ライフサイエンスコーパス: be instrumental for

1 asable vesicles within the active zone, thus being instrumental for 1st phase release.

2 chemical, radiologic, and clinical criteria, are instrumental for a better understanding of PPAP and

3 accumbens core, shell, and caudate-putamen, are instrumental for a wide-range of functions and disor

4 Intrinsic disorder is instrumental for a wide range of protein functions, a

5 at carbon surfaces immersed in electrolytes is instrumental for a wide variety of membrane processes

6 visualizing transcriptionally similar cells is instrumental for accurate exploration of the cellular

7 d demonstrates that ultrafast interfacial ET is instrumental for achieving high efficiencies in solar

8 are many cellular and molecular factors that are instrumental for adequate Treg cell functions.

9 The map will be instrumental for analysis of X linked health and fert

10 luding tumor microenvironment, and IFN-gamma is instrumental for anti-tumor immunity.

11 To determine whether this cascade was instrumental for astrocyte reactivity, we used a len

12 that multifunctional CD8(+) T cell responses are instrumental for avoiding the more severe manifestat

13 icant extension of the prewarning time would be instrumental for avoiding some of the worst damages s

14 man monoclonal antibodies from vaccinees can be instrumental for bacterial antigen discovery.

15 which generates PI(4,5)P2, by activated Arf6 is instrumental for bacterial entry, corresponding to th

16 ation could shift the virus-host balance and are instrumental for better design of strategies to reac

17 n to HUVECs, and those high-mannose moieties are instrumental for binding to DC-SIGN.

18 The algorithm is instrumental for biologists to learn the hierarchical

19 cell responses against SSX antigens and will be instrumental for both the onset and the monitoring of

20 quences of the key monoxenous parasites will be instrumental for both understanding the origin of par

21 pithelium, the stroma and the periphery that is instrumental for breast cancer cells' dissemination.

22 We propose that this run is instrumental for bringing the mental map into registe

23 This study identifies calpain as being instrumental for brush border (BB) microvillus ass

24 These findings are instrumental for cancer drug discovery aiming at act

25 ided by the blastocyst cavity are thought to be instrumental for cell sorting; however, the sequence

26 to and/or accumulation within endolysosomes is instrumental for characterizing lysosome-driven pathw

27 ction favors brain insulin resistance, which is instrumental for cognitive and metabolic impairments

28 t biosynthesis in the growing cluster, which is instrumental for coordinated motion and swarming.

29 virions and increased particle density that were instrumental for cryo-EM and cryoelectron tomograph

30 In translational terms, the knowledge is instrumental for design and synthetic engineering of

31 hy data on the E protein structure and could be instrumental for designing carbohydrate-binding antiv

32 ll contribution to ICH-induced neural injury is instrumental for designing immunomodulatory therapies

33 The data are instrumental for developing a model for the biologic

34 These findings are instrumental for developing a strategy to protect hE

35 ts into the mechanisms of AD progression and are instrumental for developing better strategies to com

36 ruption of the OTULIN-LUBAC interaction will be instrumental for developing future therapeutic strate

37 These findings will be instrumental for devising novel immunogens to protect

38 their respective target sequence sets) that are instrumental for differential downstream regulation.

39 tance offers experimental platforms that may be instrumental for disease modeling.

40 ressed by endothelial cells in target tissue is instrumental for efficient Treg recruitment in vivo.

41 er's disease (AD), such as the 3xTg-AD mice, are instrumental for elucidating genetic, pharmacologic,

42 e development of new synthetic methodologies is instrumental for enabling the discovery of new medici

43 Lesion studies have historically been instrumental for establishing causal connections be

44 prising Polycomb repressive complex 1 (PRC1) is instrumental for establishing facultative heterochrom

45 Thus, a single polar hub is instrumental for establishing polar identity and orga

46 st that these network emergence dynamics may be instrumental for explaining network details, as well

47 s-regulatory changes (domain rearrangements) are instrumental for fundamental functional innovations,

48 atlas that covers all hepatic cell types and is instrumental for further dissection of liver developm

49 y, evolution and plant development, and will be instrumental for future bioenergy applications.

50 and characterization of the mu 2 gene should be instrumental for future studies of the genetics and p

51 Provision of amino acids to the liver is instrumental for gluconeogenesis while it requires sa

52 Automated detection of SDoH may be instrumental for healthcare providers in identifying

53 ependent adhesion and the actin cytoskeleton are instrumental for heart lumen formation.

54 We believe that these data will be instrumental for helping policymakers and researchers

55 Large-scale forward genetic screens have been instrumental for identifying genes that regulate de

56 eover, we found that, the STAT1-IRF1 pathway was instrumental for IDO1 expression in RET/PTC3 express

57 asets on coding and noncoding RNAs that will be instrumental for illuminating the underlying biology

58 The research findings presented here will be instrumental for improving the design of a bivalent p

59 s of the wounds, which has been suggested to be instrumental for initiating wound healing.

