ライフサイエンスコーパス: be processed by

1 HMRs were processed by 2 observers, and reproducibility was a

2 The majority of eukaryotic pre-mRNAs are processed by 3'-end cleavage and polyadenylation, al

3 azoa the replication-dependent histone mRNAs are processed by 3'-end cleavage but not polyadenylation

4 ndard national protocol for DR screening and were processed by 3 ARIAS: iGradingM, Retmarker, and Eye

5 nts to 2192 controls without PTSD after data were processed by 32 international laboratories using EN

6 For repair, AP sites must be processed by 5' AP endonucleases in initial stages of

7 entrates containing ~10 mug of total protein were processed by 96FASP and LC-MS resulting in 700-900

8 nent hypothesis that time, space, and number are processed by a 'common magnitude system', which repr

9 Docking problems submitted to GRAMM-X server are processed by a 320 processor Linux cluster.

10 rocessing: transitions from correlated noise are processed by a distinct neural population, and with

11 es first insights how multiple modifications are processed by a DNA polymerase and, therefore, contri

12 motional states are the kinds of inputs that are processed by a general cortical network of cognition

13 highlight how diverse environmental stimuli are processed by a limited repertoire of signalling mole

14 ecombination events in the rDNA repeats that are processed by a mechanism that requires Rad22 (Rad52

15 C terminal within P200, respectively), which are processed by a protease residing at the C terminus o

16 m kininogen are agonists of the B2R and must be processed by a carboxypeptidase to generate B1R agoni

17 t in six different membrane topologies, must be processed by a protease to initiate a signaling casca

18 orally sourced (retronasal) olfactory input is processed by a brain region responsible for taste pro

19 nformation; for example, spatial information is processed by a circuit that includes the hippocampus,

20 g of ferrioxamine by the FoxA receptor, FoxR is processed by a complex proteolytic cascade leading to

21 alling from multiple stresses that relax DNA is processed by a non-conserved eight-amino-acid tail of

22 In birds, optic flow is processed by a retinal-recipient nucleus in the prete

23 solution camera (CMOS) and the reacted image is processed by a RGB (red, green and blue) analytical a

24 ric viral envelope glycoprotein gp160, which is processed by a single proteolytic cleavage into stabl

25 s a common carbohydrate motif in nature that is processed by a variety of glycoside hydrolases from d

26 The LC-MS/MS data were processed by a blended data analytics software (Xen

27 Multiple replicates of each sample were processed by a new lysis-centrifugation method and

28 of complement C3, the spasmogenic C3f, which was processed by ACE ex vivo and in vitro.

29 ocysticercosis and no viable parasites on CT were processed by Ag-ELISA and EITB.

30 The resulting U:G mismatch can be processed by alternative pathways to give rise to a m

31 g of CdTe dissolved in equimolar CdCl(2)-KCl was processed by ambipolar electrolysis, resulting in th

32 ot be individually identified, and responses were processed by an outside contractor for enhanced ass

33 r mainly in the retina, where graded signals are processed by analog circuits that transfer informati

34 enzymatic elimination of oxidized bases must be processed by AP endonucleases before they compromise

35 Shale fragments of field-collected specimens were processed by applying liquid nitrocellulose on expo

36 ing from the P2-P2' positions This substrate was processed by BACE-1 approximately 10 times more effi

37 rforms automated analysis of how information is processed by biochemical networks.

38 arides that after transport to the periplasm are processed by BoGal36A.

39 hages revealed evidence that some miRNAs can be processed by both DICER and PIWIL4.

40 Interestingly, APP is processed by both PS1- and PS2-containing gamma-secre

41 The bulk of pre-mRNAs are processed by canonical nuclear poly(A) polymerase (P

42 The array transcript is processed by Cas12a itself to release multiple mature

43 ociated coiled-coil protein kinase 1 (ROCK1) is processed by caspase-3 into an active isoform, ROCKDe

44 s a heptapeptide-nucleotide conjugate, which is processed by cellular peptidases within target strain

45 (ON) and decreases (OFF) in light intensity are processed by circuits that are structurally confined

46 4 and Cwp13 are produced as proenzymes which are processed by cleavage to produce mature enzymes.

47 precursor PDIP38 protein, consistent with it being processed by cleavage of the mitochondrial targeti

48 as localized to the BBM compartment where it was processed by cleavage of the ERM-binding motif.

