ライフサイエンスコーパス: be established as

1 as administered to 32 patients, and the RP2D was established as 0.7 mg/m(2) infused over 10 minutes.

2 The limits of quantification (LOQ) were established as 10 or 25 ug/kg, depending on the mat

3 The maximum tolerated dose of ixazomib was established as 2.97 mg/m(2) and the recommended phas

4 The MTD was established as 225 mg twice per day orally over 2.5

5 tic-pharmacodynamic data, the avadomide RP2D was established as 3.0 mg as formulated capsules on a 5-

6 s well tolerated; the maximum tolerated dose was established as 300 mg/day when two of three patients

7 e diagnostic ranges for sulfate OH stretches are established as 3580-3600 cm(-1) and can thus be dist

8 The MTD was established as 36 mg/m(2).

9 The absolute stereochemistry of 1 was established as 3S,3'S by a combination of X-ray diff

10 on, the absolute configuration of compound 5 was established as 3S,4R,7S,8S,11R,12S,13R by applicatio

11 abepilone as a 1-hour infusion every 3 weeks was established as 50 mg/m2.

12 Self-sustained Ni(I/III) cycles are established as a potentially general paradigm in pho

13 clophosphamide, and rituximab (FCR) together are established as a standard first-line treatment of yo

14 s conditions, requires further assessment to be established as a biomarker of xenoestrogen exposure.

15 and unfavorable prognostic marker that could be established as a new grading parameter for LSCC.

16 the future, the here described protease may be established as a powerful tool for production strateg

17 measure of visual field loss, but has yet to be established as a reliable diagnostic tool.

18 rated that SVIA has the high potentiality to be established as a semi-quantitative routine on-site sc

19 vatives and N-terminal cysteine residues has been established as a biocompatible reaction for site-se

20 However, economic demand has not yet been established as a biomarker of addiction-like behavi

21 DNA damage has long been established as a cause of cancer development throug

22 owever, SHANK3 overexpression per se has not been established as a cause of human disorders because 2

23 virus (ZIKV) infection in pregnant women has been established as a cause of microcephaly in newborns.

24 inases (PIKKs) target of rapamycin (TOR) has been established as a central hub for integrating extern

25 main and mucin domain (TIM)-3 has previously been established as a central regulator of Th1 responses

26 sed allylic functionalization reactions have been established as a central synthetic transformation t

27 noprotected chiral amino acids have recently been established as a class of ligand scaffolds for effe

28 he other class XIV myosin in Plasmodium, has been established as a component of the glideosome comple

29 an amine, commonly called A(3)-coupling, has been established as a convenient and general approach to

30 The PI3K/PTEN/Akt pathway has been established as a core signaling pathway that is cru

31 Iron has long been established as a critical mediator of T cell develo

32 hough vascular endothelial growth factor has been established as a critical regulator of tumor angiog

33 ases to rectify MTs is prevalent, it has not been established as a design methodology in conjunction

34 Venetoclax plus obinutuzumab has been established as a fixed-duration treatment regimen f

35 retinal pigment epithelium (RPE), have long been established as a hallmark early feature of nonneova

36 ability to maintain protein homeostasis, has been established as a hallmark of nematode aging.

37 ropropyl)-1-propylxanthine ((18)F-CPFPX) has been established as a highly selective and affine PET li

38 Estrogen receptor status has been established as a key factor in breast cancer progno

39 tide (CGRP) from the trigeminal ganglion has been established as a key player in the pathogenesis of

40 The miR-200 family has been established as a key regulator of epithelial phenot

41 endent DEX(H/D) family of RNA helicases, has been established as a major cellular quadruplex resolvas

42 nt functioning in terrestrial biomes and has been established as a major contributor in recent drough

43 inositol 4,5-bisphosphate (PIP(2)), has long been established as a major contributor to intracellular

44 to the proteasome for degradation, which has been established as a major mechanism driving neural cir

45 past few years, early life stress (ELS) has been established as a major risk factor for major depres

46 uencing-based virus diagnostics have not yet been established as a mandatory approach for ensuring co

47 ns such as lungs, liver, and kidney has long been established as a marker of progressive fibrosis.