60 MR-based attenuation correction is instrumental for integrated PET/MR imaging.

61 We demonstrate here that this activation is instrumental for integrin-dependent Rac activation.

62 dantly expressed in many types of cancer and is instrumental for intratumoral recruitment of regulato

63 roduce such cellular complexity and function are instrumental for investigating muscle pathophysiolog

64 eripheral liver clock proteins postulated to be instrumental for linking behaviour and metabolism.

65 BTV infection.IMPORTANCE Protein chaperones are instrumental for maintaining protein homeostasis, en

66 the degradation of ubiquitinated substrates, is instrumental for maintenance of muscle mass and funct

67 Microsecond-to-millisecond motions are instrumental for many biomolecular functions, includ

68 Although they were instrumental for many scientific breakthroughs, the

69 e formation of the anterior mesendoderm that is instrumental for mediating the inductive interaction

70 These experimental systems will be instrumental for metastasis studies, particularly the

71 Polo-like kinase 1 (Plk1) is instrumental for mitotic entry and progression.

72 Our technology will be instrumental for monitoring and studying cell behavio

73 inaceous complexes and replicons; hence they are instrumental for myriad cellular processes such as c

74 This induction is instrumental for neutrophil transmigration across an

75 This novel mouse model will be instrumental for not only clarifying disease mechanis

76 The formation of this complex was instrumental for Nox3-driven reactive oxygen species

77 Hematopoietic stem cells (HSCs) are instrumental for organismal survival because they ar

78 Given that mycorrhizal fungi are instrumental for P acquisition and that the two domi

79 produces a slope, lambda (Lambda), which can be instrumental for practitioners to identify transforma

80 Pharmacogenetic approaches can be instrumental for predicting individual differences in

81 models built with the ENTess descriptors can be instrumental for predicting the binding affinity of r

82 The immune system is instrumental for protection against invading organism

83 These results support the view that hAEC are instrumental for regenerative medicine as well as in

84 These findings suggest that oxytocin is instrumental for reproduction and caregiving in femal

85 d electron microscopy, we show that synapsin is instrumental for resisting vesicle dispersion and ser

86 These theories have been instrumental for revealing influences of probabilit

87 n, conferring them pacemaker properties that are instrumental for rhythmic firing of cardiac and neur

88 The database provided in this study will be instrumental for scientists interested in infant nutr

89 Partially or fully disordered proteins are instrumental for signal-transduction pathways; howev

90 We show that COL7A1 is instrumental for skin wound closure by 2 interconnect

91 ity is expressed in erythrocytes and that it is instrumental for SPH generation.

92 Knockdown of MeCP2 shows it is instrumental for splicing and inhibits Tet1 and CTCF

93 These results suggest that strong ties are instrumental for spreading both online and real-worl

94 t regulation of ClC-K2 in intercalated cells is instrumental for stimulation of Cl(-) reabsorption by

95 levant chemical biology innovations that can be instrumental for studying GPCRs.

96 Traction force microscopy (TFM) has been instrumental for studying such forces, providing sp

97 s showed that the initial production of IL-6 was instrumental for subsequent activation of STAT3.

98 Ligand design and catalyst optimization are instrumental for sustained O(2) productivity with qu

99 Our study reveals that ADAM10 is instrumental for synaptic and neuronal network functi

100 engineer control systems of gene expression is instrumental for synthetic biology.

101 rmal growth factor receptor (EGFR) signaling is instrumental for terminal differentiation of keratino

102 okine transforming growth factor B1 (TGF-B1) is instrumental for Th17 cell differentiation, it is dis

103 cavities are a key component of lasers that are instrumental for the amplification and emission of a

104 Wildlife monitoring programs are instrumental for the assessment of species, habitat

105 tional units of the DNA damage response, and are instrumental for the correct establishment of yH2AX-

106 cargo for VPS41-dependent LAMP carriers that are instrumental for the delivery of NPC1 to LE/LY and m

107 While it is clear that these interactions are instrumental for the life of the mammalian cell, the

108 e current natural history of DMD, which will be instrumental for the design of future clinical trials

109 of this important vector species and should be instrumental for the development of innovative diseas

110 insights into the pathogenesis of CMT1 might be instrumental for the development of new therapeutic o

111 These findings will be instrumental for the development of next generation p

112 chanospectroscopic concepts and methods will be instrumental for the development of novel bioanalyses

113 d adaptive strategies evolved in nature will be instrumental for the development of stress-tolerant c

114 oproteome regulation in eukaryotes that will be instrumental for the development of type III secretio

115 mmune system and the hemostatic system might be instrumental for the prevention and treatment of micr

116 of patients with high toxicity grade and may be instrumental for the prognosis of radiation therapy c

117 Cementum formation is deemed to be instrumental for the successful regeneration of perio

118 nt reserve secondary to iron overloading may be instrumental for the susceptibility of the HFE gene k

119 clohexanediamine and (2R,4R)-pentanediol has been instrumental for the development of this process.

