ライフサイエンスコーパス: be dispensable for

1 we show that CtIP-mediated DNA end resection is dispensable for A-EJ-mediated CSR using cNHEJ-deficie

2 The pKM101 OMCC cap and extended pilus also are dispensable for activation of a Pseudomonas aerugino

3 ut cells, demonstrating that phosphorylation is dispensable for activation and actin regulation.

4 ts demonstrate that, although MCPH1 function is dispensable for activation and maintenance of the dec

5 layer in PMN functions, whereas FcgammaRIIIB is dispensable for activation and phagocytosis.

6 In vivo B cells were dispensable for activation of naive 1-DER T cells b

7 version, EP3 receptors on serotonergic cells were dispensable for acute nociceptive behaviors and for

8 tes, we show that endogenous KLF4 and Krox20 are dispensable for adipogenesis in culture and for brow

9 Consistently, DEX accelerates, but is dispensable for, adipogenesis in culture.

10 rity of the CCHC motifs in the Gag NC domain is dispensable for Alix-mediated rescue of virus budding

11 two distinct BCR transgenic mouse models but is dispensable for all of these tolerance mechanisms.

12 ed in other cancers, tumor-expressed MT1-MMP is dispensable for all stages of osteosarcoma progressio

13 B complex and contains distal T domains that are dispensable for allosteric regulation.

14 haRaptorKO), we showed that mTORC1 signaling is dispensable for alpha cell development, but essential

15 tion at a low multiplicity of infection, but is dispensable for AMPK activation at the earliest times

16 Thus, the RPT domain is dispensable for amyloid formation as such but shapes

17 We provide evidence that Bcl7b is dispensable for animal survival as well as behavioral

18 interacts with APE2 and PCNA, although PCNA is dispensable for APE1's exonuclease activity.

19 hile RA-triggered transcriptional activation is dispensable for APL eradication.

20 Importantly, we find that Ppz phosphatases are dispensable for Art1 PM translocation, but are requi

21 proper complex assembly, and Vps8/miniCORVET is dispensable for autophagy, crinophagy and lysosomal b

22 In contrast to canonical bEBPs that are dispensable for bacterial growth, Rrp2 is essential

23 Although OmpB is dispensable for bacterial growth in endothelial cells

24 Here we show that AR is dispensable for basal cell maintenance, but is cell-a

25 er, our results demonstrate that mouse TrpC3 is dispensable for beta-alanine-induced acute itch.

26 of neutrophil adhesion and spreading, it may be dispensable for beta2 integrin-dependent neutrophil r

27 ty that Aurora B localization at centromeres is dispensable for bi-orientation.

28 Thus, pili are dispensable for biofilm development in this cyanobac

29 mitochondrial ATP generation, and glycolysis is dispensable for blastocyst formation.

30 mice revealed that EphrinB2/EphB4 signalling is dispensable for blood endothelial barrier function, b

31 tion of the mineralization-related genes, it is dispensable for BMP2 to induce the protein anabolism

32 the primate-specific proline-rich domain to be dispensable for both HSP90 interaction and PDE6 activ

33 We conclude that LCN2 is dispensable for both high fat diet-induced obesity an

34 d for BMP-mediated patterning of the embryo, is dispensable for both ligand-independent signaling pat

35 wn adipocytes, we found unexpectedly that GR is dispensable for brown adipose tissue development in m

36 The SH3 domain of Boi2, which is dispensable for bud growth and targets Boi2 to the si

37 Whereas beta-catenin is dispensable for CAF-mediated ECM remodelling, cancer

38 In contrast, PmrAB is dispensable for CAMP resistance in E. cloacae.

39 ts finding that both the DEP and PDZ domains are dispensable for canonical signaling only in membrane

40 rast, the C-terminal membrane-binding region is dispensable for canonical autophagy but essential for

41 Although LRRC8A was dispensable for canonical DAMP-dependent NLRP3 activ

42 classical bone-associated osteoclasts, VAOs are dispensable for cartilage resorption and regulate an

43 onstrated that IFN regulatory factor (IRF) 8 was dispensable for caspase-11-mediated NLRP3 inflammaso

44 nels and positive inotropy in the heart, but are dispensable for CaV1.2 trafficking to the adult card

45 Although crh genes are dispensable for cell viability, simultaneous deletio

46 We found that Neat1 is dispensable for cell cycle arrest and apoptosis in re

47 pment, previous studies concluded that CCNB2 is dispensable for cell cycle progression.

