ライフサイエンスコーパス: be advanced

1 ance and implications of these insights will be advanced.

2 nished collateral normal tissue toxicity can be advanced.

3 depression and describe how these ideas may be advanced.

4 perglycemia, and atherosclerosis appeared to be advanced.

5 and protein functioning in the ToMO system, is advanced.

6 to rationalize the formation of all products is advanced.

7 of exceptionally small quantities of current is advanced.

8 An explanation of this effect is advanced.

9 to rationalize the sense of stereoselection is advanced.

10 maintenance of papillae after morphogenesis is advanced.

11 e basis of its superior profile, compound 12 was advanced.

12 with high-risk myeloma whose outcome has not been advanced.

13 both hyaluronidases and exoglycosidases has been advanced.

14 ernative proposals for this interaction have been advanced.

15 g colonoscopy; none of these missed adenomas were advanced.

16 s; 37 adenomas were >/=6 mm, and 20 adenomas were advanced.

17 We find that TS is advanced (50-90% of overall surface burial) and that

18 At target sites, the needle was advanced 7 to 9 mm into the myocardium, permitting p

19 In this review, two main hypotheses are advanced: (a) Maltreatment in childhood is associate

20 ationale for the formation of these products is advanced according to which, in the absence of acids

21 enomas in 15 patients; of those, three (15%) were advanced adenomas.

22 The primary outcome measure was advanced adenomatous polyps (AAPs).

23 tor for developing carcinoma of the prostate is advanced age.

24 refusal in patients considered "too ill/old" were advanced age and low functional status.

25 ndent predictors of DNR status at enrollment were advanced age, chronic obstructive pulmonary disease

26 Independent predictors of major bleeding were advanced age, female gender, diabetes, hypertension

27 CU refusal in patients considered "too well" were advanced age, male sex, university hospital admissi

28 Available algorithms are advanced and approach the performance of radiologist

29 Which diagnoses are advanced and by how much depends on the preclinical

30 rowth it is recommended that, even when they are advanced and incurable, unlike in patients with comm

31 Atrophy is advanced and associated with iron accumulation in ros

32 During warmer spring and autumn, GSstart is advanced and GSend delayed, respectively.

33 Sc-CO(2)-related technology is advanced and has the capability to provide scaffolds

34 A ligand field rationalization is advanced and supported by DFT calculations.

35 Enteral nutrition (EN) was advanced and PN weaned as indicated.

36 A theoretical explanation of this pattern is advanced, and its practical implications are discusse

37 tigations and if successful will potentially be advanced as anti-cancer modalities.

38 the phosphoepitope encompassing Ser2808 has been advanced as a central mechanism in the pathogenesis

39 In a pediatric context, activin A has been advanced as a potential marker for the severity of

40 images at a telemedicine reading center has been advanced as a strategy for diabetic retinopathy (DR

41 As such, the intestinal microbiota has been advanced as an important contributor in the develop

42 Frustrated Lewis pairs (FLPs) have recently been advanced as efficient metal-free catalysts for cata

43 om all other reported JAK inhibitors and has been advanced as the first pseudokinase-directed therape

44 ass is among the foremost herbaceous species being advanced as a source of biomass for biofuel end us

45 y, health workforce shortages like these are being advanced as cause for repealing or "defunding" the

46 erein, the concept of the perinuclear region is advanced as a formal, identifiable structure.

47 ecfidera) is a fumaric acid ester (FAE) that was advanced as a multiple sclerosis (MS) therapy largel

48 le preclinical species, compound 5 (AMG 579) was advanced as our PDE10A clinical candidate.

49 le cross-species pharmacokinetic profile and was advanced as the clinical candidate.

50 The majority of esophageal cancers are advanced at presentation, rendering cure unlikely, e

51 est that it is more likely than adult CRC to be advanced at presentation and to have a poor outcome.

