ライフサイエンスコーパス: be essential for

1 , a specialised proteinaceous organelle that is essential for 1,2-propanediol degradation and enteric

2 idered in the selection tree, an aspect that is essential for a quantitative method's robustness but

3 Centromeres are essential for accurate chromosome segregation and ar

4 lation of phosphorylation at the kinetochore is essential for accurate chromosome alignment and prope

5 In Caulobacter crescentus, the HHK ShkA is essential for accurate timing of the G1-S cell cycle

6 g that need for family planning is satisfied are essential for achieving universal access to reproduc

7 The template-based approach has been essential for achieving high-quality models in the

8 at transmembrane serine protease 2 (TMPRSS2) is essential for activation of H7N9 and H1N1pdm IAV in m

9 Lymphocyte migration is essential for adaptive immune surveillance.

10 These changes are essential for adequate expression of maternal behavi

11 hat Ca(2+) mobilization downstream of P2Y(1) was essential for ADP-evoked fibrinogen binding, whereas

12 ), a major eukaryotic ssDNA-binding protein, is essential for all metabolic processes that involve ss

13 nformation at the Cys(6)-Pro(7) peptide bond was essential for alpha3beta4 nAChR subtype allosteric s

14 BEST PRACTICE ADVICE 2: Serologic tests are essential for an accurate diagnosis of celiac diseas

15 ve leaves depends on cultivar and to know it is essential for an adequate use.

16 Further, although female blood-feeding is essential for anautogenous mosquito reproduction, the

17 proliferation, and paracrine activity, which are essential for angiogenesis.

18 Memory stability is essential for animal survival when environment and be

19 An understanding of genetic structure is essential for answering many questions in population

20 at the organization of septin GTPases, which are essential for appressorium-mediated infection in the

21 the subunits including the subunit H, which is essential for ATPase activity.

22 e Chlorophyceae and Ulvale algae species and is essential for atpI mRNA translation in Chlamydomonas.

23 We report here that DksA is essential for B. burgdorferi to infect a mammalian ho

24 Metal detoxification is essential for bacteria's survival in adverse environm

25 PAT1 is essential for BDNF-stimulated neuronal growth cone de

26 It shows that overparameterization is essential for benign overfitting in this setting: the

27 Sulfur is essential for biological processes such as amino acid

28 Rapid and directed electron transfer (ET) is essential for biological processes.

29 RNA-RNA interactions are essential for biology, but they can be difficult to

30 Quantification of behaviour is essential for biology.

31 nucleotide exchange activity of DOCK5, which is essential for bone resorption by osteoclasts.

32 ammary placode or descending mammary bud, it is essential for both the prenatal hormone-independent a

33 tolerance mechanism or a DPC repair pathway is essential for C. albicans to maintain genomic stabili

34 , indicating that endogenous synthesis of LA is essential for C. elegans development.

35 alpha2delta-1 is essential for calcineurin inhibitor-induced aberrant

36 are recruited to the injured myocardium and are essential for cardiac repair as they can adopt both

37 These processes are essential for cell adhesion, migration, and organ de

38 /Taz transcriptional target Axl was found to be essential for cell growth dependent on the uptake of

39 roper concentrations of intracellular metals is essential for cell fitness and pathogenesis.

40 chondrial morphology and activity regulation is essential for cell survival, differentiation, and mig

41 While some metals such as iron and copper are essential for cellular functions, others such as cad

42 with myosin and other actin-binding proteins are essential for cellular viability in numerous cell ty

43 The water-soluble vitamin biotin is essential for cellular growth, development, and well-

44 Lysosome function is essential for cellular homeostasis, but quality-contr

45 phospholipids to and from the mitochondrion is essential for cellular integrity.

46 Cell surface display of EGFR is essential for cellular responses to its ligands.

47 IL-4 activation of B cells is essential for class switching and contributes to the

48 Phagocytes are essential for clearance of CDC-producing bacteria; h

49 istinct arrhythmias that may be drug-induced are essential for clinicians.

