ライフサイエンスコーパス: be responsive to

1 CAR scaffold, we generated CAR T-cells that are responsive to a hypoxic environment, a hallmark of c

2 These parallel-acting cis-regulatory modules are responsive to a multitude of distinct trans-acting f

3 These nerves are responsive to a variety of modalities of noxious sti

4 GABA(A) receptors are responsive to a wide variety of drugs, e.g. benzodia

5 tivatable magnetic resonance (MR) probe that is responsive to a key biochemical process associated wi

6 of development and regeneration events, and is responsive to a range of dynamic environmental cues.

7 istance to PLX4720, the KIAA1549-BRAF fusion is responsive to a second-generation selective BRAF inhi

8 d a seven-transmembrane helix framework that is responsive to a wide range of extracellular signals.

9 rsal anterior cingulate cortex (dACC) region is responsive to a wide variety of stimuli and psycholog

10 a spike frequency around 2 Hz. vGluT2 cells were responsive to a number of neuropeptides related to

11 Arabidopsis hydathode pores were responsive to ABA and light similar to stomata.

12 Stomatal kinetics were responsive to ABA in fern.

13 Hormone metabolites were responsive to ABA, with generally greater responsiv

14 ects during evoked migraine, and the symptom is responsive to abortive triptan treatments.

15 me soybean genes with upstream ABRE elements were responsive to abscisic acid treatment.

16 (DR) are integral to threat prediction, and are responsive to acute stressors.

17 e demonstrate that the human plasma proteome is responsive to acute exercise in an intensity-dependen

18 The compound is responsive to Aflatoxin B1 at parts per billion level

19 from lower level sensory area MT+/V5, which is responsive to all motion, to higher-order posterior s

20 al processes, because both enzymes appear to be responsive to alterations in glucose metabolized via

21 sim1a expression domain in renal progenitors is responsive to altered levels of RA, suggesting that R

22 re viable, retain their round morphology and are responsive to an in vitro physiological loading regi

23 one miRNA (miR-218) tracked with MN loss and was responsive to an ALS therapy in rodent models.

24 that affect whether MGUS plasma cell clones are responsive to anti-multiple myeloma therapy.

25 In addition, this pathway might indirectly be responsive to anti-inflammatory agents.

26 In addition, both MIR156 and SPLs are responsive to auxin signaling suggesting that miR156

27 its affinity for SRA at positions where they were responsive to base flipping, illustrating their pro

28 d directly represses 92 genes, many of which are responsive to biotic and abiotic stimuli, including

29 ws organ-specific expression, whereas others are responsive to biotic and/or abiotic stresses.

30 These highly versatile particles are responsive to both electric and magnetic fields for

31 th a different regulator, allowing the CP to be responsive to both RPs simultaneously.

32 a self-assembling rotaxane-type system that is responsive to both optical (UV-vis light) and chemica

33 ting of a hydrophilic block and a block that is responsive to both pressure and temperature, is intro

34 y was transient at warmer locations, and GPP was responsive to both winter and summer precipitation s

35 We found 83% of neurons (n = 236) were responsive to both the unimanual and bimanual loads

36 Although most differentially used exons were responsive to both U2AF subunits and their inclusio

37 The sensor is responsive to BPA down to femto molar levels, but not

38 Moreover, recruitment of Elm1 is responsive to bud emergence.

39 uble knock-out mice (WT MEF and DKO MEF that were responsive to C12, DKOR MEF): nuclei fragmented; mi

40 The multiplex cadmium biosensors were responsive to cadmium concentrations ranging from 0

41 ies to create a robust molecular switch that is responsive to calcium concentrations associated with

42 CRP/FNR family transcription factor known to be responsive to cAMP levels and during macrophage infec

43 PhoQ(W104C-A128C) is responsive to CAMP, but is inhibited for activation b

44 ructural modeling and functional analysis to be responsive to carbamazepine, was assessed in a double

45 vasopressin and non-vasopressin neurons that are responsive to cardiovascular dysregulation, but it i

46 Because the Notch receptor pathway is responsive to cell-cell contact and regulates keratin

47 on of RPO_DmdB1, suggesting that this enzyme was responsive to cellular energy charge.

