ライフサイエンスコーパス: be exacerbated in

1 ested the hypotheses that EAE severity would be exacerbated in 12/15-LO-deficient mice and attenuated

2 excitatory and inhibitory neurotransmitters are exacerbated in 22q11DS carriers with psychotic sympt

3 elevated levels of Mn(II), and these effects are exacerbated in a mneP mneS double mutant.

4 of a 12 h shift pattern and negative effects are exacerbated in a stressful and dynamic acute mental

5 dent cardiac mast cells, a process likely to be exacerbated in a chronic inflammatory background.

6 This reduction requires (p)ppGpp and is exacerbated in a gppA mutant with increased pppGpp le

7 presumed to transport Ca2+ into the vacuole, is exacerbated in a hum1 mutant strain background.

8 Interestingly, this phenotype is exacerbated in a p53(+/-) background and the tumorige

9 ology and accelerated clinical course, which is exacerbated in a significant proportion of cases by t

10 This activation is exacerbated in a strain lacking the gene encoding Co,

11 This doubt was exacerbated in a few cases as families were uninform

12 n the medial prefrontal cortex (mPFC), which was exacerbated in a model of 16p11.2 duplication, a rep

13 and ESCRT-mediated lysosomal repair defects, are exacerbated in AD tNeurons and linked to inflammator

14 l retinal neovascularization during ischemia was exacerbated in adiponectin-knockout (APN-KO) mice co

15 uced damage to hippocampal pyramidal neurons was exacerbated in adult gelsolin-deficient mice.

16 Histopathology in injured spinal cord tissue was exacerbated in aged SCI mice.

17 These effects were exacerbated in aged AD mice with marked Abeta plaqu

18 ar anticoagulants, a process that appears to be exacerbated in aging, a well-known risk factor for th

19 caspase-3 activation in normal neurons that is exacerbated in aging, stress, and neurodegenerative c

20 This was exacerbated in aHUS by genetic abnormalities associa

21 In the absence of Rpl22, ER stress is exacerbated in alphabeta, but not gammadelta, T cell

22 s, indicated by raised levels of fibrinogen, were exacerbated in Alzheimer's disease and vascular dem

23 ature-dependent failure to accumulate VirB10 is exacerbated in an attachment-deficient mutant strain

24 UPR induction in low zinc is exacerbated in an msc2 mutant.

25 These effects were exacerbated in Ang II-treated NPR-C(-/-) mice.

26 ndings suggest that malaria transmission may be exacerbated in areas of high antibiotic usage, and th

27 s reduction in LLIN effectiveness appears to be exacerbated in areas where mosquito populations are r

28 This is exacerbated in areas with relatively high exposure to

29 of wound healing in chronic schistosomiasis, was exacerbated in Batf3(-/-) mice infected with Schisto

30 This defect was exacerbated in Boc/Gas1 double mutants and could be

31 In sharp contrast, spontaneous diabetes is exacerbated in both B7-1/B7-2-deficient and CD28-defi

32 -17-dependent pathology in Zc3h12a(+/-) mice was exacerbated in both EAE and pulmonary inflammation.

33 the second week of infection, this swelling was exacerbated in C3H IFN-gamma degrees mice.

34 Hyperglycolysis was exacerbated in CA1 and CA3 hippocampus after TBI in

35 fect on EAE, experimental autoimmune uveitis is exacerbated in CD4-IRF8KO mice and disease enhancemen

36 oportions of submucosal dopaminergic neurons is exacerbated in Cdnf (-/-) animals.

37 The effect of L-dopa on PP2A and p-Tau was exacerbated in cells exposed to folate deficiency.

38 visible in untreated cells, but the defects were exacerbated in cells forced to filament by inactiva

39 This process is exacerbated in chronic liver disease, leading to fibr

40 These challenges are exacerbated in coastal communities, where population

41 inflammation associated with HIV-1 infection is exacerbated in cocaine-abusing, HIV+ individuals.

