ライフサイエンスコーパス: be required to

1 broblasts, but a profound reduction of BCCIP was required to abrogate its function in 60S biogenesis.

2 terminal amino alcohol, a different strategy was required to access lipovelutibol B and a series of N

3 7 days are required to acclimate adult fish to 37 degrees C, an

4 Our results suggest that the purine is required to accurately recruit the first nucleotide,

5 it is unclear whether epigenetic alterations are required to achieve and maintain ground state or occ

6 correction for reconstruction method biases are required to achieve higher precision of dosimetry es

7 articular when fine spatial control of light is required to achieve local specificity.

8 comprehensive, three-dimensional methodology was required to achieve a quantitative analysis: centrif

9 itioning task was used in which participants were required to achieve different tongue postures withi

10 h anti-CD20 to retain B cells whose presence were required to achieve EAE recovery.

11 nificantly, shorter radiofrequency durations were required to achieve the target LSI in the 40 W grou

12 and strengthening vision care services will be required to address poor compliance with spectacle us

13 f animal materials in gelatin-based products is required to address religious and cultural concerns,

14 A systematic and concerted research effort is required to address the deficiencies in current model

15 s for TBRF Borrelia in Eurasia, further work is required to address the neglected status of TBRF in t

16 Evolutionary dimensions are required to advance our understanding of foundationa

17 on and pathogenesis of Neisseria gonorrhoeae is required to aid development of new treatment and prev

18 Future studies are required to assess the clinical implication of these

19 Further investigations are required to assess the effect of differential barore

20 Larger randomized controlled trials are required to assess the true impact on postoperative

21 aluations of child health promotion programs are required to assess their sustainability and the need

22 Clinical studies are required to assess whether a similar antiviral effec

23 human population studies, but that more work is required to assess InHg exposures.

24 lucidating the genetic basis of these traits is required to assess models of evolution and to develop

25 Ambulatory monitoring is required to assess PVC frequency.

26 e markers in clinical practice, further work is required to assess the influence of the dose and timi

27 ies and their posterior probabilities, which is required to assess the relative preponderance of seed

28 lar analyses show that karyopherin receptors are required to authenticate, bind, and escort NLS-NCs t

29 hese enzymes, however, alternative solutions are required to avoid the side-effects of using these dr

30 Time from diagnosis to liver transplant was required to be more than 1 year.

31 physiological mechanism of plant acclimation are required to better quantify the global dimming impac

32 hose provided by paleoecological approaches, are required to better understand shifting baselines in

33 rtality at different periods post-transplant is required to better inform patients, clinicians, resea

34 Multiple missense mutations are required to block CIF2 binding in vitro and GSO1/SGN

35 d behavioral interventions that target women are required to bolster the efficacy of OAT in preventin

36 Such studies are required to bring precision medicine to the bedside

37 nstrate that blockade of both IL-4 and IL-13 is required to broadly block type 2 inflammation, which

38 y to wipe the board clean and determine what is required to build in function from the ground up in a

39 Advocacy on the basis of this evidence is required to build psychosocial resources in cancer tr

40 ructure and the electron degeneracy pressure is required to capture the measured shape of the pressur

41 A median of 12 sequential hours were required to capture 80% of the variability in spike

42 virus Disease 2019 (COVID-19), but more data are required to clarify if COVID-19 is an independent ri

43 o-head trials with novel systemic treatments are required to clarify the future role of conventional

44 ontrols at this early stage, further studies are required to clarify whether interventions such as ex

45 apacity to exit quiescence, a time when NSCs are required to clear a wave of aggregated proteins, and

46 LACC1 expression by myeloid cells in mice is required to clear bacteria and to regulate adaptive T

47 al outcome and that further intervention may be required to clinically justify rapid AST implementati

48 dicating that additional inhibitory pathways are required to complement existing therapeutics.

49 st-translational beta-catenin activation and is required to complete EGA.

