ライフサイエンスコーパス: be identified that

1 Publications were identified that (1) described the relationship betw

2 rmore, using an Ai14 reporter mouse model it is identified that 24.6% of the total lung epithelial ce

3 sitivity, no cell-autonomous mechanisms have been identified that account for the resistance of cells

4 No clear parameters have been identified that accurately predict neurodevelopment

5 It has also been identified that actin provides rest stops for Cx43

6 No studies were identified that addressed the other outcomes.

7 At least two genes have been identified that affect number of vertebrae in pigs

8 Multiple genes have been identified that affect plumage variation, but resea

9 Four loci have been identified that affect stem length (Dw1-Dw4).

10 Multiple mutations were identified that affected the same pathways, includi

11 Moreover, several miRNAs have been identified that aid the formation of inducible plur

12 a metabolomics approach, single metabolites are identified that allow a good, albeit at about 14% fa

13 Specifically, two scenarios are identified that allow for the production of compress

14 reducing agent, and reaction conditions have been identified that allow alteration in the rate- and r

15 mutations located on the surface of NC have been identified that allow NC maturation but block its e

16 efficient and salt concentration, conditions were identified that allowed the diffusion length to alw

17 gh process optimization, reaction conditions were identified that allowed the polymerization of the w

18 One compound was identified that also prevented DEPTOR-mTOR binding i

19 Twenty-one grazing responsive pathways were identified that also exhibited differential express

20 of hydrophobic residues, key positions have been identified that alter the NTD equilibrium; these li

21 Genetic modifiers were identified that alter the effect of Ven1(A619), whi

22 However, in an earlier related work , it was identified that an important trapping mechanism, res

23 Lastly, FLC-like and VIN3-like genes were identified that appear to be novel components of th

24 fr schedule of whole-breast radiotherapy can be identified that appears to be radiobiologically compa

25 wo polymorphic residues in AtRIN4 and MdRIN4 are identified that are crucial in the regulation of and

26 ndependent classes of BR-regulated COR genes are identified that are regulated in a BR- and CES-depen

27 de (that is, a 'liquid biopsy' approach) can be identified that are more universal in nature, working

28 and atopic dermatitis, common variants have been identified that are associated with disease, and th

29 a series of hereditary UGT1A1 mutations have been identified that are associated with UGT1A1 deficien

30 e stimulus(2), and accordingly, neurons have been identified that are excited by stimuli outside thei

31 Three mammalian IMP paralogs (IMP1-3) have been identified that are expressed in most organs during

32 rimidine scaffold, additional compounds have been identified that are extremely effective against acu

33 dentified, but no molecular alterations have been identified that are in common to these diseases.

34 More than 375 genes have been identified that are involved in regulating skin pig

35 Basal and luminal molecular subtypes have been identified that are linked to clinical characterist

36 e electrical and episodic disorders have now been identified that are not defects in the ion channel

37 several new classes of NMDAR agents have now been identified that are positive or negative allosteric

38 Among several biomarkers that have been identified that are present in patients with ovaria

39 Recently, lipids have been identified that are released from tissues and act l

40 Mutations in several genes have been identified that are responsible for 25% of families

41 rks of CRC, and epigenetic driver genes have been identified that are thought to be involved in early

42 act via various targets, some of which have been identified, that are triggered according to the con

43 From this effort, three compounds were identified that are 10-fold more potent toward Cif

44 Distinct PAD defective B-cell patterns were identified that are associated with unique clinical

45 r this study, hundreds of intergenic LncRNAs were identified that are expressed in myoblasts and regu

46 s, during the mobile surveys, many gas leaks were identified that are not included in the inventories

47 rly, whereas another large group of proteins were identified that are predicted to be retained locall

48 Twenty-six variants were identified that are private to a family, alter prot

49 Two nonconserved active site residues were identified that are responsible for the different r

50 Ten proteasome-specific chaperones have been identified that assist in this process.

51 ncluding members of the Mef2 protein family, are identified that begin to explain how deregulation of

