylation at C-3 of the magnesiu

68 at OVX-associated reduction in spine density is achieved by both an increase in spine loss rate and a

69 We show that such tracking can be achieved by canonical network architectures and dynam

70 The specificity of the UAD-2 assay was achieved by capturing pneumococcal polysaccharides w

71 This is achieved by careful tailoring of the azide precursor

72 ights the fact that reversible catalysis can be achieved by catalysts that follow complex mechanisms

73 dependent control over shape and composition is achieved by chemical conversion reactions on nanocrys

74 A major improvement was achieved by chemical shift selective suppression of

75 Accordingly, energy transfer to the protein is achieved by chromophore relaxation and/or reduction o

76 suggest that higher concentrations of PA can be achieved by collecting fruits before full maturity.

77 This dual function is achieved by ColN having multiple distinct OmpF-bindin

78 1) ) and high work function (~5.1 eV), which are achieved by combining a simple solution processing w

79 This is achieved by combining a rather general physics-based

80 Efficient intersystem crossing is achieved by combining the spin-orbit coupling associa

81 The high accuracy in pH determination is achieved by combining two independent measurements un

82 A higher level of fuel-driven automaton is achieved by combining two subsystems for the transien

83 Further complexity reduction is achieved by confining to a single chromosomal section

84 ndependent changes in invasion phenotype can be achieved by continuous culturing of the W2mef and Dd2

85 for a bias voltage of [Formula: see text] V is achieved by controlling the temperature of the hot el

86 The direct release of dialkylanilines was achieved by controlling the outcome of a photorearra

87 Multiple layers of regulation could be achieved by cooperations between multiple EBV transcr

88 Signal amplification in biological systems is achieved by cooperatively recruiting multiple copies

89 The improvement was achieved by coupling high-accuracy charge measuremen

90 macromolecular prodrug of talazoparib (TLZ) was achieved by covalent conjugation to a PEG(40kDa) car

91 This was achieved by creating a binary vector/helper transfor

92 Knockout of microRNA was achieved by CRISPR-CAS9 in CCLP cells (MIR1249KO) an

93 The specific diagnosis of UG-TB is achieved by culturing Mycobacterium tuberculosis from

94 5% of the gamma rays in the flat panel could be achieved by decreasing the crystal thickness and hous

95 meet the growing demand for food, and could be achieved by delaying crop senescence.

96 This is achieved by delaying cell division and enhancing mito

97 This is achieved by deriving accurate formulas for the effect

98 as stability of organic photovoltaics (OPVs) are achieved by designing ternary blends, which represen

99 This has been achieved by designing a complex-amplitude metasurfa

100 This can be achieved by differential expression of chaperones-bal

101 OOPS specificity is achieved by digesting the enriched interfaces with RN

102 We find that this sharpening is achieved by dismantling the binocular circuit present

103 of the native chromosomes of these bacteria was achieved by double-stranded breaks made by heterolog

104 y outcomes that ~90% tumor growth inhibition was achieved by Dox-loaded HER2 receptor targeted nanopa

105 likely also provides understanding how this is achieved by DsbD as well.

106 NMR-signal assignment was achieved by dynamic-nuclear-polarization enhancement

107 Tissue-specific GA depletion was achieved by ectopic expression of the GA-inactivatin

108 r dichroism studies showed that assembly can be achieved by either triplex first and duplex later or

109 Typically, this is achieved by either chemical modification or by contro

110 atalytic methane monofunctionalization could be achieved by electro-oxidation of Pd(II) to a critical

111 The hybrid epitope imprinting was achieved by electropolymerization in the presence of

112 ration of both indel and knock-in allele can be achieved by electroporation of small single-guide RNA

113 This is achieved by embedding a patient's lesion into an atla

114 r, the opposite relative stereochemistry can be achieved by employing 1,2-disubstituted dienes.

