ライフサイエンスコーパス: be impaired

1 bility to display emotions intentionally can be impaired.

2 hromosome-wide domain of the sex chromosomes is impaired.

3 early B-cell development in the bone marrow is impaired.

4 t centromeres when transcriptional silencing is impaired.

5 anosome trafficking along microtubule tracks is impaired.

6 the AI profile observed when AIF expression is impaired.

7 a-oxidation, a core function of peroxisomes, is impaired.

8 sidue is reduced when VEGFR2 pY949 signaling is impaired.

9 s in vitro, although cooperative DNA binding is impaired.

10 d and their preferential synapse development is impaired.

11 als are inhibited when translocation of EGFR is impaired.

12 and, thus, immune effector cell infiltration is impaired.

13 plasmic domain/transport-dependent targeting is impaired.

14 aggregates, which accumulate when autophagy is impaired.

15 gy machinery to the phagophore assembly site is impaired.

16 r clinical scenarios in which AMPK signaling is impaired.

17 he periphery when phagocytosis in the thymus is impaired.

18 generalized skin symptoms if quality of life is impaired.

19 l debris when microglial phagocytic activity is impaired.

20 ell as transgenic roots overexpressing DREPP is impaired.

21 ial function and related gene-set expression is impaired.

22 s, but LV diastolic function and RV function are impaired.

23 rocessing and T cell activation capabilities are impaired.

24 n both cell types, but spread in fibroblasts was impaired.

25 binding, the modulation of PDE6 cGMP levels was impaired.

26 l cells of mice on a glucosinolate-free diet was impaired.

27 m-lamina propria ratio while iron deposition was impaired.

28 and when Sec-mediated protein translocation was impaired.

29 r was unremarkable, but visual task training was impaired.

30 the other two isoforms to use this substrate was impaired.

31 during elongation and long tendon formation was impaired.

32 re-expression of the developmental gene wt1b was impaired.

33 hydroperoxide, survival of the lon-2 mutant was impaired.

34 hydroperoxide, survival of the lon-1 mutant was impaired.

35 dependent responses, and secondary responses were impaired.

36 , in AD mice, SWR-DW and spindle-DW coupling were impaired.

37 ivation, proliferation, and differentiation, were impaired.

38 ction was suppressed, and ATP and GTP levels were impaired.

39 crophage polarization and iron sequestration were impaired.

40 y to assess patient and family understanding is impaired; 3) relationship building is impaired; 4) pa

41 anding is impaired; 3) relationship building is impaired; 4) patient and family understanding of deci

42 sion-making concepts (e.g., palliative care) is impaired; 5) treatment limitations are often perceive

43 Mental switching performance was impaired 7% (IQR = 0-19) after indomethacin (P = 0.0

44 s to a multivalent T-independent (Type 2) Ag were impaired, a surprise finding considering the immuno

45 tic disorders, whereas automatic inhibition is impaired-a deficit that correlated with tic severity

46 amic reticular nucleus neurons, burst firing is impaired accompanied by attenuated IT.

47 Their chromatin-remodeling rates were impaired accordingly, but nucleosome binding was re

48 In hemispheric stroke, CA is impaired across the entire hemisphere to a variable e

49 t coronary artery endothelial function would be impaired after CF-LVAD intervention.

50 ypothesis that hippocampal place cell firing is impaired after PAE by performing in vivo recordings f

51 hat impacts the quality of the wound tissue, was impaired after EPA-rich oil supplementation.

52 Two monkeys were impaired after 0.1 mg/kg olanzapine and two were im

53 impaired after 0.1 mg/kg olanzapine and two were impaired after 0.3 mg/kg deschloroclozapine.

54 n proliferation of resident epithelial cells is impaired, alternative regeneration mechanisms can occ

55 glycans, but complex type N-glycan branching was impaired, although UDP-GlcNAc transport into Golgi v

56 s, glucose-induced increases in NADH and ATP are impaired and both oxidative and glycolytic glucose m

57 It is not clear why some brain regions are impaired and others spared by the etiological risks

58 neurons exhibit hyperexcitability, learning is impaired and behavioral intervention provides no bene

59 d to environmental stress when PAX3 function is impaired and that PAX3-mediated induction of mTORC1 i

60 In the cdkg1-1 mutant, synapsis is impaired and there is a dramatic reduction in the num

61 ic and tumor-infiltrating lymphocytes (TILs) was impaired and associated with enhanced tumor growth,

62 rosslinking of alpha2-antiplasmin and fibrin was impaired and fibrinolysis was enhanced.

