ライフサイエンスコーパス: be critical for

1 o These data demonstrate that AipA and Asp14 are critical for A. phagocytophilum to productively infe

2 miologic data collection and analysis, which is critical for a data-driven response to this public he

3 pression of bacterial genes during infection is critical for a pathogen to cause an infection.

4 n patients, highlighting that the FURIN site is critical for activation of ENaC.

5 fore, neuronal loss rather than inflammation was critical for AD progression in this mouse model, and

6 attenuation of global protein synthesis that is critical for adaptation to starvation-induced stress.

7 bility to extinguish conditioned fear memory is critical for adaptive control of fear response, and i

8 hieving durable brain exposures of ispinesib is critical for adequate tumor cell engagement during mi

9 isk factors specific to each eating disorder is critical for advancing etiologic knowledge and design

10 draulic traits and community trait diversity is critical for advancing predictions of the terrestrial

11 Target site accessibility is critical for AGO2-target interactions, but how target

12 Moreover, the alphakap-alpha-dbn interaction was critical for alphakap accumulation and stability.

13 he 'clover leaf' bend and sugar puckers that are critical for anchoring the 5'-phosphate to Ago 2 MID

14 Adaptive movements are critical for animal survival.

15 We also examined which genes may be critical for ATAA by performing the integrative analy

16 gether, these results demonstrate that Lon-2 is critical for B. burgdorferi to establish infection an

17 oach for quantifying intact HIV-1 proviruses is critical for basic research and clinical trials direc

18 Tools to explore the immune network are critical for better understanding the multi-layered

19 and Arg-179, which were previously shown to be critical for binding of Stx2A1 to the ribosome.

20 e, mobility and binding to antibodies, which are critical for biomedical research and disease diagnos

21 al cells, which surround the endothelium and are critical for blood-brain-barrier integrity, express

22 unding medial-temporal-lobe (MTL) structures are critical for both memory and spatial navigation, but

23 Metabolism reprogramming is critical for both cancer progression and effective im

24 etically conserved amino acid residue, F439, was critical for both transport and the binding of multi

25 Cerebrovascular function is critical for brain health, and endogenous vascular pr

26 esized that PKR-associated lysosome function is critical for cancer but not normal cell survival, rep

27 with myoferlin, a transmembrane protein that is critical for cancer progression.

28 e voltage-gated sodium channel Nav1.5, which is critical for cardiac depolarization.

29 el conducts small outward K(+) currents that are critical for cardiomyocyte membrane repolarization.

30 sides of the murine Esco2 active site cleft, are critical for catalysis.

31 in gene related peptide (PBel(CGRP) neurons) are critical for causing arousal during hypercapnia.

32 derived CCR5-loaded signaling endosomes that are critical for CCL5-induced immunological responses th

33 ubcellular organization of RNAs and proteins is critical for cell function, but we still lack global

34 Chromatin organization is critical for cell growth, differentiation, and diseas

35 ween the basement membrane and these tissues is critical for cell polarization and the ensuing morpho

36 The environmental stress response (ESR) is critical for cell survival.

37 lated transcripts, while those downregulated were critical for cell growth and division.

38 The response to DNA damage is critical for cellular homeostasis, tumor suppression,

39 Compartmentalized signaling is critical for cellular organization and specificity of

40 tute branching microtubule nucleation, which is critical for chromosome segregation.

41 on sites we identified, at least two of them are critical for circadian timekeeping as mutants expres

42 nction and early airway neutrophil responses are critical for clearing fungal conidia from the host a

43 ion, instrumentation, data processing, etc., is critical for comparison of untargeted data across lab

44 One Bacteroides thetaiotaomicron RUS variant is critical for competitive gut colonization in a diet-s

45 th complexes, its membrane-interacting loops are critical for complex II, but have only a minor role

46 Digital media are critical for contemporary activism-even low-effort "

47 dium spp., the parasite that causes malaria, are critical for control of parasitemia and associated i

48 e current study suggests that CD4(+) T cells are critical for controlling acute-stage poliomyelitis (

49 These results indicate that CFH is critical for controlling complement activation in the

50 t collaboration with the alveolar epithelium is critical for controlling infection.

