ライフサイエンスコーパス: be critical to

1 for deep soil water acquisition (WA(deep) ) are critical to a species' adaptation to drought.

2 ited to the gH/integrin beta1 complex, which is critical to aberrant Akt activation, as SHIP1 diverts

3 od for early detection for breast cancer and are critical to achieve a favorable outcome from cancer.

4 The presence of sufficient energy reserves is critical to achieve successful reproduction.

5 to treat, such as persons who inject drugs, are critical to achieving eradication.

6 CO and weakened *CO intermediates on PdH/NbN are critical to achieving higher CO(2) RR activity.

7 The rapid phase-out of fossil fuels is critical to achieving a well-below 2 degrees C world.

8 geting MSM and PWID in low-resource settings is critical to achieving the 90-90-90 HIV/AIDS targets.

9 deamidation by human tissue transglutaminase is critical to activate celiac disease pathogenesis maki

10 The perception of time is critical to adaptive behavior.

11 egies and development of new strategies will be critical to address the noted disparities and achieve

12 wever, continued tuberculosis drug discovery is critical to address the global health need and burgeo

13 ylactic, therapeutic and curative strategies is critical to address this burden but is predicated on

14 ring that effective and approachable methods are critical to advance glycoscience research, the curre

15 r simultaneous electric and thermal extremes are critical to advanced electronics for ultrahigh densi

16 nding novel approaches to probe this pathway are critical to advancing our understanding of the patho

17 the opportunity for successful treatment, it is critical to align the treatment approach with patient

18 erpinnings of abstinence from drugs of abuse is critical to allow better recovery and ensure relapse

19 in testing time without loss of sensitivity is critical to allow food processors to safely decrease

20 tion and inhibition of this ion channel will be critical to an improved understanding of the biologic

21 Proper threat-reward decision-making is critical to animal survival.

22 tanding of metal transport in the human body is critical to anticipate the side effects of metal-base

23 rstanding how this process is regulated will be critical to any vaccine effort targeting NA immunity.

24 ated that shorter and stricter reaction time was critical to approach the initial rate of NAD(+)-depe

25 pathway maps, such as the one reported here, are critical to assess progress in the field and identif

26 Understanding such nutrient allocations is critical to assessing life-history strategies and hab

27 -order regions such as the prefrontal cortex are critical to attentional processing, but far less is

28 tyrosine hydroxylase-expressing neurons that is critical to autoregulate GH secretion via a negative-

29 bullous variant of chronic CSC with RPE tear is critical to avoid inappropriate procedures and to pre

30 urther found that a length scale below 25 nm is critical to avoid the limitation of short-lived speci

31 management within and among watersheds will be critical to balance trait optimization versus diversi

32 This information is critical to balance the competing safety consideratio

33 the level of individual LH(Gad1) neurons may be critical to balancing propensity for relapse versus a

34 t broader spatial and longer temporal scales are critical to better prediction on evolution of the ca

35 asticity, and multi-generational plasticity, is critical to better understanding ecological and evolu

36 for residual disease and leukemia re-growth is critical to better understanding how they are regulat

37 onse to changes in environmental conditions, is critical to biological function.

38 between RNA-binding proteins (RBPs) and RNAs are critical to cell biology.

39 on of the peptide-binding domain in mortalin was critical to cell survival or death.

40 associated with conformational changes that are critical to cellular signaling pathways.

41 cids (FA) are a vital component of cells and are critical to cellular structure and function, so much

42 Being critical to cellular functions, they are also fund

43 nvironment-dependent association and binding is critical to cellular adaptation.