48 Successive POEM scores were found to be responsive to change in eczema severity.

49 The COPD Assessment Test (CAT) is responsive to change in patients with chronic obstruc

50 Eczema Measure as applied to young children is responsive to change, and the MCID is around 3.

51 The ADYC was responsive to change between 2 consecutive days (Guy

52 The reduced scale was responsive to change, and a minimally important diff

53 s, uncoupled respiration, and lipolysis that are responsive to changes in cyclic AMP (cAMP)-dependent

54 ar pathways that control aPKC and those that are responsive to changes in its catalytic activity.

55 modulators' upstream of the modifiers, which are responsive to changes in the cellular environment an

56 idge between halogen bond donor and acceptor are responsive to changes in the identity of the halogen

57 The results demonstrate that steroid levels are responsive to changes in the social environment, and

58 ing devices, this structure is not fixed but is responsive to changes in electrochemical potential, i

59 he assembly of the TTT-Pontin/Reptin complex is responsive to changes in energy status.

60 observations suggest that the placental RAS is responsive to changes in tissue oxygenation: this cou

61 ASSESS was responsive to changes in quality of life with a mini

62 onnaire for mechanically ventilated patients was responsive to changes in treatment modalities (trach

63 indings by demonstrating that human behavior is responsive to changing hierarchical structures and su

64 the complete set of innate immune TLR genes are responsive to chromosomal stress and the transcripti

65 the abundance of selected marker transcripts is responsive to citrate and not downstream metabolites.

66 which is a globally important pool of C that is responsive to climate change.

67 tor phenotype-positive hindbrain ependymomas are responsive to clinical drugs that target either DNA

68 e that several pathways in various organisms are responsive to CO(2) elevation (hypercapnia), it has

69 nd that vernal and northern European species are responsive to cold temperatures in the previous autu

70 r HCT, patients must have HIV infection that is responsive to combination antiretroviral therapy (cAR

71 Senescence is responsive to communication between sources and sinks

72 ndrocytes were detected in the adult CNS and were responsive to complex motor learning.

73 these T cells remained completely viable and were responsive to consecutive activation signals on sub

74 ilic inflammation caused by type 2 cytokines is responsive to corticosteroid and biologic therapies,

75 be due to an autoimmune-like hepatitis that is responsive to corticosteroid therapy.

76 r months after intraocular surgery which may be responsive to corticosteroids, but recur upon taperin

77 More transcripts were responsive to Cr(VI) during long-term exposure (24

78 This finely tuned system is responsive to developmental and physiological cues, a

79 ndance of lactose-metabolizing bacteria that were responsive to dietary adaptation to GOS.

80 entify two parallel visuomotor circuits that are responsive to different components of visual stimuli

81 rs in a variety of ways, with the polymerase being responsive to different inputs.

82 MR biomarkers are responsive to disease progression in 5- to 12.9-year

83 cific cellular gene expression programs that are responsive to distinct CTD cues.

84 New decision aids should be designed that are responsive to diverse philosophical perspectives and

85 hypertrophy and that myofiber transcription is responsive to DNA content but uncoupled from cell siz

86 contractions, generate mechanical force and are responsive to drugs.

87 lds, light, and ultrasound (US), or can even be responsive to dual or multi-combinations of different

88 f intercellular adhesion require that the AJ be responsive to dynamic changes in force while maintain

89 malian brain and in specific subregions that are responsive to E2, including the hippocampus.

90 est care and outcomes, these new initiatives are responsive to each of the IOM recommendations and de

91 gical functions or defense mechanisms, which are responsive to ecotoxicological challenges.

92 nd to increase with substrate stiffness, but was responsive to EGF treatment only above a stiffness t

93 factor receptor (EGFR) identify tumors that are responsive to EGFR tyrosine kinase inhibitors (TKI),

94 applications such as molecular devices that are responsive to electrons or current.

95 itical time-window when centriole trajectory was responsive to Emx2.

96 the Vbeta5(+) Treg subset, which is known to be responsive to endogenous retrovirus-encoded superanti

97 genetic mechanisms, such as DNA methylation, are responsive to environmental influences and have long

98 that MED12 tends to interact with genes that are responsive to environmental stimuli, including light

99 n the bone marrow are not static but instead are responsive to environmental stimuli.

