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1 al matrix expansion, and tubular hypertrophy were observed in 0-copy and A71915-treated 2-copy and 4-
2 -positive patients, culture-proven active TB was observed in 1 case.
3  15 years, follow-up end-stage renal disease was observed in 1 LD versus 7 THIN (P = 0.280).
4                        Pfk13 C580Y parasites were observed in 1.6% (14/854) of samples collected in G
5            More than 16,500 arm deformations were observed in 120 min of video.
6 7% to 12.7%); persistent bacteremia at day 5 was observed in 19 of 166 (11%) vs 35 of 172 (20%) (diff
7 ndrome was the most common adverse event and was observed in 19 patients (91%); three (14%) had grade
8 nce of adverse drug reactions and somnolence were observed in 19.7% and 15.2% of the subjects.
9                   Overall, myocardial injury was observed in 190 patients (62.3%).
10                  Progressions to advanced SM were observed in 2.9% of these patients.
11 ASH resolution with no worsening of fibrosis was observed in 24% of patients given aldafermin vs 9% o
12 t karyotype with three aneuploid chromosomes was observed in 25 cells, while two different minor kary
13 2%), and cystoid spaces of variable severity were observed in 28 eyes (32%).
14                              HCV reinfection was observed in 3 participants.
15 groups, but greater benefit of ertugliflozin was observed in 3 populations: baseline estimated glomer
16  At 12 months, moderate mitral regurgitation was observed in 3 subjects in the leaflet resection grou
17 4 (P >0.05) and at 30 days, complete closure was observed in 35 out of 36 patients.
18            Results: Advanced disease (N1/M1) was observed in 35.3% of patients (244/691) and was asso
19 vascular endothelial growth factor injection was observed in 4 patients.
20                                      Relapse was observed in 41% patients, even though final average
21 n Gastroparesis Cardinal Symptom Index score was observed in 46.6% of patients given tradipitant comp
22                           Clinical responses were observed in 48 patients (60%), including 17 (21%) w
23                                       Spread was observed in 50% of blepharospasm, 8% of cervical dys
24 raocular muscle, orbital fat volume, or both were observed in 6 patients in the teprotumumab group wh
25  (range 1 mo-25 yrs), symptomatic recurrence was observed in 61%: 15 patients at the SSIS and 19 away
26                  Objective partial responses were observed in 66 (48%; 95% CI 39-56) patients in part
27                   Bioprosthesis degeneration was observed in 7 cases and annuloplasty failure in 5.
28 lue of < 50% following osimertinib treatment were observed in 8 (3.1%) and 14 (5.5%) patients in FLAU
29                         Fundus abnormalities were observed in 8 patients (10.1%), consisting of incre
30                 Recurrence of toxinogenic CD was observed in 9 children, in 7 associated with clinica
31 nization and epidermal proliferation effects are observed in a rhino mice model.
32 Similar trends of intratumoral Treg dynamics are observed in a small cohort of patients treated with
33   Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic malignancies,
34 rus configuration through stereomutation has been observed in a number of cases.
35             Past abrupt 'regime shifts' have been observed in a range of ecosystems due to various fo
36 bility in visual reversal-learning tasks has been observed in a wide range of neurological and neurop
37                                         CDTb is observed in a preinsertion state, a conformation obse
38     Compared with AKI controls, COVID-19 AKI was observed in a higher proportion of men (58.9% versus
39 association between AF and rare LOF variants was observed in a single gene, TTN (odds ratio, 2.71, P=
40                                Hyperglycemia was observed in a tacrolimus-treated mouse model, with r
41 tigen with the A2 serotype (HLA-A2) that has been observed in about 35% of patients with acute myeloi
42  A general reduction in oxidative glycolysis was observed in accordance with the Warburg theorem.
43  and Wnt/beta-catenin signaling pathways has been observed in advanced and metastatic prostate cancer
44  in less than moderate group, no improvement was observed in all items.
45 ion between %472-C results by MAPREC and NGS was observed in all laboratories (Pearson correlation co
46 wn refractory period of ADCP, or hypophagia, was observed in all macrophage, mAb, and target cell con
47                               This variation was observed in all tested strains of P. polymyxa, but t
48                                 Moreover, Pg was observed in all the samples (saliva, supragingival,
49                                CAG expansion was observed in all tissues, but to different degrees, w
50 y meaningful improvements in quality of life were observed in all patients.