50 Robust and reproducible data are essential for confidence in analytical results and a

51 of conventional type 1 dendritic cells that are essential for cross-presentation and CD8 T cell-medi

52 complexes and that the subpellicular complex is essential for cytokinesis and viability of disease-ca

53 Low molecular weight metabolites are essential for defining the molecular phenotypes of c

54 The LRP-1-targeted functionalization was essential for delivery of carnosine to the brain, as

55 Knowledge of both pH and [OCl(-)] is essential for determination of free chlorine concentr

56 contribute to disease onset and progression is essential for developing novel therapies.

57 standing of disease seasonal synchronization is essential for developing reliable outbreak forecasts

58 Efficient S phase entry is essential for development, tissue repair, and immune

59 yos die prior to E8.5, indicating that Wbp11 is essential for development.

60 dient of actin-positive vesicle activity and is essential for developmental success.

61 y to rapidly change gene expression patterns is essential for differentiation, development, and funct

62 This knowledge is essential for discerning molecular processes in healt

63 ity to express genes ectopically in bacteria is essential for diverse academic and industrial applica

64 conclude that DNA sensing within tumor cells is essential for dMMR-triggered anti-tumor immunity.

65 In addition, oestrogen, which is essential for ductal elongation during puberty, upreg

66 that this novel RBM24-Sox2 regulatory module is essential for early eye development in vertebrates.

67 Therefore, we demonstrate that CEPT1 is essential for EC function and tissue recovery after i

68 duce these extracellular disulfide bonds and are essential for ECM degradation.

69 mechanical integrity of reservoir formations is essential for effective and safe operations.

70 ransduction pathways and cellular metabolism is essential for effective NK cells responses.

71 the fluidity of SYD-2 and ELKS-1 condensates is essential for efficient mixing and incorporation of a

72 Hindbrain catecholamine (CA) neurons are essential for elicitation of protective counterregul

73 Uncovering the underlying metabolic networks is essential for elucidating the physiological and ecolo

74 metabolite trehalose 6-phosphate (Tre6P) and is essential for embryogenesis and normal postembryonic

75 It is essential for embryonic and postembryonic plant devel

76 trans via piRNA-mediated gene silencing that is essential for embryonic development.

77 nstrating that for ABCG2 a single amino acid is essential for engaging and initiating transport of mu

78 Genome stability is essential for engineering cell-based devices and repo

79 ally, secretion of exosomes by these spheres was essential for enhancing survival while production of

80 Protein-DNA interactions are essential for establishing cell type-specific chroma

81 DNA methyltransferase DNMT3A is essential for establishment of mammalian DNA methylat

82 Genealogical tree modeling is essential for estimating evolutionary parameters in p

83 Proper chromosome segregation is essential for faithful cell division and if not maint

84 CO) formation between homologous chromosomes is essential for faithful segregation.

85 information between parental chromosomes and is essential for fertility.

86 mmunication by retrograde signaling pathways is essential for fine-tuning of responses to the prevail

87 c profiling and GWAS, we identified FADS3 to be essential for forming Delta14Z DB containing LCBs, su

88 biopolymers and of their natural substrates are essential for function.

89 s conformational changes underlying function are essential for further progress.

90 blood, (iii) the shikimate pathway gene aroA is essential for GBS growth in whole blood and plasma, a

91 paused RNA Pol II into productive elongation is essential for gene expression.

92 l phosphate pathway of isoprenoid synthesis, is essential for Gram-negative bacteria, mycobacteria an

93 show that the full-length C terminus of p73 is essential for hippocampal development.

94 ellular signal-regulated kinase (ERK), which is essential for host cell viability, remains intact.

95 hages demonstrate remarkable plasticity that is essential for host defense and tissue repair.

96 Tight regulation of NEMO is essential for host innate immune responses and for ma

97 udy, we demonstrate that MDA5/MAVS signaling was essential for host resistance against pulmonary Aspe

98 -linked glycan within the IgG-Fc tail, which is essential for IgG function, shows variable compositio

99 cognize MHC I- or MHC II-presented antigens, are essential for immune responses and develop from CD4(

100 ding the implications of these findings will be essential for improving estimates of secondary forest

101 opment and tissue-specific imprinting, which is essential for infection and autoimmunity.

