ライフサイエンスコーパス: be less effective

1 ditional control interventions are likely to be less effective.

2 sorting equipment in winery for this aim may be less effective.

3 50 7A1 expression is reduced these drugs may be less effective.

4 fied until after age 5 years, when treatment is less effective.

5 Concurrent CAD is less effective.

6 e mRNA translation by cap-dependent scanning is less effective.

7 After myopia develops, interruption is less effective.

8 peptides when the original Stachel sequence is less effective.

9 ation with the monomeric alpha-chain of C4BP was less effective.

10 3L) DNA, which expanded both subpopulations, was less effective.

11 After autoimmunity was established, HOT was less effective.

12 ich limits signaling through both receptors, was less effective.

13 ression, whereas ectopic expression of HMGA2 was less effective.

14 Doxycycline was less effective.

15 ing to type II receptors, but the short form was less effective.

16 arge B-cell lymphomas, anti-PD-1 therapy has been less effective.

17 weight or albumin-binding gadolinium agents were less effective.

18 -linolenic acids, two popular dietary PUFAs, were less effective.

19 The E-isomers ent-15a, ent-13a, and 15b were less effective.

20 s p110delta or p110beta/p110delta inhibitors were less effective.

21 d flexible sigmoidoscopy every 5 years alone were less effective.

22 ess the question of why the smaller droplets were less effective.

23 Glutathione and ascorbate were less effective.

24 3 months), whereas other antiepileptic drugs were less effective.

25 ake and antigen processing, whilst emulsions were less effective.

26 by warfarin and dabigatran, meaning that it was less effective (8.44, 8.54, and 8.59 quality-adjuste

27 Treatment is less effective after inflammation begins.

28 ; p<0.0001) but postprandial glucose control was less effective after breakfast and dinner.

29 rapies treat hematopoietic malignancies, but are less effective against solid tumors.

30 Classical apoptotic drugs are less effective against this critical subpopulation.

31 Emerging data suggest that vancomycin may be less effective against serious methicillin-resistant

32 CAR T cells have been less effective against solid tumours(3-5), in part

33 the tumor-associated isoforms CA IX and XII, being less effective against the cytosolic CA I and II.

34 d TcCA with KIs in the range of 0.5-12.5 nM, being less effective against the human off-target isofor

35 nanomolar inhibitory action against hCA II, being less effective against the other isoforms.

36 how that RNAi induced against one DWV strain is less effective against an alternate strain from the s

37 is painful, requiring local anaesthetic, and is less effective against large lesions.

38 The compound is less effective against the beta-amyloid peptide, indi

39 AE in inhibiting Listeria monocytogenes, but was less effective against Escherichia coli O157:H7 than

40 UVA alone was less effective against the second group of bacteria

41 odies that efficiently inhibit cell-free HIV were less effective against cell-to-cell transmitted vir

42 (50): 0.30 and 0.13 mg/ml, respectively) and were less effective against lipase.

43 osuppressive treatment after transplantation were less effective against the fungus than those from h

44 art failure medications), disease management is less effective among African Americans, yielding high

45 However, the intervention was less effective among FSW-IDUs, and had no effect on

46 Current treatments are less effective and have more severe side effects in

47 Doubly modified siRNAs were found to be less effective and lose their efficacy at low nanomol

48 angiotensin-II receptor type 1 blockers may be less effective and support the strategy to further in

49 admitted late after injury, tranexamic acid is less effective and could be harmful.

50 FS-DSEK was less effective and more costly compared to both DSAE

51 gFOBT was less effective and more costly than FIT.

52 er monotherapy and triamcinolone monotherapy were less effective and more costly than combination the

53 erred strategy, because RFA-RFA and SBRT-RFA were less effective and more costly.

54 Strategies based on symptom screening alone were less effective and more expensive than MMR-based st

55 While aminoglycosides appear to be less effective antimicrobial agents than other antibi

56 However, evidence suggests that patents are less effective as an incentive to innovate in the fi

57 able carbocyclic versions of these analogues are less effective as the role of the ribose in facilita

58 Upstream-based permitting is less effective as it is difficult to set reasonable p

59 hat L-arginine synthesized from L-citrulline was less effective as a substrate for arginase-mediated

60 gonists had a shorter duration of action and were less effective as pseudoirreversible antagonists.