48 CD45, identified as CD45.1 and CD45.2, have been established as a marker system to track haematopoie

49 RNA-primed DNA synthesis has been established as a mechanism for replicating the circ

50 However, NAD(P)H FLIM has not been established as a metabolic proxy in bacteria.

51 e span (RLS) of Saccharomyces cerevisiae has been established as a model for the genetic regulation o

52 Drosophila melanogaster has been established as a model organism for investigating t

53 Despite these limitations, MUC16 has been established as a molecule of significant applicatio

54 c process is of high importance since it has been established as a most promising target for the deve

55 catalyst and a carboxylic acid has recently been established as a new activation mode in Bronsted ac

56 redox center in Li-rich rock salt oxides has been established as a new paradigm in the design of cath

57 ategy for fragment-based de novo design, has been established as a new type of fragment-based inhibit

58 of CD19 antigen on leukemic cells, which has been established as a novel mechanism to escape CD19-spe

59 Mutations causing a gating pore current have been established as a pathomechanism for hypokalaemic pe

60 ripheral benzodiazepine receptor ligand, has been established as a potent hCAR deactivator in immorta

61 Mass spectrometry has been established as a powerful and versatile technique f

62 f 25-hydroxyvitamin D [25(OH)D] has recently been established as a predictor of treatment response.

63 cGAS/STING DNA sensing complex has recently been established as a predominant pathogen recognition r

64 The fruit fly Drosophila melanogaster has been established as a premier experimental model system

65 No gold standard has been established as a primary endpoint in trials of init

66 TFAP2C has been established as a prognostic factor in human breast

67 bolic profiling of cancer cells has recently been established as a promising tool for the development

68 Viscoelastic coagulation tests have been established as a rapid and reliable method to asses

69 Single-cell RNA-seq has been established as a reliable and accessible technique

70 Although the zebrafish has been established as a research tool over the past two to

71 sk human papilloma-virus (HPV) infection has been established as a risk factor for developing head an

72 ulates dendrite and spine morphogenesis, has been established as a risk gene for ASD.

73 NPAS3 has been established as a robust genetic risk factor in majo

74 However, no method has, so far, been established as a routine method for the analysis of

75 f a unique C,N-chelated dilithio dianion has been established as a solvated monomeric species using a

76 termediate hematopoietic progenitors has not been established as a source of HIV-associated hematopoi

77 ecurrent deletions at the 22q11.2 locus have been established as a strong genetic risk factor for the

78 Although mitochondria have been established as a suitable eukaryotic environment fo

79 ogression-free survival (PFS) has previously been established as a surrogate for overall survival (OS

80 However, only COX17 has been established as a target of Puf3p-mediated deadenyla

81 uced acoustic desorption (LIAD) has recently been established as a tool for analytical chemistry.

82 Photorhabdus bacteria have recently been established as a tool for investigating immune reco

83 n MoP at low temperature, which has recently been established as a triple point fermion material.

84 In addition, (18)F has been established as a useful positron emitting isotope f

85 When used appropriately, CCTA has been established as a valid noninvasive imaging alternat

86 Thus, PMCA has been established as a valuable analytical tool in prion

87 Ferrets have been established as a valuable in vivo model of influenz

88 imensional infrared spectroscopy (2D IR) has been established as a versatile tool that can uniquely p

89 1) Periodontal regeneration has been established as a viable therapeutic option for the

90 biochemically recurrent prostate cancer has been established as a widely accepted clinical indicatio

91 persistent postweaning social isolation has been established as a widely used animal model with tran

92 bly into a range of mesophase structures has been established as a widespread phenomenon.

93 w discoveries have led to prevention science being established as a discipline designed to mitigate t

94 Despite SHS being established as a risk factor for lung cancer devel

95 Thus, UBP1 is established as a component of dynamically assembled c

96 t points (CPs) made by each motor neuron and is established as a consequence of pruning that occurs d

97 papillomavirus infections, the viral genome is established as a double-stranded DNA episome.

