ライフサイエンスコーパス: be essential to

1 talytic pathway, and substrate specificities are essential to a comprehensive understanding of the bi

2 ding sites, and demonstrate that such models are essential to accurately quantify agonist and drug ac

3 ding its spatial variability and uncertainty is essential to accurately predicting how stresses and e

4 Accounting for cooperative agonist binding is essential to accurately quantify agonist and drug act

5 ing social determinants of tuberculosis (TB) is essential to achieve elimination, including in low-in

6 The global oncology nursing workforce is essential to achieving Sustainable Development Goals

7 n and reveals that this scaffold protein may be essential to activate a novel mechanism of p53-induce

8 Collectively, our results suggest that SpeB is essential to activate an IL-1beta-driven neutrophil r

9 ional modulation of the local configurations is essential to activating the in-plane chalcogen atoms

10 We hypothesized that these conformations are essential to adapt contractile output for energy con

11 animal infection, and administrative issues, is essential to address challenges faced by CE control p

12 to reliably detect neuroelectric activities is essential to addressing this challenge.

13 those characteristics of microplastics that are essential to adequately evaluate potential remediati

14 epitopes targeted by neutralizing antibodies is essential to advance epitope-based vaccine design str

15 ain metastases, enrolment in clinical trials is essential to advance our understanding of this comple

16 ral reefs, understanding coral gene function is essential to advance reef conservation.

17 anding of the TK of ionizable test compounds is essential to allow assessment of the validity of this

18 Aerobic respiration is essential to almost all eukaryotes and sensing oxygen

19 nt protein interaction with Hsp70 chaperones is essential to analyze the complex dynamics in the cont

20 Toxoplasma gondii DNA detection is essential to antenatally diagnose a congenital infect

21 The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies

22 man and machine behavior, and that it should be essential to any such comparison.

23 pectrum of NO bioactivity in plants, it will be essential to apply methodological best practice.

24 ated disease, and to fully understand CM, it is essential to appreciate the complex relationship betw

25 mmunosuppressive properties of human gliomas are essential to assess immune-based therapies.

26 roach for allergens in various food matrices is essential to assist patients in managing their allerg

27 likely will die from people, but these bears are essential to avert local extirpation.

28 Negative regulation of innate immunity is essential to avoid autoinflammation.

29 ergy expansion and biodiversity conservation is essential to avoid conflicts that compromise their re

30 ntifying these specific fundus abnormalities is essential to avoid diagnosis wandering and therapeuti

31 Accurate diagnosis is essential to avoid emergence of complications or inap

32 rmed histopathologically in routine sections is essential to avoid missing such an important high-ris

33 nd considering the soft nature of the gel it is essential to be well analyzed.

34 rstanding of the reaction mechanisms in play is essential to being able to fine-tune the selectivity

35 athogen elimination, immunity, and pathology is essential to better characterize disease progression

36 Modeling cancer cells is essential to better understand the dynamic nature of

37 gy that may influence the parasite infection is essential to better understanding of hemoparasite inf

38 ule-dependent border cell-oocyte interaction is essential to brace the cells against external morphog

39 Lipids are essential to brain functions, yet they remain largel

40 for virtually all mitochondrial proteins and is essential to build the mitochondrial proteome.

41 vents at the cellular level, this connection is essential to building a mechanism-based theory of evo

42 sible disruption of health systems that have been essential to cancer control practice.

43 A multidisciplinary team is essential to care for DBA patients, since there is a

44 These hydrocarbon pool species are essential to catalyze the methanol conversion but ma

45 otein phosphatases (PPPs) by protein kinases is essential to cell cycle progression and control, part

46 Thus, the function lost by these mutations is essential to cell survival.

47 ion, stalk formation, and hemifusion rupture are essential to cellular function, but their molecular

48 Thus, it is essential to characterize, in as much detail as possi

49 nd they represent potential drug targets, it is essential to chart the architectural features of SARS

50 Single-cell genomics is essential to chart tumor ecosystems.

51 new chemical tools with improved properties is essential to chemical and cell biology.

