ライフサイエンスコーパス: be implicated as

1 piratory viruses--the "common cold" viruses--are implicated as a principal cause, there is little evi

2 No single protein in addition to VEGF can be implicated as a contributor in all patients.

3 ted with astrocyte hypertrophy and aging has been implicated as a basis for these pathological change

4 luence homocysteine levels; homocysteine has been implicated as a cataractogenic stressor.

5 ated to classical chlamydial species and has been implicated as a cause of abortion in cattle.

6 Over 80 genes have been implicated as a cause of cardiomyopathy.

7 ediates produced during drug metabolism have been implicated as a cause of DILI, and their formation

8 Both sugar and fat consumption have been implicated as a cause of hepatic steatosis and obes

9 egulating stem-like cancer cells, which have been implicated as a cause of metastasis and treatment r

10 previously reported, FMD has not previously been implicated as a cause of MP, and the massive extent

11 Dysregulated protein synthesis has been implicated as a cause of this disease.

12 lly, mutagenic action of mismatch repair has been implicated as a cause of triplet repeat expansions

13 While cancer stem-like cells have been implicated as a cell of origin for prostate cancer

14 In the years since its discovery, IL-23 has been implicated as a central pathogenic factor in multip

15 se to an oxidative insult, wild-type p53 has been implicated as a central regulatory component of the

16 e repeat-containing protein alpha (SGTA) has been implicated as a co-chaperone and regulator of andro

17 scription factor Forkhead box N1 (FOXN1) has been implicated as a component of the mechanism regulati

18 nt of the nuclear pore complex (NPC) and has been implicated as a congenital heart disease gene throu

19 The receptor has also been implicated as a contributor to neurodegeneration ca

20 transcription factor mesogenin 1 (Msgn1) has been implicated as a cooperative regulator working in co

21 EBV origin of plasmid replication (OriP) has been implicated as a critical control element for viral

22 SRC has been implicated as a critical factor in bone metastasis,

23 on of nuclear factor-kappaB (NF-kappaB), has been implicated as a critical molecular link between inf

24 or advanced glycation endproducts (RAGE) has been implicated as a critical molecule in the pathogenes

25 utophagy, a catabolic recycling process, has been implicated as a critical pathway in cancer.

26 E2, the receptor binding protein, has been implicated as a determinant in cell tropism, host r

27 Integrin alphavbeta3 has been implicated as a driver of aggressive and metastatic

28 ACTL6A is elevated in cancer cells and has been implicated as a driver of cancer cell proliferation

29 Retinol-binding protein 4 (RBP4) has been implicated as a driver of insulin resistance in rod

30 Reactivation of the fetal gene programme has been implicated as a driver of pathological cardiac remo

31 Hence, cellular EADs have been implicated as a driver of potentially lethal cardia

32 mPTP opening has been implicated as a final cell death pathway in numerou

33 The mismatch repair gene MSH3 has been implicated as a genetic modifier of the CAG.CTG rep

34 The nucleus has been implicated as a key mechanosensor and can directly

35 e neurotrophin nerve growth factor (NGF) has been implicated as a key mediator of chronic pain.

36 Consistently, neuroinflammation has been implicated as a key mediator of secondary damage fo

37 MicroRNA (miR) has been implicated as a key regulator controlling diverse b

38 Similar to mTOR, c-myc has been implicated as a key regulator of anabolic metabolis

39 al cues from the surrounding environment has been implicated as a key regulator of cell differentiati

40 The myogenic regulatory factor MyoD has been implicated as a key regulator of myogenesis, and ye

41 IL-15 has been implicated as a key regulator of T and NK cell home

42 ge, this is the first time a tetraspanin has been implicated as a key regulator of TLR signaling.