52 Prominent theoretical proposals have been advanced attempting to find common mechanisms acros

53 o the authors, essentially the same idea has been advanced before and studied extensively from a diff

54 RC), and darkfield surface reflection (DFSR) are advanced but expensive light microscopy techniques w

55 Artificial photosystems are advanced by the development of conformal catalytic m

56 We believe that Smaldino's discussion would be advanced by a more thorough analysis of the appropria

57 s in understanding cortical oscillations can be advanced by also considering the olfactory system--wh

58 ns associated with cystic fibrosis (CF) will be advanced by an improved understanding of P. aeruginos

59 gest ways in which auditory neuroscience may be advanced by connecting early sound representation to

60 anding of pathologic perinatal processes may be advanced by considering, in varying ways, the populat

61 ate medical education in critical care would be advanced by consolidation and organization into forma

62 g of how microorganisms adapt and evolve can be advanced by genome-wide documentation of the patterns

63 ment of therapeutic strategies, continues to be advanced by imaging the penumbra in novel ways.

64 ecies distributions across broad scales, can be advanced by incorporating diverse biotic factors.

65 novel cytosine methylation inhibitors would be advanced by our structural and thermodynamic characte

66 tional studies of these nerve subtypes would be advanced by selective, effective and long-term transd

67 These goals can be advanced by testing hypotheses that emerge from cross

68 tively new field, entitled epigenomics, will be advanced by the recently completed sequence of the Te

69 pluripotent stem cell (iPSC) technology can be advanced by transcriptomics, epigenomics, and bioinfo

70 obabilistic stimulus-reward associations has been advanced by a convergence between reinforcement lea

71 ssection of signal transduction pathways has been advanced by classic genetic approaches including ta

72 f this complex and heterogeneous disease has been advanced by experimental data obtained from animal

73 athways under different metabolic states has been advanced by live cell imaging and organelle specifi

74 he study of genome architecture has recently been advanced by new techniques combining nuclear proxim

75 doped Hubbard Hamiltonian, and has recently been advanced by quantum gas microscopy.

76 associated with monoclonal gammopathies has been advanced by recent clinical studies.

77 Understanding of cell fate has been advanced by studying single-cell RNA-sequencing (RN

78 athophysiology of immunobullous diseases has been advanced by the demonstration that passive transfer

79 ection of complex phenotypic comparisons has been advanced by the development of ever more sensitive

80 of the evolution of microbial pathogens has been advanced by the discovery of "islands" of DNA that

81 microbiota and host physiology in humans has been advanced by the human gut reference catalogue(3,4).

82 ciceptive processing in the infant brain has been advanced by the use of electrophysiological and hem

83 rescent protein (GFP), and biotechnology has been advanced by the use of FPs.

84 The study of plant biological pathways is advanced by easy access to integrated data sources.

85 RDF is advanced by the World Wide Web Consortium (W3C) to en

86 romocenters, replication of chromocenter DNA was advanced by 10-15% of the length of S phase.

87 ve immunity against recurrent S. aureus SSTI was advanced by antibody and the Th17/IL-17A pathway and

88 treated control brain slices from Y1-/- mice was advanced by approximately 1 h as compared to the Y1+

89 The daily onset of LHY gene expression was advanced by approximately 4 h in det1-1 mutant plant

90 e insights into how the genome editing field was advanced by early access to biological resources and

91 lecular interactions between AKR1B1 and PGA1 was advanced by molecular modeling.

92 the driver of the synchrony, as gamma phases were advanced by 20 ms in IFJ compared to FFA or PPA.

93 2 679 acute exacerbations of COPD cases that were advanced by PM(2.5) pollution above the expected nu

94 d after the first year of follow-up) and 520 were advanced cases (stage III or IV or a Gleason score

95 ounced and prolonged when the light schedule is advanced compared with light schedule delays.

96 table definitions of nonbeneficial treatment were "advanced curative/life-prolonging treatments that

97 The greatest risk factor for late relapse was advanced disease at transplantation.

98 A pressure transducer was advanced down the airways during chest compressions

99 reflects the experiences of the authors, who are advanced endoscopists or hepatopancreatobiliary surg

100 ing targeted drug delivery system, which can be advanced for the treatment of atherosclerosis and oth

101 eloped to deliver HIV genes, only a few have been advanced for clinical trials.

