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2 vealed that tertiary contacts within the PDZ are disrupted by a partial unfolding transition that ena
4 interacts with BBS-5 and the interaction can be disrupted by a conserved mutation identified in human
6 r contextual threat-conditioned memories can be disrupted by a reminder-extinction procedure that put
10 rom the first ATG and the open reading frame is disrupted by a 1-bp insertion, expresses very small a
13 Nine Mile reference isolate, where the gene is disrupted by a frameshift mutation, resulting in a ps
14 required for optimal iron homeostasis, which is disrupted by a mechanism not yet determined in the ye
16 aptic termini, and this function of dynactin is disrupted by a mutation that causes motor neuron dise
17 inding is cooperative, but the cooperativity is disrupted by a phospho-mimic mutation S249D in the 4.
18 cal neuron subtype fate specification, which is disrupted by a psychiatric-disorder-associated geneti
20 ative geotaxis in flies, scored as climbing, is disrupted by a static EMF, and this is mediated by cr
21 ranslation, and eIF3-mediated FTL repression is disrupted by a subset of SNPs in FTL that cause hyper
22 the major flowering-time repressor gene FLC is disrupted by a TE insertion specifically in the rapid
25 alcium-binding aspartate residue, Asp307Ala, was disrupted by a c.920A>C change in one family that pr
27 d both nucleotide binding domains (NBDs) and was disrupted by a cystic fibrosis mutation in NBD1 (G55
28 virus (ADinUL79(stop)) in which the UL79 ORF was disrupted by a stop codon mutation and found that AD
30 associations with foot shock or food reward were disrupted by a highly-specific actin cycling inhibi
33 on via a lysine-phosphate salt bridge, which was disrupted by acetyl-Lys resulting in backbone flexib
38 the functions of these circadian oscillators are disrupted by age, environment, or genetic mutation,
41 point to a gephyrin-dependent mechanism that is disrupted by an autism-associated mutation at R705 an
44 mouse model in which IL-1R1 gene expression is disrupted by an intronic insertion of a loxP flanked
45 inant virus SMin92, in which pM92 expression was disrupted by an insertional/frameshift mutation.
49 ssion of B1R and CPM-E264Q in the same cell, was disrupted by antibody that dissociates CPM from B1R,
50 nstrate how MAG-ganglioside interactions can be disrupted by antiganglioside antibodies that override
54 ider how this mutator-nonmutator balance can be disrupted by beneficial mutations and analyze the cir
55 he physical interaction between TAP2 and TPN is disrupted by benzene, a compound known to interfere w
57 e cGMP-induced enhancement of LTP and memory was disrupted by blockade of Abeta, suggesting that the
58 Galphaq/11 interactions in endothelial cells are disrupted by both competitive inhibition and HS degr
59 of the AP-2 complex (AP2M) was confirmed to be disrupted by both acute and repeated fluoxetine treat
60 ive, suggesting neural connections to the PV were disrupted by both PV isolation and GP ablation.
61 repair pathway, translesion synthesis (TLS), is disrupted by BPLF1, which deubiquitinates the DNA pro
62 y of the Golgi and trans-Golgi network (TGN) is disrupted by brefeldin A (BFA), which inhibits the Go
63 interaction between TRIP8b and the HCN1 CNBD was disrupted by cAMP and that TRIP8b binding to the CNB
65 and active regulatory mechanisms, which may be disrupted by cardiopulmonary disease, but this is not
66 stribution of pulmonary perfusion, which may be disrupted by cardiopulmonary disease, but this is not
69 vels and targets of methylation are known to be disrupted by chemicals and are therefore of great int
70 After DNA damage, the MDMX-CK1alpha complex is disrupted by Chk2-mediated phosphorylation of MDMX at
71 d a functional bile canaliculi system, which was disrupted by cholestasis-inducing drugs such as trog
73 g-related shift in novel environments should be disrupted by cholinergic antagonism; and (3) in famil
74 t role in nicotine reward and their function is disrupted by chronic nicotine exposure, suggesting ni
75 ta signaling and inflammatory response genes were disrupted by CIE treatment in microglia gene networ
76 regulated and evolves; and how splicing can be disrupted by cis- and trans-acting mutations leading
79 re of motor representations is that they can be disrupted by constraints on an observed agent's actio
80 inding protein as protein.heme complexes can be disrupted by contact with an apoprotein (e.g. apomyog
81 e consolidated memory for the experience can be disrupted; by contrast, protein synthesis inhibition
82 RNA isoform transitions and are predicted to be disrupted by CUG(exp)-associated mechanisms in utero.
89 r of the two Cdc42 apical recycling pathways was disrupted by deletion of Rdi1, a guanine nucleotide
92 he molecular properties of alpha-crystallins are disrupted by diabetes and contribute to the loss of
94 her these data suggest that nuclear position is disrupted by distinct mechanisms in EDMD and CNM.
