ライフサイエンスコーパス: be disabled

1 activity of the pol III epsilon-subunit also is disabled.

2 e's territory unless their pheromone-sensing is disabled.

3 r guanosine triphosphatase (GTPase) activity is disabled.

4 influenza virus replication when NS1 protein is disabled.

5 al lethality when RIPK3-mediated necroptosis is disabled.

6 auses cell death when the osmoregulator OmpR is disabled.

7 F2, 3 and 4, while Ca2+ binding to EF-hand 1 is disabled.

8 estore apoptosis in cancer cells in which it is disabled.

9 and p53-dependent growth inhibitory pathway is disabled.

10 in a situation where cell-mediated immunity is disabled.

11 itiate degradation of the sterol side chain, are disabled.

12 ies die from prematurity, and many survivors are disabled.

13 pathways such as members of the Bcl-2 family are disabled.

14 ess cellular programs that mediate apoptosis are disabled.

15 rhythms (cardiac arrhythmias), and many more are disabled.

16 s did not undergo necroptosis, even when MK2 was disabled.

17 nsitized cells to FdUrd, especially when UNG was disabled.

18 carrying BDBV GP in which expression of sGP was disabled.

19 ion reversed the sensitivity seen when Rad18 was disabled.

20 thway that participates in sigmaF activation was disabled.

21 n which each of the cation-binding sites has been disabled.

22 cluding the possibility that the pathway has been disabled.

23 sm of allosteric regulation of catalysis has been disabled.

24 .4 years), 63% were CMV-seropositive and 15% were disabled.

25 ng COVID-19 in England, 61 416 (58%) of whom were disabled.

26 Tachyarrhythmia functions were disabled.

27 in which four of the five ACh binding sites were disabled.

28 agnet response and tachyarrhythmia functions were disabled.

29 orrhagic stroke patients were more likely to be disabled (68% versus 46%, P=0.002).

30 When mitochondrial fission is disabled, AC-induced increase in cytosolic calcium is

31 response in SAN cells when SR Ca(2+) release is disabled and CaMKII inhibition is only effective at s

32 When ATP hydrolysis by the FliI ATPase was disabled and when the pathway was locked into an ear

33 n which the capacity to bind heparan sulfate was disabled and which contained a chimeric IL-13-glycop

34 the profound virulence of EBOV and MARV--DCs are disabled, and an effective early host response is de

35 tical role in suppressing cyclin E when Fbw7 is disabled, and in the absence of p21, sustained cyclin

36 One significant pathway that is disabled as a result is homologous recombination repa

37 by visible light, the inhibition of thrombin is disabled because the probe hybridizes with the cDNA i

38 rotein in which the COOH-terminal SH2 domain was disabled bound to the PDGF receptor.

39 of mononuclear iron-containing enzymes that are disabled by oxidative stress.

40 When RyRs are disabled by ryanodine, beta-AR stimulation fails to

41 ns of the spinal cord and that this loop can be disabled by HSP90 inhibition to enhance the efficacy

42 esponse (host resistance), although this can be disabled by parasitoid countermeasures (parasitoid vi

43 y the JAK/STAT signaling pathways, which can be disabled by small molecules.METHODSWe treated a group

44 ark of multiple myeloma progression that can be disabled by targeting CK1delta/CK1epsilon.

45 ing that these protumorigenic pathways could be disabled by targeting myeloid arginine metabolism.

46 bone metastatic prostate cancer yet this can be disabled by targeting STAT3.

47 on chromosome 3 or in which p53 function had been disabled by expression of HPV-16 E6.

48 t in which all potential phosphorylation had been disabled by Ser --> Ala substitution.

49 In sco(te382) mutants, Fbn2b is disabled by a missense mutation in a highly conserved

50 This effect is disabled by a Vpr mutation that abolishes binding to

51 10p to the histone UAS is zinc-dependent and is disabled by a zinc finger mutation (C388S).

52 Others only sporulate, but if sporulation is disabled by heterozygosity at the IME1 locus, those d

53 he fast discharging, namely metal stripping, is disabled by local Na removal that deteriorates the el

54 thracis or defend against the pathogen as it is disabled by LT.

55 RecBCD(K177Q) enzyme, in which RecD helicase is disabled by mutation of the ATPase active site, compl

56 Finally, we show that this complex is disabled by mutations in human Multicilin that cause

57 roduction of sfRNAs if one of the structures is disabled by mutations or misfolding.

58 , in which the N-terminal metal-binding site is disabled by site-specific mutagenesis, can only bind

59 We show that MRX is disabled by telomeric protein Rif2 through an N-termi

60 otides necessary for integration of the vDNA is disabled by the NC mutations.

61 Export was disabled by deletion of the ca 60 amino acid residue

62 g was about 1 kcal/mol, and that the binding was disabled by phosphorylation at Thr156.

63 NURF was disabled by silencing of bromodomain PHD-finger cont

64 patients, 42 (17%) died and another 98 (40%) were disabled by 30-day follow-up.

65 %) died within 30 days, and another 26 (32%) were disabled by hospital discharge or 30 days, whicheve

66 When ryanodine receptors were disabled by ryanodine, neither IBMX nor milrinone w

67 , when Rad18, Rad51, BRCA1, BRCA2, or FancD2 was disabled, Chk1 depletion did not further sensitize t

68 d has a limit cycle when pheromone signaling is disabled, consistent with the exponential growth phas

69 Duplicated pseudogenes in the human genome are disabled copies of functioning parent genes.

70 r, atypically, the ATR-regulated DDR pathway is disabled during infection.