51                       Microplastic particles were observed in all samples with mean concentrations fo
52               Changes in genotypes over time were observed in all subjects.
53 educed proliferation and increased apoptosis were observed in alpha3beta1-deficient tumor cells, thes
54  that accelerated increase in tau-PET signal was observed in amyloid-beta-positive mild cognitive imp
55     Finally, PVAT-assisted stress relaxation was observed in an artery with white fat (superior mesen
56           Additional twist and pinch motions were observed in an open ORC conformation revealing a hi
57                             Similar findings were observed in analyses restricted to participants wit
58   Altered stress-related responses have also been observed in animal models of BDNF deficiency in viv
59 onventional transporter mechanisms - has not been observed in any high-resolution structure.
60 ology (general transcription apparatus) that is observed in Archaea.
61                   However, no such asymmetry was observed in assays performed in the presence of Munc
62                 In some MN tektites, coesite is observed in association with relict quartz and silica
63                    Outer foveal microdefects were observed in association with various macular condit
64 vestigated whether post-stimulatory activity is observed in auditory cortex and the medial geniculate
65              Abnormal sensory processing has been observed in autism, including superior visual motio
66 llergens from the birch homologous group has been observed in basic research and clinical trials.
67                           Consistent changes were observed in blood transcriptional profiles 1 to 2 w
68 ns of depression and inflammatory biomarkers are observed in both directions, particularly for IL-6;
69                Incubated cocaine seeking has been observed in both humans with cocaine use disorder a
70      A decrease in the L-type calcium influx is observed in both glutamatergic neurons and parvalbumi
71 ffect of stress on porosity and permeability was observed in both 3D models.
72 boys, but catch-up growth by 5 years post-KT was observed in both boys and girls.
73 acula with the increase in macular thickness was observed in both eyes.
74                       CB(2) -R up-regulation was observed in both livers and hearts of mice exposed t
75 ereas at 10 mol% melatonin, phase separation was observed in both samples with either POPC-d(31) or D
76  In addition, adult hippocampal neurogenesis was observed in both species, occurring at a rate simila
77                        Transformation of SMX was observed in both sulfate-reducing and methanogenic c
78               Elevated corticosterone levels were observed in both XY and XX KO mice.
79  Higher percentage area of newly formed bone was observed in CA15 and TCN60 groups when compared to C
80                              This difference was observed in case-control studies and not in cohort s
81  well as expansion of CD8 T cells, which has been observed in CD4-depleted humans.
82 or-alpha, and IL-10 and lower levels of IL-2 were observed in CDC patients versus controls.
83 the enzyme filaments known to date have only been observed in cells, but in a handful of cases struct
84  plus end grows while the minus end shrinks, is observed in cells; however, the underlying mechanisms
85 station of light-matter interaction that can be observed in chiral magnetized systems.
86 Pi-ATRi that significantly increase survival are observed in clinically relevant platinum and acquire
87 nment and accessible channels, both of which are observed in CNTs but not in the analogous all-hydroc
88  an A-type trimeric procyanidin (m/z of 863) was observed in coffee pulp.
89 xpression pattern of occludin and E-cadherin was observed in colonoids derived from DRA-KO mice and s
90                               These findings were observed in concert with increased number and fusio
91  significant intervention-related reductions were observed in conduct problems and emotional symptoms
92 obal lymphopenia and a "chemokine signature" were observed in COVID-19 ARDS.
93 ve MDR1 expression among hematopoietic cells was observed in cytolytic lymphocytes-including CD8+ cyt
94   Lower percentage of mature collagen fibers was observed in DBG/HV (P <=0.05).
95                             The highest PNFB was observed in DBG/HV when compared with the other grou
96 cases of coronavirus disease 2019 (COVID-19) were observed in December 2019 in Wuhan, China.
97 g efficacy and evidence of target engagement was observed in DMD patients after 24 weeks of treatment
98  decrease of surface endospore germinability were observed in dry heat, UV irradiation, oxygen plasma
99 exoside and diosmin through Caco-2 monolayer was observed in DSP and DSE, while protocatechuic acid a
100 nase [NAD((+))], which degrades eicosanoids, was observed in EGPA samples.