63 ription in infected cells, but nuclear entry was impaired and integration targeting was altered.

64 was observed, but rather mitotic progression was impaired and mitotic DNA synthesis triggered.

65 hypothesised that pressure natriuresis would be impaired, and BP increased, in the early phase of T1D

66 us mechanisms of compensatory plasticity may be impaired, and that exogenously activating respiratory

67 -like plasticity of the primary motor cortex is impaired, and gamma oscillations are altered in the b

68 ed, the transcription of mtDNA-encoded genes is impaired, and the electron transport chain is comprom

69 lso show that endothelial cell functionality is impaired, and when combined with angiogenic inhibitio

70 estingly, NK cell recruitment and activation were impaired, and metastatic burden was increased in E2

71 CD8+ T cell response to vaccination is impaired as a result of cDC1 dysregulation.

72 utrient delivery to fetuses and its function is impaired as a result of MO.

73 PX8 knockout cells, this signaling mechanism was impaired as sIL6R failed to activate the JAK/STAT3 s

74 at centrioles can persist when Plk1 activity is impaired, as well as when microtubule nucleating acti

75 autism manifest low perceptual construal and are impaired at traversing psychological distances, and

76 rimental effects, but blastocyst development was impaired at 25% of standard nutrient provision (redu

77 he function of the symbionts' photosystem II was impaired at high temperature, and this response was

78 Ultimately, cell cycle progression was impaired at the G1/S and G2/M transitions and regene

79 measured when visual acuity or visual fields were impaired at levels consistent with the current Para

80 sion of ISCs, but enterocyte differentiation was impaired, based on loss of enterocyte markers and fu

81 Migration of Flot1-deficient neutrophils is impaired because of a decrease in myosin II-mediated

82 they are rarely mutated/deleted, but rather are impaired by "inhibitor proteins." Two papers in this

83 mportant for clearing virally infected cells are impaired by higher negative regulatory signals durin

84 Redox signaling could be impaired by cytosolic antioxidants; hence, those targ

85 nction of heteromeric receptors is likely to be impaired by the mutation.

86 osis by Magnetic Resonance Imaging (MRI) has been impaired by a lack of validation of the specific su

87 current available analytical approaches have been impaired by a number of constraints (e.g., inabilit

88 Understanding how PELs develop has been impaired by the difficulty of infecting B cells wit

89 However, NSPC proteostasis is impaired by brain aging.

90 to predict that stress-induced transcription is impaired by factors abundantly expressed during laten

91 ty of available genome-wide CRISPR libraries is impaired by guides which inefficiently abrogate gene

92 Importantly, connectivity is impaired by insults, which mimic the diabetic milieu,

93 Our study demonstrates that maternal care is impaired by intra-BNST CRF administrations, and these

94 We show that DNA cleavage is impaired by more than 100- fold for the high-fidelity

95 nal elongation, but its functional integrity is impaired by mutant HTT.

96 the inhibitory effect on translation by FUS is impaired by mutations that reduce its RNA-binding aff

97 Vigilant attention is impaired by sleep deprivation and restored after rest

98 rminal Src kinase (CSK), an interaction that is impaired by the PTPN22 R620W variant associated with

99 ry, NANOG restored production of COL3, which was impaired by cellular aging, suggesting novel strateg

100 In contrast, reversal learning was impaired by D2R antagonism, but not D1R antagonism,

101 The development of this location specificity was impaired by hippocampal damage.

102 c segregation of retinogeniculate projection was impaired by in vivo overexpression of SN25b, but not

103 ion and/or post-stimulus memory, performance was impaired by inactivation of widespread cortical area

104 ed but not blunt, double-stranded DNA breaks was impaired by SAMHD1 depletion, which was accompanied

105 sured in both species, only Z. marina growth was impaired by the accumulative heat stress imposed by

106 it tau disaggregase activity in vitro, which was impaired by the p.Asp395Gly mutation.

107 on and degradation of phagocytosed materials are impaired, causing lipid droplet (LD) accumulation in

108 As a consequence, the silencing of TEs was impaired, causing in particular young TEs to become

109 increased and IFN-I induction and signaling are impaired compared to wild-type (wt) cells.