61 Although variant peptide vaccines were less effective as TAA expression increases, data pr

62 Lipid-depleted (LD) apolipoproteins are less effective at binding and clearing Abeta, and LD

63 Large molecules are less effective at crowding than water and ions.

64 kely source of water contamination, but they are less effective at determining the potential risk to

65 e of visual processing whereby large stimuli are less effective at driving neuronal responses than sm

66 R-transgenic effector cells lack Tbx21, they are less effective at entering the pancreas and promotin

67 out the vote message, we estimate that both are less effective at increasing turnout than a much sho

68 sion contact time revealed that PDA coatings are less effective at preventing bioadhesion when the co

69 CB[7].2,6-Ad(NH3)2 and CB[7].2,6-Ad(NMe3)2) are less effective at realizing the potential 1000-fold

70 t analyses have suggested that beta-blockers are less effective at reducing cardiovascular events tha

71 s with mutations in these conserved residues are less effective at stabilizing RecA-mediated strand e

72 ound some HIV-1-neutralizing patient sera to be less effective at blocking VS-mediated infection than

73 ture vaccines with additional serotypes will be less effective at targeting and reducing IPD in globa

74 In clinical trials, cancer vaccines have been less effective at priming T cells and extending sur

75 ulfonates and carboxylate PFAS compounds and is less effective at concentrating the smallest and larg

76 erent cellular dynamics than M1316-CHC22 and is less effective at controlling GLUT4 membrane traffic,

77 s that multisite phosphorylation, by itself, is less effective at creating switchlike responses than

78 This is less effective at generating within-group diversity w

79 Previous studies also suggest that REBOV is less effective at inhibiting host innate immune respo

80 rated from tailbud, declining Fgf signalling is less effective at initiating adaxial myogenesis, whic

81 Cancer vaccination is less effective at old than at young age, due to T cel

82 use of such a top-down attentional strategy is less effective at preventing errors caused by competi

83 is due to the fact that purifying selection is less effective at removing weakly deleterious Neander

84 The isolated DNA binding domain of Cdc13 is less effective at shielding telomeres.

85 The EPO mutant is less effective at stimulating erythroid cell prolifer

86 dvantages are negated if the fractal's field is less effective at stimulating neurons.

87 hronic treatment with morphine, compound 101 was less effective at blocking acute desensitization.

88 Because phosphorylated (p)-rC0C7-sc was less effective at damping contractile oscillations,

89 reductase (an H-TrxR homologue lacking Sec) was less effective at HOSCN turnover.

90 transfusion of c-kit(+) cells from IRKO mice was less effective at improving endothelial repair.

91 Localized BH(4) alone or combo was less effective at increasing NO-dependent vasodilata

92 reas the obligate dimeric mutant MCP-1(T10C) was less effective at inducing leukocyte recruitment in

93 That the partially processive APOBEC3G was less effective at inducing mutagenesis in a model HI

94 gh dose of TN robustly activated the UPR but was less effective at inducing steatosis.

95 ficient potency against the p110beta isoform was less effective at inhibiting the PI3K pathway in PTE

96 hereas the isogenic clone p30 knockout virus was less effective at inhibiting TLR3 and TRL4 signaling

97 Although LAT sRNA2 was less effective at inhibiting virus production, it in

98 Although percutaneous repair was less effective at reducing mitral regurgitation than

99 Antagonists were less effective at 2 h, which we demonstrate is like

100 lls lacking the ability to produce IFN-gamma were less effective at controlling pathogen load upon he

101 Strains unable to communicate via QS were less effective at defending against invaders target

102 , the DAT blockers nomifensine and bupropion were less effective at inhibiting dopamine uptake follow

103 Cells grown at high density were less effective at invading an endothelial monolayer

104 ated by skin vaccinia virus (VACV) infection were less effective at protecting mice from a lethal pul

105 kin CD8(+) TRM cells that lacked Fabp4/Fabp5 were less effective at protecting mice from cutaneous vi

106 The MDA strategies were less effective at reducing prevalence and intensity

107 Both enalapril and telmisartan were less effective at reducing renal injury in diabetic

108 domestic gardens, which tend to be smaller, were less effective at reducing summer soil surface temp

109 transplanted these mucosal cell preparations were less effective at repair.