48 However, Cep55 is dispensable for cell division in embryonic or adult t

49 d cells demonstrates that autonomous 5S rRNA is dispensable for cell growth under standard conditions

50 CR5, that are required for HIV infection yet are dispensable for cellular proliferation and viability

51 organization, yet it is widely considered to be dispensable for cellular function and organismal deve

52 The ARTEMIS C terminus is dispensable for cellular V(D)J recombination and in v

53 ough PLK4-mediated phosphorylation of Ser-78 is dispensable for CEP131 localization, ciliogenesis, an

54 ibly reflecting a regenerative response, but is dispensable for chondrocyte proliferation in vivo, an

55 achment stability and force transduction but are dispensable for chromosome congression.

56 These phosphorylated residues were dispensable for CHT7 function, but phosphorylated v

57 We observed that INPP4A is dispensable for clathrin-mediated endocytosis and is

58 d transcripts at the translational level but is dispensable for cleavage-mediated RNA interference an

59 Contrary to the existing paradigm, actin is dispensable for CME events at the plasma membrane but

60 ently show that floor plate-derived netrin-1 is dispensable for commissural neuron axon guidance to t

61 truncated variants indicated that this tail is dispensable for CpaA expression and secretion.

62 trate here that while the TNPO1 binding site is dispensable for CPSF6 nuclear import, the arginine/se

63 recruits BRD2 to co-bound sites whereas BRD2 is dispensable for CTCF occupancy.

64 The enzymatic activity of CitA is dispensable for CtrA control, and functional citrate

65 contrast, the recognition of apoptotic cells was dispensable for cytokine-dependent induction of patt

66 wever, ECT2 targeting to the central spindle is dispensable for cytokinesis, indicating that how PLK1

67 diated de novo methylation in germ cells but is dispensable for de novo methylation during embryogene

68 mulate protein aggregates showing that ClpXP is dispensable for degradation of unfolded proteins in S

69 3a and Sin3b in islet beta-cells, with Sin3a being dispensable for differentiation but required for p

70 ing during DNA replication but is thought to be dispensable for DNA end resection.

71 s share a conserved N-terminal sequence that is dispensable for DNA cleavage inhibition and have dive

72 ght preference for the leading strand, which is dispensable for DNA replication.

73 Here, we show that AIM2 is dispensable for DNA-mediated inflammasome activation

74 structure on the X chromosome in C. elegans is dispensable for dosage compensation but regulates lon

75 In agreement, RAD52 was dispensable for DSB-induced telomere synthesis.

76 our results show that SCF and KIT signaling are dispensable for early mast cell development.

77 Here we show that Sia is dispensable for early development of the embryo prope

78 While lack of only one Ral GTPase was dispensable for early peripheral nerve development,

79 in omenta of Nik(-/-) mice revealed that NIK is dispensable for ectopic kidney vascular integration a

80 In Drosophila, we find that Vps29 is dispensable for embryogenesis but required for retrom

81 We show that zygotic expression of gdf3 is dispensable for embryonic development, while maternal

82 We find that Bicoid transcriptional activity is dispensable for embryonic viability in the first hour

83 ndependently of TRF2, which reveals why TRF2 is dispensable for end protection during pluripotency.

84 ile the first dsRNA-binding motif of Loqs-PD is dispensable for enhancing cleavage of optimal substra

85 ring development, while airway smooth muscle is dispensable for epithelial branching, it is integral

86 ABSC-derived Wnt ligand production was dispensable for epithelial proliferation.

87 LD biogenesis, we provide evidence that LDs are dispensable for ERAD in mammalian cells.

88 Although FRS adapters are dispensable for ERK-1/2 activation, they are require

89 ounterintuitive observation that Klf2, which is dispensable for ESC maintenance, is required during r

90 ltaSET)); surprisingly, the Set1A SET domain is dispensable for ESC proliferation and self-renewal.

91 DOT1L is dispensable for ESC self-renewal but is required for

92 CD3/CD28 mAb-mediated induction of IL-10 but is dispensable for ex vivo IL-10 expression.

93 y choice and synaptic partner selection, but are dispensable for fasciculation.

94 In contrast, COX-1 was dispensable for FcepsilonRI-driven CysLT production.

95 Notably, ALOX12 is dispensable for ferroptosis induced by erastin or GPX

96 We also found that CcoQ is dispensable for forming an active CcoNOP subcomplex i

97 sting that gamma delta T (gammadeltaT) cells are dispensable for FSTL-1 Hypo control of pulmonary inf

98 Uniquely, ZO-1 is dispensable for function of the working myocardium.

99 d, because in some stress conditions, s-OPA1 is dispensable for fusion.