50 ight 1, participants were informed that they were required to complete a series of demanding cognitiv

51 heterogeneous mixtures, while heroic efforts were required to complete chemical and/or enzymatic synt

52 cific residues within the tatM2NX C terminus are required to confer antagonism on TRPM2.

53 Additional studies, however, are required to confirm this finding in different settin

54 iagnosed, though future longitudinal studies are required to confirm this result.

55 In situ observations would be required to confirm this hypothesis.

56 and latent structure learning, the vmPFC may be required to construct a detailed representation of th

57 thod and suggested that medium modifications were required to control regenerant variation.

58 n the Plexin-A4 receptor cytoplasmic domain, are required to coordinate the downstream signaling mole

59 Thus, the DV Wnt gradient is required to coordinate growth between dorsal and vent

60 BCG vaccination clinical trials are required to corroborate the patterns detected here,

61 ing proteins like LacI, why multiple bridges are required to create stable independent topological do

62 During oocyte growth, transcription is required to create RNA and protein reserves to achiev

63 In contrast, here we show that PPD is required to dampen the expression of viral late trans

64 Further studies are required to define causality and establish a role fo

65 Further studies will be required to define whether inter-individual variation

66 nsmission of the DNAm change, larger studies are required to definitively exclude this possibility.

67 illness although further mechanistic studies are required to definitively illustrate cause and effect

68 tely quantify expanded and non-expanded HTT, are required to delineate HTT homeostasis and to best de

69 hm is molecule generation, where the machine is required to design high-quality, drug-like molecules

70 ugh proteases with alternative specificities are required to detect sequences that are not accessible

71 e timing of low-contrast visual stimuli they were required to detect.

72 Further subset analyses are required to determine if there are clinically releva

73 Prospective intervention studies are required to determine whether such associations are

74 Future large-scale longitudinal studies are required to determine whether targeted microbiome mo

75 Further studies are required to determine whether the variation in movem

76 For example, less than 1 nmol sulfate is required to determine (18)O/(34)S ratios with 0.2 per

77 Further work is required to determine how this pathway influences ada

78 Further work is required to determine the optimal International Class

79 Further study is required to determine whether early interventions to

80 al analysis beyond the antibody binding site is required to develop a more efficacious antibody.

81 ms that lead to high-affinity IgE production is required to develop better therapeutics for preventin

82 Further work is required to develop uniform definitions and establish

83 Although technically a normal endoscopy is required to diagnose functional dyspepsia, the utilit

84 tion betaD4) and K400A (SH2 position betaD6) is required to disrupt the binding.

85 line (i.e., preindustrial) conditions, which are required to distinguish natural versus anthropogenic

86 tor engagement and proinflammatory cytokines are required to drive NK cell clonal expansion, addition

87 fic pathway of transmetallation to palladium is required to effect efficient chirality transfer to th

88 osts and factors associated with readmission is required to effectively plan resource allocation and

89 igen interactions, but computational methods are required to efficiently scale to large-scale studies

90 st1 cooperate and their sustained expression is required to elicit a transcriptional program associat

91 , reliable and integrated preclinical models are required to elucidate the mechanisms of resistance a

92 Further work is required to elucidate the mechanisms of this associat

93 ans that half as many lockdown periods would be required to end continent-wide community transmission

94 tory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-1

95 herapy, but an effective vaccine will likely be required to end the HIV epidemic.

96 d of SARS-CoV-2 suggests that a vaccine will be required to end this global pandemic.

97 lear receptor corepressors 1 and 2 (NCoR1/2) is required to engage its catalytic activity(1-3).

98 ts demonstrate that a detailed understanding is required to engineer modified FA production in oilsee

99 ot required for translational repression but is required to enrich mRNAs in the germ lineage for robu

100 pecies origin of meat used in processed food are required to ensure adequate labelling and minimize f

101 rdinated activity of the heat-shock response is required to ensure ongoing protein quality control in

102 maturation of ribosomal RNA helix 74, which is required to ensure proper construction of the NPET an

103 early disease and responses to medications, are required to establish successful biomarker discovery

104 Further studies are required to establish what proportion of patients wi

105 encompassing amino acids 99 to 159 of QX-RBD was required to establish kidney binding.

