ライフサイエンスコーパス: be poised to

1 ly and inexpensive technologies, biochemists are poised to accelerate the annotation of biochemical p

2 the residues associated with Mg(II) binding are poised to accept the metal ion.

3 Our findings indicate that hypoxic niches are poised to accumulate CSCs in a molecular process dri

4 Policymakers are poised to act and 1 proposal entails reorganizing th

5 the N1 position of G33 and N3 position of A1 are poised to act as a general base and acid, respective

6 Aided by divalent cations, P4 is poised to act as a "screw cap" on preQ1 recognition t

7 or of carbon and nucleotide metabolism, AMPK is poised to activate many of the metabolic pathways ind

8 This constellation of residues is poised to activate the substrate by Schiff base forma

9 ances in the past few years and ongoing work is poised to add even more.

10 otocol for data and specimen collection, and are poised to address this critical research need.

11 The design of sequences which are poised to adopt two very different conformations set

12 Apo-LacI appears to be poised to adopt the conformation of either the DNA- o

13 emaining questions where modeling approaches are poised to advance our understanding of complex immun

14 ce imaging ((129)Xe MRI) in pediatric asthma is poised to advance our understanding of disease mechan

15 When unperturbed, somatic stem cells are poised to affect immediate tissue restoration upon t

16 ficacy and a more favorable toxicity profile are poised to alter the landscape of RET-dependent cance

17 e neuroscience in recent decades, scientists are poised to answer this question.

18 cell death signalling pathways; these cells are poised to apoptose when survival pathways are inhibi

19 e laboratory back into the field, where they are poised to appreciate the full richness of this remar

20 on chaperone showed how well the carboxylate is poised to attack the phosphoramidate, helping to expl

21 ion of wearable bioanalytical platforms that are poised to autonomously provide frequent, real-time,

22 ssociated herpesvirus (KSHV) latent episomes are poised to be activated by the KSHV replication and t

23 red molybdenum disulfide (MoS(2)) nanosheets are poised to be at the core of low-voltage electronic d

24 , evidently, inhibit basal transcription but are poised to be removed quickly upon command.

25 small footprint and large optical bandwidth are poised to be the enabling devices for on-chip optica

26 Dipeptidyl peptidase-IV (DPP-IV) inhibitors are poised to be the next major drug class for the treat

27 While polygenic risk scores (PRSs) are poised to be translated into clinical practice throu

28 or both the new drug and the antibodies that are poised to be used against HIV.

29 syndromes and sporadic cancers, this pathway is poised to be a major driver of the metabolic conversi

30 iatal cholinergic interneurons and therefore is poised to be a positive regulator of cholinergic acti

31 Cdk4 (within the p27/Cdk4/cyclin D complex) is poised to be activated by extrinsic mitogenic signals

32 n excess of 5% and 100 GPa, respectively, GO is poised to be an extremely useful material for micro/n

33 phosphorus (BP), also known as phosphorene, is poised to be the most attractive graphene analogue ow

34 Aptamers, single-stranded DNA/RNA probes, are poised to become a chemist's antibody and have the p

35 reseeable technological scenarios where they are poised to become front runners.

36 eae, provide the bulk of human nutrition and are poised to become major sources of renewable energy.

37 These new particles are poised to become the 'atoms' and 'molecules' of tomo

38 al antibodies, molecularly targeted exosomes are poised to become the next generation of smartly engi

39 Axolotls are poised to become the premiere model system for study

40 ons of endogenous ancient DNA, paleogenomics is poised to become a key technology to better understan

41 xperimental demonstration provided here, PLM is poised to become a powerful technique for revealing t

42 this 'natural sampler DNA' (nsDNA) approach is poised to become a powerful, affordable, universal to

43 ing underlying genetic forms of hearing loss is poised to become a reality.

44 vel T3SEs and improved performance, Bastion3 is poised to become a widely used, state-of-the-art tool

45 E) is an additional ultrasound modality that is poised to become an integral part of the routine echo

46 morbidity and mortality of prematurity, and are poised to benefit from a paradigm shift in the treat

47 te function would be an effective treatment, are poised to benefit greatly from stem cell biology.

