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1 hibition binding affinity constant, 1.73 nM) was prepared in 1 step in a radiochemical yield of 14% +
2 lopentane-1-carboxylic acid ([(18)F]28) have been prepared in 10 and 1.7% decay corrected radiochemic
3 isoquinoline alkaloid, (18) F-aspergillitine is prepared in 10 % isolated radiochemical yield from th
6 id (-)-hymenosetin and its N-methyl analogue were prepared in 11 and 8 steps, respectively, from (+)-
7 tities of the target drug candidates 1 and 2 were prepared, in 12 linear steps with 25% isolated yiel
9 and the majority of the stereogenic centers, was prepared in 13 linear steps (longest sequence) in 8%
11 14-membered macrolide 6-deoxyerythronolide B is prepared in 14 steps (longest linear sequence) and 20
12 us, the all-cis 1,5,9-triene natural product was prepared in 15 steps from commercially available sta
13 C17-benzene ansamycins trienomycins A and F were prepared in 16 steps (longest linear sequence, LLS)
14 ring bryostatin analogue, macrodiolide WN-1, was prepared in 17 steps (longest linear sequence) and 3
17 as in 2008, when 1,4-dimethoxypillar[5]arene was prepared in 22% yield, and subsequent improvements i
18 ld over 11 synthetic steps and hapalindole U was prepared in 25% overall yield over 13 synthetic step
22 Results: The target compound 4-(11)C-MBZA was prepared in 46% +/- 7% radiochemical yields by react
27 sphino)phenyl)morpholine (p-Mor-DalPhos, L2) was prepared in 63% yield and was crystallographically c
28 chiometric amount of template, ExBox(4+) can be prepared in 66% yield (following crystallization) usi
29 (III) siloxide [K(18c6)][U(OSi(O(t)Bu)3)4] 2 was prepared in 69% yield by reduction of [U(OSi(O(t)Bu)
30 0-membered marine macrodiolide clavosolide A is prepared in 7 steps (LLS) in the absence of protectin
32 he polyketide natural product cryptocaryol A is prepared in 8 steps via iridium catalyzed enantiosele
35 carbons and one oxygen of the final product was prepared in 98.6% ee and 39% yield from cyclohexan-1
36 Spheres-on-sphere (SOS) silica particles are prepared in a one-pot scalable synthesis from mercap
40 , and the iridium-based photocatalyst 1a can be prepared in a 56% overall yield ( approximately 4.4 g
42 etermining the number of dosage units (k) to be prepared in a composite sample of which there may be
44 ass of neutral, monofluoroboronates that can be prepared in a one step, gram-scale fashion from readi
46 finity purified IgG glycoprotein samples can be prepared in a single run with a liquid handling platf
47 and a variety of substituted aryl groups can be prepared in a single step from a simple mixture of am
48 eight star and dendritic block copolymers to be prepared in a single step under ambient conditions.
51 elevant to neuroscience drug development can be prepared in a stereochemically comprehensive manner.
