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1 s raises the question whether the penetrance is indeed 100% as generally assumed.
2 investigation of whether charismatic species are indeed a key attractor of ecotourists to protected a
3 se results suggest that such TPT simulations are indeed a promising approach to overcome the practica
4  we determine that screened magnetic charges are indeed a result of local energy reduction and appear
5          These data indicate that xenografts are indeed a viable methodology for the production of ce
6 techniques have led to the findings that PAH is indeed a cascade of diseases exploiting multi-faceted
7 erein, we demonstrate that the CCN1 promoter is indeed a direct genomic target of YAP in endothelial
8                Here we demonstrate that ThrR is indeed a DNA-binding transcription factor that regula
9  conclusion, our findings suggest that RPE65 is indeed a dynamically-regulated palmitoylated protein
10 ether with its broad functional consequences-is indeed a fundamental characteristic of bacteria other
11 the intensity of the carotenoid Raman signal is indeed a good indicator of fruit freshness and introd
12 ve employed HDX-MS to demonstrate that HalM2 is indeed a highly structurally dynamic enzyme.
13      The results confirm that Reunion Island is indeed a hotspot of AfSV diversity and that many of t
14                                        There is indeed a large body of research that acknowledges the
15                       Here, we show that IPK is indeed a member of the plant terpenoid metabolic netw
16 amine initially identified from human semen, is indeed a milt pheromone.
17 lence and experimental results show that MSC is indeed a more effective and efficient algorithm compa
18 ted SMOX activity and concluded that miR-124 is indeed a negative regulator of SMOX.
19              Our results indicate that there is indeed a pH-dependent deep tissue penetration in ex v
20 ining the physical compactness of the genome is indeed a primary factor among ssRNA viruses' evolutio
21 e that the sequence can be a protein, and it is indeed a protein sequence, then its identity as a pro
22 cetogenic bacterium Thermoanaerobacter kivui is indeed a respiratory enzyme.
23 s that demonstrates that asteroid 2015 BZ509 is indeed a retrograde co-orbital asteroid of the planet
24                             We show that TPP is indeed a signal of trustworthiness: third-party punis
25 is largely causal, suggesting that pregnancy is indeed a strong intrinsic motivator for drug abuse ce
26 duction of CYTL1 we confirm that the peptide is indeed a strong proangiogenic factor and induces spro
27 urified components, we demonstrated that Isu is indeed a substrate of the Lon-type protease and that
28                                  Although it is indeed a very powerful predictor, more efforts are de
29    We found that (Me(4)N)(2)[Cd(4)(SPh)(10)] is indeed a very strong quencher of singlet oxygen with
30             Our results show that plasmonics is indeed a viable path to an ultracompact, highest-spee
31 mulated reads to ensure that every SNP found was indeed a false positive.
32  Here we report that "wait anaphase" signals are indeed able to diffuse outside the confines of the m
33 at indels within the Morpholino binding site are indeed able to suppress both zygotic and maternal mo
34                                           We were indeed able to delineate an early-developing Nr4a2-
35 f the slr1270 mutant showed that the S-layer is indeed absent.
36 om fast to slow evolution of drug resistance was indeed accompanied with the expected transition from
37 nii and Haloferax mediterranei, that spacers are indeed acquired chromosome-wide, although a preferen
38                     While many abundant taxa are indeed active, most bacterial species detected by co
39                These data suggest that there are indeed advantages to educating the immune system at
40 tochondrial connectivity and of MAM function were indeed altered, and correlated with disease severit
41 at the naturally evolved ED and EMP pathways are indeed among the most protein cost-efficient pathway
42 ely, our results highlight that ferrihydrite is indeed an active mineral phase in redox-dynamic envir
43 der physiological conditions, the C-terminus is indeed an alpha-helical bundle, located near the five
44 e simulation results show that our algorithm is indeed an effective genome compression algorithm that
45 neutron diffraction to show that Sr(3)CrN(3) is indeed an electride despite its partial d-shell confi
46 Cre), and whether the compensatory mechanism is indeed an increase in mitochondrial biogenesis.
47 uts and demonstrate that higher fluorescence is indeed an indicator of higher product titer.
48  verified that the protein encoded by PG1780 is indeed an SPT.
49  generating a recombinant protein that CXXC5 is indeed an unmethylated CpG binder.