115 activated 1,3-dienes, such as butadiene, has been achieved by employing different commercially availa

116 three-step synthesis of 20 kinase inhibitors was achieved by employing this oxidation-condensation pr

117 gion with improved quantum yields (QY) could be achieved by engineering a protein corona structure co

118 iation to the HBD, overall rate acceleration is achieved by enhancement of Lewis acidity of the TMSBr

119 gamma-chiral carbonyl compounds, has not yet been achieved by enzymes.

120 xperiments show that spatial integration can be achieved by establishing interdependencies among agen

121 Attenuation had been achieved by exchanging the VACV A8R intermediate tr

122 As HyperW's enhancements are achieved by exploiting fast solvent exchanges associ

123 This is achieved by exploiting a novel "controlled micellizat

124 ved imaging under these low-light conditions is achieved by exploiting both the refractive and absorp

125 The nonlocal behavior is achieved by exploiting nonlocal forces, conceptually

126 Selectivity is achieved by exploiting the lower barrier for C-CN oxi

127 A clear discrimination was achieved by exploiting (1)H NMR analysis and multiva

128 e identified that cell growth inhibition can be achieved by expressing moderate levels of PAX2 in com

129 Commonly, activation is achieved by expression of proteins from photosyntheti

130 The separation of crude mixtures was achieved by feasible chromatographic purification.

131 A significant tumor suppression is achieved by Fenton reaction-mediated ferroptosis-like

132 the limit of strong signal inactivation this is achieved by filtering out molecules that traverse non

133 This is achieved by first developing a probabilistic model fo

134 to arbitrary complex dynamic conditions can be achieved by foraging insects and may serve as inspira

135 Different moisture-to-protein levels were achieved by freeze-drying, incubation of samples at

136 conversion of adenine and cytosine bases can be achieved by fusing SauriCas9 to the cytidine and aden

137 with a standard deviation of <0.4 per mille was achieved by GC-IRMS after derivatization of >100 ng

138 ersal of vascular and cardiac phenotypes can be achieved by genetic downregulation of KATP channel ac

139 herapeutic phenotype, preferred outcomes can be achieved by genetically modifying and reprogramming c

140 y, mechanical programmability of the LC gels is achieved by genetically tuning the charge density of

141 selective inhibition of MAO-A and MAO-B can be achieved by geometric isomers of cis- and trans-1-pro

142 arged particles in an aqueous suspension can be achieved by having gas leakage through permeable wall

143 Randomisation, in a ratio of 1:1, was achieved by health centre managers separately pickin

144 Gallium oxide nanowire growth can be achieved by heating and oxidizing pure gallium at hig

145 This is achieved by high-speed focused ion beam (FIB) milling

146 Separation and determination were achieved by high performance liquid chromatography-

147 CENP-A recognition and centromere targeting are achieved by HJURP and the Mis18 complex, respectivel

148 oxylic acid)-co-poly(ethylene glycol) (TDP), is achieved by hydrolysis of ester linkages.

149 the impact differing when the CR activation is achieved by hypoxia or hypercapnia.

150 Blinding of treatment was achieved by identical appearance and taste of all sa

151 prediction and the separation efficiency has been achieved by implementation of the temperature depen

152 mmobilization of selected metals on GAC, can be achieved by impregnating oxidized activated carbon wi

153 of larger volumes of input DNA, which could be achieved by improved extraction of DNA from blood and

154 odulation by succinoglycan-defective strains was achieved by in trans rescue with a Nod factor-defici

155 Global data fitting was achieved by including experiments in the forward and

156 This is achieved by incorporating iron oxide nanoparticles in

157 Inhibition is achieved by incorporating three functional elements i

158 n stronger phyA activity in C. hirsuta; this is achieved by increased ChPHYA expression and protein a

159 Determination of a specific fate is achieved by increased synchronization of relevant pro

160 Similar effects can also be achieved by increasing the non-genetic benefits provi

161 nsity, size) with quick response performance is achieved by increasing the driving voltage with a max

162 chanical power and modified mechanical power was achieved by increasing tidal volume and decreasing r

163 monstrate that greater gamma-selectivity can be achieved by inhibitors that occupy an "alkyl-induced"

164 Sex-specific rescue is achieved by inserting sex-specific introns into the c

165 cus on the design of collective motions that are achieved by integrating, in space and time, several

166 Second, a multiband metasurface is achieved by integrating a Au visible-range metasurfac

167 re, the reduction of bioassay matrix signals was achieved by integrating a mixed-mode RP/IEX column.