101    No sex difference in time to task failure was observed in either trial.
102 r pathological response or survival outcomes were observed in extensive independent validations on mu
103                   Low levels of cytotoxicity were observed in eyesalve-treated cell lines representat
104 icant modifications in area parameters could be observed in GABA-CB1-KO mice.
105               Recently, senescent cells have been observed in glaucomatous eyes, exposing a potential
106      Extensive resorption of graft particles was observed in group DBG, which was not present in DBG/
107 osterior superior temporal gyrus (STGp) that was observed in healthy subjects.
108  artery thrombosis <=14 days from initial LT was observed in HEHE versus non-HEHE patients (4.6% vers
109 products (P < 0.05) while, maximum reduction was observed in high-fat goshtaba (HFC).
110 t, 7alpha-hydroxy-4-cholesten-3-one, or ALT, were observed in histological responders than in nonresp
111 od flow not being restored and tissue damage being observed in histology.
112                             The same pattern was observed in historically inbred lines, indicating a
113         Reduced overall TUNEL positive cells were observed in HT+M (47.1 cells/mm(2)) compared to HT
114 ons, also called inverted duplications, have been observed in human genetic diseases and cancers.
115 c islet-like distributions of islet hormones were observed in human FFPE tissues preserved for more t
116 ble for hyper-GABAergic tone in the CeA that is observed in individuals who develop addiction-like be
117 ease in API concentration while the increase was observed in interfacial protein concentration ( ).
118 on 5, a downstream molecule of PL signaling, was observed in islets from Adipoq (-/-) dams.
119     Although low vegetation productivity has been observed in karst regions, whether and how bedrock
120 R-210-positive interstitial lung macrophages was observed in knockout mice of WT-knockout pairs.
121 but not smooth muscle or adventitia, miR-210 was observed in knockout mice of WT-knockout pairs.
122 0.005), and C3 (OR = 6.56; P = 0.0003) genes was observed in late AMD patients compared with control
123 n NDV challenged versus nonchallenged spleen was observed in Leghorns at 2 dpi.
124                      Positive blood cultures were observed in less than half of patients, with Staphy
125 tly increased [(64)Cu]Cu-c[E(4)W(5)C] uptake was observed in lipopolysaccharide-treated mice (vs.
126       Adipocyte-extrinsic insulin resistance was observed in liver and muscle.
127                  None of these abnormalities were observed in liver- or muscle-specific Kbtbd2 knocko
128 2016 and the monoanion of ferrocene has only been observed in low-temperature electrochemical studies
129  to determine if operational tolerance could be observed in LTRs withdrawn from SRL and if blood/graf
130                       No cytotoxicity effect was observed in macrophages treated with extracts from t
131        Conversely, no significant difference was observed in males.
132 h inter-palm and inter-block AGB variability was observed in mature classes as a result of variations
133           Results: Higher (18)F-ASEM binding was observed in MCI patients than in controls across all
134                     These optical properties are observed in MeCN solution and the solid state.
135 70), tumor necrosis factor (TNF), and IL-10, was observed in mice after S. suis type 2 infection.
136 arrow damage as well as apoptosis in sternum was observed in mice pre-treated with CDX-301.
137 inor and transient, and very few differences were observed in mice exposed to rmTBI compared to contr
138 nic density of states at the Fermi level and is observed in most spectroscopic properties.
139 acheal instillation, labeled apoptotic cells were observed in most CD11c(+)CD103(+) myeloid dendritic
140       Lumbar puncture-related adverse events were observed in most participants.
141 own and subsequent cisplatin treatment could be observed in MSTO-211H cells.
142 ESR1 (estrogen receptor, ERalpha) expression is observed in muscle from women, men, and animals prese
143 nificantly higher antibody affinity to RSV G was observed in nasal washes from early-recovered indivi
144 n in innate lymphocytes, which has primarily been observed in natural killer (NK) cells responding to
145  P = 0.005).Conclusions: A wide range of Crs was observed in non-COVID-19 ARDS.
146 PP2R2A deficiency and ATR or CHK1 inhibition was observed in NSCLC in vitro and in vivo and was indep
147 h histone density, although slower diffusion was observed in nucleoli.
148 ons identified in human primary brain tissue were observed in organoids at different developmental st
149 it carbon mobilization and degradation as it is observed in other environments.