44 diversify genetically and antigenically, it is critical to closely monitor viruses responsible for h

45 how that canonical Wnt signaling in mesoderm is critical to confer trachea mesenchymal identity in hu

46 roscopic models for particle filtration, yet is critical to consider in the processes that control de

47 We found that neutrophils are critical to control bacterial ascent, which is in li

48 Engineering the particle size and Fe doping is critical to control extrinsic morphological factors o

49 Accurately characterizing these polymers is critical to control the product quality, to monitor t

50 cation mediated by ligand-receptor complexes is critical to coordinating diverse biological processes

51 ceae family encompass diverse symbionts that are critical to corals and other species living in coral

52 l mechanisms that stabilize these assemblies is critical to decoding and controlling cellular functio

53 rs to HIV medical care for transgender women is critical to decrease disparities among this populatio

54 -wide interaction matrices such as Hi-C data is critical to deepening our understanding of proper gen

55 hnologies and knowledge become available, it is critical to define an optimal strategy for their use.

56 To address this question, it is critical to define the identity of an individual CAR-

57 neural signals to the resulting behavior, it is critical to demix the recordings into meaningful spat

58 g mode, and interbinding site spacing, which are critical to design specific multivalent inhibitors.

59 lated in the aftermath of spinal cord injury is critical to design future manipulations aimed at impr

60 g and subsequent control of phase separation is critical to designing better pathogen inhibitors and

61 n age-related macular degeneration (AMD), it is critical to detect retinal dysfunction before permane

62 Calcium fluorometry is critical to determine cell homeostasis or to reveal c

63 tment delay on progression to severe disease is critical to determine how quickly patients need to re

64 rilizing disseminated tumor cells (DTCs), it is critical to determine the contribution of bystander e

65 With limited treatment options, it is critical to determine the risk profile of novel thera

66 Furthermore, it is critical to determine which interneuron subtypes cont

67 The mortality rates of large trees are critical to determining carbon stocks in tropical fo

68 ng the thermal stability of metallic glasses is critical to determining their safe temperatures of se

69 ith HIV and receiving antiretroviral therapy is critical to develop cure strategies.

70 lying molecular mechanisms of this condition is critical to developing new treatments for patients.

71 icular, discovery of actionable drug targets is critical to developing targeted therapies for disease

72 It is axiomatic that the actions of dopamine are critical to drug addiction.

73 he orbitofrontal cortex (OFC) is proposed to be critical to economic decision making.

74 te to the pathophysiology of G6PD deficiency is critical to eliminate ABE and KSD, especially in coun

75 Prompt recognition of microbes by cells is critical to eliminate invading pathogens.

76 oring of combustion products and composition is critical to emission reduction and efficient energy p

77 ials with high electrocaloric (EC) strengths is critical to enabling EC refrigeration in practical ap

78 lex geometries and avoid self-collisions, it is critical to encode a spatial and temporal shape evolu

79 of cases and tracing of transmission chains is critical to end outbreaks and to inform prevention me

80 These activities are critical to ending the HIV epidemic.

81 unities through scientific outreach programs is critical to engaging the next generation, exciting yo

82 Early diagnosis is critical to ensure appropriate management, counseling

83 MOLST, thoughtful discussion before surgery is critical to ensure concordant perioperative care.

84 ely risk assessment of rabies in biting dogs is critical to ensure that rabies PEP is administered to

85 Assessment of heterogeneity in meta-analyses is critical to ensure the consistency of pooled results.

86 n of the immune modulatory effects of opioid is critical to ensure the safety of clinical opioids.

87 It is critical to ensure transgender women are aware of and

88 piratory syndrome coronavirus 2 (SARS-CoV-2) is critical to eradicate the coronavirus disease 2019 (C

89 It is critical to establish NHP models of the vertical tran

90 ssessing the reactions of iodine (I) in soil is critical to evaluate radioiodine exposure and underst

91 It is critical to evaluate the CNS safety of studies using

92 ealtime care for people living with dementia is critical to evaluate the process and effects of mealt

93 pid, noninvasive actuation of DNA structures is critical to expanding the functionality of DNA nanote

94 However, it is critical to explore and understand the relative contr

95 als a novel mechanism of genome scarring and is critical to exploring therapies to counteract the apl

96 f outer membrane constriction with septation is critical to faithful division in Gram-negative bacter

97 The former is critical to feeding, mating, and predator avoidance b

98 CD4(+) T cells are critical to fighting pathogens, but a comprehensive

99 he interaction sites between Rubisco and Rca is critical to formulate mechanistic hypotheses.