168 f enamel formation, templated crystal growth was achieved by interaction of amelogenin scaffolds with

169 Their removal was achieved by introduction of a solvent extraction ste

170 actors in the positive and negative mode can be achieved by ion source optimization, respectively.

171 d that potent and selective inhibition could be achieved by just two substitutions in a UbV, which ex

172 (T)he best performance for GGG prediction was achieved by K parameter of kurtosis function followe

173 g principle that maximum therapeutic benefit is achieved by killing the largest possible number of ca

174 Upgrading the ee was achieved by kinetic resolution of the resulting benz

175 This non-trivial performance is achieved by leveraging an optimized dielectric-metal-

176 reduces and slows synaptic depression, which is achieved by lowering the probability of vesicle relea

177 Analysis of FA from biological samples can be achieved by mass spectrometry (MS), but these analyse

178 This is achieved by means of extensive molecular dynamics sim

179 venous placebo, and blinding for vemurafenib was achieved by means of a placebo tablet.

180 Blinding for atezolizumab was achieved by means of an identical intravenous placeb

181 Angle detection in the proposed detector is achieved by measuring the ratio of the absorbed power

182 to the ooplasm, and fertilization could only be achieved by mechanical injection of one sperm into th

183 gh-frame-rate, contrast material-enhanced US was achieved by mechanically scanning with a linear imag

184 In vitro characterization of FST1 activity was achieved by microbial uptake assays based on (14)C-l

185 This can be achieved by minimising position sway (stiffness contr

186 ract modeling to demonstrate how biphonation is achieved by modulating vocal tract morphology.

187 A quicker HCV diagnosis could be achieved by monitoring the time when HCV RNA is first

188 s-talk, but efficient radiosensitization can be achieved by multiple integrin targeting.

189 e fibroblasts through Cdk1 activation, which was achieved by Myc-dependent cyclin A and B induction.

190 Higher colloidal stability values were achieved by neutral endoprotease (31-89%) compared

191 The synthesis was achieved by NmSiaD(W)-dependent sequential one-pot m

192 ereochemistry of the new stereocenter at C-2 was achieved by NOESY experiments.

193 80[Formula: see text] diagonal field of view is achieved by on-axis optical configuration of the PSL

194 The same effect could not be achieved by oral dosing.

195 of excellence and innovation in research can be achieved by organizations that promote equity, divers

196 ach spices and aromatic herbs under analysis was achieved by PCA.

197 Catalysis is achieved by peptidylprolyl isomerases, a superfamily

198 t approximation to the S(1) wavefunction can be achieved by performing a small "two electrons in two

199 Channel activation is achieved by phosphorylation of its regulatory (R) dom

200 Cost reductions can be achieved by pooling (or combining) subsamples and tes

201 hite phosphorus by the molybdenum center can be achieved by post-photolysis heating at convenient tem

202 ance over a distinct population of cells can be achieved by providing biomimetic structural cues rele

203 of As(III) to As(V) with >90% efficiency can be achieved by PTMA, a radical-based redox polymer.

204 th at low osmotic pressure, but rather might be achieved by Q8-independent respiratory chain remodeli

205 ral revision of natural (+)-diplopyrone (ND) was achieved by quantum NMR calculations.