100 to induce beta-arrestin coupling, while M153 was dispensable for G protein coupling.

101 ated that OGT-1 glycosyltransferase activity is dispensable for GABA neuron function.

102 r, these results suggest that although IL-23 is dispensable for GC formation, it is essential to prom

103 While ROMO1 is dispensable for general protein import along the pres

104 e required for discriminative fear, but both are dispensable for generalized fear at high US intensit

105 CD8(+) T cell responses, Tcf1 long isoforms were dispensable for generating cytotoxic CD8(+) effecto

106 novirus condensing protein (polypeptide VII) is dispensable for genome encapsidation.

107 agy, here we show that, surprisingly, parkin is dispensable for glucose homeostasis in both beta cell

108 nhA; (ii) the RNase H2 enzymes RnhB and RnhD are dispensable for growth and (iii) RnhB and RnhA colla

109 d in somatic nuclei in vegetative cells, but is dispensable for growth and nuclear division.

110 or bacterial secretion systems, was shown to be dispensable for H. pylori-induced inflammasome activa

111 thermore, we found that STAT3 in hepatocytes is dispensable for HCC formation when mammalian sterile

112 The Satb1 homeodomain is dispensable for high affinity binding but is essentia

113 Together, our data suggest that syntaxin-3 is dispensable for hippocampal basal neurotransmission a

114 1 contains an N-terminal domain (p150N) that is dispensable for histone deposition but promotes the l

115 mplex and two ESCRT-associated Bro1 proteins are dispensable for HSV-1 replication.

116 knockdown study indicated that PRDM14 might be dispensable for human germ cell fate.

117 of the three disulfide bridges in IL-12alpha are dispensable for IL-12 secretion, stability, and biol

118 n and helps in vivo TasA-fibre formation but is dispensable for in vitro TasA-fibre assembly.

119 ed cortical neuron dendritic elaboration but is dispensable for inhibitory axon guidance.

120 muscle By contrast to previous reports, PAK1 is dispensable for insulin-stimulated glucose uptake in

121 interactions of USP7 with NF-kB subunits but is dispensable for interactions with other proteins.

122 a key component of organoid growth media yet is dispensable for intestinal homeostasis, suggesting ro

123 n Seneca valley virus (SVV), a picornavirus, is dispensable for IRES activity, while the IIId2 sub-do

124 s predominantly expressed in the beta-cells, is dispensable for islet morphogenesis.

125 ssion, demonstrating that spinal Grp neurons are dispensable for itch transmission.

126 that the N-terminal 10 amino acids of TbCAE are dispensable for its activity and mitochondrial local

127 Zf-GRF motifs (designated as Zf-GRF repeat) are dispensable for its DNA glycosylase and AP lyase act

128 e LTM related functions of CREB1/CRH-1 while being dispensable for its innate chemotaxis behavior.

129 The kinase activity of MUS is dispensable for its function in lateral root developm

130 nd found that proteolytic processing of PLD3 is dispensable for its hydrolytic activity.

131 ogenesis, we found that GTP binding of K-Ras was dispensable for its packaging within extracellular n

132 3-WT; disulfide bridge formation in FGF23-WT is dispensable for KLA binding and for cell signaling vi

133 s grow at a normal rate, indicating that LDH is dispensable for larval biomass production.

134 ce, we show that these Vbeta5(+) iTreg cells are dispensable for limiting anti-viral immunity.

135 FX is dispensable for liver transduction in mice lacking Ig

136 This study shows that lipogenesis is dispensable for liver tumorigenesis in mice treated w

137 By contrast, integrins are dispensable for LN homing, yet still contribute by i

138 Collectively, these data show that GLUT6 is dispensable for LPS-induced M1 polarization and funct

139 yroid specification, unexpectedly appears to be dispensable for lung specification.

140 main and histone binding ability of HP1gamma are dispensable for maintaining H3K36me3 levels.

141 Interestingly, Brd4 is dispensable for maintaining cell identity genes in di

142 SPEN is dispensable for maintenance of XCI in neural progenit

143 Overall, our results showed that FgAMA1 is dispensable for meiosis but important for ascospore f

144 In yeast strains for which IME4 is dispensable for meiosis, a natural polymorphism in th

145 We found that epithelial ROR2 is dispensable for midgut elongation.

146 e is required for vascular regeneration, but is dispensable for midvein formation in leaves.

