ライフサイエンスコーパス: be necessary to

1 burial, in addition to silicate weathering, is necessary to account for the positive delta(13)C inte

2 Continued genomic surveillance will be necessary to accurately assess how the population of

3 Identification of As species is necessary to accurately determine the risk associated

4 rates, and that including the 2ph processes is necessary to accurately predict the electron mobility

5 ctions (Cl2 + H2O + A- k-4k4HOCl + HA + Cl-) were necessary to accurately simulate Cl(2) concentratio

6 loping on-scalp systems is: how many sensors are necessary to achieve adequate performance/spatial di

7 s between these two neurotransmitter systems are necessary to achieve an antidepressant effect.

8 at knocking out AGO1, AGO2 and AGO3 together are necessary to achieve full impact on steady state lev

9 ially for younger and substance-using YBMSM, are necessary to achieve full PrEP effectiveness.

10 theoretical work has shown that two factors are necessary to achieve high selectivity for a threshol

11 nging as extensive decalcification protocols are necessary to achieve thin sections.

12 imens and that immunologic interventions may be necessary to achieve ART-free virologic remission.

13 gen moieties in P450 17A1 inhibitors may not be necessary to achieve inhibition but may nevertheless

14 he electrode array and retina may not always be necessary to achieve optimal visual outcomes.

15 Investing in medical imaging will also be necessary to achieve substantial survival gains, with

16 integrated design of monitoring and control is necessary to achieve robustness when extrapolating fr

17 (sLNvs) are bursting neurons, and that I(h) is necessary to achieve the high-frequency bursting firi

18 age is required for Il33 gene induction that is necessary to activate ILC2s for participation in dise

19 Interestingly, kinase activity of OsWAKL21.2 is necessary to activate rice immune responses, whereas

20 e horizontally acquired regulatory gene ssrB is necessary to activate the ancestral regulatory system

21 o the airways indicated that the environment was necessary to activate these pathways, but did not in

22 specific sites or defects of a nanoparticle were necessary to activate substrates in catalytic react

23 cal fixation and cryogenic fixation methods) are necessary to adapt biological samples to the vacuum

24 account for changes in surface potential, it is necessary to add a battery to this circuit connected

25 diverse teams of researchers and clinicians are necessary to address health disparities and improve

26 igns beyond the conventional structures will be necessary to address these limitations and to expand

27 re fueled by a skewed risk-benefit ratio and are necessary to advance therapeutic agents into human t

28 tiation of spatial from semantic information is necessary to advance research in the field of scene p

29 Therefore, it is necessary to analyze adduct formation in HILIC metabo

30 es that continued scaling of EFM computation is necessary to apply EFM to genome-scale models.

31 ause SVs and STRs range in size and type, it is necessary to apply multiple algorithms that incorpora

32 However, an extended analysis is necessary to apply this framework for hospital-indepe

33 Longitudinal follow-up studies will be necessary to ascertain the long-term neurological and

34 Future longitudinal studies are necessary to assess and understand the long-term soc

35 is phenomenon are lacking in the tropics and are necessary to assess the impact of a warming climate

36 formation refers to the precise details that are necessary to assess the quality of the experimental

37 considering combinations of these SNPs might be necessary to assess the role of polymorphisms in digo

38 tic strategies, devoid of these limitations, are necessary to attenuate the progression of HF pathoph

39 ia and fever-recovery-related QT lengthening is necessary to avoid misattributing malaria-disease-rel

40 Exchange across the front is believed to be necessary to balance the freshwater budget of the sub

41 Further field studies are necessary to better elucidate the risks associated w

42 en the atmosphere and terrestrial biosphere, are necessary to better understand the role of the terre

43 cals via a metabolic engineering approach it is necessary to better characterize both the primary met

44 Such insight is necessary to better target therapies or take preventa

45 ore a new MRI device is approved for use, it is necessary to calibrate it properly and to check its t

46 We found that multicenter studies were necessary to capture treatment effect variance; for

47 rstand the function of cortical circuits, it is necessary to catalog their cellular diversity.