48 ojections also target the striatum, oxytocin is poised to bias the balance of DA tone through multipl

49 The ferroxidase ligands (except His130) are poised to bind iron with minimal conformational chan

50 ntil a suitable host cell is encountered yet be poised to bind receptor, initiate cell entry, navigat

51 E4(4H) is poised to bind and reduce N2 through reductive elimin

52 We observed that this residue is poised to bind substrate in the active structure and

53 surface biomarkers in preclinical models and are poised to bring same-day imaging into clinical devel

54 uce a specific dimerization mode of RET that is poised to bring the two kinase domains into close pro

55 genetic engineering, and cell manufacturing are poised to broaden T-cell-based therapies and foster

56 inactive oligomers and active monomeric BiP is poised to buffer fluctuations in ER unfolded protein

57 In conformation 1, CBL is poised to catalyze the adenylation of 4-chlorobenzoat

58 tial reaction 1), and in conformation 2, CBL is poised to catalyze the formation of 4-CB-CoA from 4-C

59 This methodology is poised to change how IGH translocations are identifie

60 cause of cancer death in the world today and is poised to claim approximately 1 billion lives during

61 e Ca(2+) ions, forming a heterotetramer that is poised to compete with microbial pathogens for essent

62 These high-resolution approaches are poised to contribute new insights into mechanisms fo

63 In this area, my lab is poised to contribute significantly toward understandi

64 CCR4 is poised to contribute to central tolerance due to its

65 main link the Piezo repeats to the pore, and are poised to control gating allosterically.

66 h a multitude of substrates, gamma-secretase is poised to control neuronal function through a variety

67 sms that control their function; fibroblasts are poised to coordinate fibrogenesis in tissue injury,

68 esting that only a minority of S. pneumoniae are poised to cross the BBB.

69 vision that online electrochemical reduction is poised to decrease the complexity of sample handling

70 the respiratory tract, alveolar macrophages are poised to defend against hantavirus infection, but t

71 Only systems in which Cys70 is poised to deprotonate d-Glu were found to be catalyti

72 With this knowledge, we are poised to design the next generation of complex biol

73 se signals arise from functional groups that are poised to detect changes in the extent of channel cl

74 hannels, located at the tops of stereocilia, are poised to detect tension induced by hair bundle defl

75 ular signature of stressed HCM myocytes that are poised to die.

76 nestin-positive progenitor-like cells, which are poised to differentiate into hepatocellular carcinom

77 le retaining certain B-cell signatures, iPCs are poised to differentiate to end-stage PCs although th

78 pability to differentiate into Th1 cells but were poised to differentiate better into induced nTreg c

79 In this configuration, ORC is poised to direct the recruitment of the second hexame

80 ediates produced from methanol decomposition are poised to directly undergo hydroformylation upon mig

81 These results demonstrate that CTLs are poised to divide in transit and that their numbers c

82 dramatically changed refractive surgery and is poised to do the same for cataract surgery.

83 es BMP-mediated pSmad1/5/8 signalling, which is poised to downregulate Shh.

84 mphomas express high levels of TGFbeta, they are poised to elicit an autocrine program of senescence

85 The immune system recognizes and is poised to eliminate cancer but is held in check by in

86 pproaches with emerging molecular tools will be poised to elucidate the functional importance of endo

87 Genome Atlas initiative proposed by the NIH is poised to elucidate the contribution of somatic mutat

88 s become available for many more species, we are poised to emerge from the bottleneck and once again

89 can be eliminated, then biofabrication will be poised to emerge as the standard for nanoscale constr

90 iven their location, these aromatase neurons are poised to engage nociceptive circuits, whether it is

91 m a DNA recognition-competent structure that is poised to engage double-stranded DNA target sequences

92 ancer, a paradigm shift in clinical research is poised to ensure that new molecular insights are rapi

93 d by the US Food and Drug Administration and are poised to enter the practice of medicine for leukemi

94 s plays a pivotal role in modern biology and is poised to enter the field of molecular diagnostics.

95 f specifically targeted antiviral inhibitors is poised to enter the market.

