ライフサイエンスコーパス: be further validated

1 iction rules have been developed but need to be further validated.

2 linical utility and prognostic value need to be further validated.

3 nostic indicator in the management of cancer is further validated.

4 The relevance to human NASH and HCC was further validated.

5 g03055671 at TNFSF10 (P = 1.67 x 10-8) genes was further validated.

6 nical detection of primary SS once they have been further validated.

7 y undescribed antiviral ISGs, TAP1 and BMP2, were further validated.

8 ration count, and TP53 and CDKN2A/B deletion were further validated.

9 n via alteration of the Tsc2-mTor-Eif4e axis was further validated across MIA rodent models.

10 The optimal setup for our purpose was further validated against a set of serum samples fro

11 The models were further validated against seven new MeONPs.

12 ic variants identified by these methods have been further validated and functionally investigated in

13 us erythematosus area and severity index has been further validated and utilized in a number of studi

14 h poor HRQOL identified in this study should be further validated, and could be used in clinical prac

15 was associated with poor outcomes and should be further validated as a standard end point of chemoimm

16 nes in cancer cells, whose products may then be further validated as potential biomarkers.

17 MEGF10 was further validated as an ADAM17 substrate using ADAM1

18 d in a model-specific microarray dataset and were further validated as suitable reference genes in an

19 pper pillars with different orientations and is further validated at the atomic scale by recourse to

20 ntial expression of selected candidate genes was further validated at protein level and analyzed for

21 The results were further validated at the macroscale using prepacked

22 racting proteins in the progression of NSCLC are further validated by proteomics data.

23 These tentative criteria should be further validated by correlations with clinical trial

24 wever, the model's generalizability needs to be further validated by external datasets.

25 However, these findings need to be further validated by further research.

26 scopy technique used, which can subsequently be further validated by more quantitative AFM force spec

27 ase their affinity and stability, which will be further validated by the bioassays in the future.

28 Furthermore, top DE circRNAs have been further validated by RT-qPCR using divergent primer

29 These advances have been further validated by successful phase 2 and phase 3

30 y the photophysical properties, and this has been further validated by the time-dependent density fun

31 ys known to be associated with anti-PD1, and is further validated by 6 CRISPR gene sets associated wi

32 Flexibility of the approach is further validated by additional designs of angle-swit

33 SRA-mediated protection from CIH is further validated by adoptive transfer of SRA(+) hepa

34 The developed model is further validated by both in vitro data on isolated c

35 The model is further validated by demonstrating our ability to can

36 The model is further validated by independent data sets from addit

37 ribute more than tethered ends to HSI, which is further validated by specifically designed match frag

38 BSP is further validated by substantiated biological discove

39 The correctness of CLPred predictions is further validated by the case studies of Sox transcri

40 This is further validated by the photophysical properties of

41 Moreover, the approach is further validated by tracking, for over 80 years, the

42 ionship between inhibitors and Ca(2+), which was further validated by (19)F NMR spectroscopy showing

43 This response was further validated by a dematin-specific antibody and

44 affinity of NMK-T-057 toward gamma-secretase was further validated by a fluorescence-based gamma-secr

45 tion using sequence similarity networks that was further validated by a structural analysis.

46 The approach was further validated by an observed reduction in Euclid

47 The model was further validated by an open test on 12 additional i

48 in determining galectin-ligand interactions was further validated by analysis of galectin-3 interact

49 The mechanistic model was further validated by applying it to a test set of su

50 r of ERalpha transcriptional activity, which was further validated by assessment of direct transcript

51 IsoResolve was further validated by case studies of genes with isof

52 The resulting model was further validated by chemical synthesis of a novel i

53 The method was further validated by comparing the CpG methylation p

54 The model was further validated by comparison with reported respon

55 The ISS system was further validated by demonstrating effectiveness in

56 Biological applicability of the platform was further validated by demonstrating increase in endop

57 This was further validated by depleting gamma interferon (IFN

58 The method was further validated by detecting genomic DNA with high

59 The approach was further validated by determining the relative merope

60 The efficacy of the BSA-based method was further validated by direct comparison with commerci

61 identified targets associated with RA, which was further validated by experimental studies.