50 BOV interface, suggesting that this mutation was indeed an adaptation to the human host.
51 EGFR2lo/intracellular endothelial population was indeed an endovascular progenitor (EVP) of an interm
52  expectation, although 4-methylumbelliferone was indeed an inhibitor of hyaluronan biosynthesis, this
53 a, which suggest that SSH wavenumber spectra are indeed anisotropic.
54 ng evidence indicates that histone methylome is indeed another major epigenetic determinant for gene
55 at almost half of the 96 genes in these loci are indeed associated with abdominal subcutaneous adipos
56 d exploited them to demonstrate that F-actin is indeed associated with mitotic spindles in intact Xen
57 that depletion of Rbf1 in Drosophila tissues is indeed associated with polarity defects in the wing a
58 uclear pore complex, used by these proteases were indeed attacked at different rates and with differe
59 onsciously activated by spontaneous emotions are indeed automatically selected from a small number of
60 , which lack the phosphate binding residues, are indeed beta-mannosidases that hydrolyze beta-1,2-man
61 literature regarding whether network markers are indeed better features than genes alone for predicti
62 controversial whether larger-brained animals are, indeed, better problem-solvers.
63 d fragmentation was used to confirm that DC9 is indeed bonded with the lipids.
64 t Notch-dependent transcriptional activation is indeed "bursty"; that wild-type Notch modulates burst
65                         Whilst OMS materials are indeed capable of generating drug supersaturation, p
66  individuals with higher psychopathic traits are indeed capable of understanding the expectations of
67                            We show that DDI2 is indeed capable of cleaving NRF1 in vitro but only whe
68 validation confirmed that all detected lines were indeed carriers of the predicted mutations.
69  the encoded variables if the representation is indeed categorical.
70                             If hyperoxaluria is indeed caused by fat malabsorption, magnitudes of hyp
71                        Balancing on two legs is indeed challenging for humans under optimal condition
72 whereas the feedback from the SLu to the TeO is indeed cholinergic, the feedback from the Ipc has a m
73 eal genomes show that our proposed algorithm is indeed competitive and performs better than the best
74 e, or what fraction of metabolic adaptations is indeed complex.
75  we show that although H3S10 phosphorylation is indeed compromised in the H2Av null mutant, chromatin
76  first experienced under general anesthesia, is indeed compromised.
77                                         This was indeed confirmed by the ability of LSPD to decrease
78 w that the dorsocentral sector of the insula is, indeed, connected with the cortical circuit involved
79 trate that many rare codon cluster positions are indeed conserved within homologous coding sequences
80 hioester bond formation exhibited by SUMO E1 is indeed conserved in Ub E1.
81 iments, we show that kinetic isotope effects are indeed consistent with published models, including a
82 parent exponential decay coefficients (kexp) was indeed continuous.
83 opment of hepatocellular carcinoma (HCC) and are indeed correlated with Tak1-deficiency-induced HCC d
84 ulti-scale: the molecular chemical processes are indeed coupled to the cellular processes of cell gro
85 rate that the main source of these electrons is indeed CRAND, and that this process also contributes
86                   Because facial expressions are indeed created by moving one's facial muscles, it is
87 teractions observed in the crystal structure are indeed critical in the self-assembly and robustness
88 ty of circulating cells exhibiting donor HLA are indeed cross-dressed cells and not passenger leukocy
89     We show that this explaining-away effect was indeed crucial for the units in the face submodel to
90 s to test whether Ethiopian wing development is, indeed, decanalized.
91 ify common structures and confirm that these are indeed degraded by SOX in vitro as well as predict t
92                        Abnormal cytoskeleton was indeed demonstrated by immunohistochemistry to occur
93 nship experimentally, determining that there is indeed density-associated mutation-rate plasticity (D
94 cell viability of one of the compounds, CPX, were indeed dependent on chelation of intracellular iron
95 a-E2 measured in the plasma of the male fish was indeed derived from the external environment, most l
96                                         This was indeed discovered in experiments which however revea
97    Expression levels of APLNR in NPC tissues were indeed down-regulated.
98 T2D donors in response to cdk6 and cyclin D3 is indeed dramatically impaired.
99 -199 and found that acquired drug resistance is indeed driven by the upregulation of MCL-1 and BCL-XL
100 iffness-size relationship of amyloid fibrils is, indeed, driven by the packing densities of residues
101 trate that this so-called switch I/II pocket is indeed druggable and provide the scientific community
102 uble-deficient mice to show that this effect is indeed due to uncontrolled IL-22 activity.