48 stretch in the huntingtin protein (HTT) that is necessary to cause pathology and formation of HTT agg

49 ued vigilance and anti-poaching efforts will be necessary to combat poaching and to conserve African

50 tivated and repressed signaling pathways may be necessary to combat RA persistence.

51 g biological information with detection will be necessary to comprehensively understand the impact of

52 Longer and larger trials are necessary to confirm the effects and side effects of

53 Larger studies are necessary to confirm the pilot data presented here.

54 More studies are necessary to confirm the superior diagnostic perform

55 quately powered randomized controlled trials are necessary to confirm these data and explore the mech

56 but larger studies with greater replication are necessary to confirm these results.

57 robability scores; however, specific studies are necessary to confirm this hypothesis.

58 2 diabetes mellitus, although future studies are necessary to confirm this observation.

59 Further study is necessary to confirm these findings, and results may

60 Therefore, it is necessary to consider commonalities and differences i

61 indicated for children in Japan, however, it is necessary to consider not only topical medicine but a

62 In intractable bronchial asthma cases, it is necessary to consider the complications of other dise

63 It is necessary to consider the role of fibrinogen in NETos

64 trial conditioning procedure, and that sleep is necessary to consolidate this rapidly acquired malada

65 est that the tyrosine residue at position 16 is necessary to constrain TCR reactivity for InsB(9-23)

66 er to fully understand this relationship, it is necessary to constrain the quantity and type of degas

67 r variable temporal relationships, which may be necessary to construct maps of sequential experiences

68 emonstrate that HIF1alpha activation in cDCs is necessary to control vessel wall inflammation.

69 Adaptive behaviour is necessary to cope with the complexity of practice.

70 issue sympathetic innervation, which in turn is necessary to correct the associated functional defect

71 istinct mechanism of action, a proper choice is necessary to craft an effective vaccine formulation t

72 ding of pathophysiology of these cancers and is necessary to create a more accurate prognosis for the

73 has been hypothesized that Ras dimerization is necessary to create activated Raf dimers.

74 indicate that a suitable combination of NPIs is necessary to curb the spread of the virus.

75 To prove causation, it will be necessary to decipher which specific taxa or metaboli

76 Such an undertaking is necessary to deconstruct urbanization's biophysical p

77 arch with a systematic neurologic monitoring is necessary to define the timing of acute brain injury

78 Further studies are necessary to determine if PRSs can inform MINS surve

79 While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence fr

80 ental tools, co-polymers theoretical methods are necessary to determine the ensemble of three-dimensi

81 Neisseria gonorrhoeae culture is necessary to determine antimicrobial resistance, but

82 ccounting for both consumption and selection is necessary to determine how predators regulate prey co

83 e of these new vaccines and therapeutics, it is necessary to determine the burden of RSV disease in E

84 Such an understanding is necessary to determine the origins of structural defe

85 Further work is necessary to determine the role of immunothrombosis i

86 pathways and understand existing methods, it is necessary to determine the solution interactions betw

87 uffs produced for infants and young children is necessary to determine their daily vitamin C intake.

88 d artificial enzymes with numerous utilities are necessary to develop future bionic devices in mimick

89 Thus, it will be necessary to develop robust, reliable, and model-base

90 To further confirm this speculation, it is necessary to develop a systematic knowledge beyond me

91 ata on social and environmental determinants is necessary to develop effective outbreak response inte

92 ar events underlying PPM1A/PTEN deregulation is necessary to develop expression rescue as novel thera

93 Therefore, it is necessary to develop new methods to detect this virus

94 shaping the fitness of specific populations is necessary to devise control strategies for undesirabl

95 ust techniques to quantify PFAS in the field are necessary to diagnose environmental contamination at

96 ata suggest that activation of the OT system is necessary to direct behavior preferentially toward so

97 coherent feed-forward loop, and this process is necessary to drive vascular regeneration.