52 No subgroup could be identified that benefited from oxygen.

53 ity, several innovative farming systems have been identified that better balance multiple sustainabil

54 Potent inhibitors of bacterial IMPDHs have been identified that bind in a structurally distinct poc

55 Several different receptor proteins have been identified that bind monomeric, oligomeric, or fibr

56 Hexapeptides have been identified that bind to junctions and inhibit vario

57 ry anti-C1 monoclonal antibodies (mAbs) have been identified that bind to putative phospholipid and v

58 Increasingly, HIV bnAbs are being identified that bind to the N-linked glycans coati

59 A stable heterohexameric complex was identified that binds to GPCRs with interactions tha

60 p (SAR) study, novel irreversible inhibitors were identified that block the transamidation activity o

61 Distinct configurations are identified that can be steered towards entities pred

62 A variety of design handles are identified that can be used to modify the redox acti

63 few pattern-forming biochemical systems have been identified that can be reconstituted and studied in

64 A number of cell types have been identified that can be used to suppress alloreactiv

65 Thioether ancillary ligands have been identified that can greatly accelerate the C-H alke

66 Techniques have been identified that can modify memories at each stage,

67 Recently, compounds have been identified that can reverse HIV-1 latency in vivo.

68 Also, a 10-gene marker list was identified that can discriminate an individual metal

69 Indeed, several volatile compounds were identified that can influence mosquito behaviour, i

70 It is shown that no physical property can be identified that carries significantly less informatio

71 combination with a single acetyl transferase was identified that catalyzes the conversion of 13R-mano

72 eterozygous mutation in IL-17F (IL-17F.S65L) was identified that causes chronic mucocutaneous candidi

73 spots matching to 23, 13 and 31 unique genes were identified that changed at least 1.5 fold (p < 0.05

74 Five predominant mutational subtypes were identified that clustered PDAC into 4 major subtype

75 l influence between the research communities were identified that combine the benefits of individual

76 While some pathways have been identified that communicate information from the en

77 a subclass of weak non-canonical terminators was identified that completely depend on NusA for effect

78 However no studies have been identified that comprehensively explore both the qu

79 a total set of 3661 direct p53 target genes is identified that comprise 3509 potential targets from

80 Many treatments have been identified that confer robust cardioprotection in e

81 6), t(14;20), nonhyperdiploidy, and gain(1q) were identified that confer poor prognosis.

82 An additional gene was identified that confers resistance to an isolate of

83 Two groups of processing mechanisms are identified that conjointly adopt the particular powe

84 hybrid approach was carried on and a protein was identified that contained a Universal stress protein

85 ch viral contig, at least one fungal isolate was identified that contained each virus.

86 A unique MyoB light chain (MLC-B) was identified that contains a calmodulin-like domain at

87 In addition, 14 variants are identified that contribute to both LOAD risk and age

88 teria, and a remarkable number of genes have been identified that contribute to the regulation of thi

89 entially targetable, changes in T cells have been identified that contribute to these age-related def

90 Three quantitative trait loci (QTL) were identified that contributed to the control of homoe

91 however, relatively few specific miRNAs have been identified that control synapse formation.

92 V-status, few tumor-intrinsic variables have been identified that correlate to improved survival.

93 In addition, several molecular traits have been identified that correlate with site-specific mutati

94 patients with sepsis, 4 clinical phenotypes were identified that correlated with host-response patte

95 y was observed over time, and a key mutation was identified that correlates with a major conformation

96 Potential coaching pitfalls are identified that could interfere with each of the 3 r

97 ion, key factors leading to its success have been identified that could allow the implementation of t

98 odels a number of epigenetic mechanisms have been identified that could mediate vertical transmission

99 r distinct clusters of patients with AD have been identified that could represent endotypes with uniq

100 ng cancer subtypes and a list of new markers were identified that could be lineage-specifically assoc