49 RelB is processed by CO2 in a manner dependent on a key C-ter

50 impaired mitochondria and protein aggregates are processed by common ubiquitin-selective autophagy ma

51 ween two purification methods; 32 pancreases were processed by conventional Biocoll purification meth

52 Samples were processed by corneal smear microscopy (potassium hy

53 Several neuropeptides were found to be processed by CPA6, including Met- and Leu-enkephalin,

54 In G1-phase lymphocytes, DNA ends that are processed by CtIP are not efficiently joined by clas

55 However, other endogenous antigens are processed by cytoplasmic proteases, yielding fragmen

56 but not EndoVII, regressed origin fork DSEs are processed by degradation of the DSE and a pathway th

57 enerated in the skin by exposure to the sun, was processed by dendritic cells and T cells to the acti

58 ng RNAi, long double-stranded RNA precursors are processed by Dicer proteins into approximately 21-nt

59 It is known that dsRNAs >or=25 bp are processed by Dicer to create classic 19-bp siRNAs wi

60 ication intermediates or viral dsRNA genomes are processed by Dicer-2 (Dcr-2) into viral small interf

61 e reference plant Arabidopsis thaliana, tRFs are processed by Dicer-like 1 and incorporated into Argo

62 These transcripts are processed by DICER-LIKE3 into 24-nucleotide small in

63 t the overlapping double-stranded RNAs could be processed by Dicer-like 1 (DCL1) and/or DCL3.

64 Exogenous double-stranded RNA is processed by Dicer and RDE-1/Argonaute into primary s

65 fore possible to design a 27mer duplex which is processed by Dicer to yield a specific, desired 21mer

66 STAT3) siRNA delivered by the BAFF-R aptamer was processed by Dicer and efficiently reduced levels of

67 determine whether movements during REM sleep are processed by different motor networks than movements

68 order-disorder transitions, and vice versa, are processed by different neural mechanisms.

69 unique in that high-acuity and motion vision are processed by different pairs of eyes.

70 irus of mice (MVM) genome are dissimilar and are processed by different resolution mechanisms that se

71 Specific somatosensations may be processed by different subsets of primary afferents.

72 Glutamate signaling is processed by different receptors, including metabotro

73 k intermediate in DNA recombination and must be processed by dissolution (for double HJ) or resolutio

74 nociceptive, pruritic, and innocuous stimuli are processed by distinct molecularly defined interneuro

75 suggests instead that scenes, like objects, are processed by distinct pathways guiding recognition a

76 ct roles of context in fear memory retrieval are processed by distinct vHC output pathways, thereby a

77 We show that such motion is processed by diverse neural response types distribute

78 Machine learning is processed by dividing the dataset into training and t

79 rpin termini of adeno-associated virus (AAV) are processed by DNA repair machinery; however, how and

80 s, genomic ribonucleotides either persist or are processed by DNA topoisomerase 1 (Top1) by either er

81 vide structural insights into how r8-oxo-GTP is processed by DNA polymerases.

82 ellular DNA hairpins at double-strand breaks is processed by DNA-dependent protein kinase catalytic s

83 e required to generate longer flaps that can be processed by Dna2 in the absence of the short flap pr

84 Though this microRNA is processed by Drosha (also known as Rnasen), its matur

85 duces a recombination intermediate that must be processed by either one of the HJ pathways to retain

86 s, 5' splice sites and active enhancers, and are processed by end-joining in the absence of a canonic

87 Here, we report that APP is processed by endogenous alpha-secretase at the trans-

88 e we show that meiotic DSBs in budding yeast are processed by endonucleolytic cleavage that releases

89 p in which ex situ generated gaseous CF3CHN2 is processed by engineered myoglobin catalysts expressed

90 Igh locus AID-initiated lesions are processed by error-free and error-prone repair.

91 e uracil, and potentially neighboring bases, are processed by error-prone base excision repair and mi

92 in an error-free manner via Brca2 instead of being processed by error-prone translesion polymerases.