102 urized microfluidic biosensors have recently been advanced for portable point-of-care diagnostics by

103 ence was first reported, various models have been advanced for the structure of apolipoprotein A-I, t

104 The explanations that have been advanced for these effects are that there is either

105 everal digital data sources and systems have been advanced for use in augmenting traditional influenz

106 A robust strategy is advanced for the discovery of interacting proteins as

107 (LY317615.HCl), suppresses angiogenesis and was advanced for clinical development based upon this an

108 duced lung inflammation in a mouse model and was advanced for further development for the treatment o

109 Four compounds were advanced for further evaluation in a preclinical mo

110 rable pharmacologic properties, eight agents were advanced for secondary screening.

111 Three arguments are advanced from human and nonhuman primate infancy res

112 Since much of this knowledge has been advanced from murine studies, we focus our review o

113 s very weak (K (d) > 1 mm), and it could not be advanced further.

114 understanding of motor cortex plasticity has been advanced greatly using rodents as experimental anim

115 maintained even as the onset of the first AP was advanced >5 ms by increasing stimulus intensity and

116 tly associated with recurrence and mortality were advanced heart failure, VT cycle length, and a left

117 tocytosis (ASM) and mast cell leukemia (MCL) are advanced hematopoietic neoplasms with poor prognosis

118 Two main conjectures are advanced: (i) the appearance of grain boundary like

119 ists of the glucagon-like-peptide-1 receptor are advanced in development, and they improve prandial i

120 the highest degree of protection and should be advanced in clinical development.

121 ese data suggest that this rhIL-7 dose could be advanced in future rhIL-7 clinical studies.

122 s other than hydrogen bonding AuH-X can also be advanced in most cases.

123 Such inhibitors should be advanced in SHH-MB studies; however, molecular and ge

124 of psychosocial epidemiology and how it can be advanced in the future.

125 Therapy for WT has been advanced in part by an increasingly complex risk-st

126 imensional infrared spectroscopy (2D IR) has been advanced in recent years toward measuring signals f

127 arge number of experiments and theories have been advanced in the attempt to characterize the transfe

128 Jejunal polyposis is advanced in 1 in 5 patients, but rarely requires surg

129 The nHCs scientific community is advanced in investigating sources, atmospheric and oc

130 d flowering phenology of the plant community is advanced in years with warmer temperatures (higher cu

131 Jejunal polyposis was advanced in 21% (neo- SS III or IV).

132 With IGF-1 administration, puberty was advanced in control females, but not in females with

133 ncy analysis demonstrated that this activity was advanced in phase relative to post-block responses o

134 In boys, midadolescent height growth was advanced in the calcium group, which resulted in gre

135 cap, which suggests that plaque progression was advanced in these mice.

136 In addition, melatonin timing measures were advanced in pregnant women with a personal or famil

137 ponses were achieved when stronger responses were advanced in time relative to weaker responses.

138 Although many theories have been advanced, in the current issue of the JCI, Gonzalez

139 cerns to be overcome as tankyrase inhibitors are advanced into the clinic.

140 us limiting the number of compounds that can be advanced into clinical studies.

141 ment of novel combination therapies that can be advanced into the clinic, we have evaluated the combi

142 atoscopy whereby a 2.1-mm diameter scope can be advanced into the pancreatic duct through a duodenosc

143 nd explored how the most promising areas may be advanced into translational research.

144 Special emphasis is given to those that have been advanced into clinical trials.

145 fully obtained and seven such compounds have been advanced into early phase clinical trials for the t

146 interaction, SAR405838 (MI-77301), that has been advanced into phase I clinical trials.

147 etic and preclinical safety profiles, 10 has been advanced into phase I clinical trials.

148 t use this tetravalent vaccine component are being advanced into field trials to assess efficacy agai

149 A representative was advanced into a dog tolerability study where it was

150 Compound (S)-33a was advanced into a pharmacodynamic model in cynomolgus

151 Compound R,R-19a was advanced into a phase 1 clinical trial and produced

152 led the identification of compound 20, which was advanced into a target engagement pharmacodynamic mo

153 harmacology of VX-809, a CFTR corrector that was advanced into clinical development for the treatment

154 generate an excellent therapeutic window, 1b was advanced into clinical development.