43 ated phosphorylation of serine 36 in p66 has been implicated as a key regulatory step preceding mitoc

44 The hippocampus has been implicated as a key structure involved in or perhap

45 Protein kinase C (PKC) has been implicated as a link, but the mechanistic details r

46 However, senescence has also been implicated as a major cause of age-related disease.

47 In addition, TLS has been implicated as a major cellular mechanism promoting

48 Although senescence has clearly been implicated as a major defense mechanism against tum

49 Of many 16p11.2 genes, Kctd13 has been implicated as a major driver of neurodevelopmental

50 TGF-beta has been implicated as a major pathogenic factor in diabetic

51 he cellular oxygen-sensing machinery and has been implicated as a major regulator of trophoblast diff

52 TH17 pathway inhibition has been implicated as a mechanism by which influenza A alte

53 Nucleophilic aromatic substitution has been implicated as a mechanism for both the biotic and a

54 )-hyper-inflammatory monocytic phenotype has been implicated as a mechanism of exacerbated tissue des

55 bition of the dopamine transporter (DAT) has been implicated as a mediating factor of HIV-1 associate

56 ion to its role in anaphylaxis, PAF has also been implicated as a mediator in both allergic and nonal

57 Because uric acid has been implicated as a mediator of adjuvant activity, we s

58 e deaminase which induces DNA mutations, has been implicated as a mediator of cancer evolution and th

59 SerpinB2 has previously been implicated as a mediator of DMBA/TPA-induced skin c

60 Interleukin-1 has been implicated as a mediator of recurrent pericarditis.

61 arvation-induced stress, COPII vesicles have been implicated as a membrane source for autophagosomes,

62 m in the monoamine oxidase A (MAOA) gene has been implicated as a moderating factor in the relationsh

63 CD23 has been implicated as a negative regulator of IgE and IgG a

64 PilY1 protein of Pseudomonas aeruginosa has been implicated as a novel mechanosensor that stimulates

65 avity, is both common and modifiable and has been implicated as a novel potential CKD risk factor.

66 translation due to ribosomal dysfunction has been implicated as a part of this process.

67 Promyelocytic leukemia protein (PML) has been implicated as a participant in multiple cellular pr

68 Rationale: Obesity has been implicated as a pathogenic factor in asthma, but th

69 and systemic inflammatory responses and have been implicated as a pathogenic factor in necrotizing en

70 TP activation has been implicated as a pathogenic factor in pregnancy comp

71 Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and ICU

72 This has been implicated as a pathogenic mechanism of mitochondri

73 RNA (dsRNA) virus Leishmaniavirus (LRV1) has been implicated as a pathogenicity factor for leishmania

74 with pathogen- and self-derived peptides has been implicated as a pathway involved in the development

75 r effective immune surveillance but has also been implicated as a pathway to autoimmunity.

76 sue types in both health and disease and has been implicated as a pharmacological target in heart fai

77 iptional modification of RNA nucleosides has been implicated as a pivotal regulator of mRNA biology.

78 The pro-inflammatory factor Activin has been implicated as a positive correlate of severity in T

79 Biofilm formation has been implicated as a possible cause for these failures.

80 ed cause of intraocular inflammation and has been implicated as a possible cause of ARN.

81 Vitamin D (25(OH)D) deficiency has been implicated as a possible risk factor for asthma dev

82 from improvised explosive devices (IEDs) has been implicated as a potential antecedent for CTE amongs

83 gh historically reactive oxygen species have been implicated as a potential cause of ageing, recent e

84 d flow and pressure during in health and has been implicated as a potential cause of the dysfunction

85 Agriculture has been implicated as a potential driver of human infectiou

86 r immediate over larger delayed rewards, has been implicated as a potential intermediate phenotype (e

87 abotropic glutamate receptor 5 (mGluR5) have been implicated as a potential pharmacotherapy for a num

88 Coastal marine atmospheric fog has recently been implicated as a potential source of ocean-derived m

89 or of a number of signaling pathways and has been implicated as a potential target for oncology and d

90 Recently, CD134 (OX40) has been implicated as a potential viral entry receptor.

91 Disturbances in SG dynamics have been implicated as a primary driver of neurodegenerative

92 Although DDX3 has been implicated as a prognostic marker for many cancers,

93 for the biosynthesis of histamine (HA), has been implicated as a rare genetic cause.

94 The FtsZ cytoskeleton has been implicated as a regulator of PG synthesis during di

95 abinoid type 2 receptor (CB2) has previously been implicated as a regulator of tumor growth, bone rem

96 In established ccRCC, HIF1alpha has been implicated as a renal tumor suppressor, whereas HIF

97 Abnormal dopaminergic transmission has been implicated as a risk determinant of HIV-1-associate

98 wn, produce reactive oxygen species, and has been implicated as a risk factor for AMD.