98 ed SOX9-binding enhancer located in intron 1 was necessary to drive transcription of Snorc in the mou

99 Novel delivery strategies are necessary to effectively address glioblastoma withou

100 at multiple histological samples per patient is necessary to effectively capture these progression-re

101 n premature children in developing countries are necessary to elaborate evidenced-based preventive in

102 sting that a change in the aggregation state is necessary to elicit a (129)Xe NMR chemical shift in c

103 igh uptake will expedite reductions and will be necessary to eliminate cervical cancer in countries w

104 Further studies are necessary to elucidate the development of colistin r

105 of the neural basis of cognitive flexibility is necessary to enable treatment approaches that may tar

106 d ANO1 requires ER Ca(2+) release, which may be necessary to enhance ANO1 activation.

107 finitions of comorbidity and periodic audits are necessary to ensure data accuracy and minimize bias.

108 etiologies, but adjustments during pregnancy are necessary to ensure fetal safety.

109 rward, randomized controlled clinical trials are necessary to ensure that clinicians can treat patien

110 ed normal growth, suggesting that KBTBD2 may be necessary to ensure IGF1 signaling in other tissues,

111 y in these patients, preoperative discussion is necessary to ensure concordance of care.

112 evaluating drug delivery and efficacy, which is necessary to ensure drug viability.

113 Estimating the cost-utility of critical care is necessary to ensure reasonable use of resources.

114 To this end, it is necessary to enumerate all potential off-target sites

115 is crucial for the initial diagnostics that are necessary to establish a diagnosis as well as monito

116 of reproducible experimental approaches that are necessary to establish a direct enzymatic relationsh

117 hasic firing) of dopamine-containing neurons are necessary to establish long-term memories associatin

118 eractions and extra-chromosomal interactions are necessary to establish the observed organization.

119 Furthermore, future studies are necessary to establish the role of the apparently av

120 eneration sequencing, ILF3 was also found to be necessary to establish the dsRNA-induced transcriptio

121 size that virus-mediated disruption of APC/C is necessary to establish a unique mitotic collapse with

122 the presence of anxiety, further evaluation is necessary to establish the diagnosis and determine ap

123 larger populations of heart failure patients are necessary to evaluate the effect of this self-regula

124 Longer and larger trials are necessary to evaluate the efficacy and safety of sod

125 ive, reproducible visual function biomarkers are necessary to evaluate the efficacy of emerging treat

126 Further clinical studies are necessary to evaluate the maximum tolerated dose and

127 Future clinical trials are necessary to evaluate whether supplementation with B

128 terials for biomedical applications, it will be necessary to evaluate their biodistribution for healt

129 infection and furthermore in depth research is necessary to evaluate its potential use for Lyme dise

130 on history of a set of multiple bacteria, it is necessary to examine their pangenome, the composite o

131 Endoscopic examination of the GI tract is necessary to exclude ulcers and polyps or cancer as p

132 und two of each reward and timing mechanisms are necessary to explain our data.

133 Thus, new approaches are necessary to explore the genetic architecture of ins

134 Additional studies are necessary to explore the impact of various test perf

135 Further research is necessary to explore which factors affect patient adh

136 proper level of nuclear PER-TIM accumulation is necessary to facilitate kinase recruitment for the re

137 Routine therapeutic drug monitoring (TDM) is necessary to facilitate Tac management and to avoid u

138 In the latter case, it is necessary to filter out the trends before attempting

139 Therefore, it is necessary to find an adapted pollen season definition

140 Neuronal migration during development is necessary to form an ordered and functional brain.

141 d to control their morphology, both of which are necessary to fully realize their application potenti

142 systematic inventory of ribosomal components is necessary to fully understand how ribosome abundance

143 h diversity effects over longer time periods is necessary to fully understand the effects of tree div

144 Future research is necessary to further clarify the relationship between

145 Additional data and longer follow-up will be necessary to gain insight into these issues.

146 ng exposure risks to soilborne pathogens, it is necessary to gain a better understanding of their eco

147 cular data across multiple centers worldwide is necessary to gain statistically significant clinical

148 It is clear that it will be necessary to gather this information from disease rel

149 ssure and high horizontal gene transfer rate are necessary to generate genomic content networks with

150 Here we demonstrate that neuronal inhibition is necessary to generate appetitive or defensive motivat

151 demonstrate that faithful stimulus encoding is necessary to generate the compensatory eye movements