150 e expression in the liver in analogy to what is observed in other experimental disease paradigms.
151 y of STAT5 to mediate accessibility for BATF is observed in other Th lineages and allows acquisition
152                                No difference was observed in overall complication rates (FLR <=30%: 3
153  blood pressure (BP) response to contraction was observed in PAD rats.
154 n men and women, but an increased prevalence was observed in participants aged 20-59 years and those
155  joint destruction (including bone loss) may be observed in patients who received IACS injections.
156 dental radiotracer uptake in the breasts can be observed in patients with nonbreast malignancies.
157                 Recently, birth defects have been observed in patients with variants in the gene enco
158                             Durable survival is observed in patients undergoing adrenal metastasectom
159                   Ectopic lipid accumulation is observed in patients with cardiometabolic syndrome, i
160 ry elastase-related proteases in neutrophils is observed in patients with CatC deficiency (Papillon-L
161 west rates of immunogenicity, 10% at 1 year, were observed in patients treated with adalimumab combin
162 hest rates of immunogenicity, 92% at 1 year, were observed in patients treated with infliximab monoth
163 igher M-MDSC counts at day 14 posttransplant were observed in patients who subsequently developed can
164 ury, autophagy and vesicular transport genes are observed in PD with and without dementia and Lewy bo
165 ficant difference, favoring test conditions, was observed in percentage of both healthy PPDs (pockets
166                           A larger reduction was observed in persons with more advanced fibrosis/cirr
167 roteins of ABA pathway (ABI3, ABI4 and ABI5) was observed in planta.
168                         No group differences were observed in plasma oxytocin levels.
169 erestingly, Fgfrb-dependent polarized growth is observed in polyp but not embryonic tentacle primordi
170 rge late endosomes filled with VZV particles were observed in Pompe cells; only individual viral part
171   Increased numbers of CHI3L1-positive cells were observed in postmortem ALS motor cortex as compared
172                              No interference was observed in presence of 100 ppb arsenic, 20 ppb copp
173 ant levels of histiocytosis and inflammation were observed in pressures >= 10 psi and orientation eff
174                          Similar to what has been observed in previous studies, overall transcriptome
175 tically activated, a strong calcium response was observed in PTTH neurons during the mid-L3, but not
176 n 98 and nucleoporin 62 nuclear rim staining are observed in Purkinje cells of ATXN1[82Q] mice.
177  (at the population level) of almost 160 g/y was observed in Q1, whereas weight remained relatively s
178 ween the community phylogeny and composition was observed in rare (R(2) = 0.65) than in abundant bact
179  became cataleptic, whereas normal behaviour was observed in rats that received the PEG-haloperidol c
180 , which may mask C9 disease phenotypes, have been observed in recent C9-500 FVB/NJ-bred cohorts.
181 ar pattern of surface temperature trends has been observed in recent decades, but it remains unclear
182 e of CD4(+) T cell-mediated memory responses was observed in regard to lymphoblast expansion and cyto
183 erential expression of these PE/PPE proteins was observed in response to various stress conditions, s
184                     OsNLA1 promoter activity was observed in roots, ligules, leaves, sheaths, pollen
185 grading of angina pectoris class interaction was observed in SCD risk (P=0.019 in highly active patie
186                               No differences were observed in sensory analysis.
187 ed distributions of radiogenic (206)Pb and U are observed in several of the wetland soil samples.
188               Evidence of this third ion has been observed in several nucleic-acid-processing metallo
189 on and platelet-monocyte aggregate formation are observed in severe COVID-19 patients, but not in pat
190      Our findings suggest that myoclonus may be observed in severe acute respiratory syndrome coronav
191 eling states of the type predicted here have been observed in simulations.
