ライフサイエンスコーパス: be presumed to

1 ting proteins (RhoGAP), which have generally been presumed to act as tumor suppressors.

2 nto structural ECM proteins and these forces are presumed to activate integrin "switches." The mechan

3 tegrated viral DNA (UVD) accumulation, which is presumed to activate a cellular DNA damage response.

4 (myeloid/lymphoid or mixed-lineage leukemia) is presumed to activate Hox expression, counteracting po

5 non-coding SNPs associated with disease risk are presumed to affect gene regulation.

6 of the Epichloe symbiont and the host grass is presumed to align the coevolution of the species towa

7 rgo frequent antigenic variation (Av), which is presumed to allow reinfection of high-risk groups.

8 zes the Ca(2+)-induced opening of N-cTnC and is presumed to also destabilize cTnI-actin interactions

9 They are presumed to amplify by rolling-circle replication (R

10 Within dendritic spines, actin is presumed to anchor receptors in the postsynaptic dens

11 cell compartment, where claudin(low) cancers are presumed to arise.

12 This pattern of flow has been presumed to arise from specific features of the res

13 Cardiac neonatal lupus (NL) is presumed to arise from maternal autoantibody targetin

14 While this variability is presumed to arise from overlapping synaptic input, it

15 beta3 subunits are presumed to assemble only in the accessory subunit p

16 BEST1 is presumed to assemble into a calcium-activated chlorid

17 However, these systemic infections are presumed to be a "dead-end" for P. aeruginosa and to

18 Canonical nutrient-sensing pathways are presumed to be absent from the causative agent of ma

19 ch as CTCF facilitate DNA loop formation and are presumed to be among the major determinants of eukar

20 logical lesions in newborn piglets, but they are presumed to be antigenically distinct.

21 their immunosuppressed state, SOT recipients are presumed to be at high risk of complications with vi

22 that express mutant TERT and NLRP3 proteins are presumed to be at increased risk for mutagenesis bec

23 eous cause of this condition, whose symptoms are presumed to be caused by different mechanisms.

24 ence for three systems in the rat brain that are presumed to be components of the rat's navigational

25 Housekeeping genes (HKG) are presumed to be constitutively expressed throughout t

26 a classic example in which immune responses are presumed to be costly and therefore come at the expe

27 lf of the human genome and DNA methylome and are presumed to be densely methylated and inactive.

28 ECs are presumed to be devoid of water because they formed i

29 lutamate transporter VGlut2, the projections are presumed to be excitatory.

30 kinase module contains CDK8 or CDK19, which are presumed to be functionally redundant.

31 and yet mechanistic features of HCV variants are presumed to be held in common.

32 sory systems, a range of computational rules are presumed to be implemented by neuronal subpopulation

33 syndrome (PDS) and pigmentary glaucoma (PG) are presumed to be inherited in an autosomal dominant ma

34 y depend entirely on glycinergic inputs that are presumed to be inhibitory.

35 ext and enzymological studies; these enzymes are presumed to be involved in peptidoglycan recycling.

36 erebral microinfarcts are small lesions that are presumed to be ischaemic.

37 urface density is very low, these "silanols" are presumed to be isolated.

38 educational formats, other core competencies are presumed to be learned on the job or emphasized in c

39 ients can experience rejection episodes that are presumed to be mediated by immune mechanisms similar

40 identify patients with low-risk disease who are presumed to be most suitable for AS.

41 ors by as yet uncharacterized ligands, which are presumed to be PG fragments (muramyl di- and tripept

42 membrane, while their cognate Eph receptors are presumed to be pre-synaptic.

43 GUD(+) NSF O157:H7 strains are presumed to be precursors of GUD(-) NSF O157:H7 stra

44 ties for small molecule CCR5 inhibitors that are presumed to be present in different proportions on d

45 These tube-dwellers are presumed to be primitive metazoans, but resolving th

46 e biogenesis and protein quality control but are presumed to be proteolytically inactive.

47 per cent exhibit strong surface fields that are presumed to be residuals from the star formation pro

48 membrane envelope decorated with spikes that are presumed to be responsible for host attachment and m

49 eloma are unknown, treatment-related factors are presumed to be responsible.

50 unknown molecular mechanisms, although they are presumed to be secondary to immune activation.