52 Further studies are essential to clarify the risks and benefits of ADHD

53 ture functional analyses of ASFV genes which are essential to combat this devastating disease.IMPORTA

54 Contemporary outcome data of preterm infants are essential to commission, evaluate and improve health

55 tinct subset of mitotic Cdk1 substrates that are essential to complete cell division.

56 Longitudinal data will be essential to confirm these findings and define the tr

57 Thus, it is essential to consider bacterial community composition

58 es' that synthesize industrial compounds, it is essential to consider the ability of the cells' nativ

59 of bottlenecks in vaccine development, will be essential to containing and eradicating future pandem

60 These outcomes are essential to control many processes, including synap

61 Rapid, inexpensive, robust diagnostics are essential to control the spread of infectious diseas

62 ity of structuring material at the nanoscale is essential to control light-matter interactions and th

63 Th17)/interleukin 17 (IL-17)-driven immunity is essential to control oral and dermal candidiasis.

64 Tuning DMI is essential to control skyrmion properties, with symmet

65 noporous electrodes under applied potentials is essential to control the performance of double-layer

66 DNA replication is essential to couple genome duplication and cell divis

67 lly tailored to the populations at risk will be essential to curb transmission.

68 Power analysis is essential to decide the sample size of metagenomic se

69 ion and coordination at such regulatory loci is essential to deciphering how these regions contribute

70 nding the spectrum and pathogenesis of irAEs is essential to define strategies for prevention, early

71 tity and the pharmacology of these receptors is essential to define their specific roles in myelinati

72 nisms by which antibodies provide protection is essential to defining immunity.

73 of what virus is the causative agent-it will be essential to depend on careful analysis of safety in

74 d endocrine) as well as radio resistance, it is essential to design novel therapeutic strategies to i

75 cal, biomarker and neuropathological studies are essential to determine the underlying pathobiologica

76 d structures around the infarct is likely to be essential to determine the outcome of these intervent

77 As the climate changes it is essential to determine ecotypic diversity at the geno

78 Assessment of micropollutant biodegradation is essential to determine the persistence of potentially

79 electrical properties of biological neurons is essential to determine their complement of ion channe

80 al assays to detect antibodies to SARS-CoV-2 are essential to determining seroprevalence of this viru

81 ravasation of IA injected therapeutic agents are essential to develop strategies assuring precision a

82 ng non-invasive and widely available methods is essential to develop a successful therapy for Alzheim

83 In a progressively aging population, it is essential to develop early-life biomarkers that effic

84 te DNA sequence of the Ae. albopictus genome is essential to develop new approaches that involve gene

85 Towards this goal, it is essential to develop strategies to activate C-H bonds

86 using other methods than by candidate genes, are essential to developing methods that may predict the

87 s, particularly resin, that chemical testing is essential to differentiate them.

88 Second, NR2F2 was essential to directly activate vein-specific enhance

89 derstanding changes in species distributions is essential to disentangle the mechanisms that drive th

90 Thus, intact Itpkb signaling is essential to drive acute GVHD pathogenesis and sustai

91 requires the ETC to oxidize ubiquinol, which is essential to drive the oxidative TCA cycle and DHODH

92 RIPK1 kinase activity has been shown to be essential to driving pyroptosis, apoptosis, and necro

93 It is essential to elucidate brain-adipocyte interactions i

94 in live cells at single-molecule resolution is essential to elucidate their role in RNA metabolism.

95 tion of noncognate TCs on a sub-ms timescale is essential to enable incorporation of the rare cognate

96 ses responsible for control over selectivity is essential to enable the development of this class of

97 Synapse remodeling is essential to encode experiences into neuronal circuit

98 oordination of these wound-induced responses is essential to ensure efficient, spatially restricted w

99 Prior sample size calculation is essential to ensure that a randomized controlled tria

100 Here we report that whereas AXR1 is essential to ensure the obligatory chiasma, AXL seems

101 governments, and civil society organizations is essential to ensuring the success of interventions ta

102 apy-resistant leukemic stem cells (LSCs), it is essential to eradicate LSCs to improve patient surviv

103 s growing significance in recent decades, it is essential to evaluate the effects of climate change o

104 ecisions on the basis of sensory information is essential to everyday behaviors.

