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2 cultivar accumulates 3-methyl myricetin and is deficient in 3'-methyl myricetins, demonstrating vari
4 emia (AML) cells from most patients with AML are deficient in a critical enzyme required for arginine
5 and amplification of DVGs in A549 cells that are deficient in a variety of innate intracellular antiv
6 f SFTS in hamsters genetically engineered to be deficient in a protein that helps protect humans and
7 the activation of the NF-kappaB pathway and was deficient in a mutant K13 with three alanine substit
10 a circulating pro-regenerative mediator that is deficient in aging and mitigates fibrosis in distant
11 al observations of APECED/APS1 patients, who are deficient in AIRE, a major regulator of central T ce
16 se and the glycolytic enzyme pyruvate kinase were deficient in an mntH strain grown under manganese l
19 enome edited cells expressing only Syk-Y130E were deficient in antigen-stimulated calcium release, de
23 ells and in Med23 knockout (KO) cells, L-E1A was deficient in association with other mediator subunit
24 herefore, we investigated whether caveolin-1 is deficient in asthmatic patients and in a murine model
25 An additional PilB mutant variant, which is deficient in ATP hydrolysis and T4P assembly, support
28 lacking B cells or mice lacking CD19, which are deficient in B-1a cells, an innate-like B-cell popul
30 weakly tumorigenic and tumors that did form were deficient in BCSCs, abolishing metastatic capacity.
33 licase is essential for genome integrity and is deficient in Bloom syndrome (BS), a rare genetic dise
34 ages beyond the commitment point, cells that are deficient in both checkpoints because they lack Rad5
38 lacked Meissner corpuscles and found them to be deficient in both perceiving the gentlest detectable
40 e2-CreNox2 knockout (KO) mice (in which Nox2 was deficient in both endothelial cells and myeloid cell
41 e DWARF (DWF), and in the bzr1 mutant, which is deficient in BR signaling regulator BRASSINAZOLE RESI
43 f these agents as treatments for tumors that are deficient in BRCA2 and PTEN, among other DSB repair
46 individuals with hereditary angioedema (HAE) are deficient in C1-inhibitor and consequently exhibit e
49 (TCRalpha(-/-)) mice, which express CD1d but are deficient in CD1d-dependent NKT cells, exhibited as
52 ns demonstrate that mice lacking V2a neurons are deficient in central respiratory rhythm generation.
53 ells, which initiate excess origins and also are deficient in checkpoint activation, showed slower fo
57 (SLQ-->AAA) with mutations S478A/L480A/Q481A was deficient in clotting activity and unable to efficie
59 topenia (NAIT) possess oligosaccharides that are deficient in "core fucose" residues and appear to be
60 r patterns, the activation of Erk1/2 and JNK was deficient in Cot/tpl2 KO macrophages compared with t
61 cal G protein coupled receptor, whereas C5L2 is deficient in coupling to G proteins because of variat
67 wild-type Arabidopsis; cyp89a9 mutants that are deficient in CYP89A9 function were devoid of NDCCs b
68 urthermore, macrophages from MARCO(-/-) mice were deficient in cytokine and chemokine production, inc
69 tumor protection, as vaccines in these mice were deficient in cytotoxic T lymphocytes priming and IL
71 Using genetically modified human cells that are deficient in DC2 or KCP2 proteins, we show that loss
74 resected DNA As a result, srs2Delta mutants are deficient in DNA repair correlating with extensive D
76 e of xeroderma pigmentosum (XP) cells, which are deficient in DNA repair, rendered this assay more se
79 dies of exon alpha Pol beta revealed that it is deficient in DNA binding to gapped DNA, has strongly
81 -specificity phosphatase (msg5Delta) or that are deficient in docking to the MAPK-scaffold (Ste5(ND))
85 erated mice that express TGF-beta1(C33S) and are deficient in either integrin beta8 or TSP-1, known a
87 We have used the beige (Bg) mouse, which is deficient in endosome biogenesis, to evaluate the eff
90 g a cardiac-tissue-specific knockout of Ctr1 are deficient in Erk phosphorylation in cardiac tissue.