51 Immature osteoblasts are presumed to be the cell type harboring translocation

52 Although NMDA receptors are presumed to be the most sensitive targets of ethanol

53 rulent drainage, beta-hemolytic streptococci are presumed to be the predominant pathogens.

54 nic light chain-associated (AL) amyloidosis, are presumed to be the source of light chains that depos

55 Both enantiomers of HNE are presumed to be toxic, and GSTA4-4 has negligible ste

56 rsistent (NP) virus-vector interactions that are presumed to be transient.

57 These proteins are presumed to be trimmed proteolytically and undergo p

58 tibodies have targeted antigens that are, or are presumed to be, extracellular.

59 onments without light-sensing organs may not be presumed to be light insensitive.

60 ontained in the CAS database, while they can be presumed to be products generated during the producti

61 Untested chemicals should not be presumed to be safe to brain development, and chemica

62 dentate granule cells of the hippocampus has been presumed to be a dynamic process.

63 Myelodysplastic syndrome (MDS) has long been presumed to be a stem cell disorder, but rigorous f

64 Previously, SLC30A10 had been presumed to be a zinc transporter.

65 Nodule formation has long been presumed to be central for adjuvant activity by pro

66 by tyrosinase-expressing cells, and this has been presumed to be due to quantitative glycosylation of

67 to be uniquely sensitive to heat, which has been presumed to be due to the existence of an unidentif

68 troscopic studies, the four hemes sites have been presumed to be equivalent.

69 t and most massive asteroid, has in contrast been presumed to be homogeneous, in part because of its

70 ssociated cardiomyopathy is unknown, but has been presumed to be mediated indirectly, owing to the ab

71 T-helper type 2 responses have been presumed to be pathogenic in this disease, and a hi

72 14S particles have long been presumed to be pentamers.

73 TCR-based therapies have been presumed to be restricted to one HLA subtype.

74 st (SCT) at the maternal-fetal interface has been presumed to be the primary driver of placental meta

75 with great specificity and stability and has been presumed to be the replicative ssDNA binding protei

76 g pigment granules within chromatocytes have been presumed to be the sole source of coloration in the

77 inglet carbene cyclopropenylidene (C3H2) has been presumed to be too unstable to isolate in the labor

78 The CASK CaM-kinase domain is presumed to be a catalytically inactive pseudokinase

79 ension, diabetes, dyslipidemia, and obesity, is presumed to be a close associate of AF.

80 f creatine via increased energy availability is presumed to be a contributing factor of the restorati

81 ed to result in a truncated CLN3 protein and is presumed to be a null mutation.

82 Anemia is often observed in AML but is presumed to be a secondary consequence of leukemic cl

83 Whereas excess adiposity is presumed to be advantageous for the skeleton, studies

84 * Carnivory in plants is presumed to be an adaptation to a low-nutrient enviro

85 Photoferrotrophy is presumed to be an ancient type of photosynthetic meta

86 Cancer development is presumed to be an evolutionary process that is influe

87 The RPE/BM angulation is presumed to be caused by elevated pressure in the sub

88 e is associated with pain on movement, which is presumed to be caused by noxious stimulation.

89 Congenital heart block (CHB) is presumed to be caused by transplacental passage of ma

90 or chronic obstructive pulmonary disease and is presumed to be central to the altered responsiveness

91 uman urine in significant concentrations and is presumed to be derived from COX activity.

92 mtDNA cytosine methylation, from which 5hmC is presumed to be derived, and its expression is control

93 rogressive photoreceptor degeneration, which is presumed to be driven by metabolic dysfunction result

94 the impermeable shell-wall under irradiation is presumed to be due to an increase in internal pressur

95 ermore, the bipartite nature of the ribosome is presumed to be essential for biogenesis, since dedica

96 lastid interdependence within the plant cell is presumed to be essential, but measurable demonstratio

97 lack of pathogenicity in a non-human protein is presumed to be explained in most cases by the presenc

98 ugh reduced grey matter volumes, this region is presumed to be healthy in our sample and its grey mat

99 rved in other drug-induced liver injury that is presumed to be immune mediated.

100 of IL-7 when the cytokine is limited, as it is presumed to be in vivo.

101 n exolytic mechanism, and Gro3P substitution is presumed to be inhibitory for GDPDLd17 activity.