101 neutralization sensitive, although mutations were identified that could confer CD4-independent infect

102 (3,6-diferuloyl-2',3',6'-triacetylsucrose), were identified that could contribute to maize resistanc

103 ties in cooling and power systems operations were identified that could impact water use intensity: (

104 of human-centered problems in communication were identified that could provide the motivation for a

105 Several conserved amino acids were identified that create a hydrophobic binding pocket

106 One set of molecules was identified that, depending on the concentrations, in

107 guanine/adenine class, seven groups of RNAs were identified that deviate from the consensus sequence

108 nts of mouse cytomegalovirus (MCMV) a mutant was identified that did not elicit cell rounding and lac

109 Nevertheless, to date, very few ligands have been identified that directly interact with histidine ki

110 of the signaling cascade; however, none have been identified that directly target active beta-catenin

111 Sixty-six classifier genes were identified that distinguished infants with and with

112 4:144-154), a new route of sexual conversion is identified that does not require a prior round of rep

113 A plethora of genetic factors have been identified that drive the degeneration of motor neu

114 To date, no pyrophosphatase has been identified that employs an arginine finger fulfilli

115 Several additional important subgroups are identified that enable an estimate of the specific c

116 ures, critical enzyme-substrate interactions were identified that enable tight binding of MurNAc-alph

117 A modular Cu/ABNO catalyst system has been identified that enables efficient aerobic oxidative

118 reaction of 1,2-diketones with amidines has been identified that enables their transformation into i

119 l genes (nf2152, nf2215, nf2523, and pr2455) were identified that encode family 39 glycoside hydrolas

120 s is not fully understood, since no gene has been identified that encodes plasmanylethanolamine desat

121 the FXN homolog in Saccharomyces cerevisiae was identified that encodes an amino acid substitution e

122 Several novel HSF1-interacting proteins were identified that encompass a wide variety of cellula

123 Various chemical modifications have been identified that enhance potency of small interferin

124 Reaction conditions were identified that enhanced the RCM product yield whil

125 Ten TIMI trials were identified that enrolled >2,500 patients with NSTEA

126 Characteristics associated with SABU were identified that established higher risk for systemi

127 No eligible study was identified that evaluated the clinical impact of any

128 Ten studies were identified that evaluated ICD use in patients with

129 ough comparative analyses genes and pathways were identified that exhibit unique genetic changes and

130 naphthoquinone-based small molecule, AS4583, was identified that exhibited potent activity in tyrosin

131 A lead molecule is identified that exhibits an improved dose-response pr

132 However, no CYP2B11 gene mutations have been identified that explain this deficiency in Greyhoun

133 A subset of NKT cells was identified that expressed low levels of YY1.

134 However, many cells were identified that fired in bursts unrelated to the an

135 No studies were identified that focused on interventions targeting

136 Although many factors have been identified that function during CF closure, the mol

137 ughput reaction arrays, effective conditions were identified that gave high selectivity for the proxi

138 2,3-dihydroxypropyl cysteine at position 190 was identified that had significantly increased activity

139 ociated with heat stress in previous studies were identified that had >log2-fold up- or down-regulati

140 wever, several shortcomings of OECD 308 have been identified that hamper data evaluation and interpre

141 ver, to date, no human-derived substrate has been identified that has the capacity to interact with t

142 Seven mammalian type 1 receptors have been identified that have context-specific roles dependi

143 ma compounds from different substance groups were identified that have hitherto not been described in

144 Non-synonymous differences in viral proteins were identified that have implications for viral protein

145 In this study, two key factors were identified that have important and counterbalancing

146 An additional 1193 markers were identified that illuminated genomic regions exhibit

147 r common diseases, few genetic variants have been identified that impact risk of cirrhosis.