102 Islet vascularization is essential for intact islet function and glucose homeo

103 at maintenance of viral population diversity is essential for interhost viral spread.

104 ering and decentering of cellular components is essential for internal organization of cells and thei

105 stricting JNK pathway activity and that Gish is essential for intestinal stem cell (ISC) maintenance

106 lthy human kidneys with NEP rather than ACE2 being essential for its generation.

107 rgoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) cataly

108 h concomitant U116 18S rRNA 2'-O-methylation is essential for leukemia cell growth and survival.

109 Here, we show that ORM1 and ORM2 are essential for life cycle completion in Arabidopsis (

110 mations establish work-energy equipoise that is essential for life-long cellular homeostasis and hear

111 K29 that are involved in NS5 oligomerization are essential for localization and interaction with comp

112 the Dimerization/Docking (D/D) domain, which is essential for localization and interacting with membr

113 Robust serological assays are essential for long-term control of the COVID-19 pand

114 magnetic fields and spin-polarized currents is essential for magnetic sensors and data storage devic

115 Mitochondria-lysosome interactions are essential for maintaining intracellular homeostasis.

116 the simultaneous expression of RB and S18-2 is essential for maintaining cell stemness.

117 Our results show that TrkC is essential for maintaining glomerular integrity.

118 ceptors in an NGF-dependent manner, where it was essential for maintaining TrkA receptor phosphorylat

119 The sympathetic nervous system is essential for maintenance of cardiac function via act

120 to gametes (gametogenesis) within mosquitos is essential for malaria parasite transmission.

121 n from within membrane necks, a process that is essential for many cellular functions, from cell divi

122 Smooth muscle cell migration is essential for many diverse biological processes such

123 Oxygen is essential for many organisms who have therefore evolv

124 A better understanding of these cells would be essential for meaningful and lasting treatments.

125 that the cooperative function of EBE and TIE is essential for mediating AF-1-dependent transactivatio

126 s is known, the desmosome architecture-which is essential for mediating numerous functions-remains el

127 Plasticity within hippocampal circuits is essential for memory functions.

128 alpha4, alpha5, and the alpha5-alpha6 linker are essential for methyltransferase function, including

129 CENP-A marks centromeres epigenetically and is essential for mitotic fidelity.

130 Furthermore, GABAergic VP neurons are essential for movements toward reward in a positive

131 -mediated interactions between proteins that are essential for multiple phases of the viral replicati

132 demonstrate that the autocrine FGF/FGFR axis is essential for multiple myeloma cell survival and prog

133 Together, our studies indicate that Smyhc1 is essential for myogenesis in embryonic slow muscles, a

134 copper-exporter upregulated by mutant KRAS, is essential for neoplastic growth.

135 Netrin1, a secreted laminin-related protein, is essential for nervous system development.

136 ural-specific splicing of the Bak1 microexon is essential for neuronal and animal survival.

137 al S-adenosyl-L-methionine (SAM) enzyme that is essential for nitrogenase cofactor assembly.

138 isingly, however, some core NMD factors that are essential for NMD in simpler organisms appear to be

139 ve FA, 2-MAG and membrane lipid biosynthesis are essential for nodulation and rhizobia-soybean symbio

140 iptional programming with exquisite fidelity is essential for normal development.

141 The hippocampus is essential for normal memory but does not act in isola

142 aracterized by expression of CD206 and CD163 is essential for normal repair.

143 nhardtii, the LHCSR pigment-binding proteins are essential for NPQ.

144 se expression decreases in mice after birth, is essential for nuclear envelope breakdown prior to pro

145 t GAPDH and NAMPT form a stable complex that is essential for nuclear translocation of NAMPT.

146 in human OC associated with poor prognosis, is essential for OC progression principally by promoting

147 tion, but also revealed that phosphorylation was essential for OPN secretion.

148 (Asp14), and outer membrane protein A (OmpA) are essential for optimal bacterial entry into host cell

149 an evolutionary perspective, sensing danger is essential for organismal survival.

150 ls in the mesoderm layer of the early embryo is essential for organization of the body plan.

151 arisons of sensory inputs between body parts is essential for organizing grooming movements in sequen

152 or, kinesin-1, and an actin motor, myosin-V, are essential for osk mRNA posterior localization.