52 lactones obtained from marine sources, have been prepared in a concise and stereocontrolled manner f
53 es of anilines of industrial importance have been prepared in a continuous regime using this protocol
54 le alkaloids, 1, 2, and 3 respectively, have been prepared in a convergent manner by two related rout
56 y substituted pyrazolo[3,4-b]pyridines 4 has been prepared in a regioselective manner by the microwav
57 ne-substituted gamma- and delta-lactams have been prepared in a single step with high diastereoselect
61 re, we describe a method in which the sample is prepared in a buffer at a lower concentration than th
63 compound is soluble in nonaqueous solvents, is prepared in a single synthetic step, has a low equiva
68 ',4'-difluoroarabinouridine (2,'4'-diF-araU) was prepared in a stereoselective way in six steps from
70 ric 2,5-diazabicyclo[2.2.2]octanes 14 and 15 were prepared in a chiral-pool synthesis starting from (
71 -Azabicyclo[3.1.0]hex-2-en-1-yl phosphonates were prepared in a five-step reaction route from beta-ke
73 methylsilyl)dicyclopenta[de,mn]tetracene (4) were prepared in a one-pot, palladium-catalyzed cross-co
76 nds with a quaternary center (at C-2 or C-5) were prepared in a stereoselective fashion by engineered
77 iaza[5]helicenes with different substituents were prepared in a straightforward manner through indole
80 cid (3-MPA) capped lead sulfide quantum dots were prepared in a variety of organic solvents stabilize
83 ium content levels (ca. 6.5-30 mg Ca/100 kJ) were prepared in accordance with the guidelines of Commi
85 lternative for cellular therapy, as they can be prepared in advance, screened for pathogens and activ
91 ly tunable chiral Clickphine P,N-ligands has been prepared in an enantioselective fashion by Cu(I)-ca
94 mples of various natural colouring solutions were prepared in aqueous model matrices at a range of pH
99 ndrical cavities (4-mm diameter, 2-mm depth) were prepared in bovine incisors and restored using Bond
103 tetrasubstituted N-confused porphyrins (1-3) were prepared in ca. 3-5% yields using a [2 + 2] synthes
104 icative components from four unique species, were prepared in ca. 70% isolated yields and fully chara
105 of 1alpha,25-dihydroxy-19-norvitamin D have been prepared in convergent syntheses using the Wittig-H
106 , unlike past methods, allows the protein to be prepared in defined conditions, free of excess deterg
109 (4-dihydroxymethylsilyl)butyl side chain has been prepared in enantiomerically pure form as a potenti
110 s dramatically expand the materials that can be prepared in epitaxial heterostructures with precise i
111 f zeolite nanosheets (3 nm thick MFI layers) were prepared in ethanol following acid treatment, which
112 lfanylindolizines and 2 1-selanylindolizines were prepared in excellent yields by an intramolecular a
114 ated ynamides, a new type of building block, were prepared in excellent yields for the first time.
116 e, pentafluoroferrocene [Fe(C5F5)(C5H5)] can be prepared in five steps via a one-pot lithiation-elect
117 ral acylpyruvate derivative, which, in turn, is prepared in five steps from commercially available ma
120 unds 12a-g and the (S)-prolinate analogue 13 were prepared in five steps from 2-nitrobenzoic acid (7)
121 H-imidazo[4,5-b]quinoline-9-carbonitriles 15 are prepared in four steps from N'-arylbenzamidines 11 a
122 hus, tetrahydro-5 H-benzo[ c]fluorenes could be prepared in four steps from appropriately substituted
125 on of enantiopure 4-piperidone (-)-11, which was prepared in four steps from alpha-amino nitrile 6 th
129 structurally diverse N-aryl heterocycles can be prepared in good to excellent yields under conditions
133 eries of 2-iminoimidazolin-4-ones could also be prepared in good yields from the reaction of aryl iso
136 of new (E) and (Z)-benzoyl-homoquinones have been prepared in good yield by the parent quinone-electr
137 ings threaded by a two-binding-site axis has been prepared in good yield from relatively simple organ
140 ad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF3 CO2 K
142 aborated tetracyclic core of rhodexin A, 23, was prepared in good yield and excellent selectivity usi
144 opure C,N-palladacycles (PIN-acac complexes) were prepared in good overall yield in three steps from
146 amino acids bearing hydrophobic side chains were prepared in good to excellent yield by treating N-a