148 Host genes have been identified that impact the recombination of RNA vir

149 Several conserved bacterial riboregulators were identified that impacted this response.

150 Seventy-one relevant articles were identified that included a total of 387,569 partici

151 Two equivalent protocols were identified that included both BS and respective WC

152 Chlamydomonas reinhardtii, and 243 compounds were identified that increase triacylglyceride (TAG) acc

153 In this study, a novel compound was identified that increased SMN protein levels in vivo

154 those, a mutation in the viral hemagglutinin was identified that increases 2009 pandemic H1N1 virus b

155 Here key factors are identified that influence the mechanistic choice of

156 growing number of transcription factors have been identified that influence the EMT/MET processes.

157 complexes were performed, and a key residue was identified that influences the plant PPO's acceptanc

158 n anonymous gene variant in C14ORF39/SIX6OS1 was identified that influences the recombination rate in

159 More than 50 protein families have been identified that inhibit CRISPR (clustered regularly

160 To date, small-molecule inhibitors have been identified that inhibit HIV-1 capsid assembly and/o

161 Two mutants were identified that inhibit F-mediated fusion by stabil

162 Furthermore, various proteins have been identified that interact with APP and modulate its

163 Several PDZ domain-containing proteins were identified that interact with the PDZ-binding motif

164 Six phages were identified that interacted exclusively with Rhodoba

165 Several core groups of cellular proteins were identified that interacted with each viral protein

166 ulfoniopropionate and taurine transformation were identified that interlink members of the holobiont

167 Two potential modes of activation have been identified that involve donation of electron densit

168 new class of reversible USP7 inhibitors has been identified that is highly potent in biochemical and

169 ion, a third excited-state decay pathway has been identified that is pivotal for the performance of m

170 A TaNAC2 regulated gene was identified that is a NRT2-type nitrate transporter T

171 eriaqueductal gray (PAG)-spinal cord pathway was identified that is critical for the development of m

172 Thus, a long-range brain circuit was identified that is crucial for pain processing and t

173 inding site remote from the catalytic center was identified that is distinct from one reported for th

174 ethylene in shoots, and a DNA binding motif was identified that is important for this transcriptiona

175 difference in endogenous expression of VEGF was identified that is likely the underlying cause of di

176 of-function AKT2 coding variant (p.Pro50Thr) was identified that is nearly specific to Finns (frequen

177 ested for SH1, an H-bond involving the 4"-OH was identified that is not found in the binding of IG5F6

178 n's disease, a disease-specific physiomarker was identified that is now used to investigate adaptive

179 Genetic variations have been identified that lead to a short sleep phenotype in

180 et genes in the heart are the first genes to be identified that likely play an important role in medi

181 istical, economic, and regulatory deterrents were identified that limit the performance of AR researc

182 A key regulator of ciliary shape has now been identified that links the establishment of neuronal

183 Key amino acid residue substitutions were identified that make rabbit recombinant PrP suscept

184 Nine lake thermal regions are identified that mapped robustly and largely contiguo

185 In addition, avenues are identified that may be exploited for photosynthesis

186 ndothelium that impairs insulin movement has been identified that may contribute to type 2 diabetes p

187 Forty-four methylation markers were identified that may be able to discriminate between

188 New miR-21 targets were identified that may be important during PD fibrogen

189 al sites for nicotine structure modification were identified that may be useful in the design of new

190 netic alterations in specific pathways in MF were identified that may be viable, effective new target

191 stitutions associated with treatment failure were identified that may contribute to resistance of thi

192 Transcripts were identified that may control metabolic fluxes.

193 Several transcription factors were identified that may control these shared processes

194 Several sequence features were identified that may influence hotspot intensity and

195 Two adaptation processes were identified that may reflect central and peripheral

196 However, no Mediator subunit has yet been identified that mediates WRI1 transcriptional activ

197 Twenty-seven eligible articles were identified that met the inclusion and exclusion cri

198 improvements in preclinical study design can be identified that might also increase the likelihood of

199 for an approach by which small molecules can be identified that modulate IL-18 activity.