96 nd easy-to-use CRDS-based instrumental setup is poised to evolve into a credible challenge to the hig

97 addition, this degree of extensive CDF would be poised to exert large order-of-magnitude effects on s

98 that the mitochondrial pyruvate carrier MPC is poised to exert ultrasensitive control on the balance

99 t of [Na(+)]i and [Ca(2+)]i, neuroscientists are poised to expand the understanding of noncanonical r

100 Developmental systems biology is poised to exploit large-scale data from two approache

101 ing these challenges, neurogenetics research is poised to exponentially increase our understanding of

102 rs exist at a developmental stage where they are poised to express Foxp3 without further TCR engageme

103 Thus, in contrast to mDCs, pDCs are poised to express ICOS-L upon maturation, which lead

104 ncreased numbers of Valpha14i NKT cells that are poised to express IL-17, especially in the thymus an

105 HMGN1 binds to Sox9 chromatin in cells that are poised to express Sox9.

106 ules contact a carboxylate oxygen of caC and are poised to facilitate acid-catalyzed caC excision.

107 ging with positron emission tomography (PET) is poised to fill this unmet need through noninvasive pr

108 hen monomers access rogue conformations that are poised to form amyloid fibrils.

109 mplex are formed on the end-blocked DNA that are poised to form the holoenzyme with the polymerase.

110 s-collectively referred to as soft photonics-are poised to form the platform for tunable optical devi

111 cation site, generating a beta radical which is poised to fragment the peptide backbone.

112 , and absolute myocardial perfusion imaging, are poised to further advance our knowledge.

113 from a structurally unique hinge domain that is poised to further contribute to CjFur's regulatory fu

114 The field is poised to further delineate this paradigm, with the g

115 obank represents a new branch on a tree that is poised to grow rapidly and offer new kinds of insight

116 s, these sequence-indexed mutant collections are poised to have a larger impact on our understanding

117 linical studies, these emerging technologies are poised to have a major impact on adoptive T-cell the

118 ls for the interpretation of these data, and are poised to have a substantial effect on diagnosis, ma

119 tem cell engineering and mechanotransduction are poised to have substantial implications for stem cel

120 n important generalization of the HMM, which is poised to have a deep impact across the field of biop

121 and other ligands, this family of receptors is poised to have a significant role in complex biologic

122 Terahertz (THz) radiation is poised to have an essential role in many imaging appl

123 at which these discoveries are taking place is poised to have significant impact for patient stratif

124 This strategy is poised to help elucidate the role of variants at the

125 y addressing these challenges, iGxE research is poised to help identify the neural mechanisms underly

126 Cardiac pacing is poised to help millions of patients worldwide to live

127 Programmable protein phosphorylation is poised to help reveal the structural and functional i

128 Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision

129 rithms, artificial intelligence (AI) methods are poised to improve the precision of diagnostic and th

130 f-the-art deep learning for object detection is poised to improve the accuracy and efficiency of biol

131 The field of congenital heart surgery is poised to incorporate new innovations such as bioengi

132 increasing in intensity and size and, thus, are poised to increase in importance as disturbance agen

133 Future rates depend on many factors and are poised to increase.

134 peratures go up, the use of air conditioning is poised to increase dramatically.

135 Fertilizer use is poised to increase in the tropics, where widespread f

136 fitness remains challenging, clinal genomics is poised to increase our understanding of local adaptat

137 ode ongoing synaptic competition and, hence, are poised to influence its outcome.

138 These properties suggest that mast cells are poised to influence neural systems underlying behavi

139 e regulators of the cell cycle and therefore is poised to influence the fate of a cell at the crossro

140 Thus, O-GlcNAcylation is poised to influence trans-generational epigenetic inh

141 We find that multiple UbiB-specific features are poised to inhibit protein kinase activity, including

142 Prior to S phase, multiple origins are poised to initiate replication by recruitment of the

143 , colitogenic memory CD4+ T cell subset that is poised to initiate inflammation when there is loss of

144 The insights presented herein are poised to inspire the design of other catalyst-contr

145 With these tools, we are poised to integrate structural information gathered

146 and it suggests that the ATP lid of CheA may be poised to interact with receptors and coupling protei

147 The complex is poised to interact with H(+) from E126 (and H124) in

148 bacterial interaction with fibronectin, RevA is poised to interact with the extracellular matrix of t

149 um of PLN conformers toward a structure that is poised to interact with the regulatory target.