148 henoxazin-3-one substrates 23c, 23d, and 23e were prepared in good to high overall yield and were sel
149 for a wide array of target hydrazones, which were prepared in good to high yields under smooth reacti
152 timized reaction conditions, chiral benzoins were prepared in good yields (up to 83%) and excellent e
153 An array of C-aryl and C-vinyl furanosides were prepared in good yields and diastereoselectivities
154 alyst epoxypyrrolo[1,2-a]azepine derivatives were prepared in good yields and excellent diastereosele
155 N-alkyl sulfinamides with diverse structure were prepared in good yields and excellent enantioselect
156 variety of aryl-substituted pyrroloindolines were prepared in good yields and with high levels of ena
157 ))(n)CH(2)(R)OH, n = 1, 2, 3, R = H, Me, Ph) were prepared in good yields by selenative demetalation
158 vailable substrates, 39 examples of products were prepared in good yields with outstanding functional
160 ,5]imidazo[1,2-c]quinazoline-6-carbonitriles are prepared in high yields via three new routes: (1) a
162 -dihydro-2-vinyl-2H-1,4-benzoxazines (3) can be prepared in high yields (90-98%) and excellent enanti
166 dazo[1,2-a]pyridine (alpidem derivative) has been prepared in high chemical yield through a unique pr
167 tives that possess three chiral centers have been prepared in high yield and stereocontrol from silyl
168 Diporphyrinbenzyloxy-BODIPY derivatives have been prepared in high yields, and the photophysical prop
169 romolecular chain transfer agent (macro-CTA) is prepared in high yield (>95%) with 97% dithiobenzoate
170 B, and C as well as its synthetic analogues was prepared in high chemical yield, from 27 to 91%, usi
171 lkylated metallic nitride cluster fullerenes was prepared in high-temperature reactions and character
172 A series of alpha-quaternary arylglycines were prepared in high optical purity (up to 98% ee) by a
174 tricyclic and tetracyclic tetralin analogues were prepared in high yield and up to 20/1 diasteroselec
178 oles with desired N and O coordination atoms were prepared in high yield via click chemistry for pote
181 ne, and [(18)F]fluoroethyl-phenethyl-orvinol were prepared in high yields and quality from their 6-O-
182 new system, and the pharmaceutical ibutilide was prepared in higher yield and under milder conditions
184 oil droplets after intravitreal bevacizumab was prepared in insulin syringes by a compounding pharma
185 veral stable dibenzonorbornadienones 41 have been prepared in just two steps starting from anthracene
186 er designs, but is far more accessible as it is prepared in just five steps and 23% overall yield.
187 ived from the abundant amino acid valine and are prepared in large quantities in four steps with inex
191 ionally, 4-bromo- and 4-iodoisocoumarins can be prepared in moderate to good yields by replacing NCS
192 ,2,3-dithiazol-5-ylidene}methanes, these can be prepared in moderate yields via classical cycloadditi
193 inolines, furopyridines, and thienopyridines is prepared in moderate to excellent yields (up to 86%).
194 isting of new polyaminoisoprenyl derivatives were prepared in moderate to good chemical yields varyin
195 3-spiro[3-azabicyclo[3.1.0]hexane]oxindoles were prepared in moderate to high yields via one-pot thr
197 sly unknown, enantiopure, beta-amino ketones were prepared in modest yield by addition of lithium rea
198 the base 1,2-benzothiazine 1,1-dioxides can be prepared in most cases as the main product, in a diaz
199 is needed for the second catalytic step can be prepared in multigram quantities from inexpensive sta
200 ved from a robust heterocyclic salt that can be prepared in multigram quantities from inexpensive sta
202 and three [2,2']-paracyclophanes (pCps) has been prepared in multistep synthetic procedures involvin
203 nd 2-bromo-4-silacyclohexan-1-ones 5a and 5b were prepared in multistep syntheses, starting from trim
205 controlled length with low polydispersities were prepared in N,N-dimethylformamide using small seed
206 ite (topology type MER) with Si/Al = 3.8 has been prepared in Na, K, and Cs forms and its structural
207 ew binary compound, Zn(8)Sb(7), has recently been prepared in nanoparticulate form via solution synth
208 s, a variety of functionalized anilines have been prepared in nearly quantitative yields within 2-8 m
209 new zeolite structures, the OSDAs for EMM-17 are prepared in one simple alkylation step, making EMM-1