51 in GRA45, which has a chaperone-like domain, is critical for correct localization of GRAs into the PV

52 transport and delivery, which in turn could be critical for coupling the metabolic demands of neuron

53 extreme Cu sensitivity, indicating that MTs are critical for Cu tolerance only in the absence of ATP

54 ptors within brain regions that are known to be critical for decision-making processes in cocaine-dep

55 odifications determine macroscopic diffusion is critical for designing next generation responsive pol

56 CANCE STATEMENT Accurate estimation of speed is critical for determining motion in the environment, b

57 n evolution reaction (HER) in alkaline media is critical for developing anion exchange membrane elect

58 eraction with the tumor extracellular matrix is critical for developing strategies to deliver emergin

59 n of hematopoietic stem and progenitor cells is critical for development of new approaches to monitor

60 ways that regulate eosinophilic inflammation is critical for development of novel therapeutics.

61 anding of the processes involved in patients is critical for development of treatments.

62 itry (CRC)-dependent transcriptional network is critical for developmental tumors in children and ado

63 olic control and host genetic predisposition are critical for diabetic kidney disease (DKD) developme

64 ows that consideration of TP53 allelic state is critical for diagnostic and prognostic precision in M

65 Cdk2-dependent TopBP1-treslin interaction is critical for DNA replication initiation.

66 x, a structure generally overlooked in fear, is critical for downregulating fear when novel predictio

67 e estimation of transcript isoform abundance is critical for downstream transcriptome analyses and ca

68 ge sites and natural substrates of proteases is critical for drug discovery and to understand proteas

69 We observed that CD11c(+) APCs are critical for early priming of CD8 T cells against th

70 ry between the division and elongation zones is critical for efficient root growth; new work from Sal

71 timuli to be modified by previous experience is critical for efficient sensory processing and improve

72 Reproductive performance is critical for efficient swine production.

73 f being capped during mRNA maturation, which is critical for efficient translation initiation during

74 Further, TNFR1 was shown to be critical for elevated NMDA-mediated excitatory curren

75 understanding of context-specific metabolism is critical for elucidating metabolic drivers of larger

76 phosphatidylinositol (GPI)-anchored proteins are critical for embryogenesis, neurogenesis, and cell s

77 oice enablement using voice assistants could be critical for enabling patients with hand arthritis to

78 hosphogluconate dehydrogenase (6PGDH), PGD3, is critical for endosperm starch accumulation.

79 4)) in the N-terminal domain of KSHV gH that are critical for Eph binding and KSHV infection.

80 for autophagy-mediated ER turnover, and thus are critical for ER homeostasis and suppression of ER st

81 for miR-9/9(*)-124 and show their repression is critical for erasing fibroblast fate.

82 poorly understood developmental process that is critical for establishing a chronic infection in its

83 cles within the gastrointestinal tract (GIT) is critical for evaluating the impact of environmental e

84 and frequent monitoring of immune responses are critical for evidence-based informed decisions in th

85 uce these phenotypes, indicating that Thr 79 is critical for EWSR1/FLI1 interference with mitosis.

86 ssion.SIGNIFICANCE STATEMENT Synaptic AMPARs are critical for excitatory synaptic transmission.

87 haracterisation of novel ligands towards PSA is critical for expanding knowledge of PSA interactions

88 These pumps are critical for extrusion of antibiotics from the cell

89 Clustered ion channels at nodes of Ranvier are critical for fast action potential propagation in my

90 We propose that DCL5 and 24-nt phasiRNAs are critical for fertility under growth regimes for opti

91 by an active biotin-transport mechanism and is critical for fetal development.

92 gh strength and high electrical conductivity are critical for flexible electronics, such as electroma

93 lytical methods targeting specific compounds are critical for food safety, analytes excluded from the

94 As this pathway is critical for fungal cell wall integrity, the hexosami

95 lts suggest that molecular aberrations could be critical for future differentially tailored treatment

96 o results, several of the AdcR regulon genes are critical for GAS virulence in WT mice, whereas they

97 ycle, multisite studies of EHR interventions are critical for generalizability.

98 Mammalian protein N-linked glycosylation is critical for glycoprotein folding, quality control, t

99 imuli while ignoring task-irrelevant stimuli is critical for goal-directed behavior.