105 As the aging population rapidly grows, it is essential to examine how alterations in cellular func

106 ation and consumption during adolescence, it is essential to expand knowledge on the potential effect

107 It is essential to experimentally confirm the material prop

108 n others from the same type of infection, it is essential to explain how key processes, such as host

109 The adequate definition of pollen seasons is essential to facilitate a correct diagnosis, treatmen

110 The metastatic microenvironment is essential to facilitate growth of disseminated tumor

111 nts in agricultural systems, P fertilisation is essential to feed the world.

112 Since taste is essential to feeding, egg laying, and mating decision

113 Chocolatiers understand that melanging is essential to flavor and overall quality, however the

114 he profitability of pharmaceutical companies is essential to formulating evidence-based policies to r

115 In-depth understanding of these mechanisms is essential to foster the development of precise therap

116 Efficiently entangling pairs of qubits is essential to fully harness the power of quantum compu

117 landfills and land-application of digestate is essential to fully understand the trade-offs between

118 of sensitive local probes of magnon dynamics is essential to further understand the physical processe

119 It is essential to gain knowledge about the causes and exte

120 genomic knowledge of oomycete pathogenicity is essential to gain the full context of how these patho

121 at nutrient-dependent glycosylation of SIRT1 is essential to gate its functions and maintain physiolo

122 ease-mediated cleavage of viral polyproteins is essential to generating infectious viruses, a process

123 ance between heterochromatin and euchromatin is essential to genomic stability.

124 aration, catalysis, and biomedicine since it is essential to guarantee the framework integrity during

125 f Hippo pathway deregulation in cancers will be essential to guide the imminent use of Hippo-targeted

126 pharmacokinetic-pharmacodynamic target goals is essential to guide optimal therapy.

127 rotect the most vulnerable marine species it is essential to have an understanding of their spatiotem

128 hese findings suggest that the host cell ETC is essential to HCMV replication.

129 nce.SIGNIFICANCE STATEMENT Brain tissue iron is essential to healthy brain function.

130 nformative reporting in titles and abstracts is essential to help readers and reviewers identify pote

131 A long non-coding RNA called GRASLND is essential to help stem cells create stable cartilage.

132 Dmc1 recombinases are essential to homologous recombination in meiosis.

133 Housing is essential to human well-being but neglected in global

134 have become popular in most laboratories and are essential to identify and validate novel protein bin

135 kpoint inhibitors, additional investigations are essential to identify novel therapeutic strategies f

136 Therefore, it is essential to identify early-stage biomarkers in those

137 traditional morphological identification and was essential to identifying significant responses to fl

138 e of donation after circulatory death grafts are essential to improve graft function and to increase

139 n optimization of rehabilitative strategies, are essential to improve stroke treatments.

140 e dependence severity and treatment efficacy are essential to improve the current marginally effectiv

141 diseases, including pancreatitis and cancer, is essential to improve clinical management.

142 regulate autonomy during surgical procedures is essential to improve intraoperative learning without

143 Identifying and removing multiplets are essential to improving the scalability and the relia

144 ange of providers in different settings will be essential to increase the number of persons treated.

145 atitis C virus (HCV) elimination targets, it is essential to increase access to direct-acting antivir

146 rs who are most likely to encounter FM first is essential to increase timely access to appropriately

147 vation of caspase-4 through the GBP platform is essential to induce gasdermin-D-dependent pyroptosis

148 dentifying causal risk factors for self-harm is essential to inform preventive interventions.

149 tic cells (DCs) and downstream TLR signaling are essential to initiate antimicrobial immune responses

150 nscription factor1 (TEAD1) complex formation was essential to initiate downstream target gene express

151 Chemosensory communication is essential to insect biology, playing indispensable ro

152 and borylation of N-H bonds by [Ni(IMes)(2)] is essential to install a Bpin moiety at the N-position

153 precision and molecularly defined structure is essential to interface electronics and advance their

154 tion motifs in its N terminus, each of which is essential to its ability to establish cohesion.