42 Notably, this blockage is exacerbated in Cockayne Syndrome and xeroderma pigmen

43 Loss of RPE in yap mutants is exacerbated in combination with taz (wwtr1) mutant al

44 n KO for 2 weeks, hepatic and biliary injury were exacerbated in comparison to KO given placebo, as s

45 This cone defect was exacerbated in conditions of low levels of 11-cis-re

46 This risk can be exacerbated in countries using inactivated polio vacc

47 e, the aneuploidy of tumor endothelial cells is exacerbated in culture suggesting that these cells ar

48 s relative to WT controls, whereas arthritis was exacerbated in DEL-1-deficient mice.

49 tion of reactive oxygen species (ROS), which is exacerbated in diabetes and may affect placental deve

50 echanisms associated with these neuropathies were exacerbated in Dj-1-deficient mice but were signifi

51 eneration, sarcolemma integrity and fibrosis were exacerbated in DKO mice and were remarkably similar

52 Injury signatures were exacerbated in DMPA users who also practiced vagina

53 the super elongation complex inhibitor KL-2 are exacerbated in DOT1L knockout cells, but not in cata

54 This response was exacerbated in egr-1(-/-) mice.

55 rythrocytes with VC induced hemolysis, which was exacerbated in erythrocytes from glucose-6-phosphate

56 LKC was exacerbated in euthymic mice depleted of CD4(+)CD25(

57 s skin infections and systemic dissemination were exacerbated in F12-/- mice.

58 n social approach behavior, a phenotype that is exacerbated in female Pten(+/-); Slc6a4(+/-) mice.

59 Likewise, renal IRI was exacerbated in female estrogen receptor alpha-KO mic

60 These effects were exacerbated in female mice, contributing to the gro

61 defects in JAK/STAT or EGF-R signalling and were exacerbated in flies heterozygous for either the d-

62 n of Foxc2 induced valve degeneration, which is exacerbated in Foxc1; Foxc2 mutants.

63 Mn-LRRK2 activated RAB10 which was exacerbated in G2019S.

64 d dopaminergic dysfunction in WT mice, which were exacerbated in G2019S mice.

65 This problem is exacerbated in genes with multiple cis-acting eQTL, w

66 diet-induced obesity and insulin resistance are exacerbated in GFRAL-deficient mice, suggesting a ho

67 ractile dysfunction, and cardiomyocyte death were exacerbated in global MCU knockout mice.

68 t times of peak behavioural sensitivity that is exacerbated in gp120+ddC as compared to either treatm

69 ux through SM synthase also increases, which is exacerbated in HepG2-SMS1 cells.

70 vels increased progressively with age, which was exacerbated in Hfe-deficient mice.

71 Each of these changes was exacerbated in HIV-positive cases compared with HIV-

72 of ESRRG causes marked Rb cell death, which is exacerbated in hypoxia.

73 gh levels of IFN-gamma are secreted, disease is exacerbated in IFN-gamma or IFN-gamma receptor-defici

74 N-gamma are secreted in CIA and EAE, disease is exacerbated in IFN-gamma- or IFN-gamma receptor-defic

75 induced macrophage activation syndrome (MAS) is exacerbated in IL-18BP KO mice.

76 oduction of IFN-gamma and IL-17 from T cells was exacerbated in IL-10 knockout (KO) mice and kinetics

77 shed reports of Th2-mediated protection, CIA was exacerbated in IL-2R beta/IL-4R alpha chimeric recep

78 The severity of PGIA was exacerbated in IL-4Ralpha(-/-) and LysM(cre)IL-4Ralp

79 These effects may be exacerbated in infants because they are able to absor

80 ns in environmental oxygen levels, which can be exacerbated in intensity and duration by anthropogeni

81 s in development and cytokine secretion that are exacerbated in Itk/Txk double-knockout mice.

82 Cajal hyperplasia and mast cell hyperplasia were exacerbated in Kit(V558;T669I/+) mice.

83 model, aberrant mitochondrial bioenergetics was exacerbated in KO myocytes.