93 Here, we study how such signals are processed by Escherichia coli during chemotaxis by d

94 ro experiments that secreted osteopontin can be processed by extracellular proteasomes, thereby produ

95 Ags injected into the AC are processed by F4/80(+) APCs, which migrate to the thy

96 the vertebrate brain, yet how these channels are processed by first- and higher order brain areas has

97 experienced during free olfactory behaviors are processed by first-order olfactory sensory neurons (

98 Unipolar MEM and NIOM recordings were processed by Fourier transform analysis into 28 407

99 t remains unclear which aspects of attention are processed by fSTS neurons and how or why these might

100 Instead, pro-ADAMTS9 is processed by furin at the cell surface.

101 11) downward arrow Y(112) prodomain sequence is processed by furin.

102 Notch receptors are processed by gamma-secretase acting in synergy with

103 Homodimers can be processed by gamma-secretase to produce amyloid-beta

104 maining membrane spanning cytoplasmic domain is processed by gamma-secretase complex.

105 gion and a C-terminal cleavage region, which is processed by gamma-secretase to a series of products.

106 p B antigen and linear alpha-Gal epitope can be processed by glycoside hydrolases in family GH110, wh

107 The preparation was processed by gradient density centrifugation and sto

108 ), requiring 21% (207 of 1,009) specimens to be processed by GXP.

109 cision(+)/integration(-) transposase variant are processed by hairpin resolution, representing a link

110 In human cell culture, bacterial SLs are processed by host SL-metabolic pathways.

111 ally, telomeres lacking TRF2 and Ku70, which are processed by HR, appeared to maintain their original

112 Monkey plasma samples were processed by immunocapture purification, followed b

113 e perfused 90 min after treatment and tissue was processed by immunohistochemistry for Fos.

114 rgic rhinitis (AR), as compared to controls, were processed by immunohistochemistry and RT-qPCR for t

115 Aged adducts in serum samples were processed by immunomagnetic separation of BChE by a

116 acular edema and of a normal nondiabetic eye were processed by immunoperoxidase staining with primary

117 egg- and/or milk-based powder products have been processed by in gel or in solution digestion and an

118 After preparations, samples were processed by in vitro digestion and lutein was quan

119 Pork nuggets with 'very good' acceptability was processed by incorporating kordoi (Averrhoa carambol

120 ndicate that dimensions associated with pain are processed by independent pathways and that there is

121 th blunt-ended DNA substrate that must first be processed by integrase.

122 g enzyme-cleavable acetomethoxy ester groups are processed by intracellular esterases and accumulate

123 ive to automated extraction, fecal specimens were processed by investigational lysis/heating (i.e., m

124 Yet, it is not known whether facial motion is processed by its own distinct and specialized neural

125 e show that while queen mandibular pheromone is processed by l-ALT (lateral antennal lobe tract) neur

126 question about the brain is how information is processed by large populations of neurons embedded in

127 Their output is processed by lateral inhibition and drives a winner-t

128 site (>=5 mm) were selected and GCF samples were processed by Luminex(R) analysis to determine the c

129 emonstrated that EGF-induced ACK degradation is processed by lysosomes, not proteasomes.

130 ors by expanding the understanding of how PG is processed by lytic enzymes.

131 ated 11.7-103 Tmol S per year, most of which is processed by marine bacteria through the demethylatio

132 we report that the mature PTHrP1-36 hormone is processed by matrix metalloproteinases to yield a sta

133 How these inputs are processed by MeA neurons is poorly understood.

134 The resulting information is processed by means of the multidimensional scaling (M

135 ographical indication (PGI) "Mel de Galicia" was processed by means of different chemometric techniqu

136 R spectroscopy was applied and spectral data were processed by means of Principal Component Analysis

137 d to the cytosol, and vacuole membranes must be processed by mechanisms that remain poorly defined.

138 Little is known about how olfactory inputs are processed by medial amygdala neurons.

139 rom the samples was performed, and the reads were processed by metagenomic rapid annotation.

140 The shelterin-free telomeres are processed by microhomology-mediated alternative-NHEJ

141 ripts predicted to form stem-loop structures are processed by Microprocessor and can inhibit DNMT1-me

142 ated that exon-8-encoded amelogenin isoforms are processed by MMP-20.

143 e site cleft in a substrate-like manner, can be processed by MT-SP1 at low pH, and is a standard mech

144 ced by activation-induced cytidine deaminase are processed by multiple error-prone repair pathways.

