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2 rotein levels of Notch receptors and ligands are downregulated in a time- and learning-specific manne
3 D21A transcript, protein and activity levels were downregulated in a largely ERFVII-dependent manner.
5 tabolic pathways, and OXPHOS proteins in SAT are downregulated in acquired obesity, and are associate
6 ter, was identified, my lab observed that it was downregulated in adipocytes but not in skeletal musc
9 asthmatic patients (P < .05), whereas PGES2 was downregulated in AEC-HLF cocultures (2.2-fold, P < .
10 et ITPR1 (confirmed by luciferase assay) and was downregulated in AF atrial cardiomyocytes; microRNA-
11 egulator of G protein-coupled receptors that is downregulated in aggressive human prostate tumors.
13 nuclear mitotic apparatus protein 1 (NuMA1) is downregulated in AIS-deficient neonatal mouse brains
15 these families revealed that Zo-1 and Cldn18 were downregulated in all phenotypes, while increased Cl
18 ferator-activated receptor gamma (PPARgamma) is downregulated in APCs isolated from the lungs of emph
20 viously unknown, primate-specific miRNA that is downregulated in ASD and that regulates the epidermal
22 ant and malignant skin neoplasia, E-cadherin is downregulated in association with reduced XPC and DDB
23 Several genes that oppose T cell activation were downregulated in asthma, suggesting enhanced activa
24 d that the expression of miR-145/143 cluster was downregulated in astrocytic tumors compared to norma
25 ses in expression of the miRNA miR30a, which is downregulated in ATC compared with differentiated thy
29 pha7 nAChR-dependent calcium signal cascades are downregulated in both 15q13.3 deletion and duplicati
30 al structures, including multiple mRNAs that are downregulated in both inhibitory GABAergic and excit
36 s, we identified lncRNA 1810058I24Rik, which was downregulated in both human and murine myeloid cells
38 hat the highly conserved brain miRNA miR-219 is downregulated in brain tissue taken at autopsy from p
39 ential cellular functions, Pfn1's expression is downregulated in breast cancer, the significance of w
45 , a protein expressed in cardiomyocytes that was downregulated in cardiac hypertrophy and human heart
46 at PPM1F messenger RNA levels in human blood were downregulated in cases with symptoms of comorbid PT
47 ways and functions of the measured cytokines were downregulated in cases, except cell death pathways,
49 e expression of 10 DNA damage response genes was downregulated in cells treated with etoposide and si
50 that approximately two-thirds of transcripts were downregulated in cells expressing any of these vira
52 erently expressed, 2 were upregulated and 14 were downregulated in children with active CMA compared
57 er regulator class II transactivator (CIITA) are downregulated in CML compared with non-CML stem/prog
62 n the colon and are consistently reported as being downregulated in colorectal and other cancers.
63 evels of lipoprotein ApoA1 expression, which is downregulated in Crohn's disease patients and causall
65 eport that protein kinase C (PKC)lambda/iota is downregulated in de novo and during therapy-induced N
66 anistic target of rapamycin (mTOR) signaling is downregulated in dGBA knock-out flies, with a concomi
67 hanistic target of rapamycin (mTOR) activity is downregulated in dGBA-deficient flies and rapamycin a
71 ls multiple tumour suppressive functions and is downregulated in diverse types of human cancers throu
73 example, ERO1LB, DOCK10, IGSF11, and PRR14L were downregulated in donors with hyperglycemia and corr
76 d in Klf5 knockout (KO) embryos at E3.0, and was downregulated in embryos overexpressing Klf5 Further
77 K effector phospho-myosin light chain (pMLC) were downregulated in endothelial cells by severe hypoxi
80 pidermal expression of complement components was downregulated in ex vivo injured skin lacking the st
83 l death, inflammation, and tuft cell markers were downregulated in fat-1 mice in response to EtOH, wh
84 colleagues demonstrate that AIRE expression is downregulated in females as the result of estrogen-me
85 d ECM proteins are targets for miR-29, which was downregulated in fibroblasts grown on IPF-derived EC
88 sis demonstrates that several of these genes are downregulated in GBM, potentially through epigenetic
90 lity for small molecular tracers, and Cyp1b1 was downregulated in glioma vessels in which BBB functio
92 r (G-CSF) receptor-triggered granulopoiesis, is downregulated in granulocytic progenitors of severe c
94 ere, we demonstrated that expression of FBP1 was downregulated in HCC patient specimens and decreased
98 expression of several of the same genes that were downregulated in HCT116 cells, including the MYC on
100 ived neurotrophic factor (BDNF), a gene that is downregulated in HD, in the presence of mutant Htt.