211 Versatile trichloromethyl carbinols can be prepared in one pot from primary alcohols by treatmen
212 pports with a hierarchical cross section can be prepared in one step by hollow fiber spinning, double
214 llows functionalized gamma-butyrolactones to be prepared in one step from simple tertiary alcohol-der
215 zyl-2,4-dinitrobenzenesulfonamide (6), which is prepared in one step from commercial sources, had a p
216 weakly coordinating borate moiety (WCA-NHC) was prepared in one step from free N-heterocyclic carben
217 ide sheet with carboxyl-long-chains (GO-CLC) was prepared in one step from primitive graphite via Fri
218 n new 7'-homo-anhydrovinblastine derivatives were prepared in one or two steps from vinorelbine by me
219 Finally, highly substituted gamma-lactams were prepared in one pot from adducts obtained using ace
221 cyclic fused and spiro-4-aminopyridines that are prepared in only three steps from commercially avail
224 planar chiral paracyclophane scaffolds have been prepared in optically pure form starting from 1,8-d
225 diluted" system with a 9:1 Co/Os metal ratio were prepared in order to further probe the nature of th
226 gs were radiolabeled and potent radioligands were prepared in order to image the beta-adrenergic and
229 ally pure natural product and its enantiomer were prepared in seven steps and 22% overall yield by em
230 hexahydropyrazolo[1,5-a]pyridin-8-ium-1-ide, were prepared in seven steps from the respective commerc
234 he reactivity of these silyltriflates, which are prepared in situ, is exemplified by dipolar cycloadd
238 il that yielded poly(HEMA-co-AEMA) foam that was prepared in-situ by UV crosslinking and by sequentia
239 analogue containing a diazirine moiety that was prepared in six steps and incorporated into an a-fac
240 e synthesis, the key building block 2, which was prepared in six steps from thiophene, was arylated r
246 le and easy to use, provided the input files are prepared in the GraphML format, typically using the
249 methacrylate) diblock copolymer vesicles can be prepared in the form of concentrated aqueous dispersi
254 r sulfamethizole (SMZ) selective recognition was prepared in the form of a homogeneous thin film on t
256 size of the biocompatible PPy coating, which was prepared in the presence of cetyltrimethylammonium b
257 f FAs in the activity, a mixture of four FAs was prepared in the ratios measured in the dust samples
264 ns, twenty-eight (28) heteroarylated ketones were prepared in this study to demonstrate the substrate
270 g the 1, 2, and 3 positions methyl-protected was prepared in three steps from a commercially availabl
272 ctional diaryl- and diheteroarylzinc species were prepared in toluene within 10 min to 5 h through an
273 ural and starter culture fermented cucumbers were prepared in triplicate in sodium chloride brines an
275 uced the latency at which habitual responses were prepared, in turn increasing the likelihood of thei
278 be commercially available from Aldrich, can be prepared in two steps using an abundant plant feedsto
281 culate formulations of clopidogrel bisulfate were prepared in two crystal forms (Form I and Form II).
288 uoromethylated oxygenated heterocycles could be prepared in very good yields through a single synthet
289 ree conformationally distinct amyloid states were prepared in vitro using Syrian hamster recombinant
290 rming photoinitiated substrate turnover have been prepared in which four different fluorotyrosines (F
292 R[N(SiMe3)2]3 R = -CH3, -C identical withCPh were prepared in which coordination of the hydrocarbyl g
293 tRNA synthetase pair, two PPARalpha variants were prepared in which Leu-258 or Phe-273 were site-spec
294 Perylene dyes with N-tert-alkyl substituents were prepared in which noncovalent interactions of the c
295 triphenylphosphine-gold(I) allenyl complexes were prepared in which the alpha carbon coordinates to t
296 To explore this possibility, BLM analogues were prepared in which the disaccharide moiety was attac
297 importance of the thiophenyl moiety, analogs were prepared in which this moiety was replaced by an an
298 ns of geminal methyl and phenyl substituents were prepared in yields of 24-49% via dipyrromethane + d
299 ctionalized with the 5'-siloxyl ether linker were prepared in yields of 75-83% and incorporated last
300 oids pseudopalmatine and pseudoepiberberine, were prepared in yields up to 86% according to this stra