62 The method was further validated by histones isolated from histone

63 Conversion of LC3 was further validated by immunoblotting.

64 nt in human peritendinous scar tissue, which was further validated by immunofluorescent staining for

65 response, inflammation, and survival, which was further validated by immunohistochemical staining.

66 1 with distant metastasis in TNBC (P = 0.01) was further validated by immunohistochemistry.

67 than was AD8 Env-SERINC5 interactions, which was further validated by immunoprecipitation assays.

68 Versatility was further validated by implementing the biosensors in

69 The platform was further validated by isolating CTCs from blood sampl

70 3, one of these novel interacting partners, was further validated by isothermal titration calorimetr

71 -mir hairpins against the target gene, which was further validated by knocking down two additional ES

72 The model was further validated by mapping onto it a diverse set o

73 The performance of the apparatus was further validated by measuring rapid H/D exchange ki

74 involvement of the oxidative stress pathway was further validated by measuring the levels of the PAC

75 unotherapy in BC with lung metastasis, which was further validated by multiplex immunofluorescence an

76 urse of metal bioaccumulation in oysters and was further validated by predicting the bioaccumulation

77 The developed procedure was further validated by recovery studies by comparing w

78 This was further validated by reduced levels of Kif7 at cilia

79 d eIF2gamma in HCV IRES-mediated translation was further validated by ribozymes directed against addi

80 ision for subsequent RNA-Seq analysis, which was further validated by RT-qPCR and RNA FISH.

81 The method was further validated by showing that the 3D printed mat

82 on of TGF-beta3-mediated protein endocytosis was further validated by silencing of clathrin.

83 ate the complex model of PmrD-PmrA(N), which was further validated by site-directed spin labeling exp

84 This result was further validated by stem-loop real-time reverse tra

85 The utility of spectral counting was further validated by studying the negative effect of

86 The predictive quality of the models was further validated by successful prediction of the in

87 The method was further validated by TaqMan reactions.

88 ent with the observed carbon efficiency, and was further validated by testing for agreement with gas

89 rable environment for both cell types, which was further validated by the expression of AF tissue-spe

90 The negative regulatory role of Dok-1 was further validated by the expression of small interfe

91 The methodology was further validated by the observation of reduction in

92 The current approach was further validated by the quantification of Arg in su

93 ctivated, and the altered expression of CDK1 was further validated by Western analysis.

94 (pentose phosphate and pyruvate metabolism) was further validated by western blot analysis.

95 Pathway activation was further validated by Western blot analysis.

96 This was further validated by WNT5a-siRNA transfection assay

97 s in functional response and gene expression were further validated by an in vitro proliferation assa

98 Results were further validated by analysis of a prospectively co

99 These results were further validated by assessing the translation effi

100 e analogs (LAMe and C3) as inhibitors, which were further validated by binding studies and co-crystal

101 The CvGal ligand models were further validated by binding, inhibition, and compe

102 er cell lines, determined by MSO microarray, were further validated by bisulfite nucleotide sequencin

103 The molecular concentration changes were further validated by commonly accepted chemical ext

104 lts of this microarray platform and analysis were further validated by comparing gene expression patt

105 These surrogates were further validated by demonstrating that established

106 lecules containing fluorine, binding results were further validated by direct observations of the bou

107 translational modifications within the cells were further validated by fluorescence and proteomic ana

108 tionships activated in erythropoiesis, which were further validated by genome-wide TR4 binding studie

109 the pathways identified in the trajectories were further validated by high-level quantum chemistry c

110 Microarray data were further validated by immunoblotting and by choleste

111 The findings were further validated by immunohistochemistry (IHC) sta

112 Candidate variants were further validated by in vitro assays.

113 Selected CNVs were further validated by independent methods using qPCR

114 er of cancer-specific splicing switch events were further validated by laser capture microdissection.

115 These results were further validated by mathematical simulations.

116 Satisfying models were further validated by MCCV.

117 he key metabolites involved in wound healing were further validated by multiple reaction monitoring-b

118 CARM1 selective hits were further validated by orthogonal methods.

119 tent and face validity whereby the questions were further validated by other gastroenterologists.