103 the anticancer effect of NDI/2DG combination was indeed due to LMP and glycolysis block.
104 a subpopulation of human RBC actin filaments is indeed dynamic, based on rhodamine-actin incorporatio
105 tigations suggest that some of the catalysts are indeed efficient for stereoselective 1,4-conjugated
106 ations show that the Lewis acidity of MV(2+) is indeed enhanced by photoexcitation.
107 e sheet, we confirm that adsorption capacity is indeed enhanced on flatter surfaces.
108  Relative expression of Ltbr and Cxcr2 genes was indeed enhanced in patients with IFNbeta-resistant m
109 osis and flow cytometry, that these proteins are indeed enriched in mouse resident macrophages.
110  using purified proteins that the RA2 domain is indeed essential for activation by Rap1A.
111                              O-glycosylation is indeed essential for RPT domain function and the esta
112      Here, we show that actin polymerization is indeed essential for stabilizing the ICB when lagging
113 n primary and secondary modules they propose is indeed essential.
114                                   New trials are indeed evaluating treatments at prodromal and precli
115 patocytes in vitro confirmed that DNA damage was indeed exacerbated by extracellular ATP, subsequent
116 a-ecosystems to show that nutrient additions are indeed expected to drive loss in stability and funct
117 tory analysis to conclude that the particles were indeed explosive included HPLC-MS, Raman spectrosco
118 ject database confirms that that these genes are indeed expressed in the brain, with the expression p
119 ssion, we observed that Piwi-like Miwi2 mRNA is indeed expressed in epithelial cells of the lung in a
120              Our results here show that AstC is, indeed, expressed in DN1s, where it oscillates.
121 that such a blindfolded intracellular search is indeed favored and has more fundamental impact on the
122  Regional quantification of lung ventilation is indeed feasible and may be a useful technique for ima
123 passive acquisition of on-body biopotentials is indeed feasible and may find various uses for future
124 g to one of the helix-sheet-helix structures is indeed found to be fast on the NMR time scale while i
125                              Striated muscle was indeed found later in development surrounding the pa
126 t apoptosis initiation, and the alphaDR5-NPs were indeed found to activate apoptosis in multiple panc
127 imentally proved that predicted expressologs are indeed functional orthologs, while nonexpressologs o
128 nvasive azide handle assured that the sgRNAs are indeed functional.
129 e heme transporter B. malayi HRG-1 (BmHRG-1) is indeed functional in B. malayi In addition, BmHRG-1 l
130 it remains unclear whether or not the trimer is indeed functionally relevant.
131      This study shows that hydroxyl radicals are indeed generated by using tBuOH as the OH radical sc
132           Our findings suggest that face-FPs are indeed generated in the underlying inferotemporal co
133          To determine whether face responses are indeed generated within macaque auditory cortex, we
134 specific antibodies establish that PTHrP1-17 is indeed generated by cancer cells.
135 he lens of convex mosaics, natural fragments are indeed geometric shadows of Plato's forms.
136 e tolerance varied, as we would expect if it was indeed governed by parameters controlling the sensit
137 econstruction of the yeast metabolic network is indeed gradually improving through the iterative proc
138  that the L-type current and channel density are indeed higher in the somata of rat SNc DA neurons an
139                         T-cell proliferation was indeed higher after macrophage exposure to mannobios
140 d that Equilibrium Climate Sensitivity (ECS) was indeed higher during the warmest intervals of the Eo
141                                    Coherence was indeed higher in AG-AG compared to AG-ANT muscles in
142 we find that populations from separate caves are indeed highly genetically isolated.
143 lly, we show that attacks by single sailfish are indeed highly predictable, but predictability rapidl
144  raises a potential paradox: if phosphatases are indeed highly promiscuous, how do cells insulate the
145 utput power by 42.3%, proving that the wings are indeed highly reflective.