102 of primary sequence conservation, the linker is presumed to be intrinsically disordered.

103 Phenotypic plasticity is presumed to be involved in adaptive change toward spe

104 an enzyme mechanism where only a single step is presumed to be isotopically sensitive can be written

105 accumulation of surfactant in the lungs that is presumed to be mediated by disruption of granulocyte/

106 other high-latitude regions, glacial erosion is presumed to be minimal, where a mantle of cold ice ef

107 ld thrombosis (VLScT) occurs when resorption is presumed to be nearly complete.

108 Drd3 is presumed to be palmitoylated, based on sequence homol

109 atency persists for the life of the host and is presumed to be parasitic, as it leaves the individual

110 yclic carbene that has high-affinity for and is presumed to be subsequently captured by the heme iron

111 Improvement in protein function is presumed to be the driving force behind the evolution

112 easurements, because morphology of the brain is presumed to be the neurocranium's main shaping force

113 ns-Columbia River (SCR) flood basalts, which is presumed to be the onset of Yellowstone volcanism, ha

114 The gastrointestinal tract is presumed to be the primary site of infection and path

115 ct translational fidelity and efficiency and is presumed to be under the selective pressure.

116 ever, the general transcription factor TFIIB is presumed to be universally required for RNAP2 transcr

117 ource of this virus is currently unknown but is presumed to be zoonotic.

118 the bacteria to escape killing by drugs and is presumed to be, at least partly, responsible for the

119 sensitive to mitomycin C, and the mechanism was presumed to be a defect in the repair of interstrand

120 HPV16 was presumed to be causative in 14 of 31 biopsy specimen

121 The acquisition of both functions was presumed to be developmentally linked, but this link

122 lation was patients with cardiac arrest that was presumed to be of cardiac origin and that had occurr

123 lar activation from right ventricular pacing was presumed to be the likely cause for these maladaptiv

124 Until recently, transport of tRNA was presumed to be unidirectional, from the nucleus to t

125 f 84 germline DNA-repair gene mutations that were presumed to be deleterious were identified in 82 me

126 in NR2E3, and 2 additional sibling patients were presumed to be homozygous for a missense change bas

127 r bed ("tumoral pseudoblush") at MR imaging, were presumed to be related to tumoral microvascularity.

128 Until recently, human breast tissue and milk were presumed to be sterile.

129 lies to which the conserved T3SS enzymes had been presumed to belong.

130 esistance has been focused on compounds that are presumed to bind the Q(o) site (one of two potential

131 rminal, the C2 domain of synaptotagmin (C2A) is presumed to bind Ca2+ and the membrane in a stepwise

132 General anesthetics during surgery are presumed to block pain by dampening brain activity a

133 As their analysis is presumed to capture the dynamics of decentralized con

134 e generates the powerful oxidant HOCl, which was presumed to carry out the chlorination reaction.

135 us end-joining (NHEJ) pathways of DNA repair are presumed to catalyze their formation.

136 which indiscriminately modifies proteins and is presumed to cause pain through broadly acting mechani

137 n of beta-hexosaminidases A and B substrates is presumed to cause this fatal condition.

138 ns of RsbRA project from the stressosome and are presumed to channel sensory input to the C-terminal

139 3 to form a protein complex (terminase) that is presumed to cleave concatemeric DNA into genome lengt

140 The remaining approximately 70% are presumed to compete for metals from buffered metal p

141 quences bound by a transcription factor (TF) are presumed to contain sequence elements that reflect i

142 merase ribonucleoprotein in Candida albicans is presumed to contain at least three Est proteins: CaEs

143 lants, electrophysiological reactions (elRs) are presumed to contribute to long-distance intercellula

144 current genomic copy number alterations that are presumed to contribute to resistance to hormone ther

145 ronal recruitment in an adult animal's brain is presumed to contribute to brain plasticity and increa

146 Although inflammation is presumed to contribute to colonic neoplasia in ulcera

147 Although complement activation is presumed to contribute to organ damage and constituti

148 al injury is a common finding after TBI, and is presumed to contribute to outcomes, but may not alway

149 se I is a secreted enzyme whose function has been presumed to control "waste management" in the human

150 r EBNA proteins, in particular EBNA-2, which is presumed to coregulate transcription with EBNA-3C.