145 ProSeAM can be processed by multiple protein methyltransferases for

146 rcuit, suggesting that olfactory information is processed by multiple local circuits operating at dis

147 and to higher brain areas, odor information is processed by multiple transformations of these activi

148 es fingerprint differences on the other, can be processed by multivariate statistical analysis method

149 al were subjected to GC analysis and results were processed by multivariate chemometric methods (MANO

150 iles by Energy Dispersive-X Ray Fluorescence were processed by multivariate methods to classify 183 P

151 The data obtained using both techniques were processed by multivariate statistical analysis (PCA

152 data to perturbation-response data that have been processed by network inference algorithms, which fu

153 imuli encountered in the natural environment are processed by neural circuits.

154 del system for understanding how information is processed by neural circuits, and for investigating t

155 xpands the repertoire of conditions that can be processed by neuronal populations.SIGNIFICANCE STATEM

156 therefore understand how fluctuating inputs are processed by noisy biomolecular networks.

157 ctivate the ATM kinase, accumulate 53BP1 and are processed by non-homologous end joining (NHEJ).

158 y, the primary miRNA (pri-miRNA) transcripts are processed by nuclear Drosha complex into ~70-nucleot

159 mage checkpoint is initiated by lesions that are processed by nucleotide excision repair.

160 Coronavirus nonstructural proteins 1 to 3 are processed by one or two papain-like proteases (PLP1

161 Double-stranded RNA from various sources is processed by one of the four Dicer-like (DCL) protein

162 at most or all of Earth's mantle should have been processed by partial melting beneath mid-ocean ridg

163 osed that numerical and temporal information are processed by partially overlapping magnitude systems

164 device is based on commercial SPR chips that are processed by photolithography to provide electrodes

165 by cells within the sympathoadrenal system, are processed by plasmin to bioactive peptides that feed

166 ly to noncrossover recombinants, but instead are processed by Pol32-dependent break-induced replicati

167 Here, we show that MERS-S is processed by proprotein convertases in MERS-S-transfe

168 Ameloblastin is processed by protease(s) during enamel formation.

169 , ENaC subunits develop mature N-glycans and are processed by proteases.

170 The proNGF molecule is processed by proteases at three dibasic sites found i

171 te epitope for breast cancer vaccines, as it is processed by proteasomes and binds HLA-A2.

172 ICLs are thought to be processed by proteins from a variety of DNA repair pa

173 We show that these covalent complexes can be processed by proteolysis, followed by removal of the

174 n activated Tregs, indicating that Foxp3 may be processed by proteolytic cleavage upon cell activatio

175 a 50-kDa inactive proenzyme (Pro-LOX), which is processed by proteolytic cleavage to a functional 32-

176 Imaging data were processed by published routines in SPM and AFNI.

177 skin snip biopsy (PKDL) or venous blood (VL) was processed by quantitative PCR.

178 ed from synthetic mixtures of the metal ions were processed by radial basis function networks (RBFNs)

179 e cleavage complex into a DNA break that can be processed by RecBC.

180 Shrimp is a valuable natural sea food and is processed by removing head, tail and carapace as wast

181 erhang and 5'-overhang/5'-overhang templates were processed by resection of 3-5 bases and fill-in of

182 Signals from photoreceptors are processed by retinal interneurons, integrated by ret

183 specific target, we show that the psaL mRNA is processed by RNase E only in the presence of PsrR1.

184 The 5' end leader is processed by RNase P, and in most organisms in all th

185 wth phase or nutrient stress in culture, and is processed by RNase Y.

186 Input data were processed by rules established in the model and wer

187 nce that replication-associated DSBs need to be processed by Sae2 for repair by homologous recombinat

188 Unlike natural rewards, which are processed by sensory systems, drugs act directly on

189 t the two binocular cues for 3D motion might be processed by separate specialized mechanisms.

190 Specimens were processed by sequence-independent complementary DNA

191 phosphorylation under conditions where CDCP1 was processed by serine proteases, indicating that FAK/P

192 paired but metastable DNA intermediates that are processed by several alternative subpathways-making

193 Our results provide an example of a SP that is processed by signal peptidase and retrotranslocated t

194 The propilin is processed by signal sequence cleavage and covalent li

195 Stalled replication forks may be processed by sister chromatid recombination (SCR), ge

196 Urine samples spiked with study compounds were processed by solid-phase extraction (SPE) and consi

197 alian survival, threats to social connection are processed by some of the same neural regions that pr

198 Likewise, social support is processed by some of the same neural regions that pro

199 ong with other LPXTG surface proteins, which are processed by sortases upon specific recognition of a

200 However, certain oxidative lesions cannot be processed by SP-BER.

201 the environment, information that in mammals is processed by specialized areas in the visual cortex.