200 In addition, a variety of compounds have been identified that modulate agonist-evoked responses o

201 several novel influenza virus proteins have been identified that modulate viral infections in vitro

202 Four decades ago, it was identified that muramyl dipeptide (MDP), a peptidogl

203 a range of limitations and factors have also been identified that must be taken into consideration wh

204 ected, but no individual system has hitherto been identified that must have been formed by migration.

205 Furthermore, aptamers were identified that not only bound with high affinity,

206 aB signaling, but small-molecule derivatives were identified that only marginally affected these path

207 Twenty-four eligible studies were identified that performed a single time point scree

208 While several molecules have been identified that play key roles in spindle orientati

209 t cells, a microtubule-dependent network has been identified that polarizes the distribution of signa

210 Several derivatives were identified that possess greater protective effect i

211 minishes.IMPORTANCE Multiple antibodies have been identified that potently neutralize a broad range o

212 Recently, a less toxic variant (BC194) was identified that potently inhibits angiogenesis.

213 ichment, a metastasis-derived gene signature was identified that predicted more rapid cancer relapse

214 nts," several medical conditions among youth were identified that predispose to accelerated atheroscl

215 Regions of the pSTS were identified that preferred visually presented moving

216 mutations in a growing number of genes have been identified that produce autosomal recessive forms o

217 o Medicago truncatula Tnt1-insertion mutants were identified that produced small nodules, which were

218 the roots, an oxidosqualene cyclase, OsONS1, was identified that produces alpha-onocerin from squalen

219 Cu/nitroxyl catalysts have been identified that promote highly efficient and select

220 Only a few catalyst systems have been identified that promote the formation of quaternary

221 e amongst older adults, and few factors have been identified that promote their resilience.

222 between alpha-hemolysin and host cells have been identified that promote tissue damage and modulate

223 However, no neurobiological markers have been identified that prospectively predict MDD course tr

224 read between cells, but it has more recently been identified that protein effectors secreted by funga

225 five cross-validated consensus mutants could be identified that provide structural constraints for tr

226 ition, an array of CIB1 binding partners has been identified that provide important insight into how

227 Host biomarkers were identified that provide high predictive value under

228 Relationships were identified that provided explanations of the intera

229 Spinal afferent axons were identified that ramified extensively through many r

230 Multiple pan-ebolavirus antibodies were identified that react to the Ebola, Sudan, Bundibug

231 No flatworm target has been identified that readily explains how PZQ paralyzes

232 nd no clinically relevant interventions have been identified that reduce the number of these HIV DNA-

233 Several niche signals have been identified that regulate epithelial development and

234 Although many compounds have been identified that regulate glutamate receptor activit

235 , additional cis and new trans elements have been identified that regulate PRF in both host and viral

236 Several ionic currents have been identified that regulate SCN firing, including volt

237 chanisms originating within the plastid have been identified that regulate stromule activity, a criti

238 Several miRNAs have been identified that regulate the amplitude of the innat

239 A total of 65 key lncRNAs were identified that regulate 20 significantly enriched

240 Overall, mechanisms were identified that regulate the multifaceted roles of

241 ept that bottom-up brain-based groupings can be identified that relate to cognitive performance.

242 Two criteria were identified that relate the timing and nature of ada

243 re than 13000 of these series, key compounds were identified that represented substitution sites of a

244 ntly, a small-molecule ISR inhibitor (ISRIB) was identified that rescues translation in the presence

245 Multiple yeast prions have been identified that result from the structural conversi

246 Combination therapies were identified that resulted in complete and sustained

247 in the second family, a variant (c.1102G>C) was identified that results in a splicing defect leading

248 peptides, a few antimicrobial peptides have been identified that retain activity against encapsulate

249 Several non-bactericidal compounds were identified that reversed intrinsic resistance to be

250 Different mechanisms have been identified that reversibly change the oligomer equi

251 Cases have been identified that seem to be best suited for differen

252 LMNB2, a novel homozygous missense mutation was identified that segregated with the PME in the famil

253 Two main clusters were identified that segregated controls from all other

254 tion, structural modifications of compound 2 were identified that segregated Hsp90 inhibition from MA