106 Further studies are required to estimate cancer risk associated with the

107 dried blood spots (DBS) though more research is required to evaluate mercury (Hg) speciation in DBS a

108 etastatic cancer, new and ambitious research is required to evaluate the cost effects of palliative c

109 While new tools and strategies may be required to eventually achieve malaria elimination in

110 Randomized trials are required to examine whether moderate UF(NET) rates a

111 Further work is required to examine the specific contributions from d

112 tive diagnostic criteria for ocular-only MMP are required to exclude the other causes of scarring con

113 biting the strongest cofluctuation amplitude are required to explain a significant fraction of varian

114 esults suggest that a Janus mutation may not be required to explain co-existing Hirschsprung disease

115 nderlying zwitterionic charge-transfer state is required to explain its sensitivity to electrostatics

116 More studies are required to explore the role of the conjunctiva and

117 rodrome to neurodegeneration; empirical data are required to explore whether the same might hold for

118 understanding of microstructure development is required to fabricate high quality products by additi

119 ive splicing, and class switch recombination are required to facilitate development, activation, and

120 Thus, a tether-like protein is required to facilitate detection of small-amplitude v

121 rates sister-chromatid pairs inside TADs and is required to focus sister-chromatid contacts at TAD bo

122 rict hierarchical organization, where people are required to follow orders.

123 uggest that networks of distinct transcripts are required to form a canonical SG and provide a platfo

124 formins, suggesting that additional factors are required to fully activate the formin.

125 ssment of species exploitation), but efforts are required to fully include these models in the LCA fr

126 cement, appropriate topology-guided assembly is required to fully realize the true potential of linke

127 echniques on new types of electronic devices is required to fully utilize the unique nature of graphe

128 Additional optimization will be required to further reduce mosaicism to levels that m

129 tween hydrogen bond donor and acceptor atoms is required to gain insight into the molecular mechanism

130 Neither type I nor type II IFNs are required to generate CD122+Macs, however.

131 Field studies are required to generate evidence about UAS lifespan, fa

132 Extensive proliferation is required to generate and maintain inflationary CD8(+)

133 t population of the RNH folding intermediate is required to generate sufficient force to release a st

134 This metabolic reprogramming was required to generate a number of proinflammatory med

135 Patients were required to have a best-corrected visual acuity (BC

136 eneral non-integer and unknown a priori, but is required to hold the potential constant.

137 y address production and environmental goals are required to identify promising sustainable intensifi

138 ng of the inflammatory response to infection is required to identify potential new targets for therap

139 etection of HCC recurrence and its clonality is required to implement salvage therapies appropriately

140 New approaches are required to improve long-term outcomes after PCI.

141 Targeted interventions are required to improve oral health in this vulnerable p

142 urers and staff at shared imaging facilities are required to improve the reporting of experiments tha

143 , fundamental insight at the molecular level is required to improve performance(4,5).

144 ntification of the lethal tumour cell clones is required to improve survival of patients with urothel

145 fundamental research and considerable effort is required to improve the energy density and cycle life

146 ssion, indicating that additional mechanisms are required to increase miRNA biosynthesis.

147 Esophageal dilation might be required to increase luminal patency.

148 and that the NF-kappaB and JAK/STAT pathways are required to induce the expression of this major chem

149 The kinase RIPK3 is required to induce necrotic cell death and is strongl

150 r more responses among 78 evaluable patients were required to infer activity and three or more among

151 chanistic understanding of language recovery is required to inform research into new therapeutic inte

152 amino acid transamination,(11) respectively, were required to initiate the colipterin pathway.