152 perimental development, and thus computation is necessary to guide the structural design of mechanoph

153 Renewable energy production is necessary to halt climate change and reverse associat

154 To investigate such a construct, it is necessary to have a global multivariate model that co

155 In particular, it will be necessary to identify the most suitable biomarkers to

156 Thus, it is necessary to identify all the factors affecting the f

157 ving with HIV) and repeat HIV testing (which is necessary to identify and treat women who seroconvert

158 Further work is necessary to identify potential causal relationships.

159 ity is transformed into human behaviours, it is necessary to identify task-specific networks and anal

160 d factors leading to this diversity loss, it is necessary to identify the factors associated with urb

161 However, further research is necessary to identify the long-term needs of people w

162 Further investigation is necessary to identify the underlying pathological bas

163 sting that binding of EAEC to the epithelium is necessary to impair barrier function.

164 hat intensive control measures are likely to be necessary to impede its progress in these countries.

165 Atomically sharp epitaxial interfaces are necessary to improve performance and for device mini

166 ve, rapid, and affordable diagnostic methods are necessary to improve the clinical management of infe

167 However, it would be necessary to improve consumer acceptance through tech

168 ms underlying behavioral responses to stress is necessary to improve treatments for stress-related ne

169 with the addition of quinoa so that it would be necessary to incorporate less nitrites, or it might e

170 ures beyond expanding insurance coverage may be necessary to increase and sustain the rate of dilated

171 It is necessary to increase our understanding of the cellul

172 A complete characterization of the phenotype is necessary to increase the rate of clinical suspicion

173 hreshold volume of the residual stomach that is necessary to induce sustained weight loss.

174 t accompany tumor progression and metastasis is necessary to inform the next generation of diagnostic

175 ion at the point of treatment by ED services is necessary to inform the targeted deployment of existi

176 by Chlamydia, indicating that CD8(+) T cells are necessary to inhibit chlamydial pathogenicity.

177 he phosphatase to the plasma membrane, which is necessary to inhibit proximal TCR signaling.

178 milarly, twofold higher BT200 concentrations were necessary to inhibit ristocetin induced aggregation

179 ndrial function and cellular metabolism that are necessary to initiate and sustain myofibroblast form

180 ouse studies revealed that dermal adipocytes are necessary to initiate inflammation after injury and

181 adult murine liver but whether those ligands are necessary to initiate zonation in the immature liver

182 ratoconus in the early stages of the disease is necessary to initiate an early treatment of keratocon

183 will respond in an untested environment, it is necessary to integrate mathematical models across bio

184 Significant efforts are necessary to introduce new dietary protein sources t

185 Hence, it is necessary to introduce additional recognizing sites i

186 To best mimic the molecular structures, it is necessary to introduce the notions of directed bindin

187 Further studies are necessary to investigate genetic and phenotypic chan

188 Therefore, alternative approaches are necessary to investigate the importance of the auton

189 ommon-sense morality, and new paradigms will be necessary to investigate other key aspects of utilita

190 We argue that it is necessary to investigate markers and mechanisms that

191 Further research is necessary to investigate the pathophysiology, the pre

192 It is necessary to investigate the stability of these mAbs

193 studies of treated nAMD suggests it may not be necessary to invoke a large effect of anti-VEGF thera

194 crobial stewardship guidelines across Europe is necessary to limit antimicrobial resistance.

195 , and a vigilant follow up for complications is necessary to limit any adverse effects and improve vi

196 itionally, structural lipid characterization is necessary to link the lipid structure to lipid functi

197 To perform focused surgical approaches, it is necessary to localize all hyperfunctioning glands.

198 Our results indicate that hippocampal inputs are necessary to maintain a precise cortical representat

199 tified pathways beyond lipid metabolism that are necessary to maintain ER integrity in yeast and in C

200 by strong immunosuppressive mechanisms that are necessary to maintain homeostasis but consequentiall

201 eostasis mechanisms, requiring ATP7 and COG, are necessary to maintain mitochondria functional integr

202 Significant luminal pressure reduction would be necessary to maintain stress at normal level accordin

203 It is necessary to maintain a proactive attitude toward AI

204 evergreen trees had the deepest roots, which is necessary to maintain canopy during simulated dry sea

205 ranscriptional regulation of mRNA expression is necessary to maintain cell identity and cellular plas

206 tween roosts during seasonal swarming events is necessary to maintain EBLV-2 in the population.