98 Intraduplex DNA-mediated reduction is established as a general mechanism for the reduction

99 While DLK is established as a key regulator of axonal responses to

100 mofidied carbon nanofiber (CNF) architecture is established as a Li host via a facile fabrication met

101 all, the transition metal-semiquinoid system is established as a particularly promising scaffold for

102 beta1 integrin (encoded by Itgb1) is established as a regulator of angiogenesis based upon

103 Hymeglusin (1233A, F244, L-659-699) is established as a specific beta-lactone inhibitor of e

104 Haemopoietic cell transplantation is established as a standard treatment approach for peop

105 In this context, SL is established as a versatile approach for the controlle

106 her, carbonylation of disubstituted epoxides is established as a viable and economical entry into syn

107 ne transmission was confirmed and Zika virus was established as a cause of severe neurological compli

108 udies to Evaluate Resistance (PASER) network was established as a collaborative partnership of clinic

109 In 2014, MenAfriNet was established as a consortium of partners supporting s

110 Using luciferase assay and ChIP, KLF6 was established as a direct transcriptional activator of

111 otein required for colonizing nematode hosts was established as a new class of proteases.

112 40 mg/m2 for 6 weeks in combination with RT was established as a new standard for the treatment of l

113 This IEC-SEC strategy was established as a platform approach for direct titer

114 Newborn screening (NBS) was established as a public health program in the 1960s

115 The SRA was established as a public repository for the next-gene

116 Near infrared spectroscopy was established as a rapid and effective tool to obtain

117 2 was established as a single electron transfer reagent by

118 Immunization Systems Management Group (IMG) was established as a time-limited entity, responsible fo

119 It was established as a valuable resource for counter scree

120 Near-modern ecosystems were established as a result of rapid ecological adaptat

121 Whereas the vast majority of body plans were established as a result of the CE, taxonomic increa

122 The recommended phase II dose was established as abexinostat 45 mg/m(2) twice a day ad

123 A new record coordination number is established, as AcHe17(3+) , ThHe17(4+) , and PaHe17(

124 noses of neovascular glaucoma, CRVO and CRAO were established as affirmed with fluorescein angiograph

125 etes, dyslipidemia, and hyperhomocysteinemia were established as aggravating factors for the aortic c

126 Alkynyl-lambda(3)-iodanes have been established as alkynyl cation equivalents for the a

127 crosatellites-a class of short tandem repeat-are established as an important source of genetic variat

128 rapeutic enzyme is L-asparaginase, which has been established as an antileukemic protein drug for mor

129 n bulk thermoelectric materials has recently been established as an effective approach to scatter pho

130 Cardiac rehabilitation has been established as an effective treatment for patients

131 f plasma-derived C1-inhibitor (pdC1-INH) has been established as an effective treatment.

132 No medication has been established as an efficacious treatment for cocaine

133 ing (OC) through o-quinone intermediates has been established as an efficient and site-selective way

134 pper-catalyzed arylation of nucleophiles has been established as an efficient methodology for the for

135 arylation polymerization (DHAP) has recently been established as an environmentally benign method for

136 proteins named the evening complex (EC) has been established as an essential component of the circad

137 NK cells have been established as an important effector of innate immu

138 riments, the p38alpha MAP kinase isoform has been established as an important regulator of immune and

139 Cerebral microbleeds (CMBs) have been established as an independent predictor of cerebral

140 ed fibroblast specific protein 1 (FSP1) have been established as an inducer of metastasis and indicat

141 Fibroblast activation protein (FAP) has been established as an inducible and mesenchymal cell-sp

142 ninvolved serum free light chains (dFLC) has been established as an invaluable hematologic parameter

143 e degree to which the stimulus dimension has been established as an unreliable predictor of reinforce

144 transbronchial needle aspiration (EBUS-TBNA) is established as an alternative to mediastinoscopy in p

145 m Escherichia coli, and the function of CapP is established as an ATP-dependent capuramycin phosphotr

146 e free fatty acid receptor 1 (FFA1 or GPR40) is established as an interesting potential target for tr

147 Here, pachymetry was established as an additional tool and used to conduc

148 ods The multicenter ferumoxytol MRI registry was established as an open-label nonrandomized surveilla

149 hibian Xenopus laevis and Frog Virus 3 (FV3) were established as an experimental platform for investi

150 ogens, as well as several proteins that have been established as antigens.