84 These stressors interact and can be exacerbated in large-scale agroecosystems.

85 ed in SD-OBx hamsters; LPS-induced anhedonia was exacerbated in LD-OBx hamsters; and photoperiodic di

86 but not self-directed, repetitive behaviors were exacerbated in lesioned mice.

87 These challenges are exacerbated in lithium-ion batteries (LIBs) employin

88 n exposure will increase over onefold, which is exacerbated in low-income countries (4.08-6.49 times

89 Lastly, LPS-induced sepsis is exacerbated in LysMCre-SOCS3(fl/fl) mice and is assoc

90 We showed that HIV-1 infection is exacerbated in macrophages exposed to TB-associated m

91 Interestingly, the mutant's growth defect was exacerbated in macrophages that had been depleted of

92 model, hind paw mechanical hypersensitivity is exacerbated in male and female cKO mice in associatio

93 guingly, late-stage tenotomy-induced atrophy was exacerbated in male mice compared with female mice.

94 This behavior is exacerbated in many of the mutants associated with Ch

95 d neuroendocrine-like states, a process that is exacerbated in metastasis and by chemotherapy and is

96 The cardiomyopathic phenotype was exacerbated in MHC-PPAR mice fed a diet enriched in

97 (DSS)-induced inflammation-associated cancer is exacerbated in mice lacking Axl and Mer.

98 prevented in mice lacking both isoforms but is exacerbated in mice lacking fructokinase A.

99 1)-dependent autoantibody-mediated arthritis is exacerbated in mice lacking IAPs, and is reduced by d

100 This was exacerbated in mice deficient in IFN pathways, leadi

101 Inflammation was exacerbated in mice in which CRHR2 activity was inhi

102 Imiquimod-induced psoriasiform dermatitis was exacerbated in mice with steatohepatitis as compared

103 was reduced, and the autoimmune disease EAE was exacerbated in mice.

104 These phenotypes were exacerbated in mice with only a single copy of p300

105 nits and translation initiation defects that are exacerbated in minimal medium.

106 d NF-kappaB nuclear translocation in WT mice was exacerbated in MIOX-TG mice but absent in MIOX(-/-)

107 In addition, As-induced cytotoxicity was exacerbated in miR-124 knockout cells generated by C

108 of hyperlipidemia, such that atherosclerosis was exacerbated in Mir126(-/-) mice.

109 hepatic injury, steatosis, and inflammation were exacerbated in Mlkl-/- ->wild-type (WT) mice, where

110 PCD was found to be exacerbated in MNs expressing ALS-linked superoxide d

111 NAC-induced G(1) arrest is exacerbated in MnSOD heterozygous fibroblasts.

112 reviously led to a reward, and this tendency was exacerbated in more impulsive individuals.

113 These challenges are exacerbated in multiphoton excitation by the lower e

114 nary responses to repetitive ozone exposures are exacerbated in murine strains that are hyperglycemic

115 This process is exacerbated in mutants with low levels or mutated RPA

116 These effects of acetate were exacerbated in mutants with slowed electron transfe

117 These phenotypes were all found to be exacerbated in myb108 myb24 double mutants, which als

118 Unexpectedly, the inflammatory response was exacerbated in MyD88(-/-) mice, with enhanced neutro

119 iated with normal aging and is postulated to be exacerbated in neurodegenerative disorders.

120 ge-related cognitive decline of normal aging is exacerbated in neurodegenerative diseases including A

121 generating an inward current (IH), which may be exacerbated in NKA-subunit mutations associated with

122 Notably, autoimmune diabetes was exacerbated in NOD.MerTK(KD/KD) versus NOD mice expr

123 role because PGN-triggered eye inflammation was exacerbated in NOD2 KO mice.