146 stantial evidence that prometastatic changes are indeed identified in the tumor microenvironment of c
147 lot analysis shows that the CD147-98 complex is indeed immunoprecipitated by VH4-34-encoded IgMs from
148 found that assay sensitivity and specificity were indeed imperfect, and we were able to draw several
149 tive amounts of HDV RNA and protein in cells are indeed important for HDV replication and that the vi
150 his study, we confirm that UBA, UCA, and UEA are indeed inactivated through genetic defects at the pr
151                 In the septum, regional work was indeed increased in MI rats compared with sham (medi
152 hile in many cases the full quantum dynamics is indeed indistinguishable from classical ballistic mot
153     However, it is unclear whether these Abs are indeed induced by DENV NS1.
154 ions in Drosophila melanogaster cryptochrome are indeed influenced by magnetic fields of a few millit
155 on whether perturbations in axonal transport are indeed integral to the pathogenesis of neurological
156 dation, providing evidence that mitochondria are indeed integrated within the endomembrane system.
157  recent studies support the theory that they are indeed intertwined.
158 iding direct confirmation that the chirality is indeed inverted below Dirac point.
159   Our data proved that OsPIP1;3 and OsPIP2;6 are indeed involved in both influx and efflux of boron t
160 ant protein folding, and protein aggregation are indeed involved in several diseases including cancer
161                            We show that LRP2 is indeed involved in definitive hematopoiesis and by do
162         These findings indicate that CaMYB31 is indeed involved in the regulation of structural genes
163 data and that nucleosome positioning signals are indeed learned by a network trained on chemical clea
164  computationally to have reduced frustration is indeed less GroEL-dependent.
165           Furthermore, we show that caveolae are indeed likely to bud directly from the plasma membra
166 sts suggests that increasing moisture-stress is indeed likely to drive significant changes in florist
167  observations demonstrate that these pulsars are indeed local sources of accelerated leptons, but the
168 s confirmed that, although expression levels are indeed low for Klb, there is nonetheless a bonafide
169  confirmed that the thiols imaged by BISMORX were indeed lysosomal thiols.
170  connections from fast conducting CST fibers are indeed made exclusively from new M1 and its border w
171 of histone variant H2AZ, and this preference is indeed markedly diminished using nucleosomes from cel
172 microparticles to identify whether particles are indeed microplastics.
173 The results demonstrate that spinal networks were indeed modified after a hemisection with a clear as
174            Here we find that CaV1.4 channels are indeed modulated by PKA phosphorylation within the i
175                          The novel gene sets are indeed more correlated than the conventional ones, a
176 illogenesis by the mechano-enzymatic pathway is indeed more potently inhibited by tolcapone than by t
177 s confirmed that putative inhibitory neurons were indeed more active during desynchronized cortical s
178              The indazole-paroxetine analogs were indeed more potent than their respective benzodioxo
179  to the prediction for P7 and showed that P6 was indeed much less well-structured than P7.
180 Here we show that growth-lifespan trade-offs are indeed near universal, occurring across almost all s
181 ata indicate that the solvent reorganization is indeed near zero and increases to bulk values only wh
182 mental open question is then how many layers are indeed necessary to accurately represent the structu
183  that highly complex communication protocols are indeed necessary to fully harness the information-th
184 al membrane reorganization, and two flippers are indeed needed to "really swim," i.e., achieve high m
185 now report that in a lethal mouse model H84T is indeed nonmitogenic, and both early and delayed thera
186                             A set of objects is indeed not only characterized by its numerosity but a
187                               Induced sputum is indeed not widely available and markers of neutrophil
188 a-like protrusions and retrograde actin flow are indeed observed in cells moving in 3D ECM.
189 nd posited to occur at island boundaries, as was indeed observed in the case of phenylacetylene.
190 pylene oxide (PO) or cyclohexene oxide (CHO) were indeed obtained.
191 lude that if coronal mass ejections and jets are indeed of physically identical origin (although on d
192                           Hu antigen R (HuR) is indeed one of the most studied RNA-binding protein (R
193 that the activation of glycan polymer growth is indeed one of the relevant functions of LpoB in vivo.
194                                      The day was indeed one to be remembered.
195 RGD peptide leading to fluorescence recovery was indeed operative depending on the tumor-related angi
196 ugh the rapidity with which the virus struck was indeed overwhelming, scientists throughout the world
197 er fauna, suggesting that pressure tolerance is indeed oxygen limited.