151 Although no genes are established as associated with AD + P, the first gen

152 These seeking-circuits are established as associations are formed between drug-

153 Intracellular JH receptors have recently been established as basic helix-loop-helix transcription

154 of a two-partner secretion system, and HrpA is established as being important to adherence and intra

155 HEL/CLAVATA (WUS/CLV) negative feedback loop was established as being essential for regulating the si

156 (PAD) without intermittent claudication have been established as beneficial.

157 complex patterning in which individual faces are established as biochemically distinct domains by end

158 Tumours from 12 patients were established as BRCA wild-type, but could not be cla

159 w this epigenetic memory of Foxp3 expression is established, as CNS2 is thought to be demethylated in

160 mal growth factor receptor (EGFR/ErbB1) have been established as collaborators in cellular signaling

161 2,5-bis(tert-butyldimethylsilyloxy)pyrroles are established as competent dienes for the synthesis of

162 rotein post-translational modifications have been established as contributors but still cannot comple

163 ytometry (FC) and FC-based cell sorting have been established as critical tools in modern cell and de

164 inant group of membrane fatty acids and have been established as crucial determinants in resistance a

165 mapping and sentinel lymph node biopsy have been established as definitive procedures for the stagin

166 (A = Ca, Sr, Ba, or rare earth element) have been established as Dirac materials.

167 actor beta [TGFbeta]-binding protein 4) have been established as DMD modifiers.

168 ndary for fossil hydrocarbons has previously been established as double-bond equivalents (i.e., DBE =

169 sruptive mutations in coding genes that have been established as 'drivers' of cancer in large somatic

170 nhancer chromatin marks H3K4me1 and H3K27ac, are established as early as blastula stage and that Smad

171 A discrete apical domain is established as early as the first cell division and b

172 This bimodal pattern was established as early as the Middle Jurassic and was

173 Viruses have been established as ecologically important infectious ag

174 and well-tolerated BH3-mimetic drug that has been established as effective.

175 Cognitive behavior therapy (CBT) has been established as efficacious for obsessive-compulsive

176 uman keratinocytes, mutant E2(Y131A) genomes were established as episomes, but at a markedly lower co

177 CnnC is established as essential for functional centrosomes,

178 Carbon quantum dots (CQDs) are established as excellent photosensitizers in combina

179 In the first case, indole acetic acid esters were established as excellent partner nucleophiles for e

180 s), and photorefractive keratectomy have now been established as fairly safe procedures that produce

181 standard for early antibiotic administration was established as follows: (1) when the primary endpoin

182 Two subcohorts were established as follows: (1) users of a LABA plus lo

183 Results The TTNtv were established as founder mutations and traced to 18th

184 m disorder (ASD) risk, but few variants have been established as functional.

185 eless, it is unclear how this directionality is established as Glass bottom boat (Gbb), the known BMP

186 zed to the inner mitochondrial membrane have been established as GSH transporters in liver and kidney

187 Involvement of HS1 in T cell regulation has been established, as HS1 is required for the formation o

188 To date, many fusion genes (FGs) have been established as important biomarkers and therapeutic

189 Scaffold proteins have been established as important mediators of signal transd

190 )--deletions and duplications--have recently been established as important risk factors for both gene

191 the same time trend for new steady states to be established as in Michel and Phillips' experiments.

192 Diabetes and obesity have been established as independent risk factors for the dev

193 e-dependent multiphase character of the film is established, as is the respective impact of these two

194 nt of proline (Pro) hydroxylation has yet to be established, as it is largely unexplored in bacteria.