206 for nucleic acid melting and annealing, this is achieved by raising and lowering the concentration of

207 yrrolo[1,2-a]quinazolin-5(1H)one derivatives was achieved by reacting cyclopropane aldehydes with N'-

208 We assess how immunological tolerance is achieved by reconstruction of the immune gene reperto

209 one depletion potential for VRFB and LFP can be achieved by reducing nafion and PVDF components, resp

210 provements in photosynthetic efficiency have been achieved by reducing the optical cross-section of t

211 e pediatric cohort, minimum driving pressure was achieved by reducing tidal volume and increasing res

212 ical regulation of bone and marrow fat might be achieved by regulating functions of differentiated ce

213 anopores with high and stable efficiency can be achieved by regulating the confinement of solid-liqui

214 rotein nitroalkane oxidase reactivity, which is achieved by relatively stable 1,10-bridged flavins.

215 These profiles were achieved by relocating and resizing video signals t

216 th true D(e) < 0.1 have relative error <30%, is achieved by removing trapped regions and dead-end pat

217 re a high degree of proton-spin polarization was achieved by reversible parahydrogen exchange.

218 levant reductions in waist circumference can be achieved by routine, moderate-intensity exercise and/

219 nits of hyaluronan and keratan respectively, were achieved by S(N)2 displacement of a triflate group

220 Enantioselective separation was achieved by selective adsorption of one enantiomer f

221 Versatile angular control is achieved by selectively exciting different tips on si

222 her accuracy of elution-peak prediction than is achieved by setup-specific models.

223 e primary endpoint was met: ACR20 at week 24 was achieved by significantly greater proportions of pat

224 shows that high CD73 inhibitory potency can be achieved by simply introducing a small substituent in

225 Determination of lead at trace levels was achieved by slotted quartz tube-flame atomic absorpt

226 trates that inhibition of Notum activity can be achieved by small, drug-like molecules possessing fav

227 alpha side chain through the triazole linker was achieved by solid phase synthesis with the global cl

228 Stable patterning can be achieved by sorting through concentration dependent c

229 Scale tunability is achieved by specially designed plate like scales cons

230 In seed plants, branching is achieved by stem-cell-containing axillary meristems,

231 ropose that reversal of SERCA-PLB inhibition is achieved by stringing together its controlling module

232 ed that a further increase in drug tolerance is achieved by structural evolution of ecDNAs through ad

233 y in other complex psychiatric disorders has been achieved by studying rare de novo (DN) coding varia

234 e targeting of multiple peptidic cargoes can be achieved by subcutaneous injection of the construct.

235 icant selectivity of MMP 13 versus MMP-2 can be achieved by subtle chain contraction in a BITE-modifi

236 This can be achieved by supervised classification, which takes as

237 This was achieved by synthesizing and incorporating protected

238 Controllable ABC yields ~59% were achieved by tailoring substrate curvature levels.

239 Further, more efficient interventions may be achieved by taking such transmission heterogeneity in

240 tal syntheses of (+)- and (-)-Fumimycin have been achieved by taking advantage of strategies for the

241 This is achieved by taking advantage of the increase in the l

242 deling confirms, that maximal biologic doses were achieved by targeted alpha-therapy and demonstrated

243 transition toward circularity, which cannot be achieved by technology improvements alone-the demand

244 eficient cells, a remarkable ~25% of CSR can be achieved by the alternative end-joining (Alt-EJ) path

245 SR Ca(2+) content and Ca(2+) transients can be achieved by the same amount of inhibition of the Na(+

246 evels, confirming that glucose tolerance can be achieved by the substitution of two amino acids that

247 separation or purification, which could not be achieved by the traditional LB agar colony method.

248 ic B-ALL and selective targeting of Plk1 can be achieved by the use of siRNNs.