101 Ten genes important in cardiac metabolism were downregulated in heart failure, with SLC27A4 and KC
104 nteracting proteins, GSK3alpha and GSK3beta, were downregulated in Het mice, whereas the levels of PD
105 roduct, damaged DNA-binding protein (DDB)-2, is downregulated in high-grade colon cancers, and it pla
107 s robustly regulated by BDNF/TrkB signaling, is downregulated in hippocampus (male/female) and upregu
108 how that expression of the MHC class I genes is downregulated in HPV-positive keratinocytes in an E7-
109 oded in the same miR cluster (miR-23b/-27b), are downregulated in human metastatic prostate cancer co
110 m (CNS)-specific PGC-1alpha (CNS-PGC-1alpha) are downregulated in human PD brain, in A30P alpha-syn t
111 domain-containing 1 (PDZK1) was revealed to be downregulated in human clear cell renal cell carcinom
114 iovascular profile comparable to apelin, and is downregulated in human disease and rodent PAH models,
121 eceptor 1-related protein y/CD46) expression was downregulated in human and murine OB; and C3a, a mar
126 the transcriptional level and, like JunB, it was downregulated in human squamous cell carcinoma cells
128 We demonstrated that the level of PRDX3 was downregulated in ICP placentas as well as bile acids
129 nes, chemokines, and anti-microbial peptides were downregulated in Ikkepsilon-deficient tissues, subs
133 in contrast to RGCs, neither c-myc nor mTOR was downregulated in injured peripheral sensory neurons.
134 xpression levels of the chIL-17RA transcript were downregulated in intestinal tissues from chickens i
136 accumulating evidence indicates that Geminin is downregulated in late S-phase due to an unknown mecha
138 beta-ketoacyl CoA synthase gene (PotriKCS1) was downregulated in leaves from non-alkene-producing ac
140 acearum": the apoptosis-inducing factor AIF3 was downregulated in LsoA-infected psyllids, while the i
141 ruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have bee
143 concomitant with NAMPT upregulation, miR410 is downregulated in lungs of mice exposed to hypoxia-ind
146 cision induced Emr1 and Irf8 gene expression was downregulated in males, but not in females, followin
147 gland-specific genes and mitochondrial genes were downregulated in males with resistant Y chromosomes
149 apoptosis activators and tumor suppressors, being downregulated in many human cancers, although thei
150 r of cancer cell invasion and its expression is downregulated in many advanced, poorly differentiated
152 d that basic fibroblast growth factor (bFGF) was downregulated in MDA-MB-231-injected tibiae from the
153 ated receptor gamma (PPARG/Pparg) expression was downregulated in mDCs of smokers with emphysema and
154 order (MDD) have noted that the cAMP cascade is downregulated in MDD and upregulated by antidepressan
156 wer in AS(-/-) mice than in AS(+/+) mice and was downregulated in mice of both genotypes in response
157 ied a putative STAT3 target gene, NR4A3 that was downregulated in MKN28 GC daughter cells overexpress
159 stem cells of 11 adults with ASD that MOCOS is downregulated in most of them when compared with 11 a
160 at ten-eleven translocation protein 1 (TET1) was downregulated in mouse nucleus accumbens (NAc), a ke
161 9 (miR-29) negatively regulates fibrosis and is downregulated in multiple fibrotic organs and tissues
162 hypertrophy-promoting protein that we showed is downregulated in multiple mouse models of cancer cach
164 omponents of the myostatin signaling pathway is downregulated in muscle wasting or atrophying disease
166 ion at baseline in fresolimumab nonimprovers were downregulated in mycophenolate mofetil improvers, s
168 proteins involved in fatty acid utilization were downregulated in myocardial samples from the failin
172 reast cancer metastasis suppressor 1 (BRMS1) is downregulated in non-small cell lung cancer (NSCLC),
175 cGK (cGMP-dependent protein kinase) activity was downregulated in Npr2(+/-) valves, and CNP triggered
177 We recently showed that DNAJB3 co-chaperone is downregulated in obese and diabetic patients and that
178 ation and restricted cell motility (SHROOM2) was downregulated in OE21 but upregulated in OE33 cells.
179 ant in eye development and phototransduction were downregulated in oil-exposed larvae, with an increa
189 urthermore, both FLG and HRNR protein levels are downregulated in patients with atopic dermatitis.
