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5 The catalytic activity of the protease MALT1 is required for adaptive immune responses and regulatory
6 encoding starch branching enzyme IIb, which is required for amylopectin synthesis in the endosperm.
8 Our results indicate that TCP14 and TCP15 are required for an efficient elongation response to aux
10 lation and SIRT3-mediated oxidant scavenging are required for anoikis resistance in vitro following m
13 a GTPase-activating protein for FgRab8 which is required for apical secretion-mediated growth and pat
16 lular but not magnocellular oxytocin pathway is required for autism-relevant social reward behavior.
18 infiltration of macrophages and neutrophils is required for autoreactive CD4 T cell-mediated skin di
21 d by an aspartate residue in type P(O) SadP, was required for binding to Gb4 and, strikingly, was als
22 tivities are down-regulated by acylation but are required for biofilm formation, thus providing a def
23 s in intercellular aggregation, while groEL1 was required for biofilm maturation in M. smegmatis.
24 ntestinal lysosome-related organelles (LROs) is required for biosynthesis of most modular ascarosides
25 in vitro, and the DNA-binding ability of CST is required for blocking MRE11-mediated nascent-strand d
26 nes involved in apicoplast carbon metabolism are required for blood-stage parasite survival and organ
27 tified near RA target genes already known to be required for body axis and limb formation, thus valid
28 y, we showed that acidified amebic lysosomes are required for both amebic trogocytosis and phagocytos
29 ular evidence that transient phosphorylation is required for CAP1 functions in both actin filament tu
35 M was found to engage part of Na(V) 1.5 that is required for channel inactivation with high affinity.
36 tion (FDA) emergency use authorization (EUA) is required for clinical application of SARS-CoV-2 molec
37 Cul5, different determinants in the MVV Vif are required for cofactor binding and stabilization of t
39 and cohesin and demonstrate that while CTCF is required for cohesin binding to KSHV, they have very
43 nd direct it to a subset of viral genes that are required for completion of the viral replication cyc
45 text-responding vCA1 neurons, whose activity was required for contextual fear learning and synaptic p
48 re-T-cell receptor (TCR) signal transduction is required for developing thymocytes to differentiate f
50 iscovered that the E3 ubiquitin ligase Nedd4 is required for developmental myelination through stabil
51 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage i
52 t eight cell divisions in vivo, with BLIMP-1 being required for differentiation at division eight.
53 Our data support a model in which flotillins are required for direct control of membrane fluidity rat
54 hat RAB13-RABIF association at the periphery is required for directing RAB13 GTPase activity to promo
55 the epidermal growth factor receptor (EGFR) is required for directing STING to endosomes, where it i
64 t different chromatin remodelling activities are required for efficient repair in specific genomic co
65 is is associated with increased sleep, which is required for efficient active zone removal after inju
66 t of RAD51AP1 in FANCD2 deubiquitination, it is required for efficient HR-mediated chromosome damage
68 e show that in Caenorhabditis elegans COQ-2e is required for efficient RQ synthesis and survival in c
71 ous inward and outward lactate fluxes, which were required for efficient utilization of glucose by be
72 n of Tyr(297), Tyr(246), and Tyr(336) of Shb is required for EphB2-ephrinB1 boundary formation, as we
73 DGK4 are essential during gametogenesis and are required for ER-localized phospholipid metabolism in
75 ents, a pole of Nodal signaling emerges that is required for explant elongation via the planar cell p
76 rotein synthesis; however, protein synthesis was required for expression of Fibromodulin and Adamtsl2
78 alibration free point-of-care testing device is required for fast screening to rule-in and rule-out A
79 nacidin A, an additional ketoreductase RslO8 is required for formation of the main products rishirili
80 of multiple myc mutants confirmed that MYCs are required for full expression of red (R) light-regula
81 its ability to associate with membranes, but is required for full activation of the GTPase and for ef
82 observed that this cytoplasmic translocation is required for full activation of the JNK pathway and t
83 response to acute stress and that ATF6alpha is required for full activation of XBP1 targets, but XBP
84 nt challenge, suggesting that serratiochelin is required for full S. marcescens pathogenesis in the b
85 omprehensive, high-quality reference genomes are required for functional characterization and taxonom
86 ions according to biological characteristics is required for further BTMs validation and appropriate
87 n RNAPII reaches the middle of RDH genes and is required for further RNAPII elongation and 3'-end pro
89 l input, likely via neuron-supplied factors, is required for generation of differentiated taste cells
90 protoporphyrin IX in order to form heme that is required for growth stimulation and survival in vivo
91 major quinone of Pseudomonas aeruginosa and is required for growth under anaerobic respiration (i.e.
