ライフサイエンスコーパス: be inactivated in

1 The BAP1 protein, a nuclear deubiquitinase, is inactivated in 15% of clear cell RCCs.

2 ubunit and a putative tumor suppressor gene, is inactivated in 15-20% of many solid tumor types.

3 The p16 tumor suppressor gene was inactivated in 22 of 38 (58%) tumors.

4 It is inactivated in 30% of lung cancer cell lines but only

5 n factor essential for B-lineage commitment, is inactivated in 32% of cases of B-progenitor ALL.

6 (NF2) tumor suppressor gene on 22q12, which is inactivated in 40% of sporadic meningiomas.

7 select group of tumor suppressor genes that are inactivated in a wide range of common human tumor ty

8 complexes, at least one of which appears to be inactivated in a cell line which does not express the

9 created mice in which the MMR gene Msh2 can be inactivated in a defined fraction of crypt base colum

10 ally, in cancer patients, Aalpha is found to be inactivated in a haploinsufficient manner.

11 ing CDKN2A, a tumor suppressor gene known to be inactivated in a majority of lung squamous cell tumor

12 deleted on chromosome 10) has been shown to be inactivated in a wide variety of cancers, and the rol

13 losuccinate synthetase from Escherichia coli is inactivated in a biphasic reaction by 6-(4-bromo-2,3-

14 losuccinate synthetase from Escherichia coli is inactivated in a biphasic reaction by guanosine 5'-O-

15 sensitive phenotype can be observed when cus is inactivated in a cueR background.

16 strate that in a normal cell cycle APC(Cdh1) is inactivated in a graded manner and is not extinguishe

17 p53 is a major tumour suppressor that is inactivated in a large proportion of human cancers.

18 p53 gene is a critical tumor suppressor that is inactivated in a majority of cancers.

19 y been identified at chromosome 10q23, which is inactivated in a number of different tumor types incl

20 anscription factor and tumor suppressor that is inactivated in a number of human cancers by mutation,

21 Transcription factor RUNX3 is inactivated in a number of malignancies, including br

22 Following DNA repair, the checkpoint pathway is inactivated in a process termed recovery.

23 most human cancers or the wild type protein is inactivated in a significant number of the remainder,

24 Finally, we show that SLX4IP is inactivated in a subset of ALT-positive osteosarcomas

25 Our results demonstrate that NORE1A is inactivated in a subset of human cancers by CpG islan

26 also suggests that the RB-related gene p130 is inactivated in a subset of human NSCLCs.

27 that negatively regulates Ras signaling and is inactivated in a subset of juvenile myelomonocytic le

28 JNK1/2 is inactivated in a substantial proportion of human LSCC

29 on is believed to involve Cdk1 kinase, which is inactivated in a switch-like way after anaphase.

30 ervations and a report that KDO 8-P synthase is inactivated in a time-dependent manner with 3-bromopy

31 cumented for Arf GAP1/coatomer in which Arf1 is inactivated in a tripartite complex.

32 NORE1A is a growth and tumor suppressor that is inactivated in a variety of cancers.

33 r suppressor gene RASSF1, located at 3p21.3, is inactivated in a variety of human cancers including l

34 CIC is inactivated in a variety of human tumors and has been

35 F1A is a putative tumor suppressor gene that is inactivated in a variety of human tumors.

36 It is inactivated in a wide range of human malignancies, in

37 essor that antagonizes the PI3K/AKT pathway, is inactivated in a wide range of tumors, including 40-5

38 he phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms.

39 In this report, the cheA(2) gene was inactivated in a low-passage-number virulent strain

40 ighly purified rat liver methionine synthase was inactivated in a partially irreversible manner with

41 However, Grx was inactivated in a time- and concentration-dependent f

42 deleted in pancreatic cancer locus 4 (DPC4) is inactivated in about 50% of pancreatic adenocarcinoma

43 In addition, FHIT may be inactivated in accordance with the two-hit inactivati

44 the TP from the large pPolB polypeptide and is inactivated in adenovirids, in which TP is a separate

45 anges the longstanding definition of how p53 is inactivated in adenovirus infection and provides key

46 tion paradigm, that, unexpectedly, when Pax7 is inactivated in adult mice, mutant satellite cells are

47 When VEGF-A was inactivated in adult beta-cells, islet vascularizati

48 Hus1 was inactivated in adult mice using a transgenic strain

49 n each orthopoxvirus species, numerous genes are inactivated in all other members of the genus.