153 anges in chromatin rheology and architecture are required to insulate genetic material from mechanica

154 ed in eki, indicating that the ELIMAKI locus is required to integrate the weight-growth feedback regu

155 osolized chemo applications, further studies are required to investigate pharmacologic, pharmacodynam

156 Further studies are required to investigate the health effects of the in

157 tially explored two bell pepper replicas and were required to judge whether they possessed the same s

158 Appropriate measures are required to keep laboratory staff safe while produci

159 , metabolically-active biofabricated tissues is required to keep them viable.

160 hnicities in different geographic locations, are required to know the precise molecular mechanisms le

161 But what is required to learn a new walking pattern?

162 Importantly, TIDC were required to license the cytotoxic activity of tumor

163 rentially perturbed by cocaine, and BDNF may be required to link D2R to neuroplasticity in cocaine ad

164 rsion of centrioles to centrosomes, but both are required to load Ana1, which is essential for such c

165 Thus, nodal spectrins are required to maintain nodal Na(+) channel clusters an

166 , signal-dependent fluctuations in NS levels are required to maintain normal cell physiology and are

167 creen to identify epigenetic regulators that are required to maintain normal nuclear shape in human b

168 on of ion transport and metabolic plasticity are required to maintain osmotic and protein homeostasis

169 he transcriptional co-activators YAP and TAZ are required to maintain PROX1 expression in LVs and LVV

170 Whether protrusive activity is required to maintain adhesion in confluent sheets of

171 wever, only in late larvae and adults, UNC-3 is required to maintain expression of MN-specific TFs.

172 In addition, DNA replication is required to maintain full Pol II occupancy on viral D

173 of sterol ring and polarity due to -OH group is required to maintain high transfection.

174 utualistic host-microbiota relationship that is required to maintain homeostasis and prevent disease.

175 in many cells, Slc7a5 import of amino acids is required to maintain mTOR activity.

176 Together, our data indicate that NKCC1b is required to maintain neuronal activity-related solute

177 nal domain in the GluN1 subunit of the NMDAR is required to maintain NMDARs at dendritic spine synaps

178 We find that MFSD12 is required to maintain normal levels of cystine-the oxi

179 Here, we show that IL-2 signaling is required to maintain open chromatin at hundreds of ge

180 with the lysosomal protease cathepsin D and is required to maintain proper cathepsin D levels in oli

181 ntrols sensory ion channel localization, and is required to maintain somatosensory function in vivo I

182 The results altogether show that the DDR is required to maintain the balance proliferation differ

183 the gating module of the ER translocase and is required to maintain the ER permeability barrier.

184 t m(6)A methylation-mediated SOCS1 induction is required to maintain the negative feedback control of

185 We show that glycolysis is required to maintain the plasma membrane potential an

186 ogether, our results demonstrate that TDP-43 is required to maintain the protective functions of astr

187 teady-state, since sustained Btnl expression is required to maintain the signature TCR.Vgamma7(+) IEL

188 bstantial suppression of basophil activation was required to maintain long-term clinical tolerance af

189 New methods are required to manage hypertension in resource-poor set

190 ng field in which complex on-chip components are required to manipulate light waves.

191 In HIV-positive patients, 30% higher doses are required to match drug exposure in HIV-negative pati

192 They are required to mediate the DNA replication checkpoint (

193 ctable in asy1 mutants, indicating that ASY1 is required to mediate crossover interference.

194 he distributed signals over large areas that are required to mimic natural touch interactions.

195 t an extended sequencing context of +/- 2 bp is required to more completely capture the patterns of s

196 For 80% power, 109 participants per arm were required to observe a slope reduction in amyloid-be

197 ses two electrons from the coordinated amide are required to occupy a 3c-4e sigma* orbital which is t

198 arterial stiffening prior to this point may be required to offer cognitive benefit in older age.