150 nformations indicated that MMP-1 in solution was poised to interact with collagen and then could read

151 ntred on a hypothesis that these crabs might be poised to invade the Antarctic shelf if the recent wa

152 these features, the cyclopropenone ligation is poised to join the ranks of chemistries with utility

153 w technologies, the adult neurogenesis field is poised to leap forward in the next decade.

154 ting that the RNA-maturation protein complex is poised to leave the capsid as the first step of the i

155 The National Institutes of Health (NIH) is poised to lift its funding moratorium on research inv

156 bile nucleic acid restriction mechanism that is poised to limit internal as well as external assaults

157 cells reside in tissues where they appear to be poised to locally regulate tissue function.

158 materials developed and studied in this area are poised to make a substantial impact in real-world ap

159 3 (Asp(25)-Glu(334)-Lys(326)-Lys(328)) that are poised to make electrostatic interactions with the r

160 ve unusual profiles of transcribed genes and are poised to make rapid changes in those profiles upon

161 Synthetic biology and nanotechnology are poised to make revolutionary contributions to the 21

162 es are essential, the attributes of FTICR-MS are poised to make significant contributions.

163 from the pharmaceutical industry, the field is poised to make a breakthrough.

164 Integrated whole-cell modeling is poised to make a dramatic impact on molecular and sys

165 As the genome resources develop, the cat is poised to make a major contribution to many areas in

166 ce as a valuable tool in drug discovery, and is poised to make a major impact on the design of enzyme

167 tools has completed clinical development and is poised to make an impact on clinical practice.

168 Today, glycobiology is poised to make major new contributions to cell biolog

169 tactic to study bacterial epigenetics, which is poised to make novel and far-reaching discoveries tha

170 figuration of the loop suggests that 7SK-SL4 is poised to make ternary contacts with P-TEFb and HEXIM

171 ustrative of the unique contribution SiMPull is poised to make to in planta protein interaction studi

172 nance and recall of T-cell memory, the field is poised to make tremendous progress.

173 Even though the brain is poised to mediate the effects of GLP1 analogs, it rem

174 cs analysis reveals that B. phytofirmans PRF is poised to metabolize thiosulfate to sulfite in a sulf

175 Acots in the mitochondrial matrix are poised to mitigate beta-oxidation overload and maint

176 elp explain how a strong pOFC pathway, which is poised to moderate activity of CeM, through IM, can b

177 These findings indicate that kappaORs are poised to modulate LC activity by their localization

178 tonic arrangements and synaptic connectivity are poised to modulate olfactory processing in humans.

179 the macrophages of the islets of Langerhans are poised to mount an immune response even at steady st

180 a site of intense immune cell activity that is poised to mount an effective response against a patho

181 ent of high-throughput platforms, genotyping is poised to move into the mainstream, revolutionizing t

182 ng of chemical bonds in polyatomic molecules is poised to open new pathways for the laser-driven synt

183 of the plasma membrane in resting cells that is poised to orchestrate assembly of key signaling compo

184 Computational models are poised to play a key role in addressing these challe

185 Thus, mGluRs are poised to play a pivotal role in providing a direct

186 ial for further improvement, HASEL actuators are poised to play an important role in a paradigm shift

187 min (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinati

188 x metalloproteinase (MMP) 13 (collagenase 3) is poised to play a crucial role in bone formation and r

189 levels of MHC class II, suggesting that they are poised to present self-antigens efficiently.

190 ether, these results indicate that kappa-ORs are poised to presynaptically inhibit diverse afferent s

191 nonlinear and hyper-resolution microscopies are poised to profoundly transform many fields of biolog

192 of synaptic modulation and show that Munc13 is poised to profoundly impact information transfer at n

193 ust shape changes, but if they go awry, they are poised to promote disease states such as cancer cell

194 eliminate pathogens, and memory cells, which are poised to protect against reinfection.

195 including array-based expression profiling, are poised to provide additional insights into this grou

196 oduced by common microfabrication techniques are poised to provide integration of power sources onto

197 tography-tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules under

198 Large-scale genome sequencing is poised to provide a substantial increase in the rate

199 y advances in electron optics and detectors--is poised to radically transform our understanding of th

200 Immune memory cells are poised to rapidly expand and elaborate effector func

201 , whereas for alpha-synuclein, the oligomers are poised to rapidly form fibers.