110 utation-containing progenitor cells in vitro is impaired, consistent with down-regulated expression o

111 h mislocalized nuclei, their dark adaptation was impaired, consistent with a deficiency in chromophor

112 sed risk of schizophrenia, CA2 social coding was impaired, consistent with the social memory deficit

113 ated with acidemia only when kidney function was impaired (creatinine >2 mg/dl), as rapidly detected

114 t activates the plasma membrane proton pump) are impaired, demonstrating that the transport activity

115 deficiency, production of the cytokine IL-2 was impaired, differentiation into regulatory T cells wa

116 In obesity, IL-10 production is impaired due to insulin resistance in macrophages, wh

117 asmatic coagulation and platelet aggregation were impaired due to systemic inflammation, liver failur

118 g a semester-long course, their learning may be impaired during the initial part of the course.

119 continuously replacie olfactory neurons but is impaired during chronic inflammatory rhinosinusitis.

120 Photosynthesis is impaired during heat stress, and this limitation is o

121 ay in human B cells and that this regulation is impaired during MS disease onset.

122 specific STAT1 R274W CD8(+) T cell responses were impaired even in the presence of WT leukocytes.

123 tic transmission, and/or synaptic plasticity are impaired following kindled seizures.

124 Finally, we found that proteasome function was impaired following heat stress in senescent cells, a

125 ined motor skill, and behavioral performance was impaired following targeted molecular inhibition of

126 unperturbed environment, the SOS-off mutant is impaired for stable colonization relative to a wild-t

127 the hemoglobin/heme-binding protein Spbhp-37 was impaired for growth on heme and hemoglobin iron.

128 Alzheimer's disease (AD) spatial navigation is impaired; however, the precise cause of this impairme

129 MJ aging although its structure and function are impaired in aged animals.

130 plasticity, motor control and learning that are impaired in CB(1) receptor knockout (CB (1) -KO) mic

131 We have isolated mutant UAF1 variants that are impaired in DNA binding and tested them together wit

132 m reabsorption that offset acute rises in BP are impaired in early type 1 diabetes, and this impairme

133 These patterns are impaired in FoxP mutant flies, which present an alte

134 responsible for raising exercise heart rate are impaired in HFpEF is unknown.

135 t the ETBR-mediated diuresis and natriuresis are impaired in hypertension with unknown mechanism.

136 myocardial energetics and diastolic function are impaired in obesity, systolic function is usually pr

137 lthy remodeling in Abdsc and these processes are impaired in Om.

138 ggest specific facets of response inhibition are impaired in PWSICdel mice and that abnormal 5-HT2CR

139 nate novel object-context configurations but are impaired in recognition of novel object-place-contex

140 increases in left medial temporal lobe (mTL) are impaired in schizophrenia, as is theta phase couplin

141 ncluded that early steps of phloem formation are impaired in smxl4;smxl5 double mutants and that the

142 tants of the BON1 gene family, bon1bon2bon3, are impaired in the induction of gene expression and ABA

143 fector functions and to identify those which are impaired in the obesity setting.

144 a result, hnRNP A2 is displaced, and BC RNAs are impaired in their ability to reach synapto-dendritic

145 mmadelta T cells lacking both S1PR2 and CD69 are impaired in their maintenance within the dermis.

146 al synaptic plasticity, learning, and memory are impaired in these mutant mice.

147 Lyn(-/-) cells are impaired in virus release and are rescued when recon

148 t that both facial and vocal recognition may be impaired in DP.

149 Attention and memory may be impaired in individuals at-risk for Alzheimer's disea

150 The GLP-1 system is known to be impaired in insulin-resistant conditions, and we soug

151 significant repertoire remodeling, which may be impaired in nonresponders because of the preexisting

152 Each of these steps may be impaired in older adults.

153 us mechanisms of compensatory plasticity may be impaired in some individuals with sleep apnoea, and t

154 ibe a novel route to imitation that may also be impaired in some patients with apraxia.