92 However, lower concentrations of agonist were required for half-maximum inhibition of dopamine-in
93 d SMRT deacetylase-activating domains, which are required for HDAC3's enzymatic function, permit norm
94 d clonal analysis, we demonstrate that Ift20 is required for HF-SC migration and their contribution t
96 ribute to mitochondrial iron homeostasis and are required for high-affinity iron import during active
97 e demonstrate that the degradation of PTPN14 is required for high-risk HPV18 E7 to extend keratinocyt
98 independent of Notch activation, the latter was required for high NKp80 expression and a stage 4B-li
100 nriched at telomeres during the G2 phase and is required for histone H3.3 deposition and telomere DNA
101 Jun N-terminal kinases (JNKs) and p38s that are required for host immune response, whereas extracell
102 as the sentinel for ribosome collisions and is required for immediate early activation of both SAPK
106 e calcineurin catalytic A-subunit (CaNAbeta) is required for induction of pathological myocyte hypert
108 t studies revealed that actin polymerization is required for initiation of myelination whereas actin
109 enes, and found that only galactosylated WTA is required for InlB surface presentation and function,
111 Interestingly, PAK1 has been suggested to be required for insulin-stimulated glucose transporter 4
118 me pathways, multiple domains of the protein were required for its function, whereas in other pathway
119 says, we show that both HEPN nuclease motifs are required for Las1 nuclease activity and fidelity.
120 s IIa histone deacetylases (HDAC4 and HDAC5) are required for loading-induced Sost suppression and bo
123 , and a spermathecal-derived heme peroxidase is required for long-term Anopheles gambiae fertility.
127 ow that the lipid-droplet-related gene Fitm2 is required for maintaining cell fitness after exposure
128 man acute myeloid leukemia (AML), and ALKBH5 is required for maintaining leukemia stem cell (LSC) fun
129 gain of prefrontal GABAergic function, which is required for maintaining proper excitatory-inhibitory
130 ive to rapid turning off of the receptor and is required for maintaining RhoA-mediated transcription
133 ty, explaining why catalytically active Fig4 is required for maximal PI(3,5)P(2) production by PIKfyv
136 hrough OCA-B-MED1 interactions, this complex is required for Mediator association with the BCL6 promo
138 el states that the secreted substrate ESAT-6 is required for membrane permeabilization and that a sub
139 gy, and here, we investigated whether Ca(2+) is required for MERS-CoV fusion by screening a mutant ar
140 ter Tap1 and the aminopeptidase Erap1, which are required for MHC-I trafficking to the cell surface.
149 sed by Muller glia following neuronal death, is required for Muller glia to progress through the cell
151 em cells, we further demonstrated that MCM10 is required for NK cell terminal maturation and acquisit
156 uggest that SIRT1 in mPFC excitatory neurons is required for normal neuronal excitability and synapti
159 ental second messenger in all cell types and is required for numerous essential cellular functions, i
160 cn-Cre(+) dDG neurons identified BDNF, which was required for Ocn-Cre(+) dDG neurons mediated antianx
162 ate that cell-intrinsic adrenergic signaling is required for optimal adaptive NK cell responses.
166 lobal operation of thiol redox switches that is required for optimal usage of energy stores by the mi
167 onal insights into an essential protein that is required for organelle-specific trafficking and brain
170 s including endocytosis of hemoglobin, which is required for parasite growth and artemisinin activati
171 in with uncompromised DNA-binding activities is required for PARPi-induced innate immune response.
172 ell cytotoxicity early during activation and is required for persistence of activated CD8 T cells fol
173 ssion of the cell cycle regulatory gene CDK6 is required for Philadelphia-positive (Ph+) acute lympho
174 the CTS of Bim directly interacts with Bax, is required for physiological concentrations of Bim to a
175 tein SUMO and the SUMO E3 ligase Su(var)2-10 are required for piRNA-guided deposition of repressive c
176 that the MHC-II antigen presentation pathway is required for PIV-mediated protection against C. burne
178 ments in vivo or in cellulo indicate that it is required for Pnr- and Srp-dependent gene expression,
181 c analysis we show that intact SA-signalling is required for potato defences against the necrotrophic
182 intact SA signalling, and not JA signalling, is required for potato defences against the necrotrophic
183 hat the kinetochore proteins KNL-1 and KNL-3 are required for preanaphase chromosome stretching, sugg
184 ing and the presence of an OSRE1 in intron 1 are required for precise enhancement of hyperosmotic glu
185 X-ray clock transitions(8,12) in HCIs, which are required for precision studies of fundamental physic
186 smic reticulum (ER) aminopeptidase 1 (ERAP1) is required for processing of the signal peptide, the me
187 were expressed upon IS maturation, and OVCH2 was required for processing of the sperm surface protein
188 class of siRNAs known as WAGO-class 22G-RNAs are required for proper expression of spermatogenic and
190 ic force microscopy reveals the Y269 residue is required for proper DNA bending by APE1, providing ev
191 rain axons traversing the midbrain, and this is required for proper GABAergic neuronal migration into
192 tight balance in the Wnt-Adamts19-Klf2 axis is required for proper valve maturation and maintenance.