151 tation of one of the stems by around 80A and are presumed to correspond to the active and inactive st

152 These processes are presumed to correspond to the formal potentials for

153 tiful on the island of New Guinea (NG), they were presumed to currently exist only in captivity.

154 been formally identified, sialidase activity is presumed to derive from the sialidase A gene, named h

155 Here, an EF-hand motif substitution that had been presumed to destroy EF-hand function, that of gluta

156 Thus, a subset of T4BSS effectors are presumed to direct PV biogenesis.

157 belonging to the DN and DC subdomains, which are presumed to dock with TolC, in complex stability and

158 During cytokinesis, regulatory signals are presumed to emanate from the mitotic spindle.

159 mucolipin subfamily (TRPML1-3 and MCOLN1-3) are presumed to encode ion channel proteins of intracell

160 cy signals, whereas kainate receptors (KARs) are presumed to encode lower temporal frequencies.

161 e, intracellular replication, and virulence, was presumed to encode a T6SS-like apparatus.

162 Turnover is presumed to encompass a reversible oxidation at the a

163 rn throughout Latin America, has for decades been presumed to exchange genetic material rarely and wi

164 Hyperfunctioning thyroid nodules (HTNs) were presumed to exclude malignancy with a very high neg

165 des multiple immunosubversive functions that are presumed to facilitate the establishment and persist

166 ome a prominent cancer model system, as they are presumed to faithfully represent the genomic feature

167 Waziristan due to recent military operations was presumed to favor the widespread poliovirus infectio

168 2, and Med13 can associate with Mediator and are presumed to form a stable "CDK8 subcomplex" in cells

169 in the membrane insertion of CCMF(C), which is presumed to form the heme lyase component of the cyto

170 bulb mitral and tufted (M/T) cells, where it is presumed to form the odor percept.

171 DH(2) and O(2) in the halogenase active site was presumed to form the typical FAD(C4a)-OOH intermedia

172 t also involves Pms1 and other proteins that are presumed to function downstream of mismatch recognit

173 shown to function in insulin exocytosis and are presumed to function in actin remodeling and insulin

174 ersections between pro-octamer dimers, which are presumed to function in allosteric regulation.

175 IL-36 signaling has been presumed to function analogously to IL-1 signaling.

176 AdV protein IVa2 is presumed to function as a DNA packaging ATPase.

177 One of these proteins (SvsR) is presumed to function in protein biosynthesis, because

178 e (PAPS) in the follicle cells in which Pipe is presumed to function.

179 High-entropy and medium-entropy alloys are presumed to have a configurational entropy as high a

180 pigenetic alterations, called driver events, are presumed to have a functional role in CRC.

181 are, that have multiple affected members who are presumed to have a similar inherited cause to their

182 and staphylococci are paralogues of SecA and are presumed to have an analogous role in protein transp

183 tions explored previously, while nucleobases are presumed to have been available from hydrogen cyanid

184 In the DSM, phosphorylated carbohydrates are presumed to have been available via reactions explor

185 sitions of sulfidic sedimentary rocks, which are presumed to have formed globally through the reducti

186 lity policies, and governmental regulations, are presumed to have major influences on employment, but

187 Although patients with ARB are presumed to have no functioning bestrophin channels,

188 Nucleoside-based cofactors are presumed to have preceded proteins.

189 Human pluripotent stem cells (PSCs) are presumed to have robust DNA repair pathways to ensur

190 (aP) and whole-cell (wP) pertussis vaccines are presumed to have similar short-term (<3 years after

191 Potassium channels are presumed to have two allosterically coupled gates, t

192 Jehol is presumed to have been a predominantly closed forested

193 osphenic molar with a craggy topography that is presumed to have been used to catch, cut and crush fo

194 Observational learning is presumed to have occurred when an organism copies an

195 Consumption of lignan rich food is presumed to have positive effects on human health.

196 ears to be mediated by low copy repeats, and is presumed to have taken place prior to translocation w

197 s in several copies in the X chromosome, and is presumed to have undergone several duplications to fo

198 der climatic condition of the Little Ice Age were presumed to have caused the abandonment of the colo

199 All patients were presumed to have coronary artery disease (CAD) and

200 larial cause of death and those without, who were presumed to have died of cerebral malaria.