100 ng of short-distance migrants is believed to be responsive to environmental changes primarily under e

101 The circadian system is responsive to environmental change 1749 II.

102 ated that the DNA binding specificity of Rgg is responsive to environmental changes in a LacD.1-depen

103 lts indicate that chloroplast protein import is responsive to environmental cues, enabling dynamic re

104 We also demonstrate that SH2B1 is responsive to EPO stimulation and becomes phosphoryla

105 osplenial cortex, and parahippocampal cortex were responsive to Euclidean distance from home.

106 ncatula seedlings is a multigenic trait that is responsive to exogenous nitrate.

107 The specific endpoints that were responsive to exposure in each generation varied, b

108 nus-like supramolecular fusion proteins that are responsive to external stimuli.

109 ctive strategy, but only for individuals who were responsive to extinction.

110 SV infection in STAT2 knockout (KO) hamsters is responsive to favipiravir treatment, which protected

111 Wnt signaling demonstrated that 'ring' genes are responsive to FGF signaling at the dorsal midline, w

112 and basophils from the C57BL/6J mouse strain were responsive to fluvastatin, those from 129/SvImJ mic

113 expression of SCF and Kit in adipose tissues is responsive to food availability and environmental tem

114 We show that ChIP-seq genomic loci are responsive to FOXM1 using a real-time luciferase ass

115 that were associated with the patients that were responsive to FSH therapy versus those that were no

116 Many genes are responsive to FUS3 and to VAL1/VAL2 but with opposit

117 th a high-titer type 2 anti-A2 inhibitor who is responsive to fVIII is reported.

118 tely estimate individual age within species, is responsive to genetic and environmental interventions

119 of nonneuroendocrine TH, TRH and CRH neurons were responsive to GH in the PVH of Fluoro-Gold-injected

120 rosine hydroxylase (TH) cells, respectively, were responsive to GH in the PVH.

121 e of the ternary PPP1R15-PP1-G-actin complex was responsive to global changes in the polymeric status

122 ssion is high in the muscle, and is known to be responsive to glucocorticoid, a class of anti-inflamm

123 g regions (GBRs) in the mouse PPARgamma gene were responsive to glucocorticoid, and treatment of 3T3-

124 Protein O-GlcNAcylation is responsive to glucose and flux through the hexosamine

125 expression, indicating that NOTCH1 signaling is responsive to GSIs during active disease.

126 entially in the same respective tissues that were responsive to GSPE.

127 Producing macrocyclic mesogens that are responsive to guest encapsulation presents a signifi

128 n by the Hda-beta clamp complex in vitro but are responsive to hda expression in vivo.

129 dicate that several acetylation sites in tau are responsive to HDAC6 and that acetylation on Lys-321

130 pression of AtERF53 in wild-type Arabidopsis was responsive to heat and abscisic acid (ABA) treatment

131 nd promoter (P (mer) ), located within merR, is responsive to Hg(II).

132 codes (i.e. models predicting whether a gene is responsive to high salinity for each cell type with m

133 d HSV-2 express stress hormone receptors and are responsive to hormone fluctuations.

134 Expression of many plant microRNAs is responsive to hormones and environmental stimuli, but

135 erol pathways, either beneficial or harmful, are responsive to HPbetaCD.

136 tifier (SKOR) channel has been identified as being responsive to hydrogen peroxide.

137 ngs demonstrate the majority of OVLT neurons are responsive to hypertonic NaCl or mannitol.

138 Unlike NP cells, TonEBP targets were responsive to hypoosmolarity in wild-type MEFs, and

139 Noteworthy, none of the TonEBP target genes were responsive to hypoosmotic stimulus in control and I

140 We find that Ixodes ticks are responsive to IFNgamma acquired in a blood meal from

141 Many neurons in the entorhinal cortex were responsive to image onset, showing large deviations

142 sociated with PDGFRA and PDGFRB fusion genes are responsive to imatinib.

143 have a component of immune mediation and has been responsive to immune-based therapies; in addition t

144 Tumors with defective mismatch repair (dMMR) are responsive to immunotherapy because of dMMR-induced

145 Several tumour types are responsive to immunotherapy, as shown by regulatory

146 t, but because only a percentage of patients are responsive to immunotherapy, it is imperative to ide

147 nonparaneoplastic form of encephalitis that is responsive to immunotherapy.

148 neurons altered the mixture of actions they were responsive to in different contexts or sequences.

149 positive" and "default-mode network" (DMN)] are responsive to increasing task difficulty.