155 We therefore hypothesized that ODP would be impaired in the absence of C1q, and that V1b developm

156 While proton transfer appears to be impaired in the oxidized state (Hox), the presented d

157 te immune activation is not due to SACC-PHHs being impaired in their ability to induce interferon sti

158 ctions in response to environmental changes, is impaired in a number of neuropsychiatric conditions,

159 eration of 11-cis-retinal and visual pigment is impaired in a type 1 diabetes animal model, which neg

160 lly, using OUL, we show that memory updating is impaired in aging, 18-m.o.

161 lly, using OUL, we show that memory updating is impaired in aging, 18-m.o. mice.

162 ing why adult hippocampal neurogenesis (AHN) is impaired in Alzheimer's disease (AD) is essential for

163 ut adult life, their morphology and function is impaired in Alzheimer's disease (AD).

164 ypothalamic reactivity to glucose metabolism is impaired in AN.METHODSTwenty-four participants with A

165 responses during allergic inflammation, but is impaired in asthma.

166 efrontal cortex (PFC)-striatal circuitry and is impaired in both manifest and premanifest Huntington'

167 This innate vasoprotective mechanism is impaired in certain chronic clinical conditions, whic

168 o, we recently showed that sulfide oxidation is impaired in Coenzyme Q10 (CoQ10) deficiency.

169 rventions during their lifetime and survival is impaired in comparison with the age- and sex-matched

170 show that its genotoxin-induced degradation is impaired in ddi1.

171 nitor cells (HSPC) from the bone marrow (BM) is impaired in diabetes.

172 Pol II processivity is impaired in diauxic cells, but strains with reduced p

173 roliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia.

174 l tension, we show that chromosome alignment is impaired in extra-soft mouse oocytes, despite normal

175 t a virus lacking the UL48 gene (vDeltaUL48) is impaired in growth in cell culture and has diminished

176 tude of mismatch negativity and, critically, is impaired in healthy people who report more psychotic-

177 rther assessed whether coupling of MBF to EW is impaired in HFpEF and associated with compensatory in

178 romotes antifungal immunity in the CNS; this is impaired in human deficiency in CARD9, which leads to

179 Spatial learning is impaired in humans with preclinical Alzheimer's disea

180 metry assays revealed that condensin complex is impaired in HyperD-ALL cells, leading to chromosome h

181 sion: The nutrient-stimulated FGF19 response is impaired in ICU patients, which is mechanistically li

182 at KC-mediated mature neutrophil recruitment is impaired in IL-36gamma(-/-) mice.

183 nse to maintain normal glucose tolerance but is impaired in individuals with T2DM.

184 lin in skeletal muscle and PAK1/2 signalling is impaired in insulin-resistant mouse and human skeleta

185 the fatty acid synthesis genes FASN and ACC1 is impaired in IQGAP1-null mice.

186 nt formation with a primary caregiver, which is impaired in many children with childhood maltreatment

187 show that the development of bone lymphatics is impaired in mice that lack osteoclasts.

188 Liver regeneration is impaired in mice with hepatocyte-specific deficiencie

189 keletal muscle, as well as cutaneous wounds, is impaired in mice with myeloid-specific deficiency of

190 tal circumstances, or cognitive flexibility, is impaired in multiple psychiatric conditions, includin

191 Dynamic turnover of dendritic spines is impaired in mutant mice and is accompanied by an incr

192 Perception of the Kanizsa illusory contours is impaired in neurodevelopmental disorders such as schi

193 nstrate that reflex cutaneous vasodilatation is impaired in older hypercholesterolaemic adults but no

194 Thermoregulatory ability is impaired in persons with elevated serum cholesterol,

195 hypothesis that entorhinal-based navigation is impaired in pre-dementia Alzheimer's disease.

196 In summary, proNGF maturation is impaired in preclinical and clinical AD while mature

197 ction errors benefits learning in health and is impaired in psychosis.

198 Working memory (WM) is impaired in psychotic disorders and linked to functio

199 This release of ATP is impaired in RBCs from older adults, but the underlyin

200 This ATP release is impaired in RBCs from older vs. young adults, but the

201 Modulation of activity duration is impaired in rLG, confirming the role of reflex feedba

202 n integral role in human social dynamics and is impaired in several neurodevelopmental disorders.

203 This ability is impaired in several psychiatric disorders, such as au

204 Our study shows that outcome is impaired in sickle cell disease patients receiving ex

205 Additionally, we found that ORF24 expression is impaired in the absence of a stable vTA complex.

206 n the drought-tolerant variety, but recovery is impaired in the drought-sensitive sorghum variety.