71 ntrol of select cancer-associated ARED genes is disabled during lymphomagenesis.

72 is observed in the mutants in which the PRG is disabled, E194Q and E204Q, suggesting that the decrea

73 Since human p53 mutants are disabled for this activity, our findings raise the p

74 he fourth EF hand Ca2+-binding motif of GCIP is disabled for Ca2+ binding, and GCIP does not stimulat

75 Respondents who were disabled had significantly lower social functioning

76 h both mother-cell anchoring mechanisms have been disabled have a synergistic sporulation defect sugg

77 When autophagy is disabled, HSCs compensate by increasing proteasome ac

78 anocytes that lack the GTPase Rab27a (ashen) are disabled in myosin Va-dependent melanosome capture b

79 etration (pen) mutants of Arabidopsis, which are disabled in non-host penetration resistance against

80 Circadian clocks are disabled in Period1/2/3 triple mutant mice, resultin

81 ies of HPIV1 were separable: both activities are disabled in rHPIV1-P(C-), whereas only the anti-IFN

82 Disability was defined as being disabled in >=1 activity of daily living.

83 per expression and that the endogenous clock is disabled in AeCyc(-/-) mosquitoes.

84 dulation by inhibitory synaptic transmission is disabled in both auditory and multisensory pathways.

85 Processing is disabled in furin-deficient cells but fully restored

86 rovided compelling evidence that necroptosis is disabled in hepatocytes during homeostasis and in the

87 V1-P(C-), whereas only the anti-IFN activity is disabled in rHPIV1-C(F170S).

88 The tetrazine form is disabled in terms of light-induced cargo release, how

89 e interpreted to mean that a G2-M checkpoint is disabled in the rec1-1 mutant.

90 blastoma lines indicates that autoregulation is disabled in this subset of tumors.

91 shear, whereas such CD31-mediated detachment was disabled in apoptotic leukocytes, promoting tight bi

92 The p53-ARF-Mdm2 pathway was disabled in half of the lymphomas examined, in most

93 The vectors were disabled in primer binding site function, blocking

94 Background: The total time a patient is disabled likely has a greater influence on his or her

95 hat when Cdc13p, a telomere-binding protein, is disabled, loci close to the telomere become single st

96 AdV3 mutant virus in which formation of PtDd was disabled (mut-Ad3GFP, where GFP is green fluorescent

97 of inhibitory p53-chromatin complexes, which are disabled only if the growth factor is still present

98 Although Ras is disabled, only lovastatin substantially blocks Raf-1

99 The Na+ transport reactions are disabled or "immobilized" by exchanger inactivation

100 Over half (54%) reported being disabled or requiring assistance for at least one

101 an compensate for each other when one system is disabled or overworked, and that this can complicate

102 However, if homologous recombination was disabled (rad52 mutant background), inactivation of

103 for combating IUU, yet AIS transponders can be disabled, reducing its efficacy as a surveillance too

104 In the mutant H249A, the histidine ligand is disabled, resulting in a dramatic reduction in the ki

105 When IAV NS1 protein is disabled, RNase L restricts virus replication; howeve

106 ad group often left out of these discussions are disabled scientists/scientists with disabilities, wh

107 h use were detailed knowledge, perception of being disabled, skill in requesting use, and health prof

108 of WWP1 to Smad7, this functional interplay is disabled, switching its monoubiquitination activity t

109 , jasmonate, ethylene, PAD4, and salicylate, are disabled, the hypersensitive response (HR) typical o

110 When both SH2 domains in PLC-gamma1 were disabled, the double mutant did not associate with

111 covered that, when the DEAH box ATPase Prp16 was disabled, these spliceosomes catalyzed 5' splice sit

112 Thus, some tumour suppressor functions can be disabled through a two-step process targeting differe

113 This function of pRb is disabled through its phosphorylation by the cyclin-de

114 n of a master repressor, whose function must be disabled to allow the spread of these elements in nat

115 t, Sgo1 function of cohesion protection must be disabled to allow timely chromosome segregation, but

116 hat only a small number of gp41 bridges must be disabled to prevent fusion.

117 xpressing dimerization-defective Nef mutants were disabled to the same extent as HIV that fails to ex

118 % of whom required narcotic analgesia and/or were disabled, treatment with pramipexole improved score

119 reproductive development; when DAF-7 signals are disabled, unmodified DAF-3 Smad activity mediates da

120 g process required for neuronal homeostasis, is disabled upon actin dysregulation in the aged brain.

121 r conditions in which the endogenous SNAP-25 is disabled, we expressed botulinum toxin serotype E to

122 Wives of sepsis survivors who were disabled were more likely to be depressed (odds rat

123 protects animals against tumor formation but is disabled when overtly malignant cells emerge.

124 his domain and the nucleotide binding domain is disabled when the conserved P417 residue is mutated.

125 tasia and Rad-3 related (ATR) arm of the DDR is disabled, which prevents activation of its primary ta

126 Because PICs can be disabled with synaptic inhibition, we hypothesized th