150 ther cellular translation elongation factors are responsive to inflammation and infection remains poo

151 Finally, we demonstrate that ACE2 expression is responsive to inflammatory signaling and can be upreg

152 We identify genes that are responsive to influenza A viruses using the lung tra

153 le we have previously shown that GRbeta mRNA is responsive to insulin, the role of GRbeta in insulin

154 we find that endothelial cell contractility is responsive to interactions with metastatic cancer cel

155 h primarily measures inner retinal function, is responsive to intervention and may be a useful clinic

156 These findings indicate that AphB is responsive to intracellular pH as well as to anaerobi

157 Four of 48 patients with disease known to be responsive to irinotecan achieved partial response.

158 mized one of these NPs so that its stability is responsive to its redox environment.

159 ectal carcinoma with kinase fusions that may be responsive to kinase inhibitors.See related commentar

160 ectal carcinoma with kinase fusions that may be responsive to kinase inhibitors.Significance: A high

161 tNAA and tCr levels are responsive to L-DOPA therapy.

162 er day with predictable morning off periods, were responsive to levodopa, and were on stable doses of

163 , and an IRE1alpha mutant whose RNase domain is responsive to ligands that bind the kinase domain for

164 Importantly, 64% of these SDG8 targets are responsive to light and/or carbon signals.

165 miR-27b is responsive to lipid levels and controls multiple gene

166 is a liver-brain counterregulatory axis that is responsive to liver glycogen content.

167 Hematopoietic stem cells (HSC) are responsive to local signals from their niche and to

168 , systems science helps ensure that research is responsive to local priorities and reflect real-world

169 Neither naive CD4 nor naive CD8 T cells are responsive to low doses of IL-2.

170 In contrast, mild-moderate asthma (MMA) is responsive to low doses of inhaled CS, indicating tha

171 showed that twelve of the lettuce CBF genes were responsive to low temperature (4 degrees C), and th

172 hough both clustering and the RNase activity are responsive to luminal stress conditions and to deple

173 y tested a sensory neuro-immune circuit that is responsive to lymph-borne inflammatory signals.

174 ed to luciferase reporters and were found to be responsive to many P-TEFb-releasing compounds.

175 n cells that the K(+) channel TRAAK (K2P4.1) is responsive to mechanical forces similar to the ion ch

176 -kappaB, and support the idea that NF-kappaB is responsive to mechanical stimuli.

177 ssociated with Epstein-Barr virus (EBV), and is responsive to minimal therapy.(1) Might this represen

178 Immature langerin(high) MDLCs were responsive to MIP-3beta/CCL20 and CTAC/CCL27 chemok

179 regulators of hepatic lipid metabolism that are responsive to miR-122 inhibition.

180 ter portions of the choroid do not appear to be responsive to modest positional or hydrostatic pressu

181 lves problematic neuroadaptations that might be responsive to modulation of glutamatergic circuits.

182 rrent architectures, we discuss systems that are responsive to more than one stimulus, to finally enc

183 n and among plant populations, and appear to be responsive to multi-generational environmental stress

184 lications of stretchable living sensors that are responsive to multiple chemicals in a variety of for

185 dentify patients with alcohol dependence who are responsive to naltrexone.

186 by these C. elegans and Drosophila channels are responsive to NAM, suggesting conservation of activi

187 These results reveal that KRAS G13D is responsive to neurofibromin-stimulated hydrolysis and

188 ctivates EcR.B2 to prime mature follicles to be responsive to neuronal ovulatory stimuli, thus provid

189 F4B) to control translation in a manner that is responsive to neuronal activity.

190 s present study was to identify targets that are responsive to NFkB when p120ctn and EGFR are modifie

191 Children who are responsive to NIV will usually show improvement in t

192 eurons containing cholecystokinin (CCK(NTS)) is responsive to nutritional state and that their activa

193 table probe for photoacoustic imaging, which is responsive to one of the major and abundant reactive

194 it is possible that the AmoC(3) subunit may be responsive to other membrane stressors (e.g., solvent

195 omains in inferior temporal (IT) cortex that are responsive to particular image categories.

196 omains in inferior temporal (IT) cortex that are responsive to particular image categories.

197 ntial to develop research interventions that are responsive to patient and provider preferences.