202 hat a greater fraction of cross-bridges will be poised to rapidly produce a force-generating transiti

203 that exposes its ligand-binding site, but it is poised to rapidly assemble into intracellular signal-

204 this study suggests that the reuptake system is poised to rapidly increase its function during dopami

205 us effector lineage after antigen clearance, being poised to reacquire their lineage-specific effecto

206 of development, physiological cardiac models are poised to realise the promise of translational resea

207 , ensuring that the core apoptotic machinery is poised to receive input from a wide range of cellular

208 t counteract numerous cellular defenses that are poised to recognize viruses as nonself and to activa

209 Optical atomic clocks are poised to redefine the Systeme International (SI) se

210 d with dendrites of calbindin neurons, which are poised to reduce noise and enhance signal.

211 A new generation of technologies is poised to reduce DNA sequencing costs by several orde

212 Membrane-based separation is poised to reduce the operation cost of propylene/prop

213 embly of a type of mRNP within P-bodies that is poised to reenter translation.

214 Thus, PI3K activity is poised to regulate both ACA activation and adaptation

215 se studies demonstrate that mossy fiber BDNF is poised to regulate both direct excitatory and indirec

216 mation or nerve injury, neuropeptide Y (NPY) is poised to regulate the transmission of sensory signal

217 These data indicate that Merkel cells are poised to release glutamate and neuropeptides.

218 ed droplet microfluidic screening processors are poised to replace robotic automation by miniaturizin

219 Overall, the new oral anticoagulants are poised to replace vitamin K antagonists for many pat

220 gatran, rivaroxaban, apixaban, and edoxaban, are poised to replace warfarin for treatment of the majo

221 an improved understanding of brain disorders are poised to reshape how DBS is viewed and delivered to

222 re also addressed, as technological advances are poised to reshape resident education.

223 croscopy techniques, such as PALM and STORM, are poised to resolve, with unprecedented clarity, the o

224 The United Network for Organ Sharing is poised to resolve geographic disparity in liver trans

225 broadly evaluate whether non-native species are poised to respond more positively than native specie

226 o chromatin architecture allowing genes that are poised to respond rapidly to developmental cues to b

227 lls circulate through lymph nodes where they are poised to respond rapidly upon re-exposure to a path

228 atio motors operating at intermediate speeds are poised to respond sharply to changes in mechanical c

229 We find that animal cells are poised to respond to both increases and decreases in

230 loci may be arranged in nuclear domains that are poised to respond to diverse signals in general and

231 totoxic, and regulatory T cell subsets, that are poised to respond to environmental antigens.

232 s (ILC), a diverse class of lymphocytes that are poised to respond to environmental insults including

233 ns and an inflamed microenvironment and thus are poised to respond to immune checkpoint inhibitors (I

234 sults indicate that prospective neural cells are poised to respond to Smad2 and Smad1 signals to adop

235 s with unperturbed forks, implying that they are poised to respond to stalling and collapse.

236 These polymerases are poised to respond to the positive transcription elon

237 In summary, hepatic ILC2s are poised to respond to the release of IL-33 upon liver

238 sures a larger signal change (more molecules are poised to respond), it also reduces affinity (bindin

239 teins, which specify polarity in the zygote, be poised to respond to the centrosome.

240 esting that specific groups of organisms may be poised to respond to the wet-up event, in that they p

241 We demonstrate that the MHB region is poised to respond to calcium transients that occur in

242 d negatively and suggest that the RPP5 locus is poised to respond to pathogens that disturb RNA silen

243 ical structures below the diffraction limit--are poised to reveal in quantitative detail the stoichio

244 time-resolved RNA structure probing with TMO is poised to reveal a wide range of dynamic RNA folding

245 ISPR/Cas9 is a game-changing technology that is poised to revolutionise basic research and plant bree

246 hnologies for rapid microbial identification are poised to revolutionize clinical microbiology and en

247 the tremendous advances in cardiac modelling are poised to revolutionize medical treatment and preven