50 nding challenges the hypothesis that RB must be inactivated in all cells for cell cycle progression t

51 p53 is inactivated in all progressed tumors, with loss of th

52 re normally expressed whereas ERalpha-C gene was inactivated in all endometrial cancer cell lines.

53 rds against tumour and virus replication and is inactivated in almost all cancers.

54 , a recently cloned gene located on 18q2l.l, is inactivated in almost one half of pancreatic adenocar

55 ts degradation when the E1-activating enzyme was inactivated in an E1 temperature-sensitive mouse emb

56 d that the intrinsic resistance factor whiB7 was inactivated in an entire Mtb sublineage endemic to S

57 The alpha1,3GT gene was inactivated in ancestral Old World monkeys and apes

58 d that a specific target, such as NF-kappaB, was inactivated in animal tumors pretreated with thymoqu

59 In mutant mice in which the Fgf8 gene is inactivated in anterior neural structures, FGF-mediat

60 Although homologous genes have yet to be inactivated in any other organism, our observations a

61 In contrast, neither p15INK4B nor p16INK4A were inactivated in any stage of chronic myelogenous leu

62 Indeed, RPL22 was found to be inactivated in approximately 10% of human T-acute lym

63 This gene, which we call WTX, is inactivated in approximately one-third of Wilms tumor

64 mice show increased B cell anergy when VprBP is inactivated in B cells.

65 : introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-so

66 If these genes are inactivated in both alleles, metastatic ability is p

67 We identified eight skin-related genes that are inactivated in both cetaceans and hippos, including

68 ARCAL1 contributes to fork collapse when ATR is inactivated in both mammalian and Xenopus systems.

69 ar studies identify ADIPOR1 signaling, which is inactivated in both obesity and human cancers, as a k

70 on Hippel-Lindau (VHL) tumor suppressor gene is inactivated in both sporadic and inherited clear cell

71 ves as a master repressor of neuronal genes, was inactivated in both Ad12- and Ad5-transformed cells

72 (and was therefore less effective) when Tr* was inactivated in both rod and cone membranes.

73 FOXP3 is inactivated in breast cancer cells by a number of mec

74 The bchU gene was inactivated in C. tepidum, a BChl c-producing specie

75 xplain why only isolated DNA repair pathways are inactivated in cancer cells.

76 otential way by which tumor suppressor genes are inactivated in cancer.

77 how high levels of wild-type p53 might also be inactivated in cancer as well as the mechanisms that

78 p53 tumor suppressor gene, which frequently is inactivated in cancer.

79 This suggests a mechanism by which SMAD4 is inactivated in cancers and provides guidance for targ

80 m20C (foxl/flox) (cKO) mice, in which Fam20C was inactivated in cells expressing Type I collagen.

81 ne coding for the ubiquitin ligase Huwe1 has been inactivated in cerebellar granule neuron precursors

82 PTEN, a dual-phosphatase tumor suppressor, is inactivated in Cowden syndrome (CS), characterized by

83 anifestations of Hajdu-Cheney syndrome, Hes1 was inactivated in Ctsk-expressing cells from Notch2(tm1

84 nce, we established that (i) the group I AIP is inactivated in culture supernatants by the formation

85 red for plasma cell differentiation and that is inactivated in diffuse large B-cell lymphomas.

86 nd mutant mice, in which dopamine production is inactivated in dopaminergic neurons by gene targeting

87 r the maternal or the paternal X chromosomes are inactivated in each individual cell in females.

88 t forth the hypothesis that one X chromosome is inactivated in each cell of the female mammal.

89 A single X chromosome was inactivated in each focus, consistent with its monoc

90 gene at chromosome region 3p14.2, FHIT, that is inactivated in epithelial tumors, particularly in tum

91 of tumors seen in mice where one Apc allele was inactivated in epithelial cells from distal ileum to

92 This pathway is inactivated in FA, a devastating genetic disease, whi

93 a negative regulator of cardiac hypertrophy, is inactivated in failing hearts.

94 es only, suggesting that less corticosterone was inactivated in female placentas.

95 ng of DnaB during the initiation process and is inactivated in forming an intermediate termed the pre

96 d that a specific target, such as NF-kappaB, was inactivated in genistein-treated animal tumors and t

97 Dam methylase (HI0209) in strain Rd KW20 was inactivated in Haemophilus influenzae strains Rd KW2

98 e suppressor of cytokine signaling-1 (SOCS1) is inactivated in hematopoietic and solid cancers by pro

99 oietic differentiation, but Gata1 expression is inactivated in hematopoietic stem cells (HSCs).