110 Column experiments showed that iron minerals were less effective at retarding Tc release under flow-t

111 reduced levels of MHC class II and CD86 and were less effective at stimulating CD4(+) T cell prolife

112 Other homologues, such as Z-d-Phe, are less effective but may act through the same mechanis

113 Salt substitution with Pansalt(R) was less effective but preserved the overall flavour.

114 However, these approaches appear to be less effective, compared with other countries' approa

115 en, whereas single-monoclonal HEL antibodies were less effective despite the use of saturating doses.

116 56.6%, depending on their concentration, but were less effective, especially at lower concentrations,

117 r pediatric acute lymphoblastic leukemia but are less effective for chronic lymphocytic leukemia (CLL

118 otics, which are standard initial treatment, are less effective for treating refractory or recurrent

119 ed ties and a high degree of separation will be less effective for behavioral diffusion than networks

120 t attractive for mAb characterization-it can be less effective for precursors having high m/z values.

121 dence is scarce and such interventions might be less effective for smokers with low socioeconomic sta

122 easible in resource-limited settings but may be less effective for women living with HIV.

123 The dose deposited by (64)Cu is less effective for cell killing than gamma-rays.

124 tastatic HER2-positive breast cancer, but it is less effective for controlling metastases in the CNS,

125 pneumococcal polysaccharide vaccine (PPV23) is less effective for older adults than for young adults

126 pulations, there is evidence that vancomycin is less effective for prevention and treatment of methic

127 tive for terminating slower tachycardias but is less effective for treating AF.

128 Furthermore, the antiviral drug oseltamivir is less effective for treating influenza B virus infecti

129 The system was less effective for PM2.5 (55+/-22%) but successfully

130 We found no evidence that the nudge was less effective for poorer or less educated immigrant

131 ication of HCV genotype 1b Con1 replicon but was less effective for the 2a/JFH1 replicon and infectio

132 e that H. pylori eradication and aspirin use were less effective for improving methylation in IM than

133 edges of CDR3, whereas other polar mutations are less effective (glutamine and serine) or ineffective

134 same motor rehabilitation intervention could be less effective if administered in the presence of pai

135 PH oxidases and prevent postoperative AF but are less effective in AF secondary prevention; the mecha

136 Despite successes, oral rotavirus vaccines are less effective in developing countries.

137 paradigms were developed in male rodents and are less effective in female rodents.

138 Nonmyeloablative allogeneic transplants are less effective in heavily diseased burdened patients

139 rventions about increased risk donors (IRDs) are less effective in improving knowledge among African

140 ssic therapeutics for ischemic heart disease are less effective in individuals with the metabolic syn

141 est Rca oligomers composed of Rca-alpha only are less effective in initiating and sustaining the acti

142 hy, in people with asthma, deep inspirations are less effective in reversing bronchoconstriction.

143 However, CAR T cell treatments are less effective in solid tumors for several reasons.

144 water eutrophication, while solid phosphates are less effective in supplying the nutrient P.

145 re at a high risk of infection, but vaccines are less effective in this age group; tailored adjuvants

146 dden cardiac death (SCD) concluded that ICDs are less effective in women and the elderly.

147 Colorectal cancer screening might be less effective in black individuals, if there are rac

148 efficacy of darapladip and cause the drug to be less effective in high risk patients.

149 However, ID331 is likely to be less effective in inducing CD because of its inabilit

150 ted secondary olfactory fibers caused DiI to be less effective in labeling secondary olfactory projec

151 a brush made of mutant nsp1 that is known to be less effective in NPC-selective transport, finding th

152 restricted by age and race; the systems may be less effective in other samples.