248 They are poised to revolutionize optics by enabling complex l

249 tial, induced pluripotent stem cells (iPSCs) are poised to revolutionize stem cell biology and regene

250 assessing global transcript levels, RNA-seq is poised to revolutionize our understanding of transcri

251 field of Functional Genomics and Proteomics is poised to revolutionize the way scientists identify a

252 to the exploitation of conventional oil and are poised to rise in significance along with the exploi

253 South Africa is poised to scale up PrEP services for transgender wome

254 They are also shown to be poised to secrete high levels of immunoglobulins in r

255 mation, revealing that tissue-resident cells are poised to sense and respond to alterations in microb

256 bbs-1 acts in 15 ciliated neurons that are poised to sense external and internal nutrient level

257 Astrocytes are poised to sense glutamatergic synaptic activity over

258 is characteristic of a motile filament that is poised to sense and respond to the environment.

259 nveil a transcriptional response system that is poised to sense dietary cues and metabolic imbalances

260 The resulting bifunctional molecules are poised to serve as modular building blocks for more

261 N termini of helices for enhancing function) are poised to serve roles in substrate recognition, MIO

262 This property is poised to serve in diagnostic and therapeutic applica

263 The VA is poised to share and extend best practices to other he

264 ffspring, changes in the maternal microbiota are poised to significantly affect the newborn.

265 vere droughts associated with climate change are poised to significantly alter flow intermittence pat

266 enhancement strategies, transdermal delivery is poised to significantly increase its impact on medici

267 ve placed the field in the position where it is poised to significantly reduce the burden of nervous

268 te that catecholaminergic neurons in the NTS are poised to simultaneously coordinate activities in li

269 This structure shows that Mn1 is poised to stabilize the pentavalent transition state

270 he field of experimental genetics in rodents is poised to study discrete epilepsy mutations on a dive

271 Single-cell microfluidic devices are poised to substantially impact the hematology field

272 Use of the technology is poised to substantially advance integrated control of

273 eneral and a molecular machine in particular are poised to support protein-based heredity in the bact

274 cular recognition of polyamides with DNA, we are poised to systematically edit the structure of JH-37

275 odological challenges that their communities are poised to tackle in the near future.

276 nge in biology that computational approaches are poised to tackle.

277 ts and maternal-child health researchers who were poised to tackle this new public health challenge;

278 studies in the animal kingdom, plant studies are poised to take a lead role in this area because of t

279 into our homes, hospitals, and schools, they are poised to take on increasingly social roles.

280 e neuroscience of brain-wide neural circuits is poised to take off.

281 function and indicate that the intermediates are poised to traffic to sites of inflammation and targe

282 This subpopulation is poised to transcribe plasticity markers, OCT3/4, SOX2

283 udying bacteria and other microorganisms and are poised to transform microbiology.

284 Connected vehicles are poised to transform the field of environmental sensi

285 the interface with partner disciplines that are poised to transform the practice of drug discovery a

286 )-Cas9 (CRISPR-associated nuclease 9) system is poised to transform developmental biology by providin

287 Microbial whole-genome sequencing (WGS) is poised to transform many of the currently used approa

288 , and the emergence of personalized medicine is poised to transform pharmaceutical development and cl

289 Nanotechnology is poised to transform research, prevention, and treatme

290 tational analysis provided by these examples is poised to translate the rapidly growing structural da

291 drogen bond donor catalyzed cascade reaction are poised to undergo a McMurry coupling to form previou

292 uted unsaturated morpholine derivatives that are poised to undergo further functionalization for the

293 dition to hydrolysis, the hydrazone products are poised to undergo numerous different known synthetic

294 s TIPCARM, leads to a spiropyrrolidine which is poised to undergo a second retro-Mannich fragmentatio

295 ant) that is free of inhibitor or ligand and is poised to undergo autoproteolysis.

296 that a significant fraction of the proteome is poised to undergo phase separation under physiologica

297 , which has accumulated four [e(-)/H(+)] and is poised to undergo reductive elimination of H(2) coupl

298 h these structures in hand, researchers will be poised to use cryo-electron tomography to view protei

299 f polymeric capsules, the developed strategy is poised to usher the development of the next generatio

300 Such studies are poised to yield a detailed picture of the coupling o