124 This problem is exacerbated in noisy environmental datasets and for n

125 Although these problems are exacerbated in numerous neurological and psychiatric

126 These changes were exacerbated in nutrient-starved cells.

127 ed gammadelta T cells on epidermal structure is exacerbated in obesity as E-cadherin localization and

128 NF and IL-6), which we recently demonstrated was exacerbated in obesity resulting in severe gastroint

129 ces of prenatal viral-like immune activation are exacerbated in offspring with genetic predisposition

130 Breast cancer post-pregnancy risk is exacerbated in older first-time mothers and, in our m

131 FCCP-induced mitochondrial fragmentation was exacerbated in Oma1 KO cells.

132 The problem is exacerbated in organ sites such as the prostate, wher

133 This effect could be exacerbated in overweight individuals because DHA met

134 These phenotypes were exacerbated in p53-deficient cultures exhibiting in

135 receptors, whereas the hepatocellular damage was exacerbated in PACAP-deficient mice.

136 ressed membrane potential occur in parallel, are exacerbated in parallel by exogenous free fatty acid

137 leak occurs via ryanodine receptors and can be exacerbated in pathological states such as heart fail

138 determine which pathophysiological pathways are exacerbated in patients with HF, reduced ejection fr

139 These signatures are exacerbated in patients with overweight/obesity comp

140 Colitis is exacerbated in patients with concurrent cytomegalovir

141 long-term, chronic inflammatory disease that is exacerbated in patients with diabetes.

142 ted by inhibition of autophagy in vitro, and are exacerbated in Pax7-Cre:Rb(f/f):p107(-/-) but not Pa

143 Intimal proliferation was exacerbated in PECAM-1 grafts (57+/-5% for PECAM-1 v

144 est that adverse air pollution effects might be exacerbated in people receiving LABA or LABA plus glu

145 Drive withdrawal was exacerbated in phasic REM sleep.

146 This effect was exacerbated in placentas of male fetuses.

147 t has been hypothesised that the effect will be exacerbated in polygamous species with higher levels

148 ) mice are macrocephalic, and this phenotype is exacerbated in Pten(+/-); Slc6a4(+/-) mice.

149 alphaSyn aggregation was exacerbated in Rab27b KO neurons upon treatment with

150 The exencephaly phenotype is exacerbated in Rala(-/-);Ralb(+/-) embryos; embryos n

151 t treatment led to dermal fibrosis, and this was exacerbated in recipients of contrast-exposed marrow

152 Peroxisomal defects were exacerbated in RING peroxin double mutants, suggest

153 apoptosis in wild-type mice; these responses were exacerbated in RIP3(-/-) mice.

154 LPS-induced anorexia was exacerbated in SD-OBx hamsters; LPS-induced anhedoni

155 Mate limitation is exacerbated in self-incompatible (SI) taxa, where sha

156 These changes were exacerbated in severe PH.

157 d in LA-laden macrophages in all strains but was exacerbated in SHHF rats.

158 The issue of multiplets is exacerbated in single-cell multiomics settings, where

159 above pathological and molecular alterations were exacerbated in skin cancer lesions that spontaneous

160 t SMN-dependent downstream molecular defects are exacerbated in SMA motor neurons.

161 This problem is exacerbated in some biological systems, such as muscl

162 dicate that the lysosomal degradation defect is exacerbated in some cells because of the accumulation

163 These issues are exacerbated in specialty crop breeding programs with

164 Heatwave impacts may be exacerbated in species that engage in obligate symbio

165 ect in root-to-shoot Fe translocation, which was exacerbated in spl7 and associated with a lack of fe

166 Importantly, tissue damage and fibrosis were exacerbated in SR-AI(-/-) mice following hepatic in

167 nt on MprAB-mediated signal transduction and is exacerbated in strains of M. tuberculosis producing a

168 Furthermore, the toxicity of many salts is exacerbated in strains with a defective vacuolar H(+)

169 The phenotypes of the BSH-deficient strains were exacerbated in strains lacking the Fe-S cluster car

170 These changes were exacerbated in Tg-S466L Cbs(-/-) mice with aging.

171 lmonary hypertension and vascular remodeling are exacerbated in the absence of COX-2 with enhanced ET

172 These abnormal dilations are exacerbated in the aged brain, and result in increas

173 rmined that IFN-gamma (Th1) immune responses are exacerbated in the airways of individuals with SA, w

174 al and local stressors, and these challenges are exacerbated in the Caribbean.