120 These laboratory results were further validated by performing a small field study

121 Results were further validated by plating and sequencing of indi

122 They were further validated by pull-down/immunoblotting exper

123 a by using whole genome cDNA microarrays and were further validated by quantitative real-time PCR ana

124 The expressional difference of IL8 and MMP9 were further validated by real-time quantitative RT-PCR

125 The above results were further validated by real-time reverse transcriptio

126 The microarray results were further validated by RT-PCR and phenotypic analyses

127 These findings were further validated by Sanger sequencing, segregation

128 ell-type ratio in tension and opposite xylem were further validated by spatial transcriptomics and me

129 ites were identified using photolabeling and were further validated by the docking simulation: one at

130 The methods were further validated by their ability to efficiently r

131 Several differentially expressed proteins were further validated by tissue microarray immunohistoc

132 ue (R(2) = 0.87 and 0.88, respectively), and were further validated by using a training/test set appr

133 selected DEGs related to Alzheimer's disease were further validated by western blot and real-time PCR

134 These were further validated by Western blotting using specifi

135 genomic associations with drug efficacy have been further validated (e.g. with clopidogrel and warfar

136 brain CpGs associated with AD, some of which are further validated experimentally.

137 2D with equally optimized performance, which was further validated experimentally using light-trappin

138 s; this novel concept of differential wiring was further validated experimentally.

139 The models were further validated experimentally against seven inde

140 and internal TF activity exploration, which were further validated experimentally.

141 ped 3105 SSRs in eight rice varieties, which were further validated experimentally.

142 ing any cardiovascular or renal outcome, has been further validated for patients with diabetes, renal

143 This criterion was further validated for content and convergence.

144 This correlation was further validated for IL-1beta by immunodetection in

145 root ganglia (DRG) after nerve injury, which was further validated for its mouse homolog.

146 This variant was further validated for opposite association in two be

147 The equation was further validated for secondary organic material (SO

148 The system was further validated for studying cancer cell transmigr

149 C8 substrates from human cell lysates, which were further validated for catalytic turnover.

150 Selected compounds were further validated for inhibition of ZIKV infection

151 Four genes were further validated for protein, including LMO4, whic

152 If these results are further validated in a similar population, they coul

153 37 OTs are found in cancer genes and 23 OTs are further validated in five human cell lines by target

154 These broad patterns are further validated in similar studies of nonmammalian

155 These results need to be further validated in a larger cohort.

156 t platelet inhibition, yet this will need to be further validated in additional studies.

157 e oxygenation-associated coagulopathy should be further validated in large-scale prospective clinical

158 If these results could be further validated in patients, the novel DHI might em

159 This has been further validated in minimally invasive techniques

160 It is further validated in 39 independent test samples [thi

161 the proposed mechanism of ASMase regulation is further validated in a model of UV radiation.

162 vitro cytotoxic effect on malignant T cells is further validated in a xenograft model.

163 e suppression of cardiac remodelling by SIKE is further validated in rats and monkeys.

164 The approach was further validated in (13)C-glucose feeding experimen

165 The IPSET model was further validated in 2 independent cohorts including

166 This association was further validated in 25,042 IBD cases and 34,915 con

167 and multivariate Cox regression analyses and was further validated in 42 primary neuroblastomas using

168 blocking DR1301-restricted MBP presentation was further validated in a binding assay using an analog

169 The four-analyte test was further validated in a blind binary code study by us

170 cells characterized by PDGFRbeta expression was further validated in a cohort of human PanNET.

171 th the metabolic status of obese individuals was further validated in a cross-sectional cohort of 381

172 e protein-folding-associated toxicity, which was further validated in a model of ER-stress-induced re

173 This was further validated in a mouse model of smoke exposure

174 ity, and its association with psoriasis risk was further validated in an additional case-control coho

175 The test performance was further validated in an independent 304-patient coho

176 estational time irrespective of breed, which was further validated in an independent cohort of sows,

177 -17 cells using a decomposition analysis and was further validated in an independent prospective coho

178 h the percentage of ALDH1+ tumor cells; this was further validated in an independent set of tissue ar

179 The efficacy and safety of this approach was further validated in an ovarian cancer model with ty

180 nt study, the functional role of XRCC5 in AD was further validated in animals and humans.