91 Rab27b double-knockout (Rab27DKO) mice that are deficient in exosome secretion have a chronic, low-g
92 rted that mouse embryonic stem cells (mESCs) are deficient in expressing type I interferons (IFNs) in
93 MCPT4-deficient mice was abolished when GBS was deficient in expression of the fibronectin-binding p
94 SV-1 entry in murine dermal fibroblasts that were deficient in expression of either nectin-1 or HVEM
95 he sperm cell and the pollen vegetative cell were deficient in expression of key RNAi components.
98 OR-gammat in a MyD88-dependent manner, which was deficient in FA infants and mice and ineffectively i
99 mice, lysosomal enzymes were expressed that are deficient in Fabry and Gaucher diseases and in Hurle
103 affected daughters, chromosomal break repair was deficient in fibroblasts from the affected individua
106 ted in all cell lines, the DNA adaptor STING was deficient in FL83B hepatocytes (down by nearly 3 log
107 etically interacts with FMRP, a protein that is deficient in fragile X syndrome and is known to regul
109 As and Argonaute proteins in eukaryotes that are deficient in functional RNA interference could provi
111 ene, which encodes the lysosomal enzyme that is deficient in Gaucher's disease, are important and com
112 dies revealed that DC-beta-catenin(-/-) mice were deficient in generating CD8(+) T-cell immunity desp
113 TMEM16F-dependent lipid scrambling activity are deficient in generation of extracellular vesicles (E
117 Importantly, although mitochondrial (mt)ROS were deficient in gp91(phox-/-) phagocytes, their restor
119 reduced extracellular nuclease activity and is deficient in growth when DNA is provided as the sole
120 2 cells, deleting a Drosophila E(z) homolog, were deficient in H3K27 di- and trimethylation, with no
125 unctionally complemented a yeast strain that is deficient in high affinity ammonium transport, both a
126 activated protein kinase (MAPK) pathway that is deficient in highly aggressive BLBCs treated with che
127 We find that melanocytes depleted of MEN1 are deficient in homologous recombination (HR)-directed
128 tors in the treatment of breast cancers that are deficient in homologous recombination exemplifies th
129 line deleterious mutations of BRCA1 or BRCA2 are deficient in homologous recombination repair and the
131 ential of EXT1(-/-) mouse ESCs (mESCs), that are deficient in HS, to differentiate into primary germ
132 eport that mice with a betaCys93Ala mutation are deficient in hypoxic vasodilation that governs blood
136 urther demonstrate that beta-arr-1(-/-) mice are deficient in IL-6 expression in the colon, but have
137 ntly lower levels of inflammatory monocytes, were deficient in IL-18 production, and lacked NK cell-d
138 cohol use disorder presenting to the ICU may be deficient in important vitamins and electrolytes and