100 erning viral and tumour immunity, which will be critical to fully understand the impact of common inf

101 The generation of such datasets is critical to fully benefit from rapidly evolving metho

102 consequences of these morphological changes is critical to fully understanding how mitochondrial fun

103 that contributes to the outcome of interest is critical to future efforts to address population disp

104 ological variable in atherosclerotic disease is critical to future precision medicine strategies to m

105 ecific binding of transcription factors (TF) is critical to gene regulation.

106 SF regulated proteins primarily in mPFC that are critical to glutamate signaling and synapse maintena

107 s of treatment with different pulse duration is critical to guarantee the effectiveness: 2 folds or h

108 Maintenance of genome integrity is critical to guarantee transfer of an intact genome fr

109 Therefore, it is critical to have a finely regulated transport system

110 Hepatitis C virus (HCV) screening is critical to HCV elimination efforts.

111 These results indicate that POL2A is critical to heterochromatin structure and function, a

112 he observed interactions with fibrinogen may be critical to host colonization and it is hypothesized

113 Safe, reliable, and equitable water access is critical to human health and livelihoods.

114 The human gut microbiota (HGM), which is critical to human health, utilises complex glycans as

115 Therefore, it is critical to identify alternate therapies to improve p

116 n of invasive species in introduced areas it is critical to identify and understand the mechanisms dr

117 aw B-scan images of both the RNFL and macula is critical to identify artifacts and true glaucoma prog

118 As methamphetamine use increases, it is critical to identify those at risk of acquiring HBV i

119 ets and model-data fusing methodologies will be critical to identifying both the scale-dependent mode

120 erturbations in metabolism are related to AD is critical to identifying novel targets for disease-mod

121 (T2DM) and heart failure (HF) worldwide, it is critical to implement optimal prevention and treatmen

122 Early diagnosis is critical to improve outcomes in rheumatoid arthritis

123 g tumor resistance to T cell immunotherapies is critical to improve patient outcomes.

124 for behavioural differences among mutualists is critical to improve predictions from network models.

125 Early identification of sepsis is critical to improving patient outcomes.

126 Rapid infection diagnosis is critical to improving patient treatment and outcome.

127 f the intricate cellular milieu of the heart is critical to increase our understanding of cardiac hom

128 ich pooled transfections of multiple vectors were critical to increasing scale and throughput.

129 (NPIs) to mitigate the spread of SARS-CoV-2 is critical to inform future preparedness response plans

130 est immune responses following HIV infection is critical to inform future vaccines and therapeutics.

131 Such research is critical to inform the development of effective progr

132 imates of the burden of SARS-CoV-2 infection are critical to informing pandemic response.

133 not convey the tests' clinical value, which is critical to informing decision-making.

134 iological control of coral biomineralization is critical to informing future models of coral vulnerab

135 ciency virus (SHIV)-macaque model of latency is critical to investigate eradicative and suppressive s

136 n-cell autonomous-mediated neurotoxicity, it is critical to investigate the contribution of glia to a

137 luding novel, mannan-specific esterases that are critical to its deconstruction.

138 All of these function are critical to juvenile survival.

139 me to a large variety of immune cells, which are critical to maintain normal tissue functions.

140 moval of damaged mitochondria, is thought to be critical to maintain neuronal homeostasis.

141 This anchoring is critical to maintain microtubule organization by oppo

142 s (P), a major plant nutrient, as fertilizer is critical to maintain P level for crop production and

143 sion of cellular reprogramming in germ cells is critical to maintaining cell fate and fertility.

144 Control of the inflammatory response is critical to maintaining homeostasis, and failure to d

145 affolding component of the nuclear envelope, is critical to maintaining the NMJ in mice.

146 um evolution of submicron particulate matter is critical to making efficient remediation policies to

147 h the brain operates, and understanding them is critical to making progress in revealing the neural m

148 ads to formation of membrane-less organelles is critical to many biochemical processes in the cell.