198 determined that artificially matured CbHydA1 is indeed oxygen tolerant in the absence of reducing age
199 fication revealed that fibroid blood vessels were indeed perfused and stained with the lipophilic mem
200 a PP2A regulatory subunit TAP46-like (TAP46) were indeed phosphorylated by BnMPK4.
201 negative regulation of reprogramming process is indeed poor in contrary to the identification of posi
202 on enhancement analysis showed that the R696 is indeed positioned close to the center of the bilayer,
203  that the duration of carriage of a serotype is indeed positively correlated with the prevalence of r
204                      Both pigment parameters were indeed positively associated with abundances of par
205 a; however, class 1 and class 2 test results are indeed possible in the setting of a nonmelanoma mali
206 riments are then used to demonstrate that it is indeed possible to create stable single-crystal blue-
207 a computational challenge to test whether it is indeed possible to differentiate ecological interacti
208 g and eliminates evaporation to show that it is indeed possible to drive submicron particle and cell
209 ell adapted to a particular host environment is indeed possible, emphasizing the great potential of t
210         Our findings show that tropical EBPR is indeed possible, highlight the translational potentia
211 iting shows that single-atom magnetic memory is indeed possible.
212 ubunit (DNA-PKcs) activity, we found that it was indeed possible to preferentially augment the effect
213 quired for axonal outgrowth and myelination, are indeed posttranslationally modified at their ICDs.
214 ell-defined carcinogen mutational signatures are indeed present in tumour genomic DNA from a variety
215 ce show that Kir6.1-containing KATP channels are indeed present in vascular endothelium.
216 al CoV receptors and virus-priming proteases were indeed present in TEMs.
217 by mass spectrometry analysis that P1N-PISPO is indeed produced in SPFMV-infected plants, in addition
218 he principles behind the detection mechanism is indeed providing substantial information about the de
219   Future experimental work can test if these are indeed rebels with a cause.
220 g and unusual properties of this 2D material were indeed recently investigated and exploited in sever
221 d significantly deregulated subnetworks that were indeed recognized to be involved in two well-studie
222 plied, the periodicity in the binding energy is indeed recovered.
223               Whereas a TDP-43 subpopulation is indeed recruited to SGs, mature aggregated TDP-43, pr
224          We find that Pol delta bound to DNA is indeed redox-active at physiological potentials, gene
225 ese compounds confirm a mode of binding that is indeed reflective of the transition state at the CARM
226                         HAX-1 protein levels are indeed regulated through frataxin modulation.
227 s indicate that many genes in driver modules are indeed related to metastasis, and our methods have i
228  a certain fraction of DNA lesions at C:G bp was indeed repaired in an error-free manner via Brca2 in
229 ration of those high-level cognitive factors are indeed represented in the lPFC.
230                                        PfPP1 is indeed required for efficient replication, but is abs
231 dy with Stat1(-/-) mice confirmed that STAT1 is indeed required for the IFNgamma mediated Ncx1 gene r
232 nvestigated whether a physiological stimulus is indeed required for thirst to be experienced.
233  assay confirmed that this ATF4-binding site is indeed required for transcriptional up-regulation of
234 e points, we show that the dpp stripe source is indeed required for wing disc growth, also during thi
235        Typing HLA genes in patient and donor is indeed required in hematopoietic stem cell and solid-
236             An extra in-plane magnetic field is indeed required to achieve deterministic switching, a
237            We show that che-1 autoregulation is indeed required to maintain the differentiated state
238            This confirms that the gap states are indeed responsible for generating the two-photon up-
239  katB mutant from H2O2, suggesting that KatB was indeed responsible for detoxifying the externally ad
240 vide the first evidence that LYVE-1 dynamics are indeed restricted by the submembranous actin network
241 show that selinexor-induced thrombocytopenia is indeed reversible when TPO agonists are administered
242          To determine whether these contacts are indeed selective, connectivity was traced back from
243 trate that the strength of actin association is indeed sensitive to the ABD conformation, predict the
244 ymers, we show that crystallization pathways are indeed sequence dependent.
245  after 3' to 5' degradation of the mRNA body are indeed short enough to be decapped by DcpS.
246                                           It is indeed shown that H-bond formation of the reacting NH
247                          We found that there are, indeed, significant changes in characteristics of r
248 itously expressed low-Gini-coefficient genes was indeed sound.