199 eq, and ChIP-seq analyses reveal that ARID1A is required to open chromatin accessibility on promoters

200 Further investigation is required to optimize model performance and evaluate c

201 al approaches to mobilize antitumor immunity are required to overcome primary and acquired resistance

202 cal condition, case ascertainment strategies are required to overcome reporting stigma.

203 ificant limitations, and alternative methods are required to overcome them.

204 Awardees were required to participate in a cross-site evaluation

205 FM1 is required to perceive echo delay for target ranging; F

206 Moreover, Ror was required to position dsh and Axin in dendrites.

207 suggested different calibration coefficients are required to predict behaviours on land versus foragi

208 dization energetic and magnetic interactions is required to predict the resulting crystal morphology.

209 osynthetic gene clusters, but prioritization is required to predict which gene clusters may yield pro

210 Increased efforts are required to prevent further losses to terrestrial bi

211 The Ca(2+) channel CCH-1 was found to be required to prevent the translocation of PAF26 across

212 To claim that avoidance of animal products is required to prevent chronic disease is not supported

213 irmation of Streptococcus pyogenes infection is required to prevent complications of infection.

214 Therefore, a biochemical gate-keeping step is required to prevent error-prone immature ribosomes fr

215 hat platelet-derived angiopoietin-1 (Angpt1) was required to prevent neutrophil-induced leaks.

216 ir acidic pH inside the granule lumen, which is required to process precursors of granzymes and perfo

217 it remains unclear which genes and proteins are required to produce this complex adaptation.

218 the remarkable ring expansion reaction that is required to produce the distinct carbon scaffold of c

219 Furthermore, co-production of PRXQ with FAD4 was required to produce Delta3-desaturated FAs in yeast.

220 nd establish that the ATPase domain of HELLS is required to promote DSB repair.

221 t-unidentified nonsecreted cell wall protein is required to promote the early epithelial transmigrati

222 4, only the interaction with alpha-actinin 4 is required to promote tumor cell invasion.

223 The Zalpha2 domain of ZBP1 was required to promote this inflammasome activation and

224 Th17 cells were required to promote depressive-like behaviors by AI

225 However, further research is required to prospectively investigate this and whethe

226 Innovative solutions are required to provide mental health support at scale i

227 More work is required to pull slowly ejecting proteins out of the

228 chastic, ensembles of meso-scale simulations are required to quantify hot spot ignition and growth an

229 Longitudinal data are required to quantify the implied risk of vision loss

230 Both high resolution and high precision are required to quantitatively determine the atomic stru

231 e light and a low-red to far-red light ratio are required to rapidly enhance phototropism in Arabidop

232 ial and structural barriers to HIV care will be required to reach national targets of the ending the

233 al new patient visits per day (295 per year) were required to recover scribe costs (range, 0.89 [card

234 We further show that PDS5 proteins are required to recruit WRN helicase-interacting protein

235 n BBSome reveal that a conformational change is required to recruit the complex to the ciliary membra

236 Both receptors are required to reduce flees from females and either AR

237 r-energy imaging tracers such as (18)F-PSMA, is required to reduce false-positives.

238 the diffusive half-time, i.e., the time that is required to reduce the amount of protein in the budde

239 g demands; therefore, an attention mechanism is required to regulate limited cellular metabolism leve

240 That parallel pathways are required to release the vacuole from Myo2 suggests t

241 Novel biotechnologies are required to remediate iron ore mines and address the

242 They found that UAP56 helicase activity is required to remove R loops formed from different sour

243 mber 31, 2017 in the 9 states where surgeons were required to report postoperative visits.

244 , new mathematical and computational methods are required to represent and analyze gene-expression ch

245 of CrI(3) but quantum rescaling corrections are required to reproduce its thermal properties.

246 by cancer cells, and show that this pathway is required to resist cytotoxicity induced by the cytoki

247 GluA2-lacking AMPARs or ryanodine receptors, was required to restore robust LTP.

248 ytes, localizes to perisynaptic contacts and is required to restrict neuropil infiltration by astrocy

249 y organizations interested in women's health is required to reverse these trends.