153 ion (HCV(+) ) has historically been shown to be less effective in patients with a heavy drinking hist

154 suboptimal (low) systemic exposure that can be less effective in patients with higher rates of drug

155 othesized that MFE-derived ambiguities would be less effective in separating bound and unbound molecu

156 catheter aortic valve replacement (TAVR) may be less effective in small surgical valves because of pa

157 vide short-term ecological benefits, but can be less effective in the long term, compared to a low-pe

158 itors of IAPP amyloid formation are shown to be less effective in the presence of GAGs.

159 ed largely by purifying selection, which has been less effective in primates than in rodents, presuma

160 tivity in hematological malignancies, it has been less effective in prostate cancer and other solid t

161 tivity in hematological malignancies, it has been less effective in solid tumors, including EOC.

162 mals to deliver gene editing constructs have been less effective in songbirds, likely due to immune s

163 n to remove weakly deleterious mutations has been less effective in the history of non-Africans.

164 In contrast, RAS pathway inhibitors have been less effective in treating epithelial malignancies,

165 The latter result may be related to miR-H2 being less effective in inhibiting ICP0 expression in tr

166 However, this technique is less effective in accurately identifying transcript i

167 ined by the advent of endocrine therapy that is less effective in African American women because of t

168 GW7647-mediated PPARalpha activation; GW7647 is less effective in cells that do not express FABP1.

169 tially explaining why glucocorticoid therapy is less effective in controlling macrophage-dominated in

170 Influenza vaccination is less effective in elderly as compared to young indivi

171 no measurable effect on cationic current and is less effective in influencing intercellular Ca(2+) co

172 ay of treatment for cerebral malaria, but it is less effective in later stages of disease when the ho

173 3, with an efficacy that depends on TMEM173, is less effective in mHAQ mice than in wild type mice.

174 ns are predicted to result in a product that is less effective in neutralizing negatively charged lin

175 O2 as found for other hemoproteins, but H2O2 is less effective in oxidizing the peptide, and further

176 For that purpose, CTA is less effective in patients with calcium score >/=600

177 py trials suggested that cytotoxic treatment is less effective in patients with estrogen receptor (ER

178 ll death in actively proliferating cells, it is less effective in quiescent cells.

179 Lightweighting EVs is less effective in reducing greenhouse gas emissions t

180 However, the surgery is less effective in the 15-30% of patients whose lesion

181 nd mortality risk, but the influenza vaccine is less effective in the elderly.

182 us (HIV) natural course, and HBV vaccination is less effective in the HIV infected.

183 e early phase of Parkinson's disease, but it is less effective in the long term.

184 durance athletes, which may explain why HIIT is less effective in this group.

185 We discovered that RNAi is less effective in zebrafish at least partly because A

186 pITAM peptide strongly activated GST-SYK but was less effective in activating upSYK untagged with GST

187 filaments from forced depolymerization, but was less effective in both assays than full-length dystr

188 Treatment for PAH was less effective in CTD-PAH compared with IPAH in term

189 r cells caused a marked cytolytic effect and was less effective in HBV control.

190 to induce protective immunity, although this was less effective in heterologous challenge situations,

191 wo groups, whereas in historical data, G-CSF was less effective in patients with diabetes.

192 NAC treatment was less effective in recovering ATP and mitochondrial G

193 In netrin-1(+/-) mice, resolvin D1 (RvD1) was less effective in reducing neutrophil influx promoti

194 Treatment was less effective in reducing the occurrence of clinica

195 st completely rescued HttQP103 toxicity, but was less effective in rescuing HttQ103 toxicity.

196 R: 0.15, 95% CI: 0.06-0.41, p = 0.0002), but was less effective in reversing the methylation that occ

197 Nevertheless, in general, ellagic acid was less effective in scavenging ROS (IC(50) from 1.7 to

198 Microstimulation was less effective in shifting perceptual choices toward

199 tervention after grade 1 damage had occurred was less effective in suppressing proinflammatory genes

200 We then confirmed that BMP4 was less effective in suppressing the tumor growth of TS

201 The AC was less effective in the field than in the laboratory,

202 that in vivo FLT3 inhibition by lestaurtinib was less effective in the relapsed patients compared wit

203 In behaving mice, cholinergic stimulation was less effective in the theta (4-10 Hz) band yet it al

204 ment with pegylated interferon and ribavirin was less effective in this population than is implied by

205 ration by S. aureus and S. pyogenes; NeoForm was less effective in withstanding these organisms.