99 is an inflammatory chronic disease that has been implicated as a risk factor for cardiovascular dise

100 Periodontitis has been implicated as a risk factor for metabolic disorders

101 Photoperiod or the duration of daylight has been implicated as a risk factor in the development of m

102 Climate change has been implicated as a root cause of the recent surge in n

103 Fc-mediated antiviral activity has been implicated as a secondary correlate of decreased HI

104 NO has also been implicated as a signal in biotic and abiotic respon

105 ined elusive; however, DNA rereplication has been implicated as a source of gene amplifications.

106 biosynthesis of the NAD cofactor, which has been implicated as a target for developing new antimycob

107 Grp94 has been implicated as a target for several therapeutic area

108 ngosine 1-phosphate (S1P) lyase has recently been implicated as a therapeutic target for the treatmen

109 al sensor for pH/bicarbonate/CO2, and it has been implicated as a therapeutic target, e.g. for diabet

110 pyridoxal 5'-phosphate-dependent enzyme, has been implicated as a treatment for hepatocellular carcin

111 Cytosolic M. tuberculosis DNA has been implicated as a trigger for IFN production, but the

112 of Paneth cell differentiation that has also been implicated as a tumor suppressor in CRC.

113 major H3K36 trimethyltransferase, which has been implicated as a tumor suppressor in mammals.

114 Bacillus subtilis bacteriophage varphi29 has been implicated as a wall teichoic acid hydrolase.

115 ient receptor potential 3 (TRPV3), which has been implicated as a warmth detector, becomes responsive

116 The CX3CR1 gene is implicated as a candidate gene for age-related macula

117 IL6-mediated activation of STAT3 is implicated as a critical therapeutic target for cance

118 Chronic viral infection by CMV is implicated as a driver of clonal T cell proliferation

119 rticularly within cortico-striatal circuits, is implicated as a fundamental mechanism in Tourette's s

120 The medial temporal lobe is implicated as a key brain region involved in the path

121 CNS, and the virus-specific immune response is implicated as a mediator of neuronal damage.

122 end of an intergenic region on Chr11p13 that is implicated as a modifier of cystic fibrosis airway di

123 The tail-anchored protein Fis1 is implicated as a passive tether in yeast mitochondrial

124 Neuroinflammation is implicated as a pathomechanism, but the upstream mech

125 tified, but platelet-activating factor (PAF) is implicated as a potential rate-limiting effector agen

126 TREM1 is implicated as a potential target to treat stroke and

127 BACKGROUND & AIMS: Dietary fiber is implicated as a risk factor for diverticulitis.

128 The European badger (Meles meles) is implicated as a wildlife reservoir and is the subject

129 The European badger (Meles meles) is implicated as a wildlife reservoir of infection.

130 Death-associated protein 1 (DAP1) was implicated as a candidate gene in a previous familia

131 pressed in myeloid and bone marrow cells and was implicated as a checkpoint regulator of inflammatory

132 Moreover, rs910083-C was implicated as a cis-methylation quantitative trait l

133 Macrophage colony stimulating factor (M-CSF) was implicated as a contributing upstream activator of m

134 r the outbreak could be determined, wildlife was implicated as a disease vector.

135 , which is decreased in Alzheimer's disease, was implicated as a potential mediator of long-term chol

136 orylation-regulated kinase 1 A (DYRK1A) gene was implicated as a risk factor for autism spectrum diso

137 Various components of NETs have also been implicated as activators of coagulation.

138 Glia are implicated as active participants in these changes.

139 SP6 has also been implicated as an AI candidate gene through its stud

140 in functionally conserved in eukaryotes, has been implicated as an early regulator for biogenesis of

141 a interferon (IFN-alpha/beta) responses, has been implicated as an EBOV-encoded factor that contribut

142 regulated by transcription factor HSF-1 has been implicated as an effector mechanism, the role and p

143 IFN-beta has been implicated as an effector of oviduct pathology resu

144 nase GAS6/AXL signaling pathway has recently been implicated as an essential mediator of metastasis a

145 Similarly, A20 has recently been implicated as an essential regulator of inflammatio

146 covered in Drosophila, the Hippo pathway has been implicated as an evolutionarily conserved pathway i

147 Glutamine has been implicated as an immunomodulatory nutrient, but how

148 Glutamine has been implicated as an immunomodulatory nutrient, but its

149 ncompletely understood, oxidative stress has been implicated as an important contributor in the devel

150 ing via the IL-6 signal transducer GP130 has been implicated as an important driver of MM pathogenesi

151 ed derivative of 5-methylcytosine (5mC), has been implicated as an important epigenetic regulator of

152 ng osteomyelitis, and the msaABCR operon has been implicated as an important factor in modulating exp

153 ng is increased in menopausal women, and has been implicated as an important mediator of hot flushes.