120 ydricity, a thermodynamic parameter that has been instrumental for the rational design of synthetic m

121 Patient stratification has been instrumental for the success of targeted therapies

122 endoplasmic reticulum to mitochondria, which is instrumental for the apoptotic action of the receptor

123 ecrosis factor (TNF)-alpha-producing T cells is instrumental for the bone loss induced by estrogen de

124 Disregulated IFN-gamma production is instrumental for the bone loss induced by ovariectomy

125 'pillar' microtubules, and that this network is instrumental for the coordinated orientation and stab

126 nts that modulate multidrug resistance (MDR) is instrumental for the design of more effective treatme

127 mor-mediated mechanisms that impair immunity is instrumental for the design of new cancer therapies.

128 Identification of allergenic IgE epitopes is instrumental for the development of novel diagnostic

129 he mesencephalon (mes) and rhombomere 1 (r1) is instrumental for the development of three distinct br

130 The microscopic assessment of tissue samples is instrumental for the diagnosis and staging of cancer,

131 g) cells to lymphoid and non-lymphoid tissue is instrumental for the effective control of immune resp

132 enzymes involved in epitranscriptome shaping is instrumental for the elucidation of the functional ro

133 ARD3 and VAP, we showed that phosphorylation is instrumental for the formation of ER-endosome contact

134 e details of excitation-contraction coupling is instrumental for the further understanding of patholo

135 actin bundling/cross-linking protein plastin is instrumental for the generation of potent cortical ac

136 lear factor (NF)-kappaB transcription factor is instrumental for the immune response and the survival

137 nesthesia done outside of the operating room is instrumental for the maintenance of exemplary quality

138 is non-canonical cleavage at Ala-470-Asn-471 is instrumental for the onset of catalysis in sigmaPre2,

139 f the EtCONHC6F5 in comparison to EtCONHC6H5 is instrumental for the presence of a larger population

140 Whether silencing of IRF-7 by methylation is instrumental for the process of tumorigenesis remains

141 est a model in which protein phosphorylation is instrumental for the recruitment of these proteins to

142 Our resource is instrumental for the systematic molecular characteriz

143 EPN3-induced partial EMT is instrumental for the transition from in situ to invas

144 The overlap between these responses is instrumental for the understanding of host evolution

145 was a pioneer in targeted cancer therapy and was instrumental for the discovery and deployment of the

146 The formation of the froth layer was instrumental for the preservation of coesite, promot

147 CD4+ T cells were instrumental for the induction of such readily tran

148 a layer of extracellular matrix (ECM), which is instrumental for their development and maintenance.

149 ith splenic microenvironmental ligands/cells is instrumental for their survival and accumulation duri

150 We show that glycolysis was instrumental for their migration and was initiated b

151 components within the metastatic cascade may be instrumental for therapeutic discovery to curb promet

152 GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications

153 We hypothesized that sulfatases are instrumental for this bacterium, and related Bactero

154 ted the hypothesis that the motor cortex can be instrumental for translating foreign language vocabul

155 een network theory and zeolite synthesis can be instrumental for translating key findings of individu

156 ualizing glomerular filtration function will be instrumental for translation of organoid technology f

157 iving the present changes of the NHSM system are instrumental for understanding and predicting future

158 the basic body plan-the mechanisms of which are instrumental for understanding embryonic programming

159 These results are instrumental for understanding mechanisms of tumorig

160 of genetically engineered mouse models that are instrumental for understanding why AD is a neuronal

161 nd elucidating the role of this receptor may be instrumental for understanding neurogenesis during ey

162 This clock will be instrumental for understanding the biology of ageing

163 ltiple linear regression framework which can be instrumental for understanding their prediction perfo

164 Bone marrow cultures and mouse models have been instrumental for understanding the mechanisms that

165 rstood; with experimental infections of bats being instrumental for understanding reservoir-pathogen

166 functional diversity of [FeFe] hydrogenases is instrumental for understanding how these remarkable e

167 es and interactions of differentiating cells is instrumental for understanding organ development and

168 ning the molecular origin of spectral tuning is instrumental for understanding the function and devel

169 kets of the latent Factor D conformation and was instrumental for understanding the binding requireme

170 ryotic microbes (e.g., Dinoflagellata) would be instrumental for unraveling the genetic mechanisms by

171 our universal light-driven rotation platform is instrumental for various scientific research and engi

172 This process is instrumental for virulence in the mouse model of infe