202 expressed as an inactive precursor and must be processed by specific proteases to become bioactive.

203 In trypanosomes, mRNAs are processed by spliced leader (SL) trans splicing, in

204 The changes in the chromogenic arrays data were processed by statistical analysis (PCA).

205 The acquired data were processed by summing extracted ion chromatograms (E

206 nty-seven specimens with low bacterial loads were processed by SWGA before sequencing, and 12 of 27 w

207 lly modified peptide (RiPP) natural products are processed by tailoring enzymes to create complex nat

208 well a word's acoustic and phonetic features are processed by the brain at the time of its utterance.

209 How sounds are processed by the brain during sleep is an important

210 derstanding of how ambiguous sensory signals are processed by the brain to elicit a robust behavioral

211 nsist entirely of cleavable RNA strands, and are processed by the cell's RNA machinery to convert the

212 rate understanding of how misfolded proteins are processed by the cellular proteostasis network.

213 Sounds are processed by the ear and central auditory pathway.

214 tual stability in which perisaccadic stimuli are processed by the early visual system, but these sign

215 that carry miRNA genes form transcripts that are processed by the endogenous RNA-interference pathway

216 ts gaps in our understanding of how antigens are processed by the ERAP enzymes.

217 an make the types of memories that in adults are processed by the hippocampus-dependent memory system

218 distinct sensory aspects of noxious stimuli are processed by the human brain.

219 gested that wh-in-situ questions in Japanese are processed by the incremental formation of a long-dis

220 disulfide bridges between CX9C motifs; they are processed by the Mia40 oxidative-folding pathway in

221 purified precursor peptides HalA1 and HalA2 are processed by the purified modification enzymes HalM1

222 anscripts may form double-stranded RNAs that are processed by the RNA interference machinery into sma

223 ree to which appetitive and aversive stimuli are processed by the same or different neuronal circuits

224 signals in both superior and inferior retina are processed by the same postreceptoral circuitry.

225 ate whether these two forms of communication are processed by the same system in the human brain.

226 mote the formation of HRR intermediates that are processed by the Sgs1-Rmi1-Top3 complex.

227 e particles containing Gag polyproteins that are processed by the viral protease into individual comp

228 How sensory signals are processed by the visual cortex is not fixed but chan

229 e effector procaspase-3, procaspase-9 cannot be processed by the apoptosome as a typical substrate.

230 After a memory is formed, it continues to be processed by the brain.

231 nthesized as an inactive protein that has to be processed by the inflammasome to generate the mature

232 DNA double-strand breaks (DSBs) can be processed by the Mre11-Rad50-Nbs1 (MRN) complex, whic

233 Protein aggregates cannot be processed by the proteasome; instead, they are freque

234 induced structural change allows the RNA to be processed by the RNAi machinery, ultimately resulting

235 ination intermediates that accumulate cannot be processed by the Sgs1-Top3-Rmi1 complex (STR).

236 d in the assembly of adenovirus virions must be processed by the virally encoded adenovirus proteinas

237 ibit properties of reversed forks, including being processed by the Exo1 nuclease.

238 not only results in less of the fixated word being processed by the language system; ensuing fixation

239 and tetramer staining, indicating that hTERT is processed by the AAPCs and that the two peptides are

240 tivates pseudomonic acid as a thioester that is processed by the acetyltransferase HolE to catalyze t

241 We also show that sfRNA is processed by the antiviral RNA interference machinery

242 ing that transmission of sensory information is processed by the appropriate specialized neural circu

243 How information is processed by the brain during awake and anesthetized

244 also further our understanding of how color is processed by the brain.

245 n about how nitrofurazone-induced DNA damage is processed by the cell.

246 e arenavirus glycoprotein (GP) precursor GPC is processed by the cellular site 1 protease (S1P) to ge

247 precursor of the major pilus subunit, PilS2, is processed by the chromosomally encoded prepillin pept

248 f the ribosome, mRNA, and a deacylated tRNA, is processed by the concerted action of the ribosome-rec

249 CA1 that originates in entorhinal cortex and is processed by the dentate gyrus and area CA3.

250 In summary, bilateral CI stimulation is processed by the developing human auditory brainstem

251 assay in which the full-length HIV-1 GagPol is processed by the embedded PR, we examined the effect

252 avage at additional sites when the precursor is processed by the embedded, but not the mature, PR.