201 ildren who could not access dialysis died or were presumed to have died.

202 107 (36%) of 294 children with ESKD died or were presumed to have died.

203 fissures and previous water flooding events were presumed to have evaporated and sublimed away.

204 admitted to the surgical and cardiac ICU who were presumed to have heparin-induced thrombocytopenia a

205 In approaches 2 and 3, patients were presumed to have sporadic CRC if the tumor lacked M

206 didate transmission hypotheses by which bats are presumed to host and transmit potentially zoonotic v

207 ms, but they do not secrete autoantibody and were presumed to ignore self-Ag.

208 The acidic vaginal milieu is presumed to inactivate pathogens but is neutralized b

209 -yl (NBD) group on the sn-2 C6 position, and were presumed to include phosphatidylcholine and phospha

210 Interaction rates are presumed to increase with density, but there is litt

211 Although cholinergic deficiency is presumed to increase delirium risk and use of medicat

212 t has been associated to echolocation, as it is presumed to indicate a relatively enlarged number of

213 Receptor binding is presumed to induce conformational changes in G that s

214 t, whereas activity of indirect-pathway SPNs is presumed to inhibit movement.

215 granule cells and periglomerular cells that are presumed to integrate into the synaptic circuits of

216 se TRX functions remain largely unknown, but are presumed to involve its histone H3K4 methyltransfera

217 al LPFC unexpectedly impaired processes that are presumed to involve rostral LPFC.

218 plane specification in animal cells has long been presumed to involve direct contact between microtub

219 e human nasopharynx by Moraxella catarrhalis is presumed to involve attachment of this bacterium to t

220 ul recognition of partially occluded objects is presumed to involve dynamic interactions between brai

221 The copper(I) chloride catalyzed reaction is presumed to involve the formation of highly active ar

222 rom a snail first host to an ant second host is presumed to lead to a puppeteer parasite in the ant's

223 This intake is presumed to maintain a minimally acceptable liver con

224 ro-L-galactose residues, the latter of which are presumed to make the polymer recalcitrant to degrada

225 primary neuromuscular transmitter, has long been presumed to mediate this activity-dependent process

226 sp-, and Met-Asn-starting protein N termini, is presumed to Nt-acetylate 15% of all yeast and 18% of

227 Although polyubiquitination had been presumed to occur by transferring ubiquitin molecul

228 So pre-mRNA splicing has been presumed to occur exclusively in the cell nucleus.

229 n until unidirectional blockage by CTCF that is presumed to occur in mammals.

230 This is presumed to occur predominantly by coughing but may a

231 This is presumed to occur through direct interactions of one

232 y correlated with facile (1)O(2) production, was presumed to occur via S(1)-->T(1) intersystem crossi

233 species under the US Endangered Species Act is presumed to offer a defense against extinction and a

234 Pathogens are presumed to originate from the nasopharyngeal ecosys

235 Defective myosin-IIA complexes are presumed to perturb megakaryocyte (MK) differentiati

236 asts and animals, the GTPases Cdc42 and Rac1 are presumed to play a central role in organizing the mo

237 These regulatory cues are presumed to play a key role in tumorigenesis through

238 may modulate the callosal interactions that are presumed to play a role in coordinating bilateral wh

239 Although these proteins are presumed to play a role in the process of biomineral

240 Although CTTs are presumed to play important roles in MT networks, the

241 ecifically exosomes and microvesicles (MVs), are presumed to play key roles in cell-cell communicatio

242 rgely unknown, although bacteria and viruses are presumed to play roles in metabolic interactions, im

243 t plant health, and small-molecule signaling is presumed to play a central role in plant rhizosphere

244 with a wide variety of cellular proteins and is presumed to play a fundamental role in dynein assembl

245 e natural hosts of Avian Influenza (AI), and are presumed to pose one of the most likely vectors for

246 Adiponectin is presumed to possess antiatherogenic and cardioprotect

247 Thus, biophysical constraints should not be presumed to preclude a protein's ability to evolve.

248 NOS reaction has been well-characterized and is presumed to proceed through a compound I heme species

249 biosynthesis, conversion of PCA to pyocyanin is presumed to proceed through the intermediate 5-methyl

250 his novel nucleophilic aromatic substitution is presumed to proceed via a precoordination of the orga

251 interaction between gammaherpesviruses that are presumed to profit from B cell activation and a cell

252 al cell capacity for IFN signal transduction is presumed to protect against respiratory viral infecti

253 ts with TWIST1 directly and this interaction is presumed to protect TWIST1 from degradation.