195 PSD-95/Dlg proteins have been established as key components of the postsynapse.

196 Chemical modifications of RNAs have long been established as key modulators of nonprotein-coding

197 MicroRNAs (miRNAs) recently have been established as key regulators of transcriptome repr

198 MicroRNAs (miRNAs) have been established as key regulators of various biological

199 PURPOSE OF REVIEW: Cognitive abilities are established as major deficits in those with schizoph

200 Marine tetrapods quickly diversified and were established as marine top predators after the end-P

201 s, and the doses used in cohorts B, E, and H were established as maximum tolerated doses and patients

202 LD) and its product, phosphatidic acid, have been established as mediators of mitogenic activation of

203 tures derived from retinoblastoma tumors can be established as non-adherent tumorspheres when grown i

204 Raman microspectroscopy and Raman imaging were established as nondestructive marker-independent te

205 ed responses when conditioned stimuli had to be established as nonpredictive for an outcome, whereas

206 of the dissipation of a single molecule has been established as not exceeding 310(-7)kg/s.

207 THz spectroscopy of aqueous solutions has been established as of recently to be a valuable and com

208 adation mechanisms at the microscale has not been established, as of yet.

209 gnetic resonance (NMR) spectroscopy has long been established as offering unique atomic-scale and ele

210 pruce (Picea glauca), a gymnosperm tree, has been established as one of the models for conifer genomi

211 ilable, the diarylprolinol silyl ethers have been established as one of the most frequently used in a

212 etting to a more water-wetting condition has been established as one of the most notable effects of l

213 Dissolved organic matter is established as one of the most relevant photosensitiz

214 ble the continuous selection of SCNAs, which are established as ordered events that often occur in pa

215 ensing and afferent endocrine signaling have been established as parallel systems communicating metab

216 cytocidal effective concentration (CEC(50))) was established, as part of the lead selection process.

217 The selected optimized parameters were established as PC/EF molar ratio 1/15, enzyme load

218 ected with HPV, only 10 to 20% of infections are established as persistent infections.

219 Bisacylphosphane oxides (BAPOs) are established as photoinitiators for industrial applic

220 Glycosylation has been established as playing a pivotal role in various as

221 Dopaminergic signalling is established as playing an important role in novelty r

222 "Hypervalent" iodine(III) derivatives have been established as powerful reagents in organic transfo

223 imetic divalent ligands, which have recently been established as powerful tools for acute perturbatio

224 ed responses when conditioned stimuli had to be established as predictive.

225 Primary culture of MRECs was established as previously described and was used to

226 Although enzymatic techniques have been established as promising tools in biofuel productio

227 Prostaglandin D2 has been established as promoting the resolution of inflamma

228 (CL) and Cell Line Ontology (CLO) have long been established as reference ontologies in the OBO fram

229 primary causes of death in the 1109 infants were established as respiratory distress syndrome (502 [

230 The mechanism of action was established as Rg3 targeting of FoxO3a, which inhibi

231 s where infection-prevention bundles of care are established as routine practice.

232 Such innovative methodologies need to be established as routine testing procedures to detect a

233 ivated, photosensitizer-based therapies have been established as safe modalities of tumour ablation f

234 methods to investigate MRD because they have been established as sensitive and specific enough to all

235 Finally, the relevance of SF2 function was established, as SF2 strongly correlated with cyclin

236 NDINGS: Although hypomethylating agents have been established as standard of therapy for MDS in the n

237 Preoperative chemoradiotherapy (CRT) has been established as standard treatment for locally advan

238 ts (rs1805007, rs1805008 and rs1805009) have been established as strongly correlated with red hair.

239 lthough promoter-associated CpG islands have been established as targets of DNA methylation changes i

240 d clearance of different Abeta isoforms have been established as targets of proposed disease-modifyin

241 A recommendation that the 4 materials be established as the first World Health Organization In

242 Inheritable genetic mutations have now been established as the cause of mitral valve insufficie

243 of this species to the west of Eurasia have been established as the cause of the unjustified allocat

244 These drugs have been established as the cornerstone of any therapeutic s

245 Halonium ions have long been established as the critical intermediates in haloge

246 ve behavior therapy for insomnia (CBT-I) has been established as the first-line recommendation for th

247 lesions by fractional flow reserve (FFR) has been established as the gold standard.

248 Silicon has long been established as the material of choice for the micro

249 pediatric) or 20 mg/m(2)/d (adolescent) have been established as the MTD/RPIID.