154 rmation of cusp pattern, the Shh pathway has been implicated as an important player.

155 C-type lectin expressed in renal tissue, has been implicated as an important trigger of complement ac

156 However, KIF3C has also been implicated as an injury-specific kinesin that is a

157 UV-induced prostaglandin E2 has been implicated as an intermediary in the effects of UV

158 it of the miRNA regulatory complex RISC, has been implicated as an oncogene in hepatocellular carcino

159 lial transition factor ( MET) activation has been implicated as an oncogenic driver in epidermal grow

160 e (2-HG) production, and 2-HG has previously been implicated as an oncometabolite.

161 The dysregulation of PI3K signaling has been implicated as an underlying mechanism associated wi

162 Calcium cycling instability has been implicated as an underlying mechanism of electrical

163 Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas a

164 Interleukin-33 (IL-33) is implicated as an epithelium-derived danger signal pro

165 Flavonols are plant metabolites that have been implicated as antioxidants; however, their antioxid

166 As KtrAB and its homolog TrkAH have been implicated as bacterial pathogenicity factors, the

167 Although glucose oxidation has been implicated as being essential for thermogenesis, it

168 ids and inorganic polyphosphate (polyP) have been implicated as being important (patho)physiologicall

169 Vitamin D has been implicated as being important for maintaining cogni

170 mmalian target of rapamycin (mTOR) signaling was implicated as being involved in the regulation of mi

171 ement of the orphan receptor Tie1, which has been implicated as both a positive and negative regulato

172 the alkyne complex and the metallacycle that are implicated as catalytic intermediates.

173 ty of autism is high and multiple genes have been implicated as causal.

174 is, environmental stress, and aging have all been implicated as causative factors in this process.

175 though polar biotransformation products have been implicated as causative genotoxic agents, no specif

176 Both hyperinflammation and immunosuppression are implicated as causes of morbidity and mortality.

177 impaired clearance of apoptotic cells, have been implicated as causes of failure to resolve gut infl

178 Increasingly, nonfecal sources of FIB have been implicated as causes of poor microbial water qualit

179 Neural lineages have been implicated as cells of origin, as have glia.

180 Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and lo

181 lular nonreceptor tyrosine kinase, which has been implicated as central immune modulator promoting al

182 rotein (APP) into Abeta peptides, which have been implicated as central players in the pathology of A

183 ome arms 1p and 19q (1p/19q codeletion) have been implicated as clinically relevant markers of lower-

184 plexes, the Tic110 and 1 MDa complexes, have been implicated as constituents of the TIC translocon, a

185 bute to impaired beta-cell function and have been implicated as contributing factors to this disease.

186 Complement activation has been implicated as contributing to neurodegeneration in

187 -body energy homeostasis; its disruption has been implicated as contributing to the development of in

188 he composition of stem cell populations have been implicated as contributors to aging.

189 Many microbial agents have been implicated as contributors to cancer genesis and de

190 ypes and bone marrow-derived fibrocytes have been implicated as contributors to fibrotic lesions beca

191 n (DC-SIGN) and heparan sulfate proteoglycan were implicated as coreceptors because only the combinat

192 Thus, T. gondii PTMs are implicated as critical regulators of cell division a

193 Ral GTPases have been implicated as critical drivers of cell growth and m

194 enchymal-to-epithelial transition (MET), has been implicated as critical in the metastatic colonizati

195 regulatory factor (IRF) family members have been implicated as critical transcription factors that f

196 tine tegmentum alongside the caudate nucleus were implicated as critical structures.