100 Soil nitrogen (N) availability is critical for grassland functioning.

101 tion of the gastrointestinal (GI) epithelium are critical for health and survival of multicellular or

102 The tympanic membrane (TM) is critical for hearing and requires continuous clearing

103 Thus, the mesoaccumbal pathway in primates is critical for high-effort motivation but not for all f

104 Epigenetic mechanisms are critical for hippocampus-dependent memory formation.

105 second receptor-binding domain was found to be critical for host cell toxicity and the di-heptamer f

106 lorectal cancer (CRC) risk prediction models are critical for identifying individuals at low and high

107 lar mechanisms driving response to radiation is critical for identifying regulatory routes that could

108 FOXP3+CD4+ regulatory T cells (Tregs) are critical for immune homeostasis and respond to local

109 we have identified a new B-cell subset that is critical for immunological tolerance through interact

110 nd biochemical properties of the sensor that are critical for in planta measurements, including speci

111 ns, and maternal responses to infant signals are critical for infant survival and development.

112 recognize two distinct antigenic sites that are critical for inhibiting viral entry into cells.

113 studies have suggested that the AKT2 isoform is critical for insulin-regulated glucose metabolism, wh

114 uit in the mouse accessory olfactory system, is critical for interpreting social chemosignals.

115 tified polymorphisms in murine CD300LF which are critical for its function as an MNV receptor.

116 aroma and winter-flowering properties, which are critical for its successful sexual reproduction.

117 to its movements and patterns of space use, is critical for its conservation.

118 t Vpx interaction with NPC-associated Nup153 is critical for its efficient nuclear translocation.

119 mammalian cells, NF2's lipid-binding ability is critical for its function in activating the Hippo pat

120 ses revealed that the Y128 site of P protein is critical for its interaction with IIGP1.

121 ough the lymphotoxin-beta receptor (LTbetaR) is critical for kidney organogenesis both in the LN and

122 ese findings, and we also found that Tyr-251 is critical for LAIR-1's inhibitory function.

123 ating multiple activities of complex enzymes is critical for life, including transcribing, replicatin

124 id detection of Acinetobacter baumannii (AB) is critical for limiting healthcare-associated infection

125 Although disrupting the viral life cycle is critical for limiting viral spread and disease, it ha

126 ability in acidic intracellular compartments is critical for long-term activity.

127 ociated pore-forming protein Perforin-2 (P2) is critical for LPS-induced endotoxic shock in wild-type

128 Type 3 innate lymphoid cells (ILC3s) are critical for lung defense against bacterial pneumoni

129 (FSTL-1) is highly expressed in the lung and is critical for lung homeostasis.

130 Although pyroptosis is critical for macrophages against pathogen infection,

131 NE holes and protect its unique composition are critical for maintaining its functions.

132 d in Atp7b (-/-) mice, and nuclear receptors are critical for maintaining metabolic homeostasis.

133 r matrix (ECM) and DNA epigenetic regulation are critical for maintaining stem cell phenotype and can

134 t1 oligomers, acting as an exocytosis clamp, are critical for maintaining the balance among the diffe

135 Singing in such gregarious contexts is critical for maintaining and learning songs; however,

136 vasoconstriction (functional sympatholysis) is critical for maintaining blood flow during exercise-m

137 Thyroid hormones are critical for mammalian brain development.

138 To date, it remains unknown which cell types are critical for mediating the disease as well as the me

139 Crossover recombination is critical for meiotic chromosome segregation, but how

140 Selecting a set of valid genetic variants is critical for Mendelian randomization (MR) to correctl

141 e ribose at 3'-end (2'-O-methylation, 2'Ome) is critical for miRNA function in plants and Drosophila.