155 The compound was advanced into clinical development.

156 ent pan-JAK inhibitor 2 (PF-06263276), which was advanced into clinical studies.

157 ability and safety profile, 14f (BMS-986142) was advanced into clinical studies.

158 ), a potent inverse-agonist of 5-HT(2A) that was advanced into clinical trials for the treatment of i

159 ology and other favorable characteristics, 4 was advanced into human clinical studies.

160 basis of its noteworthy preclinical data, 8 was advanced into human clinical trials and successfully

161 A 0.030-inch-diameter IVMRI detector coil was advanced into isolated human aortoiliac arteries and

162 Compound 21 (ICA-17043) was advanced into phase 3 clinical trials for SCD.

163 s a result of its promising activity, R,S-7c was advanced into phase I clinical studies.

164 sis of its preclinical profile, compound 10g was advanced into preclinical safety studies.

165 This compound was advanced into rat pharmacokinetic and pharmacodynami

166 transesophageal echocardiography transducer was advanced into the esophagus.

167 hrough a standard 17-gauge introducer needle was advanced into the liver, and real-time measurements

168 At selected sites, the needle was advanced into the myocardium.

169 A latex balloon was advanced into the right atrium.

170 nhibition, and CYP3A4 TDI, several compounds were advanced into in vivo target engagement and efficac

171 Two dmAbs, PGDM1400 and PGT121, were advanced into nonhuman primates for study.

172 Several compounds were advanced into pharmacodynamic studies and demonstra

173 The arterial guide wire and catheter were advanced into the heart with x-ray fluoroscopic gui

174 Indications for prenatal diagnosis were advanced maternal age (46.6%), abnormal result on D

175 omaly and in 1.7% of those whose indications were advanced maternal age or positive screening results

176 parahisian ventricular electrogram (SVE) has been advanced, may help in this diagnosis.

177 date of the solitary bee Andrena nigroaenea is advanced more by higher temperatures than is flowerin

178 polyps detected at CT colonography proved to be advanced neoplasia and did not differ significantly a

179 possible explanations for this mismatch have been advanced, none has addressed the laboratory chamber

180 A new mechanistic proposal for O2 reduction is advanced on the basis of thermodynamic considerations

181 rged heart was gently tented, and the needle was advanced on delivery of radiofrequency.

182 scillator can recover although its phase may be advanced or delayed relative to the original cycle.

183 Likewise, the timing of expression could be advanced or delayed.

184 uiescence even when the timing of quiescence is advanced or delayed by changing temporal identity fac

185 pressure-monitoring microcatheter, which can be advanced over a traditional coronary guidewire, facil

186 (CML) and acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell field.

187 rmined that a T7 elongation complex (EC) may be advanced past a halted T3 EC, and that after the coll

188 There are advanced plans to implement these and other quantum

189 Cancer nurse specialists are advanced practitioners who offer continuity of care

190 ostate cancer were ascertained, 448 of which were advanced prostate cancer.

191 Each of these topics has been advanced recently, strengthening models for how com

192 A number of conflicting claims have been advanced regarding the role of the left inferior fr

193 ML29 as a Lassa virus vaccine candidate have been advanced, showing high levels of protection in nonh

194 n LPHL patients, negative prognostic factors were advanced stage (P = .0092), Hb less than 10.5 g/dL

195 classic 'bottom-up' formation mechanism have been advanced, starting with C2 units that build up to f

196 Nevertheless, arguments can be advanced suggesting that a physically consistent desc

197 The most common method employed is advanced surface ablation using the excimer laser, su

198 onance (MR) imaging and perfusion MR imaging are advanced techniques that provide information not ava