207 In contrast, the pathway is impaired in the glioma stem-like cells resulting in t

208 Here we provide evidence that mitophagy is impaired in the hippocampus of AD patients, in induce

209 tion in response to exogenous RGF1 treatment is impaired in the rgi1/2/3/4/5 quintuple, yda single, a

210 duction of lysosomal biogenesis and function is impaired in the RPE from miR-211(-/-) mice that show

211 Mitochondrial import of USP30 substrates is impaired in USP30 knockout (KO) cells, suggesting tha

212 ealed that: i) thymic and bone marrow output was impaired in 4 out 5 patients at the time of PML deve

213 wever, TCPOBOP-induced cell cycle activation was impaired in [MET KO + EGFRi] mice due to defective i

214 Postprandial repression of Cyp7a1 was impaired in Areg(-/-) mice, and recombinant AREG dow

215 OVERLY SENSITIVE1 and Na(+)/H(+) ANTIPORTER, was impaired in camta6 mutants.

216 Iron efflux was impaired in Cp KO astrocytes and Heph KO oligodendro

217 l tolerance to oxazolone, mediated by Tregs, was impaired in Dock8(-/-) mice.

218 than that of WT, suggesting that the mutant was impaired in drought-induced gene expression.

219 Moreover, proximal TCR signaling was impaired in galectin-9-deficient T cells, and prolif

220 Shh signaling was impaired in gigaxonin-null zebrafish and was correct

221 The Deltahda-2 strain was impaired in its ability to colonize Arabidopsis root

222 This mechanism was impaired in Mcoln1 (-/-) mice, which showed diminish

223 Mitochondrial function was impaired in mdKO mice, but energy charge was preserv

224 onsistent with these findings, wound healing was impaired in mice lacking IL-6 or GPR39.

225 Conversely, fibroblast activation was impaired in mice with a fibroblast-specific deletion

226 genic resolution after CCl(4) administration was impaired in mice with Alb-Cre-mediated L-Fabp deleti

227 Evoked vascular reactivity was impaired in mice with CAA, which corresponded to slo

228 However, IFN-gamma responsiveness was impaired in microglia/macrophages irrespective of si

229 n a behavioural paradigm of active-avoidance was impaired in MT mice, strengthening the conclusion th

230 Synaptic transmission was impaired in neurons expressing mutant variants, whic

231 s, such as ASH1L, DYRK1A, MED13, and SHANK3, was impaired in our Drosophila models.

232 S-competent cells promoted cell survival, it was impaired in OXPHOS-defective cells because of inhibi

233 In conclusion, CA during thrombolysis was impaired in patients who did not respond to therapy.

234 Microgliosis was impaired in PS2APP;Trem2(ko) mice, with Trem2-defici

235 Working memory was impaired in rats with mEC lesions, but the occurrenc

236 response, the protective epidermal function was impaired in Ric(EKO) mice, as revealed by increased

237 ecycling via the retromer and WASH complexes was impaired in the absence of ARPC1B.

238 Alanine transport was impaired in the cycA mutant, and this correlated wit

239 inward-rectifying K(+) (K(+) (in) ) channels was impaired in the guard cells of cipk23 mutants, where

240 Moreover, interoceptive performance was impaired in the HHD group.

241 longation of hypocotyls in response to auxin was impaired in the mutant.

242 Insulin signaling at the level of Akt2 was impaired in the nonexercised muscle on the exercise

243 tiation of the temporoammonic pathway to CA1 was impaired in the postictal period, but only when seve

244 activity of TAM, M1-like TAM differentiation was impaired in the s.c. tumor microenvironment of mTORC

245 Although control LTP was impaired in the young transgenic mice, it was not TN

246 ow that a PLY-deficient S. pneumoniae mutant was impaired in triggering human neutrophil transepithel

247 the ventral tegmental area following mating was impaired in TRPM8(-/-) males.

248 F. nucleatum unable to consume sialic acids was impaired in vaginal colonization.

249 In vitro Th17 differentiation was impaired in VHL-deficient T cells.

250 5xFAD mice of the same age were impaired in a hippocampal-dependent memory task.

251 nal model when voltage-gated sodium currents were impaired in basket cells (BCs).