95 are present in each NS1 monomer, and tubules are disrupted by divalent cation chelation and restored
98 tion delocalization and Coulomb gap collapse are disrupted by doping-induced disorder, suppressing th
103 ells on adjacent epithelial cancer cells can be disrupted by either inhibiting VEGF-C in EMT cells or
104 en this differential proliferation mechanism is disrupted by either ectopic overexpression or mutatio
108 target promoters and VirR : promoter binding was disrupted by exogenous addition of the signalling mo
109 get tissue after the blood brain barrier has been disrupted by exposure to a hyperosmolar mannitol so
113 h the skin occurs when skin barrier function is disrupted by, for example, genetic predisposition, me
117 Here, we discuss how transcriptional control is disrupted by genetic alterations in cancer cells, why
119 e line (Gad1(-/-)) in which GAD67 expression is disrupted by genomic insertion of the green fluoresce
121 n the blood-rich marginal zone and follicles is disrupted by GRK2 deficiency and by mutation of an S1
125 in with H3K4 unmethylated histone tails that is disrupted by histone H3K4 methylation and histone ace
126 nscription factor coexpression profiles that is disrupted by HIV infection and suggest a role for HIV
127 C2) complex components, and this interaction was disrupted by HIV Tat, suggesting that LINC00313 may
129 ration governed terminal differentiation and were disrupted by human skin barrier disease-associated
130 a highly complex collection of proteins that is disrupted by hundreds of gene mutations causing over
132 trandings suggests that their navigation may be disrupted by increased radio frequency noise generate
133 mer dilution, where WT receptor dimerization is disrupted by increasing expression of nonfunctional C
135 stin assembly during the saccular stage that is disrupted by inflammatory signaling and could be amen
137 The emergence of these correlated networks was disrupted by inhibiting vCA1 shock responses during
138 ed reinstatement and synaptic depotentiation were disrupted by inhibiting AMPAR internalization via i
139 n 10 nm of one another and that the clusters are disrupted by inhibition of Src and Syk family kinase
140 thogenesis, and suggest that T4P systems may be disrupted by inhibitors that do not preclude componen
141 s, which revealed that vimentin localization is disrupted by inhibitors of signaling that belong to a
143 monstrate that cellular actions of metformin are disrupted by interference with its metal-binding pro
145 some phospholipid bilayer, the bilayer would be disrupted by laser irradiation so that drug release w
148 othalamic E2 were observed, thermoregulation was disrupted by letrozole in females only, indicating s
151 ioning required extracellular prosaposin and was disrupted by lipid raft perturbation using methyl-be
152 In some individuals, mineral homeostasis can be disrupted by long-term therapy with certain antiepile
156 We also find that these activity patterns are disrupted by manipulating cadherin or gap junction e
157 eration and subsequent fetal stages can also be disrupted by maternal immune activation in the 1st tr
158 elopment of event-related neuronal responses was disrupted by MeCP2 mutation, suggesting that impaire
159 prediction error and incentive value signals were disrupted by methamphetamine in the left nucleus ac
160 ed increased co-localisation with LDs, which was disrupted by microtubule depolymerising agent nocoda
161 growth is a highly ordered process that can be disrupted by misalignment of individual amino acids a
164 lar, mostly electrostatic, interactions that were disrupted by mutating a positively charged (Lys-ric
168 st if the structure of Lys(48)-linked chains is disrupted by mutation of ubiquitin or if chains are l
169 Moreover, if this normal folding nucleus is disrupted by mutation, the interdomain interface is s
170 588) of ATDC and the RING domain of RNF8 and was disrupted by mutation of ATDC Ser-550 to alanine.
171 cells that nucleolar localization of RPL23aA was disrupted by mutation of various combinations of fiv
175 a compact platform-like architecture, which is disrupted by mutations implicated in developmental di
176 norhabditis elegans muscle, but this pattern is disrupted by mutations in the mitochondrial fission c
177 level of Ribosomal Protein L27a (RPL27a) and is disrupted by mutations in the two paralogs RPL27aC an
178 membrane homeostasis, and that this function is disrupted by mutations that cause CMT4J and YVS.
179 ion in the human thymic epithelial cell line was disrupted by mutations in the homogenously staining
180 In contrast, axonal targeting of the VMAT2 was disrupted by neither dominant-negative SEC24C nor do
182 ing respiration, posture and locomotion that are disrupted by neurodegenerative diseases such as amyo
186 the normal asymmetric localization of Vangl2 was disrupted by overexpressing Vangl2 in clusters of ce
187 r Tks5 but decreased when XB130/Tks5 binding was disrupted by overexpression of XB130 N-terminal dele
188 d that this wild-type/pathogenic heterodimer is disrupted by oxidative stress, leading to DJ-1/E163K
191 anguage disorders, and that this interaction is disrupted by pathogenic mutations affecting either pr
195 plete picture of how hERG surface expression is disrupted by pentamidine at the cellular and molecula
196 ntrinsically active interface that could not be disrupted by peptides derived from the Nox4 C-terminu
197 yme required for normal lung development can be disrupted by perinatal inflammation in preterm infant
198 more, this match is activity-dependent as it is disrupted by perturbing pyramidal cell activity.