192 role for retromer in Snc1 recycling can also be observed in single and double mutants harboring vps35
193                          Perinatal lethality was observed in Slc7a7Lbu/Lbu and Slc7a7Bay/Bay mice on
194 igh tumour mutational burden (hypermutation) is observed in some gliomas(1-5); however, the mechanism
195                         Trace amounts of CBT were observed in some column effluents, but this did not
196  alpha-amylase and reduced lipase activities were observed in sprouted oat powder, which are promisin
197 elf-renewing tissues, higher levels of mtDNA were observed in stem/proliferative compartments compare
198 ty consistent with model-free moral learning was observed in subgenual anterior cingulate cortex (sgA
199 ectancy followed a dose-response pattern and was observed in subgroups of participants of different o
200                A decline in these lipids has been observed in such diseases as Alzheimer's and chroni
201                              Similar results were observed in survivors of European ancestry, albeit
202                                   No changes were observed in systemic inflammation.
203 posed to blue light, while the least (1.69%) was observed in T. kotschyanus grown under red-blue ligh
204  oxalate (C(2)O(4)(2-)), blip-type responses are observed in the amperometric i-t trace even when the
205 i(3+) and Fe(4+) , whereas Ni(4+) and Fe(3+) are observed in the n = 5 superlattice.
206 ITO film, a lossy-mode resonance (LMR) could be observed in the optical domain, where electrical prop
207  failure and poor immune reconstitution have been observed in the absence of myeloablation.
208  recapitulates the moderate disease that has been observed in the majority of human cases of COVID-19
209           Localized high concentrations have been observed in the oxygen minimum zones (OMZs) of the
210                      Such topography has not been observed in the piriform cortex, whose responses to
211 ion in resource use for end-of-life care has been observed in the US for chronic diseases.
212 r, a significant rising trend in temperature is observed in the area.
213 nd to generate an Fe-alkoxide species, which is observed in the AsqJ crystal structure.
214                                   A decrease is observed in the fluorescent platelet signal at the wa
215 Mitofilin rescues the loss of mitophagy that is observed in the IRGM KD cells, suggesting that IRGM r
216 nd to glycine and glutamate relative to what is observed in the presence of barium-calmodulin.
217 tent with previous work, a resonant behavior is observed in the resistively detected NMR measurements
218                    No significant difference was observed in the 3-year incidence of late RT-related
219                Herein, higher NDEL1 activity was observed in the blood and several brain regions of a
220 periphery of individuals with MAS; no uptake was observed in the bones of healthy controls.
221 he total contents and glucosinolate profiles was observed in the Brassicaceae species, with the total
222 nto the tissue at its maximum hydrated state was observed in the chemical images showing the distribu
223 vatives was demonstrated and good efficiency was observed in the construction of sterically congested
224 tering of the selected child health outcomes was observed in the country.
225  A higher incidence of biliary complications was observed in the DCD SLK group, with ischemic cholang
226 ete remission with incomplete count recovery was observed in the DE arm.
227 osis, and mononuclear leukocyte infiltrates, was observed in the dorsal root, autonomic, and enteric
228 e of mitochondrial salvage and cell survival was observed in the EVLP lung tissue compared with lungs
229 ate-severe paravalvular aortic regurgitation was observed in the Evolut R/PRO group at 1-year follow-
230                    A more modest improvement was observed in the fish oil arm [5.9 (4.8, 7.0) to 5.2
231 microglial soma size-to-process length ratio was observed in the frontal cortex of children and young
232      However, within-group decrease in MMP-9 was observed in the HIIT group [104.3(51.9) to 65.2(69.1
233 es not impact the longevity as no difference was observed in the life span of mosquitoes with differe
234     Importantly, uptake higher than expected was observed in the lung and heart for up to 24 h.
235 tly increased systemic complement activation was observed in the majority of COVID-19 patients during
236                                  An increase was observed in the n3 FA content in egg yolk in experim
237 ter increase in IOP from baseline to 2 weeks was observed in the prednisolone group compared with the
238 ation and metabolic activity of the bacteria was observed in the presence of hydrogel.
239 rough August of 2019 was twice the rate that was observed in the same months in 2018.
240 ted States, where the first cluster of cases was observed in the Seattle metropolitan area in Washing
241 9 was 12.6%, yet a higher prevalence (23.6%) was observed in the subset of 55 patients younger than 2
242  early-recovered and late-recovered patients was observed in the titers of nasal wash antibodies, esp
243 chment of cell-cycle and DNA repair pathways was observed in the USP22-sensitive transcriptome and ub
244                   Notably, a metastasis case was observed in the vehicle but not in the test mice gro
245          Surprisingly, morphological changes were observed in the bile duct, including ductal epithel
246 ality rate (HR, 0.50; 95% CI, 0.27 to 0.90), were observed in the BMDex arm.