100 C) to identify a novel gene whose expression is inactivated in high grade prostate cancer.

101 analyses for protein-coding genes that have been inactivated in hippos and cetaceans.

102 INK4B), have tumor suppressor activities and are inactivated in human cancer.

103 e mechanisms by which tumor suppressor genes are inactivated in human cancers.

104 ne mechanism in which tumor suppressor genes are inactivated in human cancers.

105 e mechanisms by which tumor suppressor genes are inactivated in human cancers.

106 All three genes have been inactivated in human tumors.

107 ed by SMARCB1, hereafter called SNF5), which is inactivated in human malignant rhabdoid tumors (MRTs)

108 pancreatic transcription factor PTF1A, which is inactivated in human patients with cerebellar agenesi

109 The p53 tumor suppressor gene is inactivated in human tumors by several distinct mecha

110 indicate that specific paternal centromeres are inactivated in hybrids due to the disruption of asso

111 nes encoding molecules involved in autophagy are inactivated in immune effector cells.

112 uence the choice of which X chromosome is to be inactivated in individual cells.

113 on regulon genes in iron-deficient yeast but are inactivated in iron-replete cells.

114 Both alleles of the NF1 gene are inactivated in leukemic cells in some patients with

115 Mycobacterium tuberculosis was inactivated in lung sections of these mice by gamma-

116 The gene, ald, was inactivated in M. tuberculosis, which resulted in th

117 Seoul virus persistence, regulatory T cells were inactivated in male rats by using an anti-rat CD25

118 be an important mechanism by which 3OC12-HSL is inactivated in mammals.

119 Because E-cadherin is inactivated in many adenocarcinomas we hypothesized t

120 has diverse tumour-suppressor functions and is inactivated in many cancers, germline RB1 mutations p

121 r gene phosphatase and tensin homolog (PTEN) is inactivated in many human cancers.

122 The cell cycle inhibitor p16INK4a is inactivated in many human tumors and in families with

123 t, it is likely that the T beta R-I receptor is inactivated in many of these cases.

124 The pyruvate dehydrogenase complex (PDC) is inactivated in many tissues during starvation and dia

125 pRB is inactivated in many types of cancer and this raises t

126 , the tumor suppressor gene TP53 is found to be inactivated in MB due to overexpression of its negati

127 genes are intricately linked on 9p21 and can be inactivated in melanoma and non-Hodgkin's lymphoma.

128 We conclude that Apaf-1 is inactivated in metastatic melanomas, which leads to d

129 degradation disappears in obesity when JNK1 is inactivated in mice.

130 ccurred in humans, dogs, and chimpanzees but was inactivated in mice and rats.

131 novel tumor suppressor gene that is found to be inactivated in more than 40 types of sporadic cancers

132 in these two essential cell regulators that are inactivated in most cancers and operate within multi

133 Caveolae-associated protein 3 (cavin3) is inactivated in most cancers.

134 i gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers.

135 The adenomatous polyposis coli (APC) protein is inactivated in most colorectal tumours.

136 Accordingly, p53 is inactivated in most human cancers by different mechan

137 are components of a regulatory pathway that is inactivated in most tumor cells.

138 ffected when the integrin beta1 gene (Itgb1) is inactivated in motor neurons.

139 ained and limb formation is normal when Fgf4 is inactivated in mouse limbs, thus contradicting the mo

140 gression of pancreatitis, TGF-beta signaling was inactivated in mouse pancreata by overexpressing a d

141 f origin for neurofibromas, both Nf1 alleles were inactivated in mouse Sox10+ cells, leading to class

142 hat RORA is another very large CFS gene that is inactivated in multiple tumors.

143 The SLN1 gene was inactivated in murine embryonic stem cells, and knoc

144 he dTDP-rhamnose synthesis gene, rmlD, could be inactivated in Mycobacterium smegmatis only in the pr

145 r protein p53, the "guardian of the genome", is inactivated in nearly all cancer types by mutations i

146 SWI/SNF (BAF) chromatin-remodeling complex, is inactivated in nearly all pediatric rhabdoid tumors.

147 ed as a candidate tumor suppressor gene that is inactivated in nearly half of all pancreatic carcinom

148 The Smad4/DPC4 tumour suppressor is inactivated in nearly half of pancreatic carcinomas a

149 18q21.1 and found that both alleles of DPC4 were inactivated in nearly one-half of the pancreatic ca

150 p16, a tumor-suppressor gene, is inactivated in neoplasms by mutation, deletion, or me

151 pitope, HIV modified to express this epitope is inactivated in NHS.