181 rvival in 126 HPSCC and LSCC patients, which was further validated in another cohort of head and neck

182 already established for DESI-MS imaging, and was further validated in cancer margin assessments using

183 ghly disease-specific antibody (C9RANT), and was further validated in carriers using repeat-primed po

184 ho) RD experiments in studying slow exchange was further validated in characterizing an exchange as s

185 connection within the JAK/STAT pathway, and was further validated in characterizing perturbed signal

186 The prognostic accuracy of the 5-gene score was further validated in European and US patients with h

187 The potential of this formulation was further validated in nonhuman primates, where high l

188 This conclusion was further validated in permanent cell lines expressing

189 This finding was further validated in the same sample set by stem-loo

190 The prognostic value of the IHC4 score was further validated in the second separate cohort.

191 Prognostic value of the models was further validated in the TCGA data set, and, as obse

192 was upregulation of miRNA-194 (miR-194) that was further validated in vitro and in vivo.

193 sis, nevus biology, and fibrogenic signaling was further validated in vivo by the demonstration of st

194 the acetylation-dependent regulation of p53 was further validated in vivo by using a knock-in mouse

195 The necessary function of NK cells was further validated in vivo through selected antibody

196 Selected combinations were further validated in a neutropenic murine pneumonia

197 ifferential expression and network analyses, were further validated in an independent cohort includin

198 The major results were further validated in an independent cohort of cross

199 Successfully replicated SNPs were further validated in beta-blocker treated participa

200 me activity assays, and the in vitro results were further validated in cell culture experiments.

201 Maturation effects were further validated in cortical organoids, spinal mot

202 These observations were further validated in doxycycline-inducible CC10-IL-

203 The findings in cell lines were further validated in human prostate cancer tissues.

204 These findings were further validated in mice bearing transplantable MT

205 These results were further validated in the GOGO subsets without radio

206 SNPs with P < 1 x 10(-3) were further validated in the OncoArray study of oral an

207 rted significant SNPs (P value < 1 x 10(-7)) were further validated in two additional independent lun

208 Main biological findings were further validated in two independent cohorts.

209 n sites, notably R158, R282, and R283, which were further validated in various cancer cell lines.

210 The bioreporters were further validated in vetch (Vicia hirsuta), produci

211 Our approach is further validated on modified D0(3)-CSRO detected in

212 The gene that showed the highest correlation was further validated on an independent set of specimens

213 This pPIB frame range was further validated on the extended AD and FTLD cohort

214 This successful prediction was further validated on three structurally diverse comp

215 The results were further validated on a soft benchmark by comparing

216 The results were further validated on an independent cohort of relap

217 These classifiers were further validated on an independent high-risk ALL c

218 lthough the methodology performance needs to be further validated, results support the applicability

219 Although certain findings remain to be further validated, the present study substantiates Du

220 Model results are further validated through close agreement between co

221 Its efficacy and generalizability are further validated through cross-family and cross-typ

222 Models are further validated through Monte Carlo experiments in

223 Reported results are further validated through well-known biological sign

224 The confirmed device's high performance is further validated through its integration in three di

225 In vivo off-target deamination is further validated through target site deep sequencing

226 alterations after JQ1 treatment; each miRNA was further validated through BRD4 binding to its predic

227 This experimental result was further validated through DFT calculations showing t

228 sterification under salt stressed conditions was further validated through in vitro experiments in wh

229 d serial analysis of gene expression results were further validated through immunohistochemical analy

230 markers and the model robustness/performance were further validated through internal 7-fold cross-val

231 athways and species-specific pathways, which were further validated through the use of single cell da

232 vealed the top 10 predictive features, which were further validated through XGBoost's internal featur

233 Present results must be further validated to substantiate use of (68)Ga-DOTAT

234 Nine of the novel partners were further validated to bind syndecan-4 in HEK293 cell

235 l PEM water electrolysers, and its stability was further validated under industrial testing condition

236 t maps with limited data availability, which are further validated using an established mouse inner-e

237 These results are further validated using likelihood and Akaike weight

238 Significantly dysregulated metabolites are further validated using pure standards and targeted

239 These markers will be further validated using a large clinical cohort.

240 t lenient significance levels, which need to be further validated using larger samples in the future.