207 is that endothelial cell-initiated signaling is necessary to maintain self-renewal of dental pulp ste

208 While sustained LIN9 is necessary to maintain taxane resistance, there are no

209 This is necessary to make predictions in patients with brain

210 heart rate (HR) in response to exercise and is necessary to match metabolic demand and prevent prema

211 tively detecting impacts of drought on crops are necessary to meet the 21st-century challenge of food

212 to infer values of the correction terms that are necessary to minimize the discrepancy between the mo

213 of total water levels during extreme storms is necessary to minimize coastal impacts.

214 In particular, how many descriptors would be necessary to model the degradation behavior of ocean

215 olding mechanism of multidomain proteins, it is necessary to monitor multiple intra- and interdomain

216 . other than B. henselae Additional research is necessary to more fully define the utility of WB for

217 able detection in complex biological samples is necessary to obtain a complete evaluation with greate

218 elevates circulating levels of GDF15, which is necessary to obtain its beneficial effects on energy

219 The hypothesis that the energy sensor AMPK is necessary to offset the metabolic burden of overnutri

220 Thus, comprehensive treatment plans are necessary to optimize care.

221 d by these types of strategies will probably be necessary to optimize SCI treatment.

222 nd interventions to prevent nonadherence may be necessary to optimize stroke prevention.

223 aches considering FADS genetic variation may be necessary to optimize the design of future clinical s

224 Further research is necessary to optimize the management of patients with

225 xplored environment, and hippocampal outflow is necessary to organize this phenomenon.SIGNIFICANCE ST

226 nd a complex of full length Rabex5/Rabaptin5 was necessary to pattern Rab5 into membrane domains.

227 iosignatures during spaceflight missions, it is necessary to perform separation science in situ.

228 ays at critical phases of palate development is necessary to pioneer novel prenatal interventions.

229 of precipitation in water-limited ecosystems is necessary to predict interannual variation and trends

230 eper knowledge of NK-mediated alloreactivity is necessary to predict its contribution to graft-versus

231 oper circadian alignment of feeding behavior is necessary to prevent metabolic disease, and thus it i

232 Clear communication with ordering providers is necessary to prevent overutilization of blood culture

233 y dynamic of reversible binding interactions is necessary to produce distinct responses to different

234 d losses by limiting pollen dispersal, which is necessary to produce fruit in the mostly female flowe

235 ng molecular wires becomes more feasible, it is necessary to progress from the simple anchor groups u

236 nsive training for all health-care providers is necessary to promote preparedness and efficacy in cri

237 nges, such as exercise and high dietary fat, is necessary to promote skeletal muscle health and atten

238 e also show that activation of the OT system is necessary to promote social behavior and that mice wi

239 and cofilin (actin depolymerization factor) is necessary to promote synaptic growth during t-SP.

240 the incorporation of normal tissue toxicity is necessary to properly balance efficacy with toxicity.

241 For DPT, further studies are necessary to provide data supporting the standardiza

242 eting patients declining anticoagulation may be necessary to raise the rate of anticoagulation.

243 Greater uptake of this approach is necessary to rapidly advance understanding of speciat

244 Furthermore, dSol-1 is necessary to rapidly increase the abundance of DKaiR1

245 Long-term clinical studies are necessary to reach final conclusions.

246 d sink tissues, plus transport processes may be necessary to reach the full yield potential of a crop

247 Effective treatment of obesity is necessary to reduce the associated burdens of diabete

248 th sizes and optimize antithrombotic therapy is necessary to reduce the incidence of these detrimenta

249 close proximity-as a first exercise session is necessary to reduce the muscle glycogen stores.