153 lung cancer patients before tumor resection is essential for patient selection for surgery and is co

154 Nodal signaling is essential for patterning of the AP axis while planar

155 -2 regulator NOP-1, but not centralspindlin, is essential for PGC lobe formation.

156 has led to the common opinion that carotenes are essential for photosynthesis.

157 rdiorespiratory responses to O(2) deficiency are essential for physiological homeostasis.

158 hat is not required for piRNA biogenesis but is essential for piRNA-directed TE de novo methylation a

159 yncrip (Syp) binds to msp300 transcripts and is essential for plasticity.

160 Src family kinases (SFKs) Src, Lyn, and Fyn are essential for platelet activation and also involved

161 RNA surveillance of all classes of RNA, and is essential for pre-rRNA processing.

162 The enhancer cluster was essential for prenatal and postnatal ventricular exp

163 Myosin-2 is essential for processes as diverse as cell division a

164 including the U3 small nucleolar RNA, which is essential for processing of 18S rRNA(4).

165 -box ATPase Prp2, and both proteins together are essential for promoting the transition from the B(ac

166 Our results demonstrate that EWSR1 is essential for promoting PRDM9-dependent histone methy

167 Inhibitory interneurons are essential for proper brain development and function.

168 X-EYA-DACH transcriptional networks (PSEDNs) are essential for proper development across taxa.

169 ears to be highly flexible and turned out to be essential for proper functioning of FtsH as its delet

170 ulation of inositol polyphosphate metabolism is essential for proper cell physiology.

171 nsin mediates chromosome condensation, which is essential for proper chromosome segregation during mi

172 direct evidence that the nectin-afadin axis is essential for proper palate shelf elevation and fusio

173 n esterified and de-esterified pectin states is essential for proper root clock function and the subs

174 These results indicate that ZIP9 is essential for proper zinc modulation during zebrafish

175 Lymph node stromal cells (LNSC) are essential for providing and maintaining peripheral s

176 Intraoperative diagnosis is essential for providing safe and effective care durin

177 the engagement of CAs in some brain regions is essential for providing the brain with the resilience

178 Electronic skins are essential for real-time health monitoring and tactil

179 y resolved particulate matter (PM) estimates are essential for reconstructing long and short-term exp

180 Sensorimotor integration in the cerebellum is essential for refining motor output, and the first st

181 H3 Lys 4 (H3K4) methylation and its members are essential for regulating gene expression.

182 y by promoting degradation of NEDD4-2, which is essential for removal of surface Nav1.5.

183 signaling axis specified by the endothelium is essential for reprogramming interstitial macrophages

184 rmed by six residues ((243)VLRFMT(248)) that are essential for responses to volatile anaesthetics(10)

185 r Pax proteins in adult renal epithelia that are essential for retaining water and concentrating urin

186 the transition from quiescence to reactivity is essential for retinal regeneration, whereas in mice,

187 ensory cue and prediction error signals that are essential for reward-based learning.

188 y its paralogue, TBPL2 (TBP2 or TRF3), which is essential for RNA polymerase II transcription.

189 hese cells is limited, but their recruitment is essential for root system formation, resulting in the

190 l C-terminal region which we demonstrated to be essential for Rv2509 function, though this region did

191 actor (CTCF), a crucial chromatin organizer, is essential for Schwann cell myelination and myelin reg

192 c structures within a nonmagnetic background is essential for several types of existing and proposed

193 the total neurons in the visual thalamus but are essential for sharpening receptive field properties

194 8 and Kip3 through microtubule cross-linking is essential for signaling efficient cohesin removal and

195 netic screen, we identified the ric1 gene as being essential for skeletal biology.

196 kDa), conserved macromolecular machines that are essential for soluble N-ethylmaleimide-sensitive fac

197 The GSK3alpha paralog, but not GSK3beta, is essential for sperm function.

198 harge and spin currents via spin-Hall effect is essential for spintronics.