255 More markers were identified that segregated in the maternal parent (

256 Three main clusters were identified that separated the control and chronic p

257 ic, Mediterranean, and Southern Ocean waters were identified that share a substantial percentage of r

258 hemical probes, BI-7273 (1) and BI-9564 (2), were identified that should prove to be useful in furthe

259 Three brain regions were identified that showed a systematic response prefer

260 tational modeling, potent pan-JNK inhibitors were identified that showed submicromolar activity in a

261 However, individual CC lines were identified that showed type 2 diabetes mellitus (t2

262 o determine whether distinct PD patterns can be identified that, similar to electrographic seizures,

263 A limited number of unique mutations are identified that stabilize the prefusion conformation

264 of C99, subtle changes in hinge flexibility were identified that substantially affected helix bendin

265 xpected for a tegument protein, interactions were identified that suggest distinct roles for pUL103 a

266 One hundred eighty two GIS genes were identified that suppressed GCR formation.

267 Several toxins from venomous animals have been identified that target ASICs with high specificity

268 promising therapeutic candidates for FD have been identified that target the underlying mRNA splicing

269 ous examples of unprompted coaching behavior were identified that target intraoperative performance.

270 Here it was identified that the food-safe and common cadmium che

271 In Figure 4C, it was identified that the Histone H3 and alpha-Tubulin pur

272 In Arabidopsis, a genetic toolbox has been identified that tightly controls stomatal developme

273 tein-peptide interaction, and four mutations were identified that together improved the affinity for

274 al positions in the ECL3s of GCGR and GLP-1R were identified that tolerate SphK mutagenesis and subse

275 Short ciliary targeting sequences (CTS) have been identified that trigger the transport of ciliary pr

276 A variety of fluorescent proteins have been identified that undergo shifts in spectral emission

277 a collection of host virus resistance genes was identified that, upon silencing, increased polioviru

278 HIV/macaque model, HIV-1 Env proteins should be identified that use mCD4 as a functional receptor and

279 No studies were identified that validated the surrogate endpoints.

280 lausible region of the simulator input space was identified that was 10(11) times smaller than the or

281 A distinct TEMRA CD8(+) T cell subpopulation was identified that was characterized by expression of F

282 Rather, a hybrid pathway was identified that we call the modified K-R (MK-R) path

283 to the phylogenetics of RSV, emergent clades were identified that we termed High Titre (HiT) clades o

284 s-of-function variants of X-chromosomal TLR7 were identified that were associated with impaired type

285 Within the population, 4 growth patterns were identified that were each characterized by worsenin

286 ing assays, 466 highly promiscuous compounds were identified that were examined for known pan-assay i

287 ext-generation sequencing, 96 SHFV body TRSs were identified that were functional in both infected MA

288 n modules (four modules totaling 8398 genes) were identified that were highly preserved across divers

289 Previous cell wall proteins (CWPs) were identified that were implicated in C. difficile adh

290 By conditioning on this variable, biomarkers were identified that were more likely to be effective in

291 to date, derangements in HDL-P subfractions were identified that were more severe in HFrEF than HFpE

292 fied across experiments, whereas new Mn QTLs were identified that were not found in individual experi

293 Another 438 cooperatively acting GIS genes were identified that were not GIS genes, but suppressed

294 Corresponding residues in Bem4p were identified that were required for interaction with

295 Several growth-related proteins were identified that were ubiquitinated and degraded mor

296 nd tissue inhibitor of metalloproteinases 1) were identified that, when combined through a classifica

297 Characteristic "ion groups" and "key ions" were identified that, when combined with their CAD produ

298 e no naturally tool-using congeners have yet been identified that would enable informative comparison

299 s, multiple preserved communication pathways were identified that would allow such long-range signali

300 Thirteen low concentration PSs were identified that would otherwise not have been disti