198 Furthermore, Foxn1 expression is responsive to perturbations.

199 These novel MNPs can be tailored to be responsive to pH variations, redox potential, enzymat

200 Osteosarcoma cell lines are responsive to pharmacologic and genetic inhibition o

201 range of action potential morphologies that are responsive to pharmacological stimulation.

202 Furthermore, they were responsive to pharmacological treatments with the G

203 "Smart" biomaterials that are responsive to physiological or biochemical stimuli h

204 via the use of urea and that these channels were responsive to physiological concentrations of ligan

205 t manner; however, in vivo Thpo serum levels are responsive to platelet mass rather than HSC demands,

206 sponded to both SA and PM, but certain genes were responsive to PM infection alone.

207 Frizzled and Wnt/beta-catenin signaling and were responsive to porcupine (PORCN) inhibition in vivo,

208 Animals are responsive to predation risk, often seeking safer ha

209 We predict that this assemblage will be responsive to projected increases in temperature and

210 t that the vast C bank at depth in peatlands is responsive to prolonged warming.

211 l response, indicating that some G3 NENs can be responsive to PRRT.

212 Specifically, whereas subclone 4 is responsive to PTH stimulation and capable of matrix m

213 To test whether MET in HPCs was responsive to purely physical mechanical cues, we mi

214 Patients were responsive to pyridostigimine alone or combined wit

215 RNase A) function and develop a protein that is responsive to reactive oxygen species (ROS) for targe

216 he measured delta(18) O(cell) along the ring was responsive to RH variations in both treatments.

217 e found that tonsil but not blood leukocytes were responsive to S1P gradients, suggesting that T cell

218 ermore, a large number of soybean WRKY genes were responsive to salicylic acid.

219 To establish which RSA parameters are responsive to salt stress, we performed a detailed t

220 ), and that three and six of them could also be responsive to salt and heat stresses, respectively.

221 lity distributions, chromatic actuators that are responsive to selected wavelength ranges are achieve

222 e that mouse models of neuroendocrine cancer are responsive to selective Cdk5 inhibitors and biomimet

223 Whether this model is responsive to selective serotonin reuptake inhibitors

224 All three genes were shown to be responsive to senescence-inducing stimuli and posttra

225 he results presented here show that AtWRKY30 is responsive to several stress conditions either from a

226 Here we show that endothelial NOTCH1 is responsive to shear stress, and is necessary for the

227 Rats are responsive to shock from an early age, but eyeblink

228 lts suggest that resistance to ciprofloxacin is responsive to short-term variation in antimicrobial u

229 relevant biomarkers including CMAP and MUNE are responsive to SMN restoration, and abrogation of phe

230 ated that SHH-MBs harboring a PTCH1 mutation were responsive to SMO inhibition, whereas tumors harbor

231 Progenitors of these interneurons are responsive to sonic hedgehog and are organized into

232 y cells in the medial entorhinal cortex that are responsive to space.

233 rigeminovascular neurons sample neurons that are responsive to stimulation of dural areas in the ante

234 rdings we show that neurons in the mouse SCN are responsive to stimuli with these characteristics, tr

235 ay between TF mobility and RNA bursting that is responsive to stimuli strength, type, modality, and d

236 ues, we found that model configurations that were responsive to stimuli and demonstrated significant

237 eins and a substantial number of their genes are responsive to stress-associated phytohormones.

238 icate that leaky scanning like re-initiation is responsive to stress conditions and that leaky scanni

239 methylenetetrahydrofolate reductase (MTHFR) was responsive to supplementation with riboflavin-the co

240 The DQ score was responsive to surgery with a mean change of 51 +/- 3

241 (+)CD4(+)) and show that this group of cells is responsive to sustained nicotine exposure.

242 Furthermore, transplanted HIO-derived tissue was responsive to systemic signals from the host mouse f

243 tumors often carry genetic alterations that are responsive to targeted therapy.

244 - and HPV-18-transformed cells were found to be responsive to targeted HPV genome-specific DNA cleava

245 euronal injury in the disease course and may be responsive to tau phosphorylation in the brain throug

246 Plants are responsive to temperature, and some species can dist

247 demonstrate that lung tumor-associated pDCs are responsive to the activation of AIM2 that promotes c

248 ed to identify transcriptional networks that are responsive to the conserved secretogranin II-derived

249 g let-7f-5p and miR-181a-5p) and 4 tRNA that are responsive to the dynamics of prior stress experienc

250 which convert 5-methylcytosine (5mC) to 5hmC are responsive to the presence of Abeta.