155 The invasive behavior of glioblastoma is essential to its aggressive potential.

156 for any evaluation, the quality of reporting is essential to learning from, and disseminating, the re

157 the proteome, platforms for ligand discovery are essential to leverage insights from genomic analyses

158 Numerous redox transformations that are essential to life are catalyzed by metalloenzymes th

159 , let alone eradication, are practicable, it is essential to limit any further local range expansion

160 through the IFN-alpha/beta receptor (IFNAR) is essential to limit virus dissemination throughout the

161 te produced by Lp to supply amino acids that are essential to Lp, allowing it to grow in imbalanced d

162 ciated with different cellular compartments, are essential to maintain cellular homeostasis during de

163 CD4(+) Foxp3(+) regulatory T cells (Treg) are essential to maintain immune tolerance, as their los

164 strate that Lats1/2, the core Hippo kinases, are essential to maintain Wnt pathway activity and intes

165 n daily life, effective management of stress is essential to maintain a healthy life.

166 e show that the cytoplasmic function of YAP1 is essential to maintain adult RPE differentiation.

167 conclude that LAL-regulated lipid metabolism is essential to maintain antitumor immunity.

168 f insulin release from pancreatic beta-cells is essential to maintain blood glucose homeostasis.

169 nesis is an expensive metabolic process that is essential to maintain cellular respiratory capacity a

170 For some therapeutic cargoes, it is essential to maintain contact with the bloodstream to

171 genes and minicircle-encoded guide RNA genes is essential to maintain efficient respiration.

172 Winter wheat (Triticum aestivum L.) is essential to maintain food security for a large propo

173 cient and faithful replication of the genome is essential to maintain genome stability.

174 The DNA damage response is essential to maintain genomic stability, suppress rep

175 s and that active transcriptional elongation is essential to maintain H3K27ac abundance.

176 eterotypic communication between LCs and BCs is essential to maintain lineage fidelity in glandular e

177 l homologous recombination in allopolyploids is essential to maintain optimal fertility of the specie

178 ism of glucose, amino acids, and fatty acids is essential to maintain overall energy homeostasis, the

179 We demonstrate that CBFbeta is essential to maintain the mesenchymal phenotype of tr

180 apid regression, indicating that alpha3beta1 is essential to maintain tumor growth.

181 ly repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preven

182 ty and the inter-habitat movement of species is essential to many areas of biological inquiry.

183 Multivalent binding is essential to many biological processes because it bui

184 disease and how interrelations between them are essential to maximize allergic responses.

185 l engagement of transcription factors, which are essential to mediate physiological fed-fast-refed tr

186 gene transcription and cell differentiation, is essential to mediate sprouting angiogenesis.

187 Controlling gain of cortical activity is essential to modulate weights between internal ongoin

188 riptomic workflows from cryopreserved tissue is essential to move this emerging immune monitoring tec

189 Synapses are essential to neural signal transmission.

190 cortical representations of odor thought to be essential to olfactory learning and behaviors.

191 h to caring for pregnant patients with lupus is essential to optimize outcomes.

192 e safety of contemporary defibrillator leads is essential to optimizing treatment for patients receiv

193 nals regulating MBC development and function are essential to overcome current challenges hindering s

194 -solution NRs through thermal post-treatment are essential to overcome the obstacle of morphology/str

195 e disruption of CD133 signal to PI3K pathway is essential to overcome Melanoma resistance to fotemust

196 Although this process of myotube guidance is essential to pattern the musculoskeletal system, the

197 Hence, it is essential to perform detailed analyses prior to sketc

198 multidisciplinary biological approaches has been essential to pinpointing the origins of amphibian-p

199 -specific regulation of BDNF gene expression is essential to precisely adjust BDNF levels that are dy

200 nsfer as well as quality changes during IMCD is essential to predict accurately drying processes and

201 le and rapid access to testing for employees is essential to preserve the health, safety, and availab

202 tionally repressive heterochromatin, LSH may be essential to prevent deleterious meiotic recombinatio

203 g on cardiac cells during heart failure (HF) is essential to prevent adverse ventricular remodeling a

204 ntraerythrocytic replication of the parasite is essential to prevent clinical malaria.