175 s display distinct degenerative defects that are exacerbated in the double homozygotes, we conclude t

176 assembly of the spore protective layers that are exacerbated in the presence of a functional GerA rec

177 suggest that early vascular-tau associations are exacerbated in the presence of amyloid, consistent w

178 pid deposition in the BMPR2-mutant RV, which are exacerbated in the presence of dietary lipids.

179 These barriers are exacerbated in the setting of critical illness or ac

180 These challenges are exacerbated in the study of shaped adsorbents due to

181 logical processes underlying atrial fibrosis are exacerbated in the transition from paroxysmal to per

182 lity, the effects of losing these inputs may be exacerbated in the face of increasing climate-related

183 hat accompanies severe astrogliosis and this is exacerbated in the absence of either the hsf2 or hsf4

184 causes partial loss of membrane repair that is exacerbated in the absence of extracellular Ca(2+) .

185 tic reduction in conidial germination, which is exacerbated in the absence of GNA-1.

186 pressed in vivo or in vitro, and this effect is exacerbated in the absence of IFN-gamma.

187 ssue damage caused by gut barrier disruption is exacerbated in the absence of NF-kappaB, with failure

188 t injury-induced systemic autoimmune disease is exacerbated in the absence of Ro52/Trim21 and is driv

189 photosynthetic efficiency in G. fascicularis is exacerbated in the presence of prometryn.

190 This reduced core interaction is exacerbated in the presence of sigma70, which compete

191 This defect is exacerbated in the presence of Spi-1 haplo-insufficie

192 restingly, TNF-mediated intestinal pathology was exacerbated in the absence of MAPKAP kinase 2, yet s

193 e G2/M phase caused a mutator phenotype that was exacerbated in the absence of the exonuclease Exo1.

194 Axonal demyelination was exacerbated in the absence of tPA or plasminogen, in

195 Accordingly, oxidation of KCNB1 channels was exacerbated in the brain of a triple transgenic mous

196 Damage after ischemia reperfusion injury was exacerbated in the congestive kidney and accumulatio

197 Cone cell loss was exacerbated in the inferior retinal region, with onl

198 ulted in formation of cysts, and this effect was exacerbated in the Pkd2(+/-) kidneys.

199 proach, anti-IgE produced acidification that was exacerbated in the presence of 100 microM Zn(2+).

200 Phase delay in this mutant on DD1 was exacerbated in the presence of a single functional a

201 antly with changes in ambient conditions: it was exacerbated in the presence of Mn(2+) or by increase

202 Ischemic stroke-induced brain injury was exacerbated in the presence of supraphysiologic brai

203 Heme protein deficiencies were exacerbated in the iron-loaded mitochondria, sugges

204 bances and reduction in muscle strength that were exacerbated in the KO condition.

205 nome-wide DNA methylation alterations, which were exacerbated in the placenta compared to the embryo.

206 Outer hair cell losses were exacerbated in the same time frame ( approximately

207 jor role in excitotoxicity, it is thought to be exacerbated in this region by two forms of post-ischa

208 Furthermore, both neuronal and pSC injury were exacerbated in tissues from mice lacking the inhibi

209 dels of systemic lupus erythematosus-disease is exacerbated in TLR9-deficient mice but attenuated in

210 cal cerebral ischemia and epileptic seizures was exacerbated in TNFR-KO mice, indicating that TNF ser

211 Spontaneous scratching was exacerbated in transgenic mice that overexpressed TR

212 due to molecular breakdown over time, which is exacerbated in tropical settings(1-3).

213 r and humoral immune responses were found to be exacerbated in vaccinated iNOS-deficient mice, vaccin

214 Biliary-type liver injury is exacerbated in Vdr(-/-) mice by limited adaptive resp

215 eurological health outcomes; risks likely to be exacerbated in young children attending schools adjac