199 lved in normal regulation of mMHCII, TMEM127 was essential for SteD to suppress both mMHCII antigen p

200 nformative, and functional molecular markers are essential for studying a wide range of genetic param

201 ides insight showing that AdhE filamentation is essential for substrate channeling within the filamen

202 g 90-day episodes has not been conducted but is essential for success in bundled reimbursement models

203 e show that anti-parallel strand orientation is essential for such a replicative organization of DNA,

204 is upregulated in multiple cancer types and is essential for supplementing NAD+ for glycolysis and N

205 The pollination services provided by bees are essential for supporting natural and agricultural ec

206 Because B vitamins are essential for survival, null mutations often have em

207 ugh behavioral responses to predatory threat are essential for survival, the underlying neuronal circ

208 tion and depression capable of branching and is essential for survival and learning.

209 and anoctamin 1 (ANO1) was tested since each is essential for SW and tone generation.

210 neurotransmitter receptor trafficking, which is essential for synaptic plasticity.

211 vate cytoplasmic Ca(2+) concentration, which is essential for T cell activation, differentiation and

212 ion of highly reactive nitroso intermediates is essential for target inactivation in vivo.

213 e and distribution of asymptomatic infection is essential for targeted interventions.

214 why certain individuals are more susceptible is essential for targeted treatment and prevention.

215 In contrast, its downstream target KCTD1 is essential for terminal differentiation of early stage

216 l to maturing erythroid precursors (EPs) and is essential for terminal erythropoiesis.

217 sequences (CNSs) were also determined, which are essential for the activity of the promoter.

218 istent, demonstrating that fast fluctuations are essential for the allosteric control of PTP1B activi

219 These results indicate that striatal ChIs are essential for the control of complex movements, and

220 Tropomyosin-receptor kinases (TRKs) are essential for the development of the nervous system.

221 the NAC-induced regulations of SRP activity are essential for the fidelity of cotranslational protei

222 Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain

223 Nutrients are essential for the healthy development and proper mai

224 tal appendages (DAs) of the mother centriole are essential for the initial steps of ciliogenesis in G

225 ndicating that epidermal PIF4-auxin pathways are essential for the temperature responses.

226 the fact that mimicry of these gradients may be essential for the functionality of engineered graft t

227 eristics of the light-adapted state may also be essential for the long-range signaling capabilities o

228 iversity within P. vivax transcriptomes will be essential for the prioritisation of novel vaccine tar

229 in recombinant spidroins, but are thought to be essential for the spiders' natural spinning process.

230 BMRMs, with the CX3CR1/CX3CL1 signaling axis being essential for the maintenance and regeneration of

231 Importantly, we also showed that CDK8 is essential for the ABA-induced expression of RAP2.6 an

232 LuxS is essential for the activated methyl cycle and generate

233 The assembly of this catalytic centre is essential for the addition of ADP-ribose moieties aft

234 at the synergy of H(2)O(2) and gluconic acid is essential for the antibacterial activity of honey.

235 The Arp2/3 complex is essential for the assembly of branched filamentous ac

236 ines; (c) TRPV4-dependent activation of Rac1 is essential for the augmentation of intracellular stiff

237 he Pseudomonas virulence factor (pvf) operon is essential for the biosynthesis of two very different

238 o focus on the behaviorally relevant signals is essential for the brain to cope with the continuous,

239 The maintenance of genome stability is essential for the cell as the integrity of genomic in

240 he diagnosis of multiple sclerosis (MS) that is essential for the detection and follow-up of the dise

241 signals and uncertainties in climate models is essential for the detection, attribution, prediction

242 a negative regulator of Ras-MAPK signaling, is essential for the development and maintenance of lymp

243 Thus, Dcc is essential for the development and maintenance of the

244 ability to understand and predict reactivity is essential for the development of new reactions.