199 A mechanistic framework has been advanced that involves one Mg(2+)-independent and t

200 Several hypotheses have been advanced that link physical forces to intracellular

201 A hypothesis has been advanced that the incursion of woody plants into wo

202 A mechanistic model is advanced that accounts for the basis of selectivity o

203 A stereochemical model for this reaction is advanced that is in line both with these features and

204 noside ring in higher carbon sugars, a model is advanced that relates the relative configuration of t

205 A hypothesis is advanced that SUT4-mediated tonoplast sucrose fluxes

206 er, although the genetics of type 1 diabetes is advanced, the genetics of islet autoantibodies needs

207 ary hospitalisation rates vary so much could be advanced through a more fine-grained analysis of the

208 Tropical cyclone epidemiology can be advanced through exposure assessment methods that are

209 able technologies, and how new discovery may be advanced through machine learning approaches.

210 apidly growing field of nanoscale lasers can be advanced through the discovery of new, tunable light

211 esistance and pathogenesis, all of which can be advanced through the large-scale generation of full-l

212 standing in the field of transplantation has been advanced through genetic and genomic studies.

213 Our understanding of the disease has been advanced through its molecular characterization.

214 thogen Mycobacterium tuberculosis (Mtb) have been advanced through phenotypic screens of extensive co

215 ES) technologies have arrived, they too have been advanced through the study of animal models.These m

216 This intermediate is advanced through six additional steps to the target a

217 The catheter, which was advanced through an 18-gauge sheath, showed resoluti

218 idine-alpha-sulfone hydroxamate 35f (SC-276) was advanced through antitumor and antiangiogenesis assa

219 Compound R,R-19a (MK-1903) was advanced through preclinical studies, was well toler

220 Flexible synthesized MoS2 transistors are advanced to perform at GHz speeds.

221 ers inserted at the sacral hiatus can easily be advanced to a lumbar or thoracic level.

222 Moreover, this approach could be advanced to an unprecedented stereodivergent resoluti

223 rocess and the products of the arylation can be advanced to complex polycyclic molecules by sequentia

224 ork demonstrates that graphene synthesis can be advanced to control the nucleated crystal shape, regi

225 We show that fragment hits can be advanced to furnish selective ligands that affect the

226 challenge and because it is marker free, can be advanced to human vaccine trials.

227 se novel chemical entities could potentially be advanced to the clinic as new drug candidates for tre

228 d glycosylation sites; the top features will be advanced to the primary sieve analysis.

229 Although underfunded, it has been advanced to be competitive with corn ethanol; howev

230 eral small molecules targeting Na(V)1.7 have been advanced to clinical development, no Na(V)1.7-selec

231 bioavailable NS3 protease inhibitor that has been advanced to clinical trials in human beings for the

232 Analogue 13-15 has been advanced to clinical trials.

233 Analogue 12-3 has been advanced to clinical trials.

234 Gene therapy has been advanced to early phase clinical trials for the rep

235 ptual model of movement ecology has recently been advanced to explain all movement by considering the

236 neural computation, and multiple models have been advanced to explain behavioral and neural responses

237 ytoplasmic face, and mechanistic models have been advanced to explain how ESCRT-III filaments and the

238 social networks, and theoretical models have been advanced to explain it.

239 Several models have been advanced to explain the flexible binding of protein

240 Several theories have been advanced to explain the nature of enzymatic control

241 mer's disease (AD) and several theories have been advanced to explain the relationship.

242 No general linguistic mechanism has been advanced to explain this striking variation in rate

243 Moreover, although several hypotheses have been advanced to explain virus-induced exacerbations, th

244 and pharmacokinetic profile, PF-06282999 has been advanced to first-in-human pharmacokinetic and safe

245 ve been developed, and several have recently been advanced to genome-wide scale using arrays and next

246 A repurposed compound has been advanced to human clinical studies.

247 Additionally, one compound has been advanced to human clinical studies.

248 led to the identification of 19d, which has been advanced to human clinical trials for weight manage

249 t time, the state-of-the-art methodology has been advanced to include triplet states.