241 s ligand-induced dimerization of HYB(DeltaC) is further validated using analytical ultracentrifugatio

242 This phenomenon is further validated using the patient-derived explant (

243 In the present studies, the Yale CQ method was further validated using 2 SPECT gamma cameras and 2

244 with the LPS concentration logarithm, which was further validated using a Griess reagent kit.

245 ll reduction in HIF transcriptional response was further validated using a hypoxia response element (

246 Data was further validated using a validation cohort; and was

247 The structure was further validated using an anti-iC3b mAb that was sh

248 their potential use as preneoplastic markers was further validated using an independent model of prem

249 Up-regulation of these genes was further validated using combinations of real-time re

250 Stress-induced modulation of Pr1 was further validated using glutamate-sensitive murine h

251 The model was further validated using independent data obtained fr

252 the WDXRF data for six of the cumin samples was further validated using inductively coupled plasma-a

253 The result was further validated using knockdown of DvABCB1 by RNAi

254 he function of expressed olfactory receptors was further validated using MDL12330A, which can specifi

255 The model was further validated using N. tabacum cell extracts or

256 This was further validated using NanoLuc-Based Protein Comple

257 P-2 gene which exhibited highest prevalence, was further validated using RNase R assay and Sanger seq

258 The umami taste of GK-15 was further validated using sensory evaluation, which su

259 site P-gp pocket as the preferred one, which was further validated using site-directed mutagenesis ex

260 selective, expression-dependent RNA transfer was further validated using synthetic reporters.

261 idated) and 0.989 (conventional); this model was further validated using test compounds from two inhi

262 This finding was further validated using transgenic p16-3MR mice, whi

263 Our methodology was further validated using two consistency checking tec

264 leotide polymorphisms (SNPs), 6,257 of which were further validated using a tiling microarray.

265 Findings were further validated using an independently-collected

266 Positive samples identified in the screening were further validated using autoantibody titer quantifi

267 of chemical exposure on two affected miRNAs were further validated using breast cancer human cell li

268 The effects of CLEC12A blocking were further validated using CLEC12A knockout (KO) anima

269 y Ford Hospital (United States); the results were further validated using data from the Toronto Gener

270 nal changes in diet-exposed fecal microbiota were further validated using gut chemostat cultures and

271 otrophic factor and C-reactive protein (CRP) were further validated using immunoassay in two independ

272 Data were further validated using next-generation sequencing

273 Our findings were further validated using phospho-specific Western bl

274 These results were further validated using publicly available datasets

275 rm overlaps with respect to DEG lists, which were further validated using qRT-PCR assays on selected

276 Selected genes were further validated using real time PCR (RT-PCR).

277 Top differently regulated genes were further validated using real-time quantitative poly

278 As related to metastasis, such as HAND2-AS1, were further validated using RNAi-based loss-of-function

279 The CoMFA models were further validated using two separate test sets: one

280 Significant associations in RhinoGen were further validated using virus-induced wheezing illn

281 The flavonoid mQTL was further validated via the use of transient and stabl

282 These results were further validated via immunogold electron microscop

283 These transcripts were further validated via qRT-PCR.

284 ing the first year, but the effect needed to be further validated when PPIs were shifted to on-demand

285 future work, these potential biomarkers will be further validated with a larger patient cohort.

286 acy of our target ROI and cutoff value could be further validated with PET-autopsy data from large-sc

287 The method is further validated with blood and plasma samples.

288 The model is further validated with independent data sets collecte

289 This observation was further validated with clinical specimens and functi

290 Our framework was further validated with functional analysis and augme

291 The stability of crystal was further validated with least gyration radius (209 +/

292 This domain organization was further validated with single-chain protein construc

293 ed with clinical stages and prognosis, which was further validated with two independent cohorts of ES

294 Results were further validated with channelrhodopsin 2-assisted

295 sm pathways was significantly altered, which were further validated with genes in glucose metabolism

296 ibition of in-vitro assembled fibrils, which were further validated with orthogonal assays including

297 were statistically analyzed and the results were further validated with peripheral blood mononuclear

298 and toxicity of alpha-syn by our novel assay were further validated with the in vivo experiments.

299 Our most promising candidates were further validated with the use of targeted quantita

300 The method is further validated within a cohort of congenital heart