197 eference and stability of hemagglutinin have been implicated as crucial determinants of airborne tran

198 Natural killer (NK) cells are implicated as determinants of immune control in many

199 listic interactions among bacteria have also been implicated as determinants of the microbiota compos

200 es across the genome, and a small subset has been implicated as downstream effectors in oncogenic pat

201 Pim and AKT serine/threonine protein kinases are implicated as drivers of cancer.

202 Several transcription factors have been implicated as drivers of EMT and metastatic progres

203 pathway transcriptional coactivators YAP/TAZ were implicated as drivers in GBM progression and could

204 r consequences for cerebrovascular function, are implicated as driving cognitive impairment during ag

205 Climate change has been implicated as driving shifts of hybridizing species

206 hibition shunts the kynurenine pathway-which is implicated as dysfunctional in various psychiatric di

207 bon (C) with appropriate management and thus are implicated as effective tools in stabilizing climate

208 tein peptide-specific cytotoxic CD8+ T cells are implicated as effectors in a transgenic mouse model

209 While these substrates have been implicated as efficacy targets in multiple myeloma

210 in (Trx) and glutaredoxin (Grx) systems have been implicated as electron donors for the RNR disulfide

211 Circulating histones are implicated as essential mediators of MODS.

212 Both proteins have been implicated as essential proteins for skin barrier m

213 d play a role in neutrophil chemotaxis, have been implicated as fluid shear stress sensors that contr

214 Neutrophils have been implicated as harmful cells in a variety of inappro

215 ation factor XII, platelets, and neutrophils are implicated as important players in the pathophysiolo

216 ions between co-resident microorganisms have been implicated as important drivers of microbiome compo

217 terogeneity in host susceptibility have both been implicated as important factors that may reduce ove

218 d its endogenous peptidic ligand apelin have been implicated as important modulators of cardiovascula

219 es in the assembly process in vitro and have been implicated as important neurotoxic species in AD.

220 ets, neutrophils, and factor XII (FXII) have been implicated as important players in the pathophysiol

221 Dendritic cells (DCs) have been implicated as important regulators of innate and ad

222 Epigenetic regulators in general have been implicated as indicators, mediators, or causes of a

223 These nucleotide bases have been implicated as intermediates on the path to active d

224 f the introduced super-generalist pollinator are implicated as key in determining the roles introduce

225 Criegee intermediates are implicated as key intermediates in atmospheric, synt

226 Biased patterns of attention are implicated as key mechanisms across many forms of ps

227 immune responders in the brain, glial cells are implicated as key players in the onset and progressi

228 Atypical PKCs (aPKCs) are implicated as key regulators of epithelial polarity.

229 Serine proteases have been implicated as key drivers and facilitators of lung

230 r of G-protein signaling (RGS) proteins have been implicated as key inhibitors of 5-HT(1A)Rs, whose a

231 (III)-superoxo species (Fe(III)-O2(-.)) have been implicated as key intermediates in the catalytic cy

232 minal cobalt(IV)-oxo (Co(IV)-O) species have been implicated as key intermediates in various cobalt-m

233 Astrocytes have been implicated as key regulators of neuroinflammation i

234 nflammatory pathways and mediators that have been implicated as links between NAFLD and type 2 diabet

235 nresponsiveness in Foxp3(-) cells, have both been implicated as mechanisms to suppress dangerous immu

236 Magic-sized nanoclusters have been implicated as mechanistically relevant intermediate

237 f the glucocorticoid receptor gene Nr3c1 has been implicated as mediator of long-term effects of deve

238 tractant protein-1 inflammatory pathway have been implicated as mediators of the adverse effects indu

239 T: Small conductance K(+) (SK) channels have been implicated as modulators of spontaneous depolarizat

240 vesicles, including exosomes, have recently been implicated as novel mediators of immune cell commun

241 Several genes, including GRAMD2 and STAM, were implicated as novel ASD risk genes when integrating

242 Notch receptors have been implicated as oncogenic drivers in several cancers,

243 ate determinant, and its hyperactivation has been implicated as oncogenic in several cancers includin

244 ht are not well understood, but appetite has been implicated as one mediating pathway.