205 ss and rapid identification of this pathogen is essential to prevent disease.

206 sal fungus Candida albicans IL-17R signaling is essential to prevent OPC in mice and humans, but the

207 Proper tubular regeneration is essential to prevent progression to chronic kidney di

208 igns of this entity, because early diagnosis is essential to prevent progression to life-threatening

209 STATEMENT The nucleus accumbens core (NAcC) is essential to process information carried by reward-pr

210 S-CoV-2 and to develop therapeutic tools, it is essential to profile the full repertoire of its expre

211 gh IL-23 is dispensable for GC formation, it is essential to promote a population of Tfh-IL-17 cells.

212 cell death and inflammatory immune responses is essential to promote protection against coronavirus i

213 Accurate sepsis surveillance is essential to properly interpreting the impact of qual

214 ocess involved, multidisciplinary evaluation is essential to provide and coordinate the best treatmen

215 on tasks requiring high control accuracy, it is essential to provide teleoperators with information o

216 patients' life, leading to disability which is essential to quantify as part of Patient-Reported Out

217 found that biquadratic exchange interactions are essential to quantitatively describe the magnetism o

218 dings that are characteristic of each entity are essential to reach the correct diagnosis.

219 rug resistance, and viral load assays, which are essential to reaching the UNAIDS 90:90:90 targets.

220 phology and functionality for bioconjugation are essential to realise the concept of all-polymer-base

221 of the full range of socio-technical issues is essential to realize the full potential of sensor net

222 Therefore, it is essential to recognize the disease process at the ear

223 d heterohexameric ATPase that is believed to be essential to recruit and load MCM2-7, the minichromos

224 igh uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV

225 ondria in doxorubicin-induced cardiomyopathy is essential to reduce the barriers that so dramatically

226 nd colonization resistance, and risk factors is essential to reduce the toll of these infections.

227 Importantly, SARS-CoV-2 vaccines will be essential to reducing morbidity and mortality if the

228 le competitive advantage to resting ISCs and is essential to restore the ISC compartment.

229 uring genetic measures and brain correlates, are essential to reveal how cognition emerges from these

230 d by ribosomal protein L11, and this complex is essential to ribosome function.

231 lant consumers, particularly animals, sodium is essential to running costly Na-K ATPases.

232 rn of the P2* isoquinoline heterocycle of 21 was essential to securing the targeted potency, pharmaco

233 ms and currently available treatment options are essential to selecting optimal second line therapy f

234 Resolving the discrepancies we identify will be essential to settle the translational utility of C9-5

235 Strikingly, Mex67 is essential to stabilize newly transcribed RNA before X

236 Rapid identification of virulent pathogens is essential to strengthen the therapeutic strategy of a

237 Controlled perturbation of protein activity is essential to study protein function in cells and livi

238 th records or administrative claims records, is essential to successful recruitment in large-scale pr

239 ty evaluations of nanotechnology-based drugs are essential to support initiation of clinical trials.

240 roblasts; (4) demonstrates IGF-1R activation is essential to support TGFbeta-driven profibrotic myofi

241 owledge of varied imaging appearances of HAE is essential to suspect the condition and to make an app

242 Anthropogenic nitrogen fixation is essential to sustain a global population of 7.7 billi

243 sity of natural channels(1,2), both of which are essential to synthetically achieve proton transport

244 Understanding this heterogeneity is essential to tailoring management to individual patie

245 yndrome coronavirus 2 (SARS-CoV-2) tests and are essential to the broader response to coronavirus inf

246 lecular fragments together (cross-couplings) are essential to the discovery and manufacture of pharma

247 rapid and accurate microbiology diagnostics are essential to the practice of transplant clinicians,

248 lycosylated proteins and glycosylation sites are essential to the prevention, diagnosis, and therapy

249 by the meibomian glands (MGs) of the eyelids are essential to the protection of the eye's surface.