250 Glycan arrays have been established as the premier technical platform for a

251 apillomaviruses (HPVs), including HPV58, has been established as the primary cause of cervical cancer

252 Mammography has been established as the primary imaging screening method

253 Vertical social transmission has been established as the primary transmission mechanism o

254 Fas has already been established as the regulator of inflammation in RA,

255 These genetic variants have been established as the source of beta-casomorphins (BCM

256 luorescence In Situ Hybridization (FISH) has been established as the standard method for this purpose

257 bleomycin, vinblastine, and dacarbazine) has been established as the standard of care in patients wit

258 Although antibiotic therapy has been established as the standard of care in patients wit

259 rative portal vein embolization has thus far been established as the standard procedure for achieving

260 s sense, biosensors (7 of the 33 papers) are being established as the most promising alternative over

261 This nuclear signaling is established as the canonical or type 1 pathway for TH

262 bunit, the telomerase reverse transcriptase, is established as the dominant mechanism conferring the

263 e SET-induced biaryl cross-coupling reaction is established as the first example of a Grignard S(RN)1

264 Although the oligodendrocyte progenitor is established as the major source of remyelinating cell

265 est (in this case, phosphoenolpyruvate, PEP) is established as the objective function and time-varyin

266 c-VEDA was established as the first and largest India-based mul

267 y of 78% and a specificity of 70%, 3.51 mg/L was established as the lower margin for the therapeutic

268 otein-stable isotope probing, the RuMP cycle was established as the main carbon assimilation pathway,

269 300 mg/day was established as the maximum tolerated dose.

270 In the study, a sample mass of 400mg was established as the minimum mass required for analysi

271 Since 1+ or less was established as the most common MRSA carrier state, b

272 and, through physical DNA interactions, BNC2 was established as the most likely target gene.

273 ents were dose limiting, and 60 mug/m(2)/day was established as the MTD.

274 g thiazole rings and trifluoromethyl groups, was established as the optimal lead compound because of

275 ted dose was not reached; 800 mg twice daily was established as the recommended phase 2 dose and was

276 36309 at 500 mg twice daily (n=6); this dose was established as the recommended phase 2 dose.

277 n Monday and Thursday or Tuesday and Friday) was established as the recommended phase 2 dose.

278 mab vedotin intravenously once every 3 weeks was established as the recommended phase 2 dose.

279 ated, 200 mg twice a day); 150 mg once daily was established as the RP2D.

280 of these results, the segmented CT AC method was established as the silver standard for the segmented

281 The optimum condition for Cd(II) adsorption was established as the temperature of 318 K, initial Cd(

282 eans of a concentration effect curve, 7 mg/L was established as the upper margin.

283 Normal ranges of interocular differences were established as the 2.5th and the 97.5th percentiles

284 3.1% and 1mg/ml for PC and F3, respectively, were established as the best entrapment protocol by resp

285 uvaol, and campestanol/Delta(7)-avenasterol were established as the indicators of variety of fresh o

286 e (6beta-hydroxyetiocholanolone) glucuronide were established as the structures for these metabolites

287 of the presented compounds in EC/EL devices is established, as they are applied as cross-linked elec

288 The MTD was established as topotecan 0.6 mg/m(2)/d and ABT-888 1

289 by a trimeric (Me-DuPhos)3Ni3(OAc)5I complex was established as turnover limiting followed by rapid c

290 nt of N-Acetylneuraminic acid (NANA) and EGF are established as unique indicators for the grades of E

291 Algae have also been established as unique biofactories for industrial,

292 xp2(+) neurons and ChAT(+) neurons that have been established as unique neuron types, there is little

293 In the last two decades, hydrogen bonds have been established as useful interactions to control the s

294 The maximum tolerated dose was established as vemurafenib 960 mg twice a day in com

295 2,5-Bis(tert-butyldimethylsilyloxy)furans are established as vicinal bisketene equivalents for app

296 ement deposition on Streptococcus pneumoniae are established as virulence features for invasive disea

297 nding of how specific developmental lineages are established as well as how cell fates can be manipul

298 l provide insight into how OB microcircuitry is established as well as adult neurogenesis.

299 the ways in which transcriptional direction is established as well as its functional implications.

300 ingerprints for distinguishing these species were established, as well as a key for identification ba