245 Lysosomal alterations have been implicated as one of the main cellular defects cont

246 Although APN1 has been implicated as one of the receptors for Cry1Ac in se

247 tion between alpha-syn and copper(II), which is implicated as one of the factors inducing structural

248 The epithalamic lateral habenula (LHb) is implicated as part of the mammalian brain's circadian

249 reduced central response to hypercapnia have been implicated as pathophysiological drivers, the impac

250 amine, and norepinephrine transporters) have been implicated as playing major roles in the actions of

251 Residues A38 and G8 have been implicated as playing roles in general acid and bas

252 They have been implicated as possible carriers of the diffuse inte

253 ticular, streptococcal surface proteins have been implicated as potent neutrophil activators.

254 n autophagy and stress granule dynamics have been implicated as potential mechanisms underlying inclu

255 (D3R) partial agonists and antagonists have been implicated as potential medications for substance u

256 Muscarinic acetylcholine receptors have been implicated as potential neuroprotective targets for

257 arrhythmias are frequently reported and have been implicated as potential pathomechanisms of Sudden U

258 Both the Tyr and a conserved Asp are implicated as proton donors to the epoxide leaving g

259 ocytes found within the HCC microenvironment are implicated as regulators of tumour growth.

260 While many microRNAs have been implicated as regulators of metastatic progression,

261 ependent potassium channels, which have each been implicated as regulators of smooth muscle contracti

262 As both Tim44 and Pam17 have been implicated as regulatory subunits of the motor, thi

263 Prenatal and perinatal factors have been implicated as risks, but definite causes remain unk

264 s of the candidate genes have not previously been implicated as RP modifiers and their functions are

265 landular tissue (FGT) assessed with MRI have been implicated as sensitive imaging biomarkers for brea

266 Explosives used in construction have been implicated as sources of NO3(-) contamination in gr

267 It is implicated as suppressed TCR-signaling cascades, redu

268 astasis-associated transcripts that have not been implicated as targets, effectors or potential bioma

269 the brush border of the apical membrane has been implicated as the "receptor" mediating albumin tran

270 er butzleri is an emerging pathogen that has been implicated as the causative agent of persistent wat

271 The gene encoding sortilin (SORT1) has been implicated as the causative gene within the locus,

272 Of the validly described species, many have been implicated as the cause of serious human infections

273 culature and surrounding neural ganglion has been implicated as the cause of these symptoms.

274 Hrd1 has been implicated as the channel that mediates the transpo

275 Oligomers, in particular, have been implicated as the dominant molecular species respon

276 culation and the biological carbon pump have been implicated as the drivers behind the rise in atmosp

277 -interglacial timescales, the deep ocean has been implicated as the likely location of carbon sequest

278 Retro-aldol reactions have been implicated as the limiting steps in catalytic route

279 Although apoptosis has long been implicated as the major form of programmed cell dea

280 Family D DNA polymerases (polDs) have been implicated as the major replicative polymerase in a

281 Both apoptosis and necrosis have been implicated as the mode of cell death in various can

282 Dioxygen has been implicated as the oxidant in this unusual addition

283 In both cases the Antarctic ice sheet has been implicated as the primary contributor, hinting at i

284 support robust HIV-1 transcription and have been implicated as the primary reservoir of latent HIV-1

285 Although the accessory sex glands have been implicated as the primary sites of EAV persistence,

286 Resilience has been implicated as the principal mediator in the develop

287 function of the hypocretin/orexin system has been implicated as the underlying cause of narcolepsy wi

288 ly invisible, the second deoxygenation stage is implicated as the critical C-N product-forming event,

289 Furthermore, anthropogenic coal usage is implicated as the dominant source of modern Mississip

290 We demonstrate that elevated NEDD4 is implicated as the responsible ubiquitin E3 ligase for

291 family of antiviral DNA cytosine deaminases is implicated as the second largest source of mutation i

292 ons of the amyloid beta-peptide (Abeta) have been implicated as toxic events in the development and p

293 post-translational modifications (PTMs) that are implicated as triggers of disease pathology.

294 More than 100 drugs have been implicated as triggers for this condition, quinine

295 Monocytes have also been implicated as "Trojan horses" during viral infectio

296 They are implicated as truncated forms or interchromosomal re

297 The latter genes have previously been implicated as tumor suppressors in de novo and seco

298 dermal Growth Factor Receptor 3 (ErbB3) have been implicated as two such drivers of resistance, howev

299 Ticks are implicated as vectors of a wide array of human and a

300 protein-coding-gene regions, have frequently been implicated as well.