206 roblast cells, the less helical p27 variants were less effective in causing cell cycle arrest relativ

207 rains not expressing major virulence factors were less effective in inducing IL-1 and IL-23 release b

208 tivators xanthenone and diminazine aceturate were less effective in inducing the migration in cells f

209 although exhibited antioxidant activity, but were less effective in maintaining the muscle quality du

210 Furthermore, tocopherols were less effective in protecting the oils in the presen

211 ese subsets persisted for several months but were less effective in recall than memory precursor effe

212 herapeutics such as paclitaxel and cisplatin were less effective in targeting CSC than bulk tumor cel

213 ated peptide receptor inhibitor, olcegepant, were less effective in this model.

214 line coating, whereas the amorphous coatings were less effective in this respect.

215 Immature dendritic cells were less effective in transferring surface molecules on

216 rthermore, gemcitabine and radiation therapy were less effective in tumor cells treated with HPSC-CM.

217 However, ERK2-T183A/Y185F was less effective, indicating the requirement of TEY si

218 to disrupt the secondary structure of VQDLL were less-effective inhibitors of P. gingivalis adherenc

219 re found to loosen eudicot cell walls but to be less effective on grass cell walls, whereas the rever

220 of CCR4(+) activated CD4 cell migration but was less effective on memory cells where alpha(4)beta(1)

221 tion rate, based on linear stability theory, are less effective once the instability becomes fully no

222 lts indicate that antiamyloid therapies will be less effective once p-tau pathology is developed.

223 n reducing CV risk in the general population are less effective or ineffective in favorably modifying

224 It is generally accepted that CA is less effective or even inactive at frequencies > appr

225 ibited PIV3, whereas IFIT2, IFIT3, and IFIT5 were less effective or not at all.

226 However, when compared with CABG, PCI was less effective (OR, 1.36; 95% CI, 1.18-1.58; P<0.001

227 fferent animal species, but fictive outcomes are less effective than actual outcomes in the increment

228 onclude that poorly hydrolyzable nucleotides are less effective than ATP at opening CFTR channels eve

229 blood pressure alone and that beta blockers are less effective than expected.

230 3) the determination that short light pulses are less effective than sustained light if the goal is t

231 derived dendritic cells (DC) from aged miced are less effective than their young counterparts in indu

232 The combination was shown to be less effective than (177)Lu-DOTATATE alone.

233 strategies prioritizing elderly persons may be less effective than believed at reducing serious morb

234 ation on chronic wound management appears to be less effective than blended education and more effect

235 psychiatric side effects, are also likely to be less effective than brain-permeable CB(1) antagonists

236 icts that once a week dosing of GM-CSF would be less effective than daily, twice a week, or three tim

237 Why zinc seems to be less effective than expected at all ages, and ineffec

238 ed data suggest that laser endonasal DCR may be less effective than external DCR.

239 as been suggested that acellular vaccine may be less effective than previously believed.

240 r influenza, but have recently been shown to be less effective than previously thought.

241 erapeutic targeting of a single cytokine may be less effective than strategies such as dual inhibitor

242 To understand why the program has been less effective than expected, the paper then turns

243 Dronedarone is less effective than amiodarone for the maintenance of

244 Moreover, apoE4 is less effective than apoE2 in promoting Abeta transpor

245 acking one of the two actin-binding domains, is less effective than dystrophin in regulating actin dy

246 r results show that increasing the viscosity is less effective than increasing the energy density in

247 rrhythmic drug treatment after cardioversion is less effective than is long-term treatment, but can p

248 JA-Ile to 12OH-JA-Ile, and that 12OH-JA-Ile is less effective than JA-Ile in promoting the formation

249 and-treat with a highly sensitive diagnostic is less effective than mass drug administration owing to

250 an induce tumor killing deep within body, it is less effective than NIR-PIT, possibly related to the

251 health value of the novel product even if it is less effective than oral PrEP.

252 rgin of -15%, the null hypothesis that cSEMS is less effective than plastic stents was rejected.