252 However, hookworm-infected hamsters were impaired in detecting a displaced object.

253 Both processes were impaired in fibroblasts from children with HGPS and

254 nction and fatty acid and glucose metabolism were impaired in HF-patients compared with HC (P<0.05).

255 ed monkeys received fornix transection, they were impaired in learning new visuospatial discriminatio

256 omains and tethering to the nuclear envelope were impaired in mutant cells.

257 c pulses of glycine onto outside-out patches were impaired in mutant receptors, as deactivation was a

258 All 3 strain indices were impaired in patients with MACE (all P<0.001).

259 d HSF1 nuclear localization and distribution were impaired in senescence.

260 , and parasites carrying a single APX allele were impaired in their ability to infect macrophages and

261 Although some MxA super-restrictors of THOV were impaired in their restriction of H5N1 influenza A v

262 decline, and EC identity and gut homeostasis are impaired, including pathological reprograming and co

263 kin Na(+) excess, but the lymphatic drainage was impaired (isovolumetric pressure in patients with HF

264 e absence of connexin channels, Ca(2+) waves are impaired, leading to a reduction in the number of ri

265 ale mice, neutrophil maturation and function are impaired, leading to elevated metastatic burden in t

266 ation to save energy during food deprivation is impaired, leading to increased fat loss.

267 , the recruitment and activation of NK cells is impaired, leading to uncontrolled viral proliferation

268 iabetic conditions, this IFNbeta-Setdb2 axis was impaired, leading to a persistent inflammatory macro

269 Proton reduction in the variants is impaired mainly by limiting the turnover rate, which

270 completion (e.g., when lysosomal degradation is impaired) may instead exacerbate disease in some case

271 nhances presynaptic glutamate release, which is impaired on alpha2delta1 knockdown.

272 at T cells deleted for ESYT1 and ESYT2, SOCE was impaired only in Jurkat T cells, suggesting that the

273 the possibility that other forms of learning are impaired, our findings suggest that some of the majo

274 ifferentiation capability of knock-out cells was impaired, owing to the inability to cope up with inc

275 Microglial clustering around plaques was impaired, plaques were more diffuse, and the Abeta42

276 Among the hallmarks of melanoma are impaired proteostasis and rapid development of resis

277 hout of CO(2), if cerebrovascular reactivity is impaired, reduces respiration.

278 nsulin are misread and proinsulin processing is impaired, reducing insulin content and secretion.

279 nter survival of birds in egalitarian groups was impaired relative to despotic groups in forests rece

280 ural dynamics change when a sensory modality is impaired remains unclear.

281 itory stimuli, or exposure to novel objects, were impaired, reminiscent of findings in schizophrenia

282 and neurons is reduced, and neuron migration is impaired, resulting in disorganization of the cerebra

283 their motility on detyrosinated microtubules is impaired, showing shorter runs and more frequent and

284 The most common pathophysiology was impaired substrate delivery (n = 158, 54.1%) manifes

285 ysiologies contributing to the poor outcomes were impaired substrate delivery (n = 158, 54.1%) and in

286 If the ability of Spd-2 to recruit Polo is impaired, the scaffold is initially assembled around

287 or junctional incorporation of ZO-1 clusters is impaired, then TJs lose their mechanosensitivity, and

288 e dawn of agriculture, crop yield has always been impaired through abiotic stresses.

289 ersity x ecosystem-function relationship can be impaired under non-favorable conditions in soils, and

290 When nuclease cleavage is impaired, we observe a reduction in strand-displaceme

291 This response was impaired when the minimum EBE was fused with a thymi

292 the two processing pathways, whereby one can be impaired while the other develops typically.

293 ional sympatholysis and endothelial function are impaired with ageing, resulting in compromised blood

294 and that both mLV integrity and CSF drainage are impaired with ageing.

295 vasodilatory response to reactive hyperaemia is impaired with advancing age, but it is unclear whethe

296 Yet, the degree to which this mechanism is impaired with age, and contributes to variability in

297 vasodilatory response to reactive hyperaemia is impaired with age, but it is unknown whether this is

298 asoconstriction ('functional sympatholysis') is impaired with age.

299 demonstrate that hippocampal memory updating is impaired with aging and establish that the OUL paradi

300 QOL is impaired with endotherapy, but alimentary satisfactio