142 the cis-Golgi protein nucleobindin-1 (NUCB1) is critical for MMP2 and MT1-MMP trafficking along the G

143 rom the DR to the PBel via 5HT(2a) receptors is critical for modulating the sensitivity of the PBel(C

144 sine kinase (Syk) activation induced by heme were critical for most proinflammatory signaling pathway

145 Dopamine (DA) signaling is critical for movement, motivation, and addictive beha

146 d that toll-like receptor 2 (TLR2) signaling is critical for nerve injury-induced activation of spina

147 Here, we show that CUL3 is critical for neurodevelopment.

148 Myelin plasticity is critical for neurological function, including learnin

149 Moreover, independent of this activity, Trx1 is critical for NLRP3 inflammasome activation and IL-1be

150 forming toxins associated with S. aureus EVs were critical for NLRP3-dependent caspase-1 activation o

151 ction to maintain niche cell wrapping, which is critical for normal gonad development.

152 Hydrolysis of c-di-AMP is critical for normal growth and differentiation in Str

153 We found that GSH is critical for normal growth in vitro and provides prot

154 Brain dopamine is critical for normal motor control, as evidenced by it

155 uding changes in extracellular matrix (ECM), is critical for normal processes such as development and

156 red in the presence of IL-7, a cytokine that is critical for normal T cell function and that plays a

157 These observations suggest that Gli3 is critical for OEC development in the nasal mucosa and

158 interaction between Pol delta and LigI that is critical for Okazaki fragment joining in vitro.

159 regrowth of axons, suggesting that microglia are critical for orchestrating the injury response.

160 ishing preexisting and de novo immunity will be critical for our understanding of susceptibility to a

161 This subnetwork appears to be critical for overall brain integration, as even in co

162 , therefore, hypothesized that nickel import is critical for P. mirabilis urease activity and pathoge

163 odel membrane surfaces suggested that Arg-88 is critical for P2-membrane interactions, in addition to

164 d that bioelectric events in nonneural cells are critical for pattern regulation, but their study has

165 two distinct functions of SGP wrapping that are critical for PGC quiescence and survival.

166 ical composition of individual particles can be critical for pharmaceutical scientists to evaluate dr

167 inner segment (IS) to the outer segment (OS) is critical for photoreceptor function and vision.

168 e expression and activity of deubiquitinases are critical for physiology and can go awry in various d

169 Successful apical nuclear migration is critical for planar-orientated cell divisions in dens

170 menting-1-related protein kinase-2s (SnRK2s) are critical for plant abiotic stress responses, includi

171 l microenvironment in combination with STAT5 is critical for post-thymic gammadeltaT17 development an

172 chanisms that sustain asthmatic inflammation is critical for precision therapies.

173 hazard and the underlying driving mechanisms is critical for predicting future changes for better ada

174 Understanding these patterns is critical for predicting the effects of future climate

175 The process of decidualization is critical for pregnancy maintenance in mice and humans

176 In conclusion, ZPR1 is critical for preventing accumulation of co-transcript

177 Detecting pathogens in trade is critical for preventing their continued movement and

178 lity to identify single-nucleotide mutations is critical for probing cell biology and for precise det

179 ronal communication and their precise timing is critical for processes like learning, memory, and com

180 subset of the regulatory regions, that they were critical for production of the mRNAs, and that they

181 Gratitude and joy are critical for promoting well-being.

182 The mechanical properties of these bundles are critical for proper force transmission and force bea

183 t highly correlated electrical activity that is critical for proper maturation and circuit refinement

184 apy (RLT) performed in Bhutan, knowing which is critical for proper planning and successful delivery

185 intaining a healthy proteome throughout life is critical for proper somatic stem cell function, but t

186 This approach will be critical for protecting patients and hospital staff.

187 These findings are critical for rational drug discovery, as limiting a

188 e mechanism of cell death induced by CX-5461 is critical for rational clinical development in these p

189 gating the impact of ionizing radiation will be critical for realizing fault-tolerant superconducting

190 e insulin-like growth factor 1 receptor that is critical for receptor activity.

191 ions for the prevention and treatment of HDP is critical for reducing SMM risk.

192 ndages (that is, follicles and glands), that is critical for regulating body temperature and the rete

193 whether projections between the Pir and OFC are critical for relapse to fentanyl seeking.

194 ring to investigate whether 5S rRNA autonomy is critical for ribosome function and cell survival.

195 supply, sanitation, hygiene, and food safety are critical for robust long-term typhoid control, and t

196 y-discovered mechanisms of the Dorsal module are critical for robustness.