200 clones and activated ex vivo CD8(+) T cells was disrupted by pharmacological inhibition, knockdown o
201 -1A-5RK/A mutant complex with SUR1 could not be disrupted by PIP2, consequently reducing PIP2 activat
203 (LO) circuits: extracting targets from noise is disrupted by PPC stimulation, in contrast to judging
204 that the efficiency of A(H3N2)v transmission is disrupted by preexisting immunity induced by seasonal
205 he radial symmetry of spherulitic growth can be disrupted by preferentially selecting the molecular o
208 nnection was very strong at river sites, but was disrupted by processes occurring in rivermouths (the
210 stablishment of a tolerant B cell repertoire is disrupted by PTPN22-R620W action during immature B ce
216 nt DNA methylation-driven gene silencing can be disrupted by selectively targeting this coiled-coil c
217 that oligomeric forms of defensin, which may be disrupted by serum, contribute to the anti-HIV-1 acti
219 ow that the interaction and SETX sumoylation are disrupted by SETX mutations associated with AOA2 but
229 lts suggest that mGluR1a signaling in cancer is disrupted by somatic mutations with multiple downstre
233 ly after training is so unstable that it can be disrupted by subsequent new learning until after pass
236 g gene, SHANK2, located on Chromosome 11q13, was disrupted by SVs in 14% of MYCN nonamplified high-ri
237 ins conserved despite the fact that it would be disrupted by synonymous mutations, which raises the p
239 ly related members of the DUF579 family have been disrupted by T-DNA insertions contain less xylose i
240 6/Eto2 is a transcriptional corepressor that is disrupted by t(16;21) in acute myeloid leukemia.
241 transmission of B. burgdorferi to humans can be disrupted by targeting 2 key elements in its enzootic
243 e altered when early and recycling endosomes are disrupted by the expression of dominant-negative mut
244 tinoblastoma (pRb) tumor suppressor pathways are disrupted by the human papilloma virus (HPV) E6 and
246 re, we demonstrate that this interaction can be disrupted by the addition of an NCL binding aptamer (
247 delocalization in redox-active polymers may be disrupted by the heterogeneity of the environment tha
248 ydrolysis of plasma triglycerides by LPL can be disrupted by the protein angiopoietin-like 4 (ANGPTL4
251 9 Kb downstream of TAL1 and this interaction is disrupted by the -31CBS inversion in T-ALL cells.
254 We previously reported that this association is disrupted by the binding of the second messenger Ap4A
256 ion is conferred by the LRRK2 Roc domain and is disrupted by the familial R1441G mutation and artific
257 c, requires the ZnF-UBP domain of USP22, and is disrupted by the inactivating H363Y mutation within S
259 ysosomal positioning, and that this function is disrupted by the most common PD-causing LRRK2 mutatio
261 inely tuned allosteric PKA signaling network is disrupted by the oncogenic J-C subunit, ultimately le
263 whereas at dusk EMF1 binding to FT chromatin is disrupted by the photoperiod pathway, leading to prop
265 reversed by reassociation with PKAc, and it is disrupted by the presence of AKAP peptides, mutations
266 is the first to show that sodium regulation is disrupted by the presence of citrate-capped Ag NPs, a
267 This finding suggests that BBSome assembly is disrupted by the R632P substitution, providing molecu
268 ory intramolecular interaction within DIAPH1 is disrupted by the sequential binding of RhoA and IQGAP
269 lved xenon in an aqueous liquid crystal that is disrupted by the shear forces of bubbling, and we obs
274 ffected by the infusion of cycloheximide but was disrupted by the DNA methyltransferase inhibitor, 5-
277 ed on the extent to which normal social life was disrupted by the illness and depended on the age and
278 ly identified site between adjacent subunits was disrupted by the M3 G329I substitution, both propofo
281 y fatty acid synthesis and lipolysis), which were disrupted by the FFD, were found to be modulated by
282 tein reveals that a common molecular process is disrupted by these mutations, implying an active role
285 to motoneurons (MNs) and Renshaw cells (RCs) is disrupted by thoracic spinal cord transection at post
287 with VDACs when the function of mitochondria is disrupted by treating cells with the proton uncoupler
289 A mutant protein in which the NLS motif was disrupted by triple mutation (RRR to AAA) was able t
291 r flowered, possibly because Tre6P signaling was disrupted by two unidentified disaccharide-monophosp
292 requires U1:pre-mRNA base-pairing, which can be disrupted by U1 antisense oligonucleotide (U1 AMO), t
293 ion experiments, PAR4 formed homodimers that were disrupted by unlabeled PAR4 in a concentration-depe
297 r genes, including cytokine regulators, that are disrupted by virus integration, and we determined me
299 ween the substrate- and product-side ligands are disrupted by water in nonprocessive cellulase clefts