247                   No changes in PACAP levels were observed in the central nucleus of the amygdala.
248                   No significant differences were observed in the components of the primary end point
249      Significant strain-specific differences were observed in the contents of aroma compounds after r
250    Up to four different subtypes of C. acnes were observed in the deep tissues of a single patient.
251                       Significant variations were observed in the distribution of glycan types as wel
252  and more significant periodontal attachment were observed in the DPSC + THSG group.
253 re fragments and higher molecular mass bands were observed in the Gd-P gel image.
254 nes and the lipophilic antioxidant activity, were observed in the grilled meats.
255 at binding to HTR: while no relevant changes were observed in the hydrodynamic sizes of HTR-free comp
256                              Similar results were observed in the ICU cohort.
257 ting chemoradiotherapy (CRT), no differences were observed in the incidence of grade 3-4 mucositis be
258               However, no marked differences were observed in the lung sound parameters based on the
259 ge-related increases in CD36 mRNA expression were observed in the male hippocampus and female midbrai
260 beta, IL-6, and tumor necrosis factor-alpha) were observed in the medium as well as in the infected c
261                   No significant differences were observed in the number of A, B, DRB, DQA, and DQB V
262  cells, while two different minor karyotypes were observed in the other cells.
263 ificant differences in mechanical properties were observed in the perpendicular loading direction.
264       Nucleation and growth of new particles were observed in the perturbation chamber.
265                                   No changes were observed in the primary motor cortex (M1).
266 to characterization of oxidized procyanidins were observed in the procyanidins-rich fraction after th
267                   No significant differences were observed in the rate of patients achieving mRS 0-2
268 r survival rates (39% versus 90%, P = 0.002) were observed in the SBTx group.
269                              Similar results were observed in the sensitivity analysis (n = 20,174).
270 regate accumulation and microglia activation were observed in the spinal cord white matter of 7-month
271      Cannabis use by risk group interactions were observed in the striatum and OFC.
272 tion, a very good functional group tolerance was observed in these reactions.
273 t specificity, and robust antitumor activity were observed in these models after a single dose of the
274 s age-induced periodontal bone and root loss are observed in this mouse model.
275  and oral microbiota to immunologic features were observed in this cohort of subjects with or without
276 uorine and Ln-containing high-mass fragments were observed in this experiment, including the molecula
277 choice and psychological health that may not be observed in traditional laboratory studies.
278                      The pattern indeed also was observed in traumatic or degenerative conditions.
279           An impressive clinical success has been observed in treating a variety of cancers using imm
280 to be dependent on TRPA1, similar to was has been observed in TRPA1 KO mice.
281 gulation in the expression of CERK and SPHK1 was observed in tumor tissues in local and TCGA cohort.
282 ation and delays its peak, and these effects are observed in two different optogenetic mouse lines.
283 e bleeding (P >0.05), while delayed bleeding was observed in two subjects from the SG and three from
284 contrast, more limited TCR repertoire mixing was observed in two women with less frequent subclinical
285                      Some hexagonal crystals were observed in two subjects.
286                             Similar findings are observed in Type 2 Hi asthma, where high levels of b
287 favored compared to other binding modes - to be observed in typical host-guest complexes.
288  h post-injury, while no substantial changes were observed in UCH-L1, Iba-1 or IL-6 over 6 h.
289          However, no significant differences were observed in UDVA, UIVA, and patient satisfaction.
290         T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source an
291 thy where misalignment of cardiomyocytes has been observed in utero.
292 cle, synergistic effects on lipid metabolism are observed in vitro and vivo.
293 ers, adders, and intermediate phenomena have been observed in vitro [9-12], but it is unclear how thi
294 tion of individual activated hypnozoites has been observed in vitro for the first time by Voorberg-va
295 o model reproduces much of the behavior that is observed in vitro under genetic knockout conditions.
296  relative to intact ones analogously to what is observed in vivo Massively deleted viral sequences fo
297                         Lengthened lifetimes were observed in water microdroplets but not in microdro
298 any ST2(+) (IL-33R(+)) Treg cells develop as are observed in wild-type mice.
299                           No increased risks were observed in women whose BMI normalized from childho
300 r esophagitis with an eosinophilic component is observed in young pigs rendered allergic to hen egg w

 
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