245 gmentation, and the linkage of her1 and her7 is essential for the development of the body axis in zeb

246 Coordination of cell growth is essential for the development of the brain, but the m

247 mTEC expression of LTbetaR is essential for the development thymic tuft cells which

248 demonstrate that Fatty Acid Oxidation (FAO) is essential for the differentiation of blood cell proge

249 s for ME/CFS through a provocation challenge is essential for the elucidation of the ME/CFS pathophys

250 vidence that a Ln(3+)-coordinating aspartate is essential for the enzymatic functions of XoxF MDHs an

251 an effector of the Hippo signaling pathway, is essential for the establishment of pregnancy in a pos

252 cise pattern of motor neuron (MN) activation is essential for the execution of motor actions; however

253 The CD27-CD70 costimulatory pathway is essential for the full activation of T cells, but som

254 se gene editing of mitochondrial DNA (mtDNA) is essential for the generation of model systems to stud

255 Together, these results show that CsrA is essential for the growth of A. baumannii on host-deri

256 expression on CDK11 could explain why CDK11 is essential for the growth of many cancers.

257 Basal autophagy in kidney cells is essential for the maintenance of kidney homeostasis,

258 blood thrombosis and antithrombotic therapy is essential for the management of patients in a variety

259 nknown MIWI2-associated factor, SPOCD1, that is essential for the methylation and silencing of young

260 The bone morphogenetic protein (BMP) pathway is essential for the morphogenesis of multiple organs in

261 propriate control of hepatic gluconeogenesis is essential for the organismal survival upon prolonged

262 Autocatalysis is essential for the origin of life and chemical evoluti

263 ICOS) is a multisubunit protein complex that is essential for the proper architecture of the mitochon

264 king a local H3K9 trimethylation signal that is essential for the proper execution of HDR.

265 Protein quality control is essential for the proper function of cells and the or

266 of urban roads resilient to flooding events is essential for the provision of public services and fo

267 Phosphorylation of the p.Y783 residue is essential for the proximal activity of wild-type PLCg

268 ediate the monoubiquitination of BIK1, which is essential for the subsequent release of BIK1 from the

269 cy now over 17%, a long operational lifetime is essential for the successful application of organic s

270 ched for glycolytic enzymes whose expression is essential for the survival of cancer cells with high

271 ood vessels after myocardial infarction (MI) is essential for the survival of existing and regenerate

272 A continuous supply of oxygen is essential for the survival of multicellular organisms

273 chanisms that give rise to genetic variation is essential for the understanding of evolutionary proce

274 biquinone produced by the mevalonate pathway was essential for the growth of p53-deficient tumor orga

275 d eight transcription factors, each of which was essential for the transition from primordial to prim

276 tional clathrin-mediated vesicle trafficking were essential for the maintenance of VAMP4-mediated spo

277 nsive and scarce metal generally believed to be essential for their electrochemical performance.

278 excitation in van der Waals materials, which is essential for their applications in optoelectronic de

279 Communication between organelles is essential for their cellular homeostasis.

280 cently discovered van der Waals ferromagnets is essential for their integration in future spintronics

281 defence systems, mediated primarily by MGEs, is essential for their persistence.

282 Mammalian Piezo2 channels are essential for transduction of innocuous mechanical f

283 n to sexual differentiation into gametocytes is essential for transmission to mosquitos.

284 Access to analytical code is essential for transparent and reproducible research.

285 controls the phosphorylation of TSC2, which is essential for TSC exchange.

286 hat the LJBSF is a highly organized subfield are essential for understanding its possible role in cor

287 tes of global gross primary production (GPP) are essential for understanding the response of the terr

288 a hallmark of biological visual systems, may be essential for understanding the accuracy, flexibility

289 Elucidating this cryptic Se cycle is essential for understanding and predicting Se behavio

290 major global sources of BVOCs, so its study is essential for understanding BVOC dynamics.

291 arbon (SOC) stocks and other soil properties is essential for understanding how soils will respond to

292 ty to directly measure dopaminergic activity is essential for understanding its physiological functio

293 gulates the development of the root meristem is essential for understanding stem cell function.

294 EndoT-derived and coronary endothelial cells is essential for understanding the revascularizing strat

295 Voltage-gated proton channels (H(V)1) are essential for various physiological tasks but are st

296 rtant drug target, synthesizes viral RNA and is essential for viral replication.

297 Saliently, we report that VAMP3 is essential for viral trafficking and release of infect

298 mation of corticospinal (CS) circuits, which are essential for voluntary movements, involves both gui

299 KDM4C was essential for Wnt-induced gene expression and tumori

300 Sustained cell migration is essential for wound healing and cancer metastasis.