249 ong drawback: polarized fluorescence imaging is indeed spatially limited by optical diffraction, and
250 r studies, we find that captodative radicals are indeed stabilized by polar solvents, as measured by
251  The full-length, membrane-bound CH120.6 Env is indeed stable and conformationally homogeneous.
252 me areas, in particular the marine reserves, were indeed still dominated by structurally complex cora
253  demonstrating that the community of nations are indeed stronger together.
254 and magnetism in FeSe under applied pressure are indeed strongly coupled.
255                 We found that these proteins are indeed subject to proteasomal degradation.
256 x molecules expressed in periodontal tissues are indeed substrates of FAM20C.
257 wledge, that Li-decorated monolayer graphene is indeed superconducting, with Tc approximately 5.9 K.
258 rceived orientation of the Flash-Grab Effect is indeed supported by feedback signals in the cortex.
259 at about two-thirds of the novel annotations were indeed supported by the available ribosome profilin
260 r 31 or NGC 224), which erupts annually(11), is indeed surrounded by such a super-remnant with a proj
261 ittle variation has been lost and such rates are indeed sustainable in the future.
262 ected Rab-GTPase proteins revealed that they are indeed T4SS secreted substrates.
263 results imply that the promoter polymorphism is indeed the associated as well as in itself a causal v
264                       Here we show that this is indeed the case by demonstrating that the human motor
265 robe transient absorption, we show that this is indeed the case for deoxy-Mb.
266                                         That is indeed the case in the absence of mechanical load.
267                  A study now shows that this is indeed the case in the Drosophila sensory organ precu
268             The strongest evidence that this is indeed the case relied on the observation that the ox
269  and pulldown experiments revealed that this is indeed the case: phosphorylation of serine 298 decrea
270 ncing of MRGPRX2, we now report that MRGPRX2 is indeed the dominant codeine receptor of dermal mast c
271                                         This is indeed the first fluorescent peptide biosensor which
272                      This sort of correction is indeed the main novelty of the paper, being crucial t
273          Our findings confirm that the liver is indeed the main source of circulating ApoL1.
274 eral reasons though, it is unclear that TMC1 is indeed the MET channel pore: 1) in other animals or t
275 r in AM2, indicating that the peripheral H27 is indeed the origin of the low pK(a)'s of H19 in wild-t
276 the postulated active state of the LBD dimer is indeed the preferred configurational state, which rem
277 the particles that contributes to the signal is indeed the same as that of the applied field, indicat
278 ctive gyrase enzyme, nor whether that enzyme is indeed the target for the quinolone and aminocoumarin
279 emains controversial whether such reservoirs were indeed the source of the carbon that drove the warm
280              Results revealed that economics were, indeed, the primary barrier to implementation/expa
281                      If spatiotopic updating is indeed this slow, it cannot contribute to perceptual
282  common conjugal plasmids, even when costly, are indeed transferred at sufficiently high rates to be
283 NAs are stored in dry seeds and whether they are indeed translated during seed germination.
284 uman and zebrafish mRNAs and found that many are indeed translated.
285 s, provide evidence that anomalous transport is indeed ubiquitous in porous media.
286 l power in neuroscience: on average, studies are indeed underpowered-some very seriously so-but many
287                   We found that the pressure is indeed uniform within the abdomen and thorax, congrue
288 adduct formation and protein ion suppression are indeed unrelated effects that may occur independentl
289 ic nephropathy, we show that Notch signaling is indeed up-regulated in such settings.
290 examples suggesting that allosteric proteins are indeed used in this capacity: allosteric proteins pl
291 of evolutionary information between residues is indeed useful in DNA-binding residue prediction and e
292 of evolutionary information between residues is indeed useful in DNA-binding residue prediction.
293 ponse functions of source and sink processes are indeed very different in trees, and need to be consi
294             The use of 1D and 2D NMR spectra is indeed very helpful to investigate the covalent graft
295 ctrochemical and two spectroscopic responses is indeed very useful, providing essential advantages in
296 e found that the bSi wafers with nanopillars were indeed very effective in rupturing and killing the
297 trate that the actions of the IFITM proteins are indeed virus and cell-type specific.
298 lagged increase in canopy tree mortality, as is indeed widely observed, and eventually neutralise car
299 strate that across different samples, people are indeed willing to gamble, subjecting themselves to e
300 l stewardship to determine if implementation is indeed worth the added costs.

 
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