152 ined using a model system in which p53 or RB was inactivated in normal human foreskin fibroblasts (HF

153 Thus TSGs such as WT1, p16(CDKN2a) and p53 are inactivated in only a minority of cases.

154 R; during a long depolarization, the SR must be inactivated in order to achieve realistic Ca(2+) conc

155 all three formate dehydrogenase systems must be inactivated in order to disrupt the formate-oxidizing

156 We suggest that the genes that were inactivated in our PA2231 mutant are required for t

157 We investigated if the PPP2R1B gene was inactivated in ovarian cancer by single strand confo

158 The von Hippel-Lindau tumour-suppressor gene is inactivated in over 75% of sporadic cases.

159 was the X-linked deubiquitinase Usp9x, which was inactivated in over 50% of the tumours.

160 The devB/SOL homolog was inactivated in P. aeruginosa PAO1 by recombination w

161 ancer patients with shorter survival and can be inactivated in patient-derived xenograft cells by inh

162 ber of the TGF-beta/BMP receptor family that is inactivated in patients with hereditary hemorrhagic t

163 The VHL tumor suppressor gene is inactivated in patients with von Hippel-Lindau diseas

164 TEN, a negative regulator of PI3K signaling, was inactivated in PDAC by the formation of an intramole

165 t explains, at least in part, why Rb and p16 are inactivated in phenotypically distinct carcinomas.

166 others have shown that the cystatin E/M gene is inactivated in primary human tumors, pointing to its

167 At the head process stage, BMP signaling is inactivated in prospective neural plate, while it is

168 smembrane calcium-dependent efflux pump that is inactivated in prostate cancer.

169 generated mice in which both Pten and SRC-3 were inactivated in prostate epithelial cells (Pten3CKO

170 In contrast, when RPTPbeta/zeta is inactivated in PTN-stimulated cells, the sites that a

171 When both Ung and Fpg were inactivated in recBCD cells, survival was significa

172 r data provide evidence that the p53 pathway is inactivated in retinoblastoma and that this cancer do

173 One mutant was inactivated in rrlA (23S rRNA), another in ftsJ (rrm

174 rereplicative complexes during G1 phase, but are inactivated in S phase to prevent rereplication.

175 When telomerase is inactivated in Saccharomyces cerevisiae, telomeric DN

176 Replicative senescence was inactivated in secondary cultures of human skin fibr

177 in tumor suppression, as SLIT-encoding genes are inactivated in several types of cancer, including lu

178 These results indicate that FHIT may have been inactivated in six cell lines from five (45%) indiv

179 l component large tumor suppressor 1 (LATS1) is inactivated in small remodeled pulmonary arteries (PA

180 nd MTS2 (CDKN1, p15INK4B) located at 9p21-22 are inactivated in some human cancers via several mechan

181 thermore, a mutant in which the Osterix gene was inactivated in Sox9-expressing cells exhibited a lac

182 In many organisms the X and Y chromosomes are inactivated in spermatocytes, possibly as a defense

183 son's disease, there is evidence that parkin is inactivated in sporadic Parkinson's disease.

184 mologues of the core MMC genes mutS and mutL were inactivated in strain FA1090.

185 e p16/Ink4a protein has been demonstrated to be inactivated in subsets of familial and sporadic melan

186 tor in the choice of which X chromosome will be inactivated in the developing female mouse embryo.

187 ion using mice in which miRNA biogenesis can be inactivated in the liver.

188 escape negative selection in the thymus must be inactivated in the periphery.

189 Alternatively, soil Pb and Cr6+ may be inactivated in the soil by plants and soil amendments

190 Although the pcyA gene could not be inactivated in the wild type, pcyA was easily inactiv

191 ied in cow and chicken, Fbn3 appears to have been inactivated in the mouse genome, perhaps during chr

192 The gene encoding ASPA has been inactivated in the mouse model of CD, and here we s

193 ces corresponding to oxyR, but this gene has been inactivated in the tubercle bacillus because of the

194 urofibromatosis type 2 tumor suppressor gene is inactivated in the development of familial and sporad

195 rocess by which one of the two X chromosomes is inactivated in the female soma.