147 evidence suggests that the leading edge may be dispensable for migration, raising the question of wh

148 in B3 are viable-indicating that the protein is dispensable for mitotic divisions-but are sterile.

149 -dependent kinetochore assembly pathway that is dispensable for mitotic growth but becomes critical u

150 lementary approaches demonstrating that MLL1 is dispensable for MLL-fusion-mediated leukemogenesis.

151 opoietic stem cells (HSCs), we found that it is dispensable for mouse and human HSC function.

152 gote and in the preimplantation stage embryo is dispensable for mouse development.

153 Here we show that Cep55 is dispensable for mouse embryonic development and adult

154 Together, this suggests that PAK4 is dispensable for mouse pancreas development.

155 We focus on PARP3 as it is dispensable for murine viability and has druggable ca

156 We conclude that HIF1alpha and HIF2alpha are dispensable for muscle stem cell function under norm

157 ese data provide genetic evidence that Fndc5 is dispensable for muscle development and basal metaboli

158 Importantly, we determined that BRD4 was dispensable for MYC expression in the most resistant

159 yeloid cells during inflammation and hypoxia are dispensable for myeloid cell tissue trafficking.

160 Eosinophils were dispensable for myocarditis induction but were requ

161 Whereas MDR1 was dispensable for naive CD8+ T cell development, it wa

162 We show that UNC-45A is dispensable for neuron survival but required for neur

163 lasts, the actin-binding domain of Nesprin-2 was dispensable for neuronal migration.

164 KLF12 was dispensable for NK cell development, IFN-gamma produ

165 wild type and demonstrates that sperm cells are dispensable for normal pollen tube development.

166 essential for breast cancer cell growth, but is dispensable for normal cell proliferation.

167 y length and mucociliary transport but which is dispensable for normal ciliary number, radial structu

168 d state at CGI-associated gene promoters and is dispensable for normal gene expression.

169 aining leukemia stem cell (LSC) function but is dispensable for normal hematopoiesis.

170 ntact pathway of the plasma clotting cascade is dispensable for normal hemostasis, but contributes to

171 Lastly, we found that CHD4 is dispensable for normal human astrocyte survival.

172 DRL-1 was dispensable for Orsay replication from an endogenous

173 shape the temporal ERK activity profile but are dispensable for oscillations.

174 ly through inflammasome activation, but PAFR is dispensable for PAF-induced inflammasome activation i

175 most of them translated, and found that nine are dispensable for pancreatic endocrine cell developmen

176 p97 was dispensable for Parkin ligase activity in iNeurons.

177 it to act as a transcriptional repressor but is dispensable for partition.

178 oothened extracellular domain, a region that is dispensable for Patched1-Smoothened coupling.

179 recent studies have revealed that this motif is dispensable for PC1 trafficking to cilia.

180 demonstrate that dKDM4A demethylase activity is dispensable for PEV.

181 In contrast, Gle1 self-association is dispensable for phosphorylation and nonstressed trans

182 In contrast, ATPase activity of TDRD9 is dispensable for piRNA biogenesis but is essential for

183 ylation sites identified and studied to date are dispensable for PKA modulation of LTCC; however, a C

184 We show that the CTD is dispensable for Pol IV catalytic activity and Pol IV

185 Taken together, our findings show that CP is dispensable for polarized actin growth and motility i

186 Thus, integrin function is dispensable for pre-follicle cell polarity but is req

187 Tumor cell-expressed Angpt2 was dispensable for primary tumor growth, yet in-depth a

188 is conserved among different viral strains, is dispensable for production of infectious HCMV virions

189 th inhibition and stimulation of elongation, is dispensable for promoter-proximal pausing.

190 quired for optimal NK cell proliferation but is dispensable for protection against ECTV and MCMV, two

191 we found that specific hydroxylated prolines were dispensable for protein stability but required for

192 We propose that BRCA2 is dispensable for RAD51-mediated fork reversal, but ass

193 While SLX4 was dispensable for RAD52-mediated ALT telomere synthesi

194 genesis experiments show that this extension is dispensable for receptor interactions.IMPORTANCE The

195 We found that eNPCs are dispensable for remyelination but protect partially

196 at the Herpesviridae conserved ICP27 protein is dispensable for replication and disease induction in

197 Previous studies suggested that UL21 is dispensable for replication in cell cultures, but a r

198 fically controls dendritic morphogenesis but is dispensable for repulsive guidance events.