197 tum effects in low-loss optical fibers which is critical for scalability of real applications with la

198 Genome organization is critical for setting up the spatial environment of ge

199 ells are innate skin regulatory T cells that are critical for skin homeostasis, and that IL-17 has du

200 Regional specification is critical for skin development, regeneration, and evol

201 Forests are critical for stabilizing our climate, but costs of m

202 fore a distinctive NCR of naive T cells that is critical for steady-state maintenance of quiescence a

203 bly, OSCA1.3 and its phosphorylation by BIK1 are critical for stomatal closure during immune signalli

204 iquitination but not proteasomal degradation was critical for structural and functional presynaptic C

205 te segmentation and classification of tumors are critical for subsequent prognosis and treatment plan

206 tion of this aberrant function is thought to be critical for successful treatment.

207 Production of reactive oxygen species (ROS) is critical for successful activation of immune response

208 Decisions about when to act are critical for survival in humans as in animals, but h

209 rryover effects operating within species may be critical for survival and shape life histories among

210 utilization of amino acids has been shown to be critical for survival, immune evasion, and escape, wh

211 ements in the real world with precise timing is critical for survival in animals, including humans.

212 Olfaction is critical for survival in neonatal mammals.

213 Learning about rewards and punishments is critical for survival.

214 to treat wastewater in decentralized systems are critical for sustainable development.

215 and terrestrial water storage (TWS) in China are critical for sustainable management of water resourc

216 Animal-mediated pollination is critical for sustaining agricultural economies and bi

217 In turn, the Amo1-enriched subdomain is critical for Swi6 association with FACT that preclude

218 ex to the post-synaptic density (PSD), which is critical for synapse and dendritic spine development.

219 hange of crucial biochemical information and are critical for T-cell immunity.

220 These processes were critical for TAM polarization and activity, both in

221 PRE), specifically the CNGGN-type pentaloop, is critical for TENT4-dependent regulation.

222 Dermal macrophages (Mphi) are critical for the coordinated defense against invadin

223 Directed cell growth or migration are critical for the development and function of many eu

224 tion neurons (SPNs) evoked by drugs of abuse are critical for the development of addiction.

225 that events at the airway epithelial surface are critical for the development of the disease.

226 broadly neutralizing antibodies (bNAbs) that are critical for the efficacy of a prophylactic HCV vacc

227 rt the hypothesis that LC projections to CeA are critical for the expression of defensive responses e

228 s and deletions to identify side chains that are critical for the inhibitory binding of RD3 to RetGC.

229 Human neutrophils are critical for the innate immune response to S. aureus

230 scillations in the neocortex and hippocampus are critical for the integration of new memories into st

231 cations, and chromatin structure regulation, are critical for the interactions between tumor and immu

232 n and anticorrosion properties, all of which are critical for the long-term surface heating membrane

233 ation) and the presence of BRCA1-bound RAP80 are critical for the normal interaction of BRCA1 with so

234 e to build a nest or where to lay your eggs, are critical for the offspring's fitness and survival in

235 is sensitive to invariant relationships that are critical for the perception of natural stimuli.

236 eme nucleation and supercoil dynamics, which are critical for the processing of genomic information.

237 ins (e.g., PhnA, PhnB, PqsR, and RhlI) which are critical for the production of QS signal molecules P

238 ateral nuclear complex (BNC) of the amygdala are critical for the regulation of emotion.

239 Both components of this complex are critical for the regulation of global gene expressio

240 , which has been shown by genetic studies to be critical for the attractant response to L-serine and

241 pendence, suggesting that microglia may also be critical for the development and progression of alcoh

242 part of the LiaR regulon, SpxA2 was found to be critical for the growth of S. mutans under envelope s

243 Impaired learning of this probability may be critical for the pathogenesis of anxiety or reckless

244 ards or away from the observer) was found to be critical for the recognition of fear and anger.

245 The p47phox-p22phox interaction is critical for the activation of the catalytical NOX2 d

246 independent of visual experience, experience is critical for the alignment of these early representat

247 her, these findings suggest that cholesterol is critical for the cannabinoid-GlyR interaction in the

248 The GlyR activation is critical for the control of key neurophysiological fu

249 ight-switchable subunits in a confined space is critical for the design of synthetic molecular machin

250 hat the presence of a beta-pyridinium moiety is critical for the desired C-C bond formation.