249 ars, substantial progress in ECR systems has been achieved by the exploitation of various novel elect

250 This cardinal feature of adaptive immunity is achieved by the assembly of a functional AgR gene on

251 This unwinding activity is achieved by the ATP-dependent nonstructural protein 3

252 lved pathway in which global hypomethylation is achieved by the coupling of active and passive demeth

253 ant SH versus NO from 2 with the pendant SMe is achieved by the employment of [Mn(III)((TMS)PS3)(DABC

254 es.IMPORTANCE The entry of enveloped viruses is achieved by the fusion of viral and cellular membrane

255 ion requires efficient cell migration, which is achieved by the generation of persistent and polarize

256 A pH sensitivity of the dyes is achieved by the introduction of an electronically dec

257 ER protein retrieval is achieved by the KDEL receptor, which recognises a C-t

258 This process is achieved by the matrix protein VP40.

259 This separation is achieved by the nuclear envelope, which controls the

260 w that the desensitization of the ABA signal is achieved by the regulation of OST1 (SnRK2.6) protein

261 Furthermore, effective cellular activity is achieved by the stapled 1:1 alpha/Sulfono-gamma-AA pe

262 tion in energy-averaged sound pressure level was achieved by the active control system in the presenc

263 ormation of beta,beta-disubstituted alcohols was achieved by the addition of an external hydrogen sou

264 patients (area under the curve = 0.90) than was achieved by the best of the cognitive tests (area un

265 of the proposed indicators (67.5% agreement) was achieved by the completion of Round Two.

266 The selectivity of the method was achieved by the coupling of negatively charged carbo

267 This was achieved by the generation of a library of Cys mutat

268 Improvement in body composition was achieved by the intervention group (n = 13) with a m

269 out 415 folds enhancement in detection power was achieved by the optimized method relative to the con

270 This significant advance was achieved by the replacement of the poorly understood

271 Subsequent oxidation of S(0) was achieved by the sulfur oxidation enzyme complex (SOX

272 ivation of such a kinetically inert molecule was achieved by the use of bismuthinidene catalysts, aid

273 Specificity of the detection was achieved by the use of hairpin surface-tethered prob

274 Specificity was achieved by the use of human p53 protein (p53Ag) imm

275 ume thresholds to define high-volume centers were achieved by the Chi-Squared Automatic Interaction D

276 tional shielding performance of Ti(3)CNT (x) was achieved by thermal annealing and is attributed to a

277 cuss in detail the scientific goals that can be achieved by these analyses, their advantages, and the

278 which the oxidation of unactivated alcohols is achieved by thiyl radical mediated hydrogen-atom abst

279 our knowledge of cellular metabolism and can be achieved by tracking an isotopically labeled precurso

280 These attributes often cannot be achieved by traditional molecular sensors i.e. reacti

281 This process is achieved by trapping intermediate BCP-metal species w

282 re, the most intriguing character of SRN can be achieved by tuning the channel thickness.

283 The polarization control of the THz emission is achieved by tuning photoexcitation of ultrafast photo

284 conformations and that functional regulation is achieved by tuning the thermodynamic balance between

285 Allocation concealment was achieved by use of a randomisation schedule that req

286 We show that this can be achieved by using a separation of the two components

287 The electrical characterisation is achieved by using a combination of techniques, includ

288 Label-free levitational assembly is achieved by using a custom-designed magnetic system i

289 the ODHP reaction over boron-based catalysts is achieved by using online synchrotron vacuum ultraviol

290 This is achieved by using the negative differential resistanc

291 droalkylation of alkenes at room temperature is achieved by using the photooxidative redox capacity o

292 nce that significant welfare improvement can be achieved by utilising slow-growing breeds.

293 Such cannot be achieved by utilizing capsid sequence data alone but

294 Such cannot be achieved by utilizing sequence data alone but require

295 ticularly, the multimodal perception ability is achieved by utilizing a learning algorithm based on t

296 hly antiaromatic to strongly aromatic, could be achieved by varying the substituent.

297 , endoplasmic reticulum, and plasma membrane-was achieved by varying the nature of the tetracyclic sy

298 ficient facial expression recognition cannot be achieved by visual analysis alone but additionally re

299 scribes the aspiration that these goals will be achieved by working with a diverse community of volun

300 age compensation in female placental mammals is achieved by X-chromosome inactivation (XCI).