199 Additionally, Mre11 endonuclease activity is dispensable for resection in G1.

200 CTCF-associated domain boundaries were dispensable for RT.

201 Despite Nkx2-5 being dispensable for SAN morphogenesis during embryogen

202 required in both fusion partners, whereas it was dispensable for SC proliferation and differentiation

203 RalGTPases were dispensable for SC function in the naive uninjured

204 on through interactions with tumor cells but are dispensable for SCC metastasis.

205 table silencing of the foreign gene gfp, but are dispensable for silencing of the endogenous gene oma

206 Unexpectedly, morc-1 is dispensable for siRNA inheritance but is required for

207 USP13 was dispensable for sister chromatid cohesion in HCT116

208 CR5, and recent studies have shown that CCR5 is dispensable for SIV infection of SM in vivo and that

209 ys, we demonstrate that the Hec1 tail domain is dispensable for Ska complex recruitment to kinetochor

210 Of note, AMPKalpha1 in B cells was dispensable for stability of the bone marrow-residen

211 We determined that ldtD is dispensable for stalk elongation; rather, stalk LD-tr

212 ical role in T cells, the murine Trx1 system is dispensable for steady-state myeloid-cell hematopoies

213 Here, we report that microRNAs (miRNAs) are dispensable for stem-cell self-renewal and neuron pr

214 GC receptor (GR) expression in immune cells was dispensable for successful therapy of allergic airwa

215 Furthermore, the TCA cycle is dispensable for survival during osteomyelitis, and S.

216 ensal C. glabrata, Pho4 is required but Pho2 is dispensable for survival in phosphate starvation and

217 findings show that mitochondrial respiration is dispensable for survival of growth plate chondrocytes

218 ial physiology and redox poise, an axis that is dispensable for survival under normoxic conditions bu

219 orthologs and their effectors, the exocyst, are dispensable for synaptic vesicle exocytosis.

220 Surprisingly, MIIC targeting is dispensable for T cell-dependent immunity.

221 LRRC8A-dependent VRAC activity is dispensable for T-cell development and function.

222 r motif in Bcl11b protein, which by contrast is dispensable for T-lineage commitment.

223 exquisitely dependent on xCT expression, xCT was dispensable for T cell proliferation in vivo and for

224 d expansion of differentiated Treg cells but was dispensable for T(H)1/T(H)17 effectors.

225 Thus, Tfh induced in classic GC reactions are dispensable for T1D, but the autoimmune process in t

226 Although PKC- is dispensable for TCR-independent Treg proliferation pe

227 rary, we demonstrate that HAT/DESC proteases are dispensable for term development, postnatal health,

228 Vps41, a target of the vacuolar kinase Yck3, is dispensable for tethering and fusion but can affect t

229 but not systemically delivered allergens but is dispensable for TFH function and IgE production.

230 nd the interaction with Eph family receptors are dispensable for the colonization of the B cell compa

231 tical cell differentiation and apoptosis but are dispensable for the formation of the definitive cort

232 suggesting that these cells or their subsets are dispensable for the induction of AAD in IL-15-defici

233 Forty amino-terminal C protein residues are dispensable for the interaction with P, and the carb

234 moters of skin carcinogenesis, although they are dispensable for the maintenance of the malignant phe

235 nglionic eminence (MGE)-derived neurons, but are dispensable for the survival of early telencephalic

236 Conversely, cysLTs are dispensable for the tuft cell response induced by in

237 horing the complexes at the PM, was found to be dispensable for the association of Gag with the gRNA

238 in preformed chromatin compartments and may be dispensable for the formation of higher order chromat

239 Therefore, CaMKIIdelta signaling seems to be dispensable for the progression of VO-induced maladap

240 is early involvement for TNF, IL-1 signaling is dispensable for the development of acute myocarditis.

241 n lysine in Ufbp1 that undergoes ufmylation, is dispensable for the development of plasmablasts, but

242 However, Satb1 is dispensable for the differentiation and non-pathogeni

243 although important for radiation resistance, is dispensable for the end-ligation and hairpin-opening

244 experimental murine lupus, but its activity is dispensable for the expansion of antigen-specific Tfh

245 We show that vezatin is dispensable for the formation of synapses but plays a

246 t the highly expressed imprinted lncRNA Meg3 is dispensable for the function of HSCs during homeostas

247 ghly metastatic melanoma, we found that CDK5 is dispensable for the growth of primary tumors.

248 ing consensus that Th17/IL-17 axis signaling is dispensable for the immunopathogenesis of VVC.

249 , suggesting that endogenous CD83 expression is dispensable for the inhibitory capacity of Tregs.