250 Various algorithms have been advanced to operate on such contact data to produce

251 ly developed KOR antagonist tracer has since been advanced to PET imaging of KOR in humans and consti

252 ived 20S human proteasome inhibitor that has been advanced to preclinical development, [(1R)-1-[[(2 S

253 rations of intravenous cyclophosphamide have been advanced to reduce toxicity without sacrificing eff

254 These foundational results are being advanced to control the current worldwide human co

255 [(11)C]-1R is now being advanced to human trials as a first-in-class HD PE

256 c cancer and therapeutic treatments that are being advanced to target the stroma as a critical part o

257 In four additional steps, this intermediate is advanced to (+/-)-actinophyllic acid.

258 A conformational model is advanced to account for these observations.

259 es and the hard-soft acid-base (HSAB) theory is advanced to explain the observed reactivity trends.

260 treating older adults, and a research agenda is advanced to facilitate the development of rationally

261 The Mucus Shaver is advanced to the distal endotracheal tube tip, inflate

262 a a daily subcutaneous injection; study drug was advanced to a dosage of 1.8 mg/d during the first 30

263 tion in an in vivo pharmacodynamic assay and was advanced to a long-term efficacy study.

264 This cocrystal form was advanced to clinical development as a potential firs

265 As a result of these findings, 3S,3aR-27d was advanced to clinical studies.

266 the balloon-based endoscopic ablation system was advanced to each PV ostium, and arcs of laser energy

267 Compound 15d was advanced to efficacy studies in a model of neuropath

268 Compound 7 was advanced to first-in-human trials for the treatment

269 Compound 25 was advanced to first-in-man trials for the treatment of

270 in the discovery of BMS-986166 (14a), which was advanced to human clinical evaluation.

271 Compound 1 was advanced to human clinical trials, and it exhibited

272 An optimized derivative, compound 6c, was advanced to in vivo studies, where it demonstrated e

273 iazole fragment 3, and the resulting product was advanced to intermediate 11 possessing the thiazolin

274 Compound 2 was advanced to phase II depression trials to test the h

275 s of a compelling data package, 20 (AM-6494) was advanced to preclinical development.

276 ubstituents led to quinoline amide 21, which was advanced to preclinical development.

277 Two decades later, RECIST was advanced to streamline WHO and improve its reproduci

278 Compound 3a was advanced to the clinic.

279 e for cases and their corresponding controls was advanced to the date of first recorded prescription

280 lindenes to prepare a [6-7-6] framework that was advanced to the hetidine skeleton.

281 artery, and a 0.035-cm (0.014-in) guidewire was advanced to the iliac artery, guided by x-ray fluoro

282 op SNPs (or their surrogates) from discovery were advanced to a stage-2 evaluation in additional Hena

283 in the identification of two compounds that were advanced to clinical studies: (R)-1-(4-benzoyl-2-me

284 Throughout the 1900s, a number of theories were advanced to explain the numerous growths that cover

285 Elite transgenic lines were advanced to multiyear field trials, which demonstra

286 two precandidates from this subseries, which were advanced to preclinical safety studies and subseque

287 lopability and safety profile, compound 8 is being advanced toward human clinical trials.

288 der EUS guidance, a 19-gauge EUS fine needle was advanced transhepatically into the portal vein and a

289 The needle system was advanced under real-time MR imaging to puncture the

290 The RF electrode was advanced up the midline between lingual arteries and

291 Of the 800 treated seeds, 415 germinated and were advanced up to four (M4) generations by selfing.

292 lowed by the 7 French imaging catheters that were advanced up to the proximal stent edge.

293 d of macromolecular signal amplification has been advanced using conjugated polymers, chirality in po

294 model systems: first, the types of questions being advanced using these new models; and second, the e

295 een studied at the single-molecule scale can be advanced, using chiral chromatography as an example c

296 rapeutic antibody with the immune system has been advanced, using both manipulation of the immunoglob

297 embly of a masked N-aryl tetramic acid which is advanced via a highly selective conjugate addition/in

298 ism of integrin signaling and activation has been advanced with truncated ectodomain preparations; ho

299 Many explanations for TLD have been advanced, with recent efforts focused on recombinat

300 posals for this unconventional behavior have been advanced, yet a consensus remains elusive.