250 Divalent metal cations are essential to the structure and function of the ribos

251 s, to catalyze side reactions is believed to be essential to the evolution of novel biochemical activ

252 dide ICH(2) SiMe(3) during the Mn-I exchange being essential to the aryl homocoupling process, wherei

253 of equivocation suggests clinical judgement is essential to the confirmation of CDI.

254 iders the specific features of circular RNA, is essential to the development of systematic annotation

255 nges, such as cold or excess calorie intake, is essential to the fitness and survival of mammals.

256 food supply, and uncontaminated water bodies is essential to the good health of millions of urban res

257 dinitrogen (N(2)), and hydrazine (N(2)H(4)) is essential to the lifestyles of diverse organisms.

258 While the apical complex is essential to the parasitic lifestyle, little is known

259 lasso determines the amount of shrinkage and is essential to the performance of variable selection.

260 e intrinsic variability of radiomic features is essential to the proper interpretation of changes in

261 This region is essential to the torsional properties of the molecule

262 along with its regulatory protein dynactin, is essential to the transport of organelles within cells

263 l to find, in an unbiased manner, genes that are essential to these processes.

264 Contour perception is essential to this process and can occur despite break

265 ntifying progress towards achieving the SDGs is essential to track global efforts towards sustainable

266 Protein glycosylation is essential to trafficking and immune functions of huma

267 Expert-labeled data are essential to train phenotyping algorithms for cohort

268 In all living organisms, it is essential to transmit genetic information faithfully

269 derstanding the structure of gamma-Al(2)O(3) is essential to tuning its physicochemical property, whi

270 defined linear and branched polysaccharides are essential to understand carbohydrate structure and f

271 arisons in combination with long time series are essential to understand the effects of environmental

272 y to identify these OCT changes reproducibly is essential to understand better the natural history of

273 tion between spatiality and dynamic response is essential to understand biological output, its robust

274 a may contribute to therapeutic failures, it is essential to understand how insulin and insulin recep

275 It is essential to understand how the topological nature of

276 viability of their hosts, and therefore, it is essential to understand the biogenesis of this class

277 duit diameter is central for conductance, it is essential to understand the cause of this remarkably

278 To achieve better removal of Cr (VI), it is essential to understand the chemical reactions that l

279 cross a range of temporal and spatial scales is essential to understand the mechanisms of plant growt

280 Knowledge of the chemical form(s) of U(IV) is essential to understand the release mechanism, yet th

281 during inflorescence and floral development is essential to understand their role in the evolutionar

282 To dissect the roles of metabolites, it is essential to understand their signaling pathways and

283 of metabolic activities of individual cells are essential to understanding questions in diverse fiel

284 functional aspects of these protein motions are essential to understanding the interplay between the

285 ny-body physics, electron-phonon interaction is essential to understanding and manipulating charge an

286 Understanding the impact of rare variants is essential to understanding human health.

287 lationship between pain and task performance is essential to understanding the disruptive nature of p

288 y that modifies the structure of DNA and RNA is essential to understanding the role of epigenetic mod

289 nalysis of organelles and protein assemblies is essential to understanding the role of individual com

290 dentifying and interpreting pleiotropic loci is essential to understanding the shared etiology among

291 ces between specific points in nucleic acids is essential to understanding their behaviour at the mol

292 ontributing to variation in 'biological age' is essential to understanding variation in susceptibilit

293 g of particle motion in microfluidic devices is essential to unlock additional technologies for shape

294 ur results revealed that multiple indicators are essential to unravel the degree of SOC decomposition

295 uggests that different types of interneurons are essential to unravel the mechanisms underlying place

296 haracterizing the interconnectivity of genes is essential to unravel the underlying biological networ

297 The identification of sensitive biomarkers is essential to validate therapeutics for Huntington dis

298 fibers with several beneficial features that are essential to various applications ranging from envir

299 The spatial configuration of chromosomes is essential to various cellular processes, notably gene

300 s demonstrate that keratinocyte-produced SCF is essential to wound closure due to the increased recru