250 based studies revealed that the synergy site is dispensable for the initial contact of alpha5beta1 wi

251 beta1 syntrophin is dispensable for the morphology and function of insuli

252 Here we find that TRF2 is dispensable for the proliferation and survival of mou

253 its role in development, Hedgehog signaling is dispensable for the proliferative expansion of callus

254 Surprisingly, ERRalpha is dispensable for the regulation of its classic targets

255 so relies on (p)ppGpp, the alarmone molecule is dispensable for the repair of topoisomerase type II (

256 Unexpectedly, KLK7 was dispensable for the development of AD-associated ski

257 a-klotho expression in glutamatergic neurons was dispensable for the effects of dietary protein restr

258 Although the inflammasome was dispensable for the emergence of HSPC, it was intrin

259 TCF-1 was dispensable for the generation of specified EILPs, b

260 Further, IRF-7 expression was dispensable for the induction of a virus-specific CD

261 nistic studies revealed that CD18 expression was dispensable for the initial attachment of the bacter

262 ase activity was required for the former but was dispensable for the latter, indicating that TRAF6-me

263 her studies, Batf3 expression by CD8 T cells was dispensable for the primary response.

264 r DAG-regulated PKCs (PKCalpha and PKCdelta) were dispensable for the acquisition of a mesenchymal ph

265 B and T cells were dispensable for the onset of swelling but required

266 or Hog1-mediated protection against arsenic, were dispensable for the response to osmotic stress, and

267 We also demonstrate that DNA excision is dispensable for their biogenesis in this ciliate.

268 on of beta cell-autoreactive CD8 T cells but was dispensable for their activation in pancreatic lymph

269 ons was error-free, and Pol nu and Pol theta were dispensable for their replicative bypass.

270 ling directly to adipose tissues during cold is dispensable for thermoregulation, central FGF21 signa

271 Intriguingly, EDEM mannosidase activity was dispensable for these protective effects.

272 secretion, and TLR9 activation, but Cagbeta was dispensable for these responses.

273 of coagulation, tissue factor, was found to be dispensable for this antimicrobial activity.

274 bly, the classical esterase activity of AChE is dispensable for this activity.

275 c stability by NORAD whereas binding of RBMX is dispensable for this function.

276 however, FASN's synthetic product palmitate is dispensable for this process since cells satisfy thei

277 diac morphogenesis and direct reprogramming, was dispensable for this process.

278 man basophils, but IL-33 and other cytokines were dispensable for this effect.

279 iously been linked to PrLD phase separation, were dispensable for this recruitment.

280 ugh we find that Arp2/3-dependent pseudopods are dispensable for three-dimensional locomotion, their

281 Here, we report that, despite being dispensable for thymocyte clonal deletion, RasGRP1

282 ly similar process of protein farnesylation, is dispensable for thymocyte egress but contributes to p

283 However, ERG is dispensable for TM expression in high SS conditions.

284 er, these results suggest that primary cilia are dispensable for TonEBP-dependent osmoadaptive respon

285 Additionally, we show that TRAPPC14 is dispensable for TRAPPII complex integrity but mediate

286 However, intrinsic MAVS signaling was dispensable for Treg proliferation and suppressive c

287 xicity in vivo, our results indicate that it is dispensable for tRNase activity in vitro.

288 ibuted to tumor growth and progression while being dispensable for tumor initiation.

289 r driver genes, suggesting that many fusions are dispensable for tumour fitness.

290 tions in the gK locus, but UL21 was shown to be dispensable for UL20(Syn) and UL24(Syn) To test wheth

291 Interestingly, we found that both proteins are dispensable for UQ biosynthesis under anaerobiosis,

292 a suggest that core interaction with betaarr is dispensable for V2R endocytosis and ERK activation an

293 ntial for NMD in simpler organisms appear to be dispensable for vertebrate NMD.

294 Our results reveal that MCU is dispensable for vertebrate photoreceptor function, co

295 idase-like N11 protein is unknown because it is dispensable for viral infection or the release of H18

296 ed into virions with high efficiency despite being dispensable for virion assembly.

297 l for GAS virulence in WT mice, whereas they are dispensable for virulence in S100a9 (-/-) mice, indi

298 mammalian and tick cells, showing this site was dispensable for virus multiplication.

299 AK2 in glycolytic mouse muscle, whereas PAK1 is dispensable for whole-body glucose homeostasis and in

300 PRADC1 is dispensable for whole-body metabolism when mice are f