253 5R-Tg is processed by the Escherichia coli UvrA and UvrABC pro

254 lic presence of Bid, a BH3-only protein that is processed by the initiator caspase-2.

255 in a number of cancer cell lines and that it is processed by the Microprocessor complex to produce ma

256 rved region at the carboxy terminus of ORF1a is processed by the nsp5 proteinase (Mpro) into mature p

257 ced with the corresponding N domain of FlgA1 is processed by the prepilin peptidase, but it does not

258 esses the cytoplasm by protein transduction, is processed by the proteasome, and NY-ESO-1 peptides pr

259 nverted to double-stranded break, which then is processed by the RecBCD pathway, followed by associat

260 mechanistic understanding of how the signal is processed by the recipient cell into precise and prop

261 urogenic ectoderm by the Spitz ligand, which is processed by the Rhomboid protease.

262 demonstrate here that the S. intermedius AIP is processed by the S. intermedius AgrB protein to gener

263 The circularization site is processed by the tRNA splicing endonuclease.

264 The first ORF produces a polyprotein that is processed by the viral cysteine protease into six non

265 Upon viral budding, Gag is processed by the viral protease to liberate distinct

266 The input data for STarMir is processed by the web server to perform prediction of

267 l tremor and 27 age-matched control subjects was processed by the Golgi-Kopsch method.

268 l CD8 T cell responses to E1A(234-243) which was processed by the same professional APCs, from the sa

269 One randomly numbered specimen was processed by the USP method and the other by the NAL

270 The data show that surface materials were processed by the action of water within the interio

271 experts as "plus" or "not plus." All images were processed by the computer-based Retinal Image multi

272 colour modulations of the chromogenic array were processed by the principal component analysis (PCA)

273 herin, ACRBP, ADAM5, and SPINK2 (alias SAAI) were processed by the proteasome in a capacitation depen

274 tides, it has been suggested that these PPTs are processed by their cognate reverse transcriptases (R

275 tent with the type of information presumably being processed by this region.

276 es and differences in the ways in which pain is processed by this patient group, whereas electrophysi

277 creted, glaucoma-associated protein myocilin was processed by this pathway.

278 re is a small, highly basic polypeptide that is processed by three enzymatic cleavages before its inc

279 conclusion, pro-HD-5 in the intestinal lumen is processed by trypsin in a complex in which chymotryps

280 Most animal pri-miRNAs are processed by two cleavages, the first at a loop-dist

281 atement: In most vertebrates, olfactory cues are processed by two largely segregated neural pathways,

282 rine hepatitis virus (MHV), nsps 1, 2, and 3 are processed by two papain-like proteinase activities w

283 ) is mediated by replicase polyproteins that are processed by two viral proteases, papain-like protea

284 rly stages of visual processing, information is processed by two major thalamic pathways encoding bri

285 ems (one conventional and two organic ones), were processed by two types of small-scale drying (oven

286 fter lysozyme exposure, suggesting that RsiV is processed by unknown protease(s) prior to the action

287 The resulting uracils are processed by uracil base excision and/or mismatch re

288 Resulting uracil-guanine mismatches are processed by uracil DNA glycosylase (UNG)-mediated b

289 ced by activation-induced cytidine deaminase are processed by uracil-DNA glycosylase (UNG) and mismat

290 ith proteinuria, as filtered plasminogen may be processed by urokinase, released from renal tubular e

291 PA images were processed by using a commercially available CAD, an

292 Examinations were processed by using a convolutional neural network (

293 Brains were processed by using standard histologic methods for

294 Tumor-bearing organs were processed by using tissue clearing and imaged with

295 enomes are translated into polyproteins that are processed by viral proteases to yield functional int

296 enome results in a single polypeptide, which is processed by viral and host proteases into at least 1

297 major representational joints in how actions are processed by visual regions of the brain.

298 sing convenience, full-scan and DDA data can be processed by well-established software.

299 community, and the DNA of the isolated cells was processed by whole genome amplification (WGA) and hy

300 ining assay, we find that a substrate, which is processed by WRN, is ligated by X4L4, thus further su