253 arting iron treatment after the onset of IDA is less effective than prevention.

254 ions, screening of TRAM flap reconstructions is less effective than screening asymptomatic women in t

255 aser settings, PRP performed with the PASCAL is less effective than that performed with traditional a

256 hether treatment with amoxicillin for 3 days is less effective than treatment for 5 days in children

257 ts onset of effects is slower and overall it is less effective than tumor necrosis factor blockers.

258 suppresses release, and mutant PNKD protein is less effective than wild-type at inhibiting exocytosi

259 ong patients with AAV, mycophenolate mofetil was less effective than azathioprine for maintaining dis

260 ol groups, and there is no evidence that IPT was less effective than CBT.

261 Overall, non-daily PrEP was less effective than daily PrEP, especially in the U.

262 Overall, nondaily PrEP was less effective than daily PrEP, especially in the Un

263 t sustained tissue prior to reperfusion, but was less effective than direct blood flow at maintaining

264 However, HP100 was less effective than Endocut-03L due to its stabilizi

265 Preformed ferric hydroxide was less effective than freshly dosed ferric chloride in

266 artially relieved cell growth inhibition but was less effective than inhibition of AMPK.

267 oncentration intranasal naloxone (2 mg/5 mL) was less effective than intramuscular naloxone but was a

268 AR-13324 0.02% was less effective than latanoprost by approximately 1 m

269 Seasonal snail control, implemented alone, was less effective than mass drug administration, but co

270 so reduced diabetic nephropathy, although it was less effective than MK-801.

271 nd multivariate Cox regression analysis, KLH was less effective than MM regarding RFS (all P < .001).

272 = 0.03), and at high baseline IOP medication was less effective than other treatments.

273 However, rXlIFN-lambda was less effective than rXlIFN in preventing FV3 replica

274 reatment with either dox or AAV1-mIL-6 alone was less effective than the combination.

275 vity, the novel combination of PA-824 and MZ was less effective than the standard first-line regimen

276 Pioglitazone was less effective than troglitazone on all parameters t

277 in combination (EDTA and vitamin E acetate) was less effective than using them individually.

278 UVA alone was less effective than UVA+B2 (MD = 25.31) and UVA+B2'

279 Seasonal supplementation was less effective than was daily supplementation (P < 0

280 that dual PI3K/mTOR inhibition by apitolisib was less effective than was everolimus in mRCC, likely b

281 This mutant was less effective than wild-type human nectin-4 at prom

282 s inhibited by IFN-gamma in HEL-30 cells and was less effective than wild-type virus in induction of

283 4E9 and 1H5 were less effective than HF5 and CD6, as indicated by th

284 S-150 sorbents performed similarly to BC but were less effective than MOF for NH(3)(g) sequestration.

285 iabetic mice demonstrated that diabetic EPCs were less effective than normal EPCs at accelerating wou

286 The chimeras were less effective than SAMD14 itself in rescuing signa

287 i BCAA auxotrophic cells, but SlBCAT1 and -2 were less effective than SlBCAT3 and -4 in growth restor

288 lower doses of pegylated interferon alfa-2b were less effective than standard doses (2 to 4 fair-qua

289 e report that pharmacologic NOTCH inhibitors were less effective than targeting RBPJ in suppressing t

290 with a single N-glycan at nonconserved sites were less effective than those with one at a highly cons

291 fer experiments showed that Spi6(-/-) nTregs were less effective than wild type nTregs in suppressing

292 that existing methods for gene set analysis are less effective when sample heterogeneity exists.

293 However, PIT may be less effective when a tumor lacks "overwhelming" expr

294 d at early stages of tumor vessel growth but is less effective when administered later.

295 Thus, while a high potency therapy usually is less effective when given later, treatments at late t

296 Filtering is less effective when there is low redundancy between h

297 e or at the same time as virus infection and was less effective when added 24 h after EBOV infection.

298 Epilepsy surgery was less effective when there were extratemporal lesions

299 prevent other types of caries are likely to be less effective with HAS-ECC because the structural in

300 tment with epinephrine after PAF stimulation was less effective with time after PAF stimulation.