193 of enriched PM fractions revealed that EPS1 was required for proper PM abundance of a discrete subse
194 e expression of prostacyclin synthase, which is required for prostacyclin production after lipopolysa
195 conserved set of peroxin (Pex) proteins that are required for protein import, peroxisomal growth, and
198 upling between distant electron spins, which is required for quantum error correction, presents a cha
200 ed in <10 mus, which is far better than what is required for real-time performance, and with low erro
202 ransition from quiescence to activation that is required for regeneration, but it remains unknown if
204 Not4-mediated monoubiquitination of eS7A was required for resistance to tunicamycin, whereas E3 l
206 d by both chaperones revealed that while Hfq is required for RNA sponge-mediated downregulation of th
208 in line with the notion that mitotic arrest is required for ROS buildup and oxidation of the nucleot
218 in of unknown biochemical function, TMEM127, are required for SteD-dependent ubiquitination of mMHCII
219 vascular endothelial growth factor D (VEGFD) is required for structural integrity of dendrites and co
220 nsitive allele (Sac1(ts)), we show that Sac1 is required for structural integrity of the Drosophila r
227 than just activation of PHAS transcription, are required for targeting increased CHH methylation at
228 ll differentiation, while their decommission is required for TCRA locus activation and enforced alpha
229 e, we show that 4 bp of core-enclosing helix is required for telomerase to be active in vitro and to
232 DGFRbeta-initiated phosphorylation of PRAS40 is required for TGFbeta-induced mesangial cell hypertrop
233 key structural components of this matrix and are required for the assembly and architecture of biofil
234 t hypotheses suggest that flotillin proteins are required for the formation of complexes of membrane
235 nments strongly influence, and in some cases are required for the growth and fructification of cultiv
236 We demonstrate that IL-4/13A and IL-4/13B are required for the maintenance of a Th2-like phenotype
237 onging to the direct (striatonigral) pathway are required for the motor-impairing activity of Delta(9
238 n sorting (HOPS)-mediated vesicle tethering, are required for the phosphorylation of Vac17 in its Myo
239 he transcription factor AP-2beta is shown to be required for the differentiation of distal tubule pre
240 we show that this trait, which is thought to be required for the tolerance of abiotic stress, is not
241 s five CCCH zinc fingers (ZFs), with ZF2-ZF3 being required for the recognition of the AAUAAA poly(A)
242 a novel mitochondrial micropeptide Mm47 that is required for the activation of the Nlrp3 inflammasome
244 rosomal triglyceride transfer protein (MTP), is required for the biosynthesis of these lipoproteins,
245 c interaction indicates that functional MLH1 is required for the CAG repeat destabilizing effect of F
246 en together, our data demonstrate that Cdc23 is required for the chromosome segregation through regul
247 Taken together, our results show that Padi2 is required for the citrullination of histones within a
248 entified SMALL LEAF AND BUSHY1 (SLB1), which is required for the control of organ size and lateral br
249 pper transcription factor ATF-like 3 (BATF3) is required for the development of conventional type 1 d
252 se requires Asc as a reductant; thereby, Asc is required for the energy-dependent component of nonpho
253 r virus and demonstrate that the full capsid is required for the essential interaction with its GAG r
256 n, and that unhindered replisome progression is required for the faithful propagation of DNA methylat
258 this study, we sought to test whether DOCK8 is required for the function and maintenance of ILC subs
262 , we have demonstrated that the 5-HT(3A)-ICD is required for the interaction between 5-HT(3A) and the
268 nd proteolytic site (S2'), cleavage of which is required for the release of the fusion peptide(11,12)
269 results indicate that the endosomal pathway is required for the signaling cascade initiated by BDNF
271 coordination of multiple signaling pathways is required for the successful formation of a complete o
272 njugated and inhibited thermolysin, His-1084 was required for the conjugation and inhibition of acety
273 ohesion in HCT116 and HeLa cells, whereas it was required for the dissociation of cohesin from chroma
284 sary for ZNF165 transcriptional activity and is required for TNBC tumor growth in vivo using an ortho
285 and whether its histone-modifying activities are required for transcriptional repression remains cont
286 MUT-2) is a ribonucleotidyltransferase that is required for transposon silencing and RNA interferenc
287 itis and pancreatic tumor development and to be required for tumor development and progression in mic
288 in and the UBF1 Ser-412 phosphorylation site are required for UBF1-mediated ECT2 recruitment to rDNA,
290 d that the T cell receptor (TCR):CD3 complex is required for USSN-induced T cell activation, and that
292 Although the presence of gRNA in virions is required for viral infectivity, in its absence, Gag c
293 ccumulation of other rotavirus proteins that are required for viroplasm formation and that NSP5 hyper