149 nergy damping time in a mechanical resonator is critical to many precision metrology applications, su

150 ns of performance decay in carbon electrodes is critical to maximizing the longevity of capacitive de

151 Robust experimental studies on elasmobranchs are critical to meaningfully assess the threat of global

152 Quantitative assessment of motion is critical to medical decision-making but is currently

153 Increased grain yield will be critical to meet the growing demand for food, and cou

154 Glycosylation is critical to megakaryocyte (MK) and thrombopoiesis in

155 Microresonator solitons are critical to miniaturize optical frequency combs to c

156 f human infections, and an effective vaccine is critical to mitigate coronavirus-induced disease 2019

157 Understanding these underlying mechanisms is critical to mitigate lung function impairment.

158 of IAV transmission through exhibition swine is critical to mitigating the high incidence of variant

159 Thus, CUL3 is critical to neural development, neurotransmission, an

160 nce EXOC2 and other exocyst complex subunits are critical to neuronal function, our findings suggest

161 2 in various tissues, including brain, which are critical to normal growth and development.

162 Maintaining MYC at homeostatic levels is critical to normal cell function; overexpression driv

163 the integrated stress response (ISR), which is critical to normal cellular function.

164 It is critical to note the synergistic relationship among a

165 o 20 mus to demonstrate that such timescales are critical to observe the equilibration of a pLGIC fro

166 sensitive, and high-resolution MS techniques is critical to ongoing analytical efforts to separate an

167 ne characteristics and CLL-directed therapy, is critical to optimally manage CLL patients through thi

168 xcess mortality are complementary goals that are critical to our understanding of the pandemic and it

169 Memory, on multiple timescales, is critical to our ability to discover the structure of

170 urate characterization of near-surface winds is critical to our understanding of past and modern clim

171 Two distinct areas that are critical to PDL function were previously identified:

172 Although precise heating is critical to performing these assays, it is challengin

173 cellular therapy recipients with SARS-CoV-2 is critical to performing these potentially life-saving

174 s usually asymptomatic but earlier detection is critical to permit life-saving interventions for thos

175 etabolism of a variety of carbohydrates that are critical to persistence and pathogenicity of S. muta

176 Quantifying this balance is critical to planning the regional elimination and glo

177 ded by multitaper spectral estimation, which is critical to precisely measuring such correlations, we

178 Accurate biological models are critical to predict biotic responses to climate chan

179 lowground effects of woody encroachment will be critical to predict future changes in alpine ecosyste

180 onary history constrain community resilience is critical to predicting shifts in future ecosystem fun

181 y-state concentrations of PPRIs ([PPRI](ss)) is critical to predicting the persistence of pollutants

182 unctional telomeres to the nuclear periphery is critical to preserve telomere repeat integrity.

183 redundant mediators of immune tolerance that are critical to prevent autoimmune disease and promote a

184 role of the Stx17-CFTR protein complex that is critical to prevent defective autophagy as has been t

185 ment that maintaining adequate folate status is critical to prevent diseases due to folate inadequacy

186 ly involvement of the cardio-obstetrics team is critical to prevent maternal morbidity and mortality

187 ding the mechanisms behind beta-cell failure is critical to prevent or revert disease.

188 This balance is critical to prevent the formation of reactive oxygen

189 he leading cause of death (LCOD) among women is critical to prevention.

190 totic activity of root apical meristem (RAM) is critical to primary root growth and development.

191 or without (covert) foveating eye movements is critical to primate behavior.

192 ion of deactivation through addition of LiBr are critical to producing well-defined acrylate polymers

193 er, and early detection and accurate staging are critical to prolonging survival.

194 at these combined actions of the Ran pathway are critical to promote Kinesin-14 parallel microtubule

195 icroglia and neurons, cell populations which are critical to proper brain homeostasis and whose dysfu

196 luxes, and consideration of diel variability is critical to properly assess the total lake CH(4) flux

197 lective autophagic elimination of aggregates is critical to protein quality control, but how aggregat

198 ient Na and complete solid-solution reaction are critical to realizing high-performance P2-type catho

199 isk populations e.g. among heterosexual men, are critical to reduce syphilis.