251 ers specificity to extracellular stimuli and is critical for the development and health of cells and

252 athway activation, and anti-tumoral immunity is critical for the development of effective cancer immu

253 etermination of psychiatric diagnosis, which is critical for the development of more effective treatm

254 The Notch pathway is critical for the development of the extracellular mat

255 Emergent macrophyte species selection is critical for the effectiveness of nature-based engine

256 Mix23 is critical for the efficient import of proteins into th

257 ignaling.SIGNIFICANCE STATEMENT Inflammation is critical for the emergence of hypertension, yet the m

258 In addition, the JAK-STAT3 pathway, which is critical for the induction of reactive astrogliosis,

259 Finally, we demonstrate that IL18 signaling is critical for the induction of the key thymus-homing c

260 Lyn is critical for the latter, which consists of proteolyti

261 Regulation of quiescence is critical for the maintenance of adult hematopoietic s

262 logical regulation of sensory neurons, which is critical for the maintenance of chronic itch sensatio

263 This endosymbiosis-which is critical for the maintenance of coral reef ecosystems

264 Thus, PIPKIgammai5 is critical for the modulation of Rab7a activity, locali

265 Point mutant viruses indicated that K90 is critical for the neutralization of two MAbs, while es

266 s and a regulator of the actin cytoskeleton, is critical for the normal development and health of pod

267 lar cylindrical architecture, and this event is critical for the orderly recruitment of Plk4, a key r

268 The staphylococcal alpha-hemolysin is critical for the pathogenesis of Staphylococcus aureu

269 trongyloidiasis in immunosuppressed patients is critical for the prevention of severe disease.

270 s from morphologically unidentifiable tissue is critical for the prosecution of illegally-traded wild

271 is for this requirement has been elusive but is critical for the rational design and improvement of a

272 This regenerative process is critical for the re-establishment of axonal conductio

273 winding of double-stranded RNA intermediates is critical for the replication and packaging of flavivi

274 The unwinding of dsRNA intermediates is critical for the replication of flavivirus RNA genome

275 A large amount of high-quality data is critical for the success of machine learning models i

276 In addition, the 2'-Cl substituent was critical for the high quantum yield measured for tri

277 ermore, the MDA5/MAVS-dependent IFN response was critical for the induction of optimal antifungal neu

278 s further revealed that astrocyte-derived E2 was critical for the induction of the JAK-STAT3 signalin

279 The expression variations are critical for their activity variations, but how expr

280 The target binding properties of antibodies are critical for their efficacy and toxicity.

281 We show that mTOR expression by Treg is critical for their differentiation into effector Treg

282 understanding of the metabolic fate of TPPs is critical for their preclinical and clinical developme

283 c vessel development in prenatal mice and it is critical for their survival postnatally.

284 ter adjacent to the SEC31/SEC23-binding site was critical for this SAR1B function.

285 verall our results suggest a model where BAF is critical for timely repair of large ruptures in the n

286 These findings suggest that ILC1s are critical for tissue protection during acute liver in

287 BoV1 capsid identified several residues that are critical for transduction, capsid assembly, or DNA p

288 Reporting the sex of biological material is critical for transparency and reproducibility in scie

289 Reprograming of proline metabolism is critical for tumor growth.

290 c enzyme and transcriptional coactivator and is critical for tumor metabolism.

291 oscillations, robustness and stochasticity, are critical for understanding gene regulation during ce

292 utic targets, and elucidating their function is critical for understanding Burkholderia pathogenesis.

293 den of impairment in subsistence populations is critical for understanding selection pressures underl

294 ronmental heterogeneity and local adaptation is critical for understanding the evolutionary history o

295 drome-coronavirus 2 (SARS-CoV-2)] infections is critical for understanding the overall prevalence and

296 Such information is critical for understanding the role of tropical fores

297 ow and overcome challenges to their survival is critical for using these organisms to meet current an

298 umin-expressing (PV) inhibitory interneurons is critical for visual cortical plasticity.

299 Human ventral temporal cortex (VTC) is critical for visual recognition.

300 p growth and its responses to climate change are critical for yield estimation and prediction, especi