250 rometry (MS)-based proteogenomics approaches are required to robustly identify these non-canonical pe

251 ke up to 2 d to complete, serial testing may be required to rule out the possibility of false negativ

252 Immediate action is required to safeguard the future of the world's most

253 blue-Off system-far in excess of what would be required to satisfy traditional models of color visio

254 owing far from carrying capacity, a cost may be required to see meaningful gains.

255 In sum, Btnl proteins are required to select and to maintain the phenotypes of

256 e two phases (and not merely being together) is required to selectively hydrogenate CO(2) to methanol

257 Increasingly patients are required to self-manage their care but patient adher

258 N-methyl-D-aspartate receptors (NMDARs) are required to shape activity-dependent connections in

259 nd that only one technology, DNA sequencing, is required to simultaneously read the key and the data.

260 ind that SMTNL2 binds to actin filaments and is required to slow down the turnover of apical actin.

261 Here, we show that notch signaling is required to specify and expand the mTEC lineage.

262 Recurrent connections are required to stabilize cortical odor representations

263 f DNA polymerase epsilon and show that POL2A is required to stabilize heterochromatin silencing genom

264 Additional studies are required to strengthen these recommendations.

265 igns across the range of allergic conditions is required to strengthen the evidence base.

266 However, the DNA vaccine is required to strongly upregulate several genes involve

267 ve bioanalysis in plasma and tissues samples is required to study the pharmacokinetic and pharmacodyn

268 advanced engineering and programming skills are required to successfully implement this protocol.

269 Host-encoded ANP32A proteins are required to support influenza A virus polymerase act

270 data show that increased glucose consumption is required to support aspartate synthesis that drives t

271 , confirming that contaminating phospholipid is required to support myosin-related prothrombinase act

272 stinctive function of Elp1 as a protein that is required to sustain NGF signaling by blocking the act

273 ed for initiating transcription in vitro but is required to synthesize a full-length product.

274 ents of the evolving magnetic field strength are required to test this.

275 encing, suggesting that active transcription is required to tether SPEN to chromatin.

276 MRX is required to tether transcriptionally active loci to t

277 gmas, five MAPK kinases (MKKs), MKK1/2/3/7/9 are required to transmit upstream signals to two MPKs, M

278 cial role of actomyosin contractility, which is required to trigger the instability, and illustrate h

279 to upregulate the STAT3 target Socs3, which is required to turn off IFNAR signaling.

280 Additionally, a food signal is required to turn on TRA-1 expression in the intestine

281 vivo, the condensate-forming region of Lge1 is required to ubiquitinate H2B in gene bodies beyond th

282 At the patient level (T2), research efforts are required to understand how foundational evidence imp

283 However, further aeromycology studies are required to understand the dynamics of fungal disper

284 Additional investigations are required to understand the exercise-induced changes

285 Further studies are required to understand the pathophysiology, response

286 ls without perturbing their folding dynamics are required to understand their biological roles in gre

287 Further research will be required to understand better how a cognitive map of

288 Interdisciplinary research is required to understand educational-setting-specific i

289 ngle antiplatelet therapy, and further study is required to understand how this affects postintervent

290 tematic analysis of its afferent projections is required to understand its connectivity and modulator

291 Longer follow-up is required to understand the clinical implications of t

292 nt of high-resolution thermometry techniques is required to understand the heat dissipation processes

293 Further work is required to understand the intrapulmonary pharmacokin

294 Characterizing RGC diversity is required to understand the logic of the underlying fu

295 Further work is required to understand the mechanism of increased thr

296 tivity between abDGCs and local interneurons is required to understand their development and integrat

297 Minimal experience in coding is required to utilize the script.

298 Prospective studies are required to validate biomarkers.

299 Larger in vivo research cohorts are required to validate these findings.

300 at promise, but further prospective research is required to validate the use of this technique to pro