144 Mouse models used to test dengue vaccine are deficient in interferon (IFN) type I signaling and s
145 AK4, and MYD88; however, the deletion clones are deficient in interleukin-10 (IL-10) production.
147 e show that an E. faecalis epa mutant strain is deficient in intestinal colonization, cannot expand i
148 MAPKs, MNK1 and MSK1, whose phosphorylation is deficient in IRAK4(KDKI) macrophages stimulated throu
149 rate a SNAP25 extreme C-terminal mutant that is deficient in its ability to bind Gbetagamma while ret
150 lotting assays revealed that although fV(Q3) was deficient in its clotting activity, fV(DeltaB9/Q3) h
152 Phosphorylation-defective histone H4 mutant is deficient in K20 methylation, leading to reduced DNA
153 s in a series of primary cells and mice that were deficient in key innate immune genes involved in pa
154 rotein markers and mRNA profiles in DCs that are deficient in known or candidate genes, we classified
155 o control cells, FH iPSC-derived hepatocytes are deficient in LDL-C uptake; (3) control but not FH iP
161 By using the human cell line K562, which is deficient in MHC class I/II and CD1 expression, we ge
162 plasmic streaming, we used a Khc mutant that is deficient in microtubule sliding but able to transpor
164 tor-Tg mice to generate 2D2 CD4 T cells that are deficient in miR-146a and specific for myelin oligod
167 Animals defective in ceramide biosynthesis are deficient in mitochondrial surveillance, and additio
168 howed extreme susceptibility to Yersinia and were deficient in monocyte and neutrophil-derived produc
172 roblasts had low SELENBP1 protein levels and were deficient in MTO enzymatic activity; these effects
173 We have studied Arabidopsis mutants that are deficient in multiple MTs to learn about the functio
174 demonstration that mitochondrial biogenesis is deficient in Multiple Sclerosis patients, which could
175 elets obtained from Unc13d(Jinx) mice, which are deficient in Munc13-4 and have an exocytosis defect.
176 oated by retromer and Mvp1, and cargo export is deficient in mvp1- and vps1-null cells, but with dist
178 otective effects were abrogated in mice that were deficient in MyD88 and Trif, molecules that are cri
179 ells) and LysM CreNox2KO mice (in which Nox2 was deficient in myeloid cells) had significantly lower
181 nt of phosphorylated actin and LTP induction is deficient in neurons expressing mutant actin that mim
183 ve an open neural tube, such as embryos that are deficient in Nodal signaling or the cell adhesion pr
186 d to develop complete convergence when Mecp2 is deficient in olfactory sensory neurons (OSNs) in an o
189 veloped the Deltap35KI transgenic mouse that is deficient in p25 generation and Cdk5 hyperactivation.
190 smic domain of TF (F3) (TF(DeltaCT)) or that are deficient in PAR2 (F2rl1), as well as by pharmacolog
191 brain states of attention and arousal and to be deficient in pathologies such as Alzheimer's disease,
193 al enzyme, alpha-l-iduronidase (IDUA), which is deficient in patients with mucopolysaccharidosis type
194 nal survival motor neuron (SMN) protein that is deficient in patients with spinal muscular atrophy.
195 samine-6-sulfatase and GalN6S; E.C. 3.1.6.4) is deficient in patients with the lysosomal storage dise
199 ancisella pathogenicity island (FPI) mutant, is deficient in phagosomal escape and intracellular grow
200 yzed pheophorbide a oxygenase1 (pao1), which is deficient in pheophorbide catabolism and accumulates
202 Murine embryonic fibroblasts (MEFs) that are deficient in PICALM display several characteristics
203 nzyme hyaluronidase-2 (HYAL2) and that HYAL2 is deficient in platelets isolated from patients with in
204 of C. reinhardtii vtc1 mutant strains, which are deficient in polyphosphate synthesis, to accumulate
205 ion, and a subset of these was identified to be deficient in post-transcriptional steps of chloroplas
207 n at restriction enzyme-generated breaks but is deficient in processing topoisomerase adducts and rad
210 s assembled in the absence of VII (Ad5-VII-) are deficient in proteolytic maturation of protein VI an
211 studies in mouse and zebrafish embryos that are deficient in RA-generating enzymes or RARs have been
212 numbers correlated with disease activity and were deficient in regulatory T cells relative to healthy
213 ion and repair of UV-induced DNA damage, but is deficient in repair of mitomycin C (MMC)-induced DNA
214 failed to cluster in membrane microdomains, was deficient in restriction of particle release, and ex