200 g cause or to provide prognostic information are critical to reducing the morbidity and mortality ass

201 Efficient wound repair is critical to reestablish the mucosal barrier and homeo

202 Translation control is critical to regulate protein expression.

203 EP, precise control over the electric field is critical to regulate the induced pore densities in th

204 PKA-null cells include Ser256 of AQP2, which is critical to regulation of AQP2 trafficking.

205 n methods for soluble and insoluble glycogen are critical to research, including therapeutic studies,

206 resistance to SCN, confirming that t-SNAREs are critical to resisting SCN infection.

207 ermediates, and lattice-oxygen-stabilization are critical to reveal the lowest overpotential OER path

208 To improve anti-cancer therapy, it is critical to reveal the mechanisms by which PD-1 regul

209 Thorough systemic and ocular investigations are critical to rule out other etiologies.

210 GPR43 and GPR109A are critical to SCFA-mediated protection against this co

211 identify risk factors for suicidal behavior is critical to selected and indicated prevention efforts

212 A single amino acid change was critical to seroreactivity to peptides in a region o

213 Pitch is critical to speech understanding (particularly in noi

214 highest risk of severe disease) will likely be critical to stem the pandemic.

215 e function of sarcomeric proteins; hence, it is critical to study HCM at the level of proteoforms to

216 between humans and nonhuman primate species is critical to study the origin of network alternations

217 Controlling this proliferation is critical to successful regeneration.

218 anisms and tissue repairing functions, which are critical to support periodontal health.

219 Ontologies are critical to support the types of big data analysis n

220 of antibodies to upper respiratory pathogens is critical to surveillance, assessment of the immune st

221 ic mechanisms, and that connected wilderness is critical to sustain coexistence landscapes.

222 ing severe ultrarare mutations in genes that are critical to synaptic plasticity.

223 These results provide evidence that STP is critical to temporal context-dependent responses in t

224 0/CD86-CTLA4, PDL1/2-PD1, CD155/CD112-TIGIT) are critical to the acquisition of effector T-cell funct

225 Myeloid cells are critical to the development of fibrosis following mu

226 Fast-ion conductors are critical to the development of solid-state batteries

227 nd aggregating their diverse representations are critical to the elucidation of the genetic basis of

228 responses to climate and atmospheric change are critical to the future of the global carbon budget.

229 N-Linked glycans are critical to the infection cycle of HIV, and most neu

230 Cholesterol homeostasis and trafficking are critical to the maintenance of the asymmetric plasma

231 umor-specific antigen (TSA)-reactive T cells are critical to the success of checkpoint blockade and a

232 hcare professionals and negotiating the role are critical to the success of the implementation of the

233 laria for decades, and chemical insecticides are critical to the success of vector control programs w

234 dicated the route of both prime and boost to be critical to the location of induced resident T cells

235 s that reductions in Glx in the left STG may be critical to the pathophysiology of schizophrenia.

236 ker A motif (-GPAGTG(6)K(7)S-) were found to be critical to the PI5P-binding ability.

237 ence of human factors; these approaches will be critical to the success of artificial intelligence in

238 ic acid (C18:2) in the endoplasmic reticulum is critical to the accumulation of polyunsaturated fatty

239 water flow, detected by lateral line organs, is critical to the behavior and survival of fish and amp

240 N87K in FliC, one of the filament subunits, is critical to the change in flagellar morphology and sw

241 Optimal functioning of neuronal networks is critical to the complex cognitive processes of memory

242 ntifying traits that convey resilience to OA is critical to the continued success of abalone and othe

243 termining whether a bacterium has resistance is critical to the correct treatment of the patient.

244 anding of structure-reactivity relationships is critical to the design and optimization of cysteine-t

245 that regulate development of CD8(+) T cells is critical to the design of T cell-mediated vaccines.