250 that explicitly accounting for the disorder is necessary to reliably model the XRD patterns of high-

251 the clinical question), recorded whether it was necessary to repeat the study, and rated the presenc

252 y, we know little about which signal aspects are necessary to reproduce behavioral responses.

253 describes a minimal set of interactions that are necessary to reproduce the observed cell fates.

254 on of both nearby residues and phytol chains is necessary to reproduce this behavior.

255 he Mir181ab1 cluster, miR181a1 and miR181b1, was necessary to rescue the Mir181ab1-loss phenotype, un

256 g genomic platforms, multiplatform discovery is necessary to resolve the full spectrum of variation.

257 Our bioassays revealed that SA is necessary to restrict pathogen growth and early bligh

258 on of ZIKV through vaginal and rectal routes is necessary to restrict virus transmission and spread.

259 we demonstrate that chromatin-bound cohesin is necessary to retain elongating Pol II at centromeres.

260 truments capable of multimodal measurements, is necessary to reveal complex microstructure evolution

261 egrates concepts from metacommunity ecology, is necessary to reveal underlying mechanisms governing m

262 Imaging studies are necessary to rule out the presence of retained forei

263 n of a protective dentin bridge after insult are necessary to seal the pulp chamber in an effort to m

264 The adhesion of blood clots to wounds is necessary to seal injured vasculature and achieve hem

265 Efficient analytical methods are necessary to selectively and precisely determine the

266 thin and among species in forest communities is necessary to separate effects of species and genetic

267 ly that additional congressional action will be necessary to stabilize health care markets.

268 acts early in the recombination process and is necessary to stabilize recombination intermediates.

269 A large case series is necessary to standardize this surgical philosophy.

270 around 100 individual Fab':TCR interactions are necessary to stimulate early T cell activation.

271 al models of postviral chronic lung diseases are necessary to study the underlying mechanisms of vira

272 ding past and anticipated future GPP changes is necessary to support carbon management, the factors d

273 interface as PatS, and that this interaction is necessary to suppress inhibition and to differentiate

274 their altering the colonic microbiota, which is necessary to suppress the infection.

275 ized that PV upregulation during adolescence is necessary to sustain the increase in GABAergic activi

276 s in which accounting for noise correlations is necessary to take advantage of population-level codes

277 the embodied view that sensorimotor regions are necessary to tasks of action verb processing.

278 overed two dsRNA-binding domains of RHA that are necessary to tether JUND-NCBP1/NCBP3 to polysomes.

279 Nucleus reuniens activity appears to be necessary to the stability of medial prefrontal corte

280 However, delineating the aetiology of UC is necessary to ultimately achieve disease cure.

281 tivity analysis because nanoscale resolution is necessary to unambiguously resolve synapses.

282 Future research is necessary to uncover the causal mechanisms underlying

283 Pericyte maturation was necessary to undergo vessel remodeling during angiog

284 nd C elimination, population-based estimates are necessary to understand the burden of hepatitis B an

285 ity of photosynthetic complexes in real time is necessary to understand how macromolecular organizati

286 of the rate at which these variations arise is necessary to understand how plant development contrib

287 etween susceptible and resilient individuals is necessary to understand how plasticity of limbic circ

288 ver, additional preclinical characterization is necessary to understand important aspects of their ac

289 all providers involved in postoperative care is necessary to understand prescribing practices, identi

290 Further research is necessary to understand the different effects for coh

291 ous delivery of double-strand RNA (dsRNA) it is necessary to understand the generation of small RNA (

292 Long-term follow-up is necessary to understand the natural history of this r

293 This is necessary to understand the relationship between cell

294 ture comparative studies across environments are necessary to unravel the underlying mechanisms throu

295 However, rapid and comprehensive actions are necessary to use this potential and achieve the goal

296 As was observed with MOR, it was necessary to use the combination of kinase inhibitor

297 Moreover, it has not been ascertained if it is necessary to utilize existing color spaces to reach o

298 Further research is necessary to verify the molecular role of these antib

299 cular mechanism of this proofreading step it is necessary to visualize GTP-catalysed elongation, whic

300 These parameters are necessary to yield sufficiently fine ultrastructural