196 alpha1-antichymotrypsin, although a fraction is inactivated in the lumen by proteolysis and circulate

197 e gene in the nonneoplastic setting; (b) p27 is inactivated in the majority of BAA as a result of eit

198 rpose The von Hippel-Lindau tumor suppressor is inactivated in the majority of clear cell renal cell

199 on Hippel-Lindau (VHL) tumor suppressor gene is inactivated in the majority of clear cell renal cell

200 a negative regulator of the cell cycle that is inactivated in the majority of human tumors.

201 SMAD4 is inactivated in the majority of pancreatic ductal aden

202 a lysine auxotrophy is induced because Lys4p is inactivated in the matrix by superoxide that originat

203 NarK2 is inactivated in the presence of oxygen by an unknown m

204 vity of a new PG-null L. major mutant, which is inactivated in the two UDP-galactose transporter gene

205 function is dependent on p53, a protein that is inactivated in the vast majority of SCC tumors, leavi

206 he observed effects were abrogated when algR was inactivated in the algZ::Tc(r) background.

207 To avoid genetic compensation, Hes1 was inactivated in the context of the global deletion of

208 oped mice in which a conditional Elys allele was inactivated in the developing intestinal epithelium

209 the renal collecting system, the Lamc1 gene was inactivated in the developing mouse ureteric bud (UB

210 When Acc2 was inactivated in the germline, Acc2 knockout (Acc2KO)

211 When this motif was inactivated in the HIV-1 genome, Vif failed to exclu

212 on into the peripheral domain when kinesin-5 was inactivated in the peripheral domain itself or in th

213 Bradykinin (0.1 mmol/l) was inactivated in the presence and absence of inhibitor

214 The lsr2 gene was inactivated in the wild-type M. smegmatis mc(2)155 s

215 amined published data in which Fgf4 and Fgf8 were inactivated in the AER.

216 sed processes of the gonococcus, these genes were inactivated in the N. gonorrhoeae strain FA1090.

217 functions in whole animals, checkpoint genes were inactivated in the nematode C. elegans.

218 When all five small Cab-like proteins were inactivated in the wild-type background, chlorophyl

219 When GSK3beta is inactivated in these cells, beta-catenin gets stabili

220 comparing them with mice in which only Pten was inactivated in these cells (PtenCKO mice).

221 ne whether the remaining wild type Rb allele was inactivated in these murine MTC samples, we subjecte

222 Every neuron type in this brain region could be inactivated in this manner.

223 in which genes encoding regulatory proteins are inactivated in transgenic mice is evaluated in order

224 death pathway that works in normal cells but is inactivated in tumor cells, implying that it may be t

225 P53 is inactivated in tumors by mechanisms other than mutati

226 Being most well-known tumor suppressor that is inactivated in tumors more frequently than any other

227 in tumors from smokers, whereas the p16 gene was inactivated in tumors from nonsmokers only through p

228 In contrast, when MYC was inactivated in tumors with enforced expression of CD

229 in acute myeloid leukemia, whereas MTG16 may be inactivated in up to 40% of breast cancer and MTG8 is

230 wn that the p16(INK4a) tumor suppressor gene is inactivated in up to 98% of human pancreatic cancer s

231 in-containing backbones and imply that Ure2p is inactivated in [URE3] cells by a steric blocking mech

232 rotein) activity and weak Cdc42GAP activity, is inactivated in various human malignancies.

233 PI3 kinase/AKT/protein kinase B pathway, and is inactivated in various human tumors.

234 s or mitogen-activated protein (MAP) kinases are inactivated in vitro by MAP kinase phosphatases (MKP

235 s of NR retained activity and the ability to be inactivated in vitro when incubated with ATP.

236 endent class III histone deacetylase family, is inactivated in vitro by oxidation of critical cystein

237 The enzyme is inactivated in vitro by treatment with disulfide redu

238 A virulence-inducing peptide of S. aureus was inactivated in vitro and in vivo by reactive oxygen

239 First, 1 copy of Cxcr4 in HSPCs was inactivated in vitro by CRISPR/Cas9 editing with a s

240 These findings indicate that (a) p16INK4a is inactivated in vivo in over one-fourth (27.5%; 11 of

241 The monocistronic rca gene was inactivated in vivo and resulting mutant strains of

242 is heightened by our observation that Irs-1 is inactivated in wild-type, metastatic mammary tumors b

243 ressed in cells of the developing kidney and is inactivated in Wilms tumor, a pediatric kidney cancer