219 promoted turnover of Aurora B at the midbody was deficient in SCCRO- and KLHL21-deficient cells, sugg
220 tigated whether Lhx6 and/or Sox6 mRNA levels are deficient in schizophrenia, which may contribute to
224 encoded by the I3 alleles I3-4, -5, and -7, were deficient in self-interaction and unable to support
227 we generated Myd88/Trif/Mavs(-/-) mice that are deficient in signalling by all TLRs, RLRs and IL-1R,
230 We identify a mutant of the Ndc80 tail that is deficient in Ska recruitment to kinetochores and in o
231 w that Ca(2+) entry through CATSPER channels is deficient in Slo3 mutant sperm lacking hyperpolarizat
233 ell as the wild type on soluble alginate but was deficient in soluble secreted alginate lyase activit
234 2NLS(tm) mutant mice and wild type mice, but are deficient in splenic macrophages isolated from mutan
236 at show normal levels of basal autophagy but are deficient in stimulus (exercise- or starvation)-indu
237 protozoan parasite Trypanosoma cruzi, which is deficient in strong PAMPs, we demonstrate a requireme
239 derived from mouse spinal cord of both sexes are deficient in supporting both WT and SMN-deficient mo
243 trated that homodimeric p55 disease variants are deficient in the ability to stimulate p140; however,
245 10 myopathy patients, mutant Drosophila that are deficient in the homologue of MEGF10 (Drpr) and megf
246 However, in the CCRF-CEM-AraC-8C cells that are deficient in the human equilibrative nucleoside tran
250 nistration of rapamycin to these mice, which are deficient in the mitochondrial respiratory chain sub
253 genes in an spt16 mutant, which was found to be deficient in the assembly of normal nucleosomes on in
254 recent pathological studies show that TNFRII is deficient in the brains of Alzheimer's disease (AD).
255 to the prokaryotic pathway, and fad6, which is deficient in the chloroplast 16:1/18:1 fatty acyl des
256 omonas reinhardtii) mutant (bkdE1alpha) that is deficient in the E1alpha subunit of the branched-chai
257 Dephosphorylated Synj, on the other hand, is deficient in the endocytosis of the active recycling
259 retardation protein (FMRP), the protein that is deficient in the most common inherited form of mental
260 density protein 95 (PSD-95), a process that is deficient in the mouse model of Fragile X Syndrome, F
262 th non-NLRC4-triggering P. aeruginosa, which is deficient in the T3SS needle complex, did not alter t
264 hemical analyses showed that the tla2 strain was deficient in the Chl a-b light-harvesting complex, a
265 rn-blot analyses showed that the tla3 strain was deficient in the Chl a/b light-harvesting complex.
267 The synergism between light and heat shocks was deficient in the prr7 prr9, lhy cca1, pif4 pif5, cop
268 nt in the model system M. marinum background was deficient in the secretion of some members of the PE
269 cells rendered hyporesponsive in this manner were deficient in the ability of these cross-tolerized r
271 istent with these findings, I-A(b) mice that were deficient in the p47(phox) or gp91(phox) subunits o
272 une responses in primary cells and mice that were deficient in the RIG-I-like receptor signaling path
276 oimmune diseases, including type 1 diabetes, are deficient in their ability to control autologous pro
277 Ts and other components of HAT complexes but are deficient in their ability to restore ADA3-dependent
278 ng disulfide bonds that constrain the C-term are deficient in their ability to trigger fusion followi
279 to infants and the elderly, age cohorts that are deficient in their adaptive immune responses to such
280 is (Arabidopsis thaliana) mutant plants that are deficient in their endogenous BEs and therefore, can
281 monstrated that asthmatic airway fibroblasts are deficient in their packaging of fibrillar collagen-I
285 ading and restriction, KS-WNK1 knockout mice were deficient in these structures under identical condi
287 er, a double site1/2 mutant (OSBP-S381A/S3D) was deficient in this activity and was constitutively co
288 did not accelerate tumor growth when ERalpha was deficient in Tie2-positive cells, even in mice graft
290 The raa7 mutant (RNA maturation of psaA 7) is deficient in trans-splicing of the second intron of p
291 mmation, we examined scurfy (Sf) mice, which are deficient in Tregs and succumb to severe multiorgan
294 n an IL-12p35(-/-) dnTGFbetaRII strain which is deficient in two members of the IL-12 family, IL-12 a
300 he t-test showed that CLas-infected D. citri were deficients in zinc, iron, copper, magnesium, calciu