191 e found that the expression level of miR-19b is downregulated in patients with idiopathic rapid eye m
193 d by the histone demethylase JARID1B, MANTIS was downregulated in patients with idiopathic pulmonary
194 show that the AGEs clearance receptor AGER1 was downregulated in patients with NASH and diabetes and
200 cer of actin-depolymerizing factor activity, is downregulated in platelet messenger RNA (mRNA) from s
202 regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarc
205 on levels of the majority of imprinted genes are downregulated in primary tumors compared to normal c
206 which belongs to the largest RTK Eph family, was downregulated in primary B cells post-EBV infection
208 rget of rapamycin complex 1 (mTORC1) pathway was downregulated in proximal tubular cell lines derived
210 f the same genes were independently found to be downregulated in Q175 KI mice compared to WT (5.2e-7
211 d that miR-205 promotes radiosensitivity and is downregulated in radioresistant subpopulations of bre
212 19a-3p, broadly conserved among vertebrates, was downregulated in RAW264.7 macrophage cells of the M2
214 NC1 is specifically expressed in kidney, and is downregulated in renal cell carcinoma; also, its low
216 Aurora kinase was upregulated and pCDK1 was downregulated in resistant tumors from both xenograf
217 medulloblastoma-specific GLI1 binding sites are downregulated in response to JQ1 treatment, supporti
218 Finally, ALDH12 expression in maize and moss is downregulated in response to salt and drought stresse
219 ways, MAPK pathway, as well as redox enzymes were downregulated in response to disruption of glutamin
223 ich inhibit serotonin synthesis and release, are downregulated in SAD, and serotonin transporter avai
225 cl (Fanconi anemia, complementation group L) is downregulated in SALL4B Tg leukemic and pre-leukemic
227 own as a brake on immune cell activation and is downregulated in several gammaherpesvirus-driven mali
228 s and bioinformatics analysis show that Ate1 is downregulated in several types of human cancer sample
230 involved in cellular redox homeostasis which is downregulated in skeletal muscle differentiation.
232 we show that expression of Baf60c and Deptor was downregulated in skeletal muscle in obesity, accompa
233 c basis for previous observations that SRPK1 is downregulated in some cancer contexts and upregulated
236 -beta and guanylate-binding proteins (GBPs), are downregulated in STING knockout (KO) macrophages inf
237 A, a key enzyme in cAMP and cGMP catabolism, is downregulated in striatal projections to entopeduncul
238 , we found immune and inflammatory processes were downregulated in subgroup 2, a configuration previo
242 volved in the development of hemopathies and is downregulated in T-lymphomas, such as anaplastic larg
245 roduction and subsequent T cell recruitment, is downregulated in TAMs through Mer tyrosine kinase-dep
249 orthologue (14-3-3 protein zeta/YWHAZ) that was downregulated in temporary ponds in both species.
253 itories in the mouse, as E-cadherin needs to be downregulated in the primitive streak and in the epib
254 in-mitochondria), was uniquely identified as being downregulated in the DeltaHog1 background during g
260 s a major regulator of cardiac functions and is downregulated in the majority of heart failure cases.
261 ll group of subjects we also show that GPR56 is downregulated in the PFC of individuals with depressi
262 transmembrane ligand for the NOTCH receptor, is downregulated in the PTEN-null fibroblasts leading to
264 stochemistry and Western blotting, PPARalpha was downregulated in the corneas of humans with diabetes
266 tures compared with the Fgmcm1 mutant, which was downregulated in the expression of genes involved in
267 After seroconversion, perforin expression was downregulated in the lamina propria, but not in the
268 ed that the expression of Bmp4 and DeltaNp63 was downregulated in the mutant corneas, which was assoc
269 Sonic hedgehog (Shh) signal transduction was downregulated in the mutant forebrain, consistent wi
270 sion of genes for several thylakoid proteins was downregulated in the mutants, but the relative level
273 xpression of several cambial regulator genes was downregulated in the stems of the transgenic trees i
275 hich 46 genes were upregulated and 200 genes were downregulated in the fibrotic cell lines compared t
278 a-hydroxylase), and vitamin D receptor (VDR) were downregulated in the livers of mice fed an HFD (GSH
279 inal mucus showed that 60% of the genes that were downregulated in the luxO mutant were involved in a
280 ceptor (PPAR)-gamma coactivator (PGC)-1beta, were downregulated in the M-ERRalpha(-/-) muscles at the
282 mitochondrial function and protein synthesis were downregulated in the sensory epithelium of P0 cochl
283 enes known to be involved in spermatogenesis were downregulated in the testes of knock-out mice, as w
286 s, p-mTOR (p=0.03) and PI3K-alpha (P = 0.04) were downregulated in treatment responsive residual tumo
288 ure products of MIR-491 (miR-491-5p and -3p) are downregulated in tumors compared with the normal bra
290 ugh earlier reports showed that BR signaling is downregulated in twd1, how TWD1 is integrated in BR s
291 ough expression of CRTH2 on blood leukocytes is downregulated in UC, CRTH2 is present in colon tissue
294 changes in mitochondrial membrane potential, is downregulated in vascular smooth muscle cells in cult
295 protein kinase that modulates EGFR turnover, is downregulated in vemurafenib-resistant melanoma cells
299 markers for odontoblast differentiation that are downregulated in Wls(Shh-Cre) teeth, act as direct d