246 magglutinin (HA) naturally develop in humans is critical to the design of universal influenza vaccine

247 Such improved understanding is critical to the development of new antibiotics that d

248 pable of inhibiting amyloid-fibril formation is critical to the development of potential therapeutics

249 Early auditory experience is critical to the development of these systems.

250 The clinical assessment of fibrosis is critical to the diagnosis and management of patients

251 and historical information, and their study is critical to the discovery of new and/or recently exti

252 Providing this input is critical to the enactment of legislation that will ma

253 aproteobacteria, a conserved LTTR named VtlR is critical to the establishment of host-microbe interac

254 Because matrix remodeling is critical to the formation and growth of these lesions

255 rtant feature of CTCF binding evolution that is critical to the functional stability of a higher-orde

256 gocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity.

257 ansmission through Drd1 and Drd2 in NAc core is critical to the incubation of methamphetamine craving

258 intensity, and frequency of control efforts is critical to the management of biological invasions in

259 sibly store high densities of thermal energy is critical to the more efficient and sustainable utiliz

260 oxygen of tosylate during oxidative addition is critical to the observed selectivity.

261 dren worldwide and for which early diagnosis is critical to the outcome of behavior therapies.

262 Tongue motor control is critical to the pathogenesis of obstructive sleep apn

263 mination of Mycobacterium tuberculosis (Mtb) is critical to the pathogenesis of progressive tuberculo

264 Monitoring these inequalities is critical to the planning and delivery of dental servi

265 Harboring EGFR mutations is critical to the selective pressure and further impact

266 emerging biomarkers of therapeutic benefits is critical to the streamlining of care for individuals.

267 Understanding the sorption processes is critical to the successful design and implementation

268 The latter is critical to the transformation of nonpolar pluripoten

269 nd antiapoptosis signals within cancer cells is critical to therapeutic resistance.

270 Deubiquitinating enzymes are critical to this process, as they mediate removal of

271 e potent regulators of biologic systems that are critical to tissue homeostasis.

272 t H-bond between residues T176 and Y226 that is critical to transduce the inhibitory effect of Ca(2+)

273 It is critical to tune the cell chemistry of Li-O(2) batter

274 tions, community partners, and policy makers are critical to ultimately reduce the burden of cardiova

275 chanism of nonequilibrium ET dynamics, which is critical to uncovering the molecular nature of many b

276 ot examined in refugee populations, yet they are critical to understand granular health trends.

277 h, where, and when DDXs are targeted by Gle1 are critical to understand.

278 rstanding of keratinocyte carcinogenesis, it is critical to understand epigenetic alterations, especi

279 currently resides in the atmosphere, and it is critical to understand how soil greenhouse gas (GHG)

280 It is critical to understand how the predictive value of th

281 ithelial hierarchy and lineage heterogeneity is critical to understand its regenerative properties an

282 Continual molecular epidemiology is critical to understand the evolutionary processes mai

283 V-mediated transcription regulatory networks is critical to understand viral-associated lymphomagenes

284 C) membrane organization and gene regulation are critical to understanding sight and retinal degenera

285 s (both social cognition and peer relations) are critical to understanding the way in which pubertal

286 Simple stimuli have been critical to understanding neural population codes i

287 Reconstructing diet is critical to understanding hominin adaptations.

288 sulfur cycle and associated isotopic change is critical to understanding how climate, atmospheric ox

289 ining high-resolution structural information is critical to understanding how such designs function.

290 requirements for maximal cytotoxic capacity is critical to understanding how viral clearance might b

291 Knowledge of their 3D structures is critical to understanding mechanisms of drug action.

292 lowing Mass Drug Administration (MDA), which is critical to understanding serostatus in trachoma-ende

293 Understanding meteoroid impacts is critical to understanding the source processes of the

294 supercritical aqueous fluids under pressure is critical to understanding their mass transport in the

295 Further validation work is critical to unleashing the full potential of coagulat

296 It is critical to upregulate or activate the iPSC-enriched

297 This work highlights that the [4Fe4S] center is critical to UvrC.

298 Social connection is critical to well-being, yet how the brain reflects ou

299 ion.SIGNIFICANCE STATEMENT Social connection is critical to well-being, yet how the brain reflects ou

300 Effective contraception is critical to young women with HIV-associated tuberculo