254 We tested this variant since it is presumed to provide nutritional advantage in specific

255 In general, TLR-2s are presumed to recognize lipoteichoic acid of Gram-posi

256 oteins (IAP) baculoviral IAP repeat-3 domain are presumed to reduce the threshold for apoptotic cell

257 Such instances are presumed to reflect the presence of conserved suites

258 n vivo marker of aging, disease, and insult, is presumed to reflect atrophy of surrounding brain regi

259 This buildup is presumed to reflect the final stages of planning and

260 heir nesting areas; an aggregation pheromone is presumed to regulate this process.

261 cision of skilled forelimb movement has long been presumed to rely on rapid feedback corrections trig

262 is complex to specific regions of the genome is presumed to rely on interactions involving one or mor

263 Hence, inactive Mcm complexes are presumed to remain stably bound from early G1 throug

264 DNA methylation at the promoter of a gene is presumed to render it silent, yet a sizable fraction

265 These findings are presumed to represent normal bone remodeling.

266 my is surprising because autonomy would have been presumed to represent the final, irreversible, leuk

267 Although these structures have been presumed to represent the pre-triggered state 1 of

268 DG uptake in patients suspected of having CS is presumed to represent active inflammation.

269 ctable homologs only in other eukaryotes and is presumed to represent proteins that emerged specifica

270 to end-stage de novo lesions, were found and were presumed to represent healed RCNs.

271 CaV1.2, however, are incompletely known, but are presumed to require phosphorylation of residues in a

272 All of these activities are presumed to require translocation of the protein on

273 tions at positions 120 and 121 in PIB, which are presumed to reside in loop 3 that forms the pore con

274 kemia (CML) and acute myeloid leukemia (AML) are presumed to reside in specific niches in the bone ma

275 most of which are unique to each family and are presumed to result in loss of function.

276 This effect has been presumed to result from higher brain inputs activat

277 ion in terms of receptor activation and have been presumed to result in increased levels of FGF/FGFR

278 This relation is presumed to result from the cooperative binding of th

279 ymptom of subarachnoid hemorrhage (SAH) that is presumed to result from transient intracranial circul

280 In retinal capillaries, pausing is presumed to result from vasomotion-which has been pos

281 Glaucoma is presumed to result in the selective loss of retinal g

282 y targeted at rapidly cycling cells and have been presumed to retain labels such as the thymidine ana

283 2 bp downstream in all eukaryotes, so Pol II is presumed to "scan" further downstream before starting

284 cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via

285 ntres (ncMTOCs) have a variety of roles that are presumed to serve the diverse functions of the range

286 f mammalian non-REM sleep, during which they are presumed to shape activity-dependent plasticity in n

287 A unique multilayer structure of nanosheets is presumed to significantly reduce energy consumption d

288 ng required for uptake of the colicin and it was presumed to somehow serve as both receptor and trans

289 Like most microRNAs, which are presumed to suppress translation of target mRNAs, we

290 that is embryonically indispensable and has been presumed to suppress oncogenesis via an autophagy-m

291 ce of radiocarbon dates, bat extinctions had been presumed to take place during the last glacial-inte

292 Although T4 and its analogs are presumed to target the parasite's lipid metabolism,

293 s in oxidative phosphorylation (OxPhos) have been presumed to trigger an overall bioenergetic crisis

294 ylated 3' untranslated region (UTR) that has been presumed to undergo translation in a cap-dependent

295 uld generate these mutations, TLS mechanisms are presumed to underlie cancer development.

296 Estrogens are presumed to underlie, at least in part, the greater

297 archical relationship (CMP-GMP-MDP-monocyte) is presumed to underlie monocyte differentiation.

298 MEF2C hypofunction in neurons is presumed to underlie most of the symptoms of MCHS.

299 tein-coupled receptor kinases and arrestins, is presumed to underlie these effects, but such a mechan

300 rAAV is presumed to use a pathway of DNA double-strand break