251 eporter gene expression in Schwann cells and are responsive to the transcription factor SOX10, which

252 verload revealed signaling networks that may be responsive to the endogenous decreases in miR-133a du

253 erived from 307 distinct genes were found to be responsive to the levels of the splicing factors PTB1

254 conceptualised as a cyclical process, which is responsive to the context and allows for continuous i

255 The analysis shows that people's behavior is responsive to the cost of self-protection, the report

256 We show that the coronal layer structure is responsive to the dielectric constant of the medium a

257 d, indicating that QS-dependent colonization is responsive to the intrinsic conditions within the hos

258 This trade-off is responsive to the levels of dietary carbohydrates and

259 ly in a closed system, and its concentration is responsive to the rate of fuel supply.

260 We show that the topology of the aggregate is responsive to the solvent in which the assembly takes

261 ssion of another ARS-associated gene, pitx2, was responsive to the estimated level of wild-type Foxc1

262 these differences, ventral hippocampal theta was responsive to the navigation task; theta frequency,

263 PeMYB11 was responsive to the red spots in the callus of the lip

264 We found that a subset of vCA1 neurons were responsive to the aversive shock during context con

265 Notably, although sO(2) readings were responsive to the challenge, deoxyhemoglobin (HbR)

266 9 cells that, in contrast to the MDCK cells, were responsive to the internalin domain alone.

267 east cancer samples, only ER-ve mammospheres were responsive to the ligand Wnt3a.

268 d evidence for unconventional receptors that were responsive to the nAChR agonists 1-dimethyl-4-pheny

269 young and aged mice, suggesting old animals were responsive to the reprogramming scheme.

270 Finally, we found that mice with PSD were responsive to the tri-cyclic antidepressant imipram

271 and powered catalytic micro/nanomotors that are responsive to their surrounding environment.

272 CN patients are responsive to therapeutically high doses of G-CSF an

273 of metabolism, since many of these disorders are responsive to therapy that targets pathophysiologica

274 Similarly, the THI4 gene is responsive to thiazole.

275 emarkable results, although not all patients are responsive to this therapy.

276 These atypical NK cells are responsive to TLR stimulation and thus are most abun

277 gnant of all primary brain tumors in adults, is responsive to TOP2 poisons.

278 ut intervention, and subsequent mild uveitis was responsive to topical corticosteroids.

279 The ocular hypertension was responsive to topical medicines.

280 control of the AlcA:AlcR gene switch, which is responsive to trace levels of ethanol.

281 we demonstrate that differentiated TH1 cells are responsive to trans-presented IL-15.

282 Notably, we found that ceRNA networks are responsive to transcription factor up-regulation or

283 -derived mediators in biological fluids, and are responsive to treatment with mast cell-stabilizing o

284 The measure is responsive to treatment and discriminates the severit

285 of individuals with truncating variants and was responsive to treatment with anti-epileptic medicati

286 y increased at exacerbations (P = 0.001) and was responsive to treatment with antibiotics.

287 all depends on the intraluminal pressure and was responsive to treatment with phenylephrine (PE) (10(

288 al growth factor intravitreal injections and were responsive to treatment.

289 aineurs, whose symptoms of cranial allodynia are responsive to triptan treatment.

290 Nano-formulations that are responsive to tumour-related and externally-applied

291 Plants are responsive to UV-B via the UVR8 photoreceptor.

292 is growing interest in creating solids that are responsive to various stimuli.

293 In addition, ToxR is thought to be responsive to various environmental cues, such as bil

294 bly, we found that both miR-10b and miR-196b are responsive to vascular endothelial growth factor sti

295 e (nt) vsRNAs, whereas an additional pathway is responsive to viral mRNA derived from segment 10.

296 result from strong local electric field and are responsive to visible and near-IR light.

297 "usual drug resistance" phenotype that will be responsive to widely registered standard-of-care comp

298 r, the cell types within the cerebellum that are responsive to WNT signaling remain unknown.

299 urce and a protein-translation rheostat that is responsive to WNT and suggest that manipulation of th

300 ells, a subset of cochlear supporting cells, were responsive to Wnt signaling.