ライフサイエンスコーパス: be severely compromised

1 develop and function normally, gametogenesis is severely compromised.

2 formation of astrocytes in the white matter is severely compromised.

3 f sister chromatids within these chromosomes is severely compromised.

4 on factor broad), the encapsulation response is severely compromised.

5 lasia, in which steroid hormone biosynthesis is severely compromised.

6 ny embryonic structures, including the limb, is severely compromised.

7 one deacetylase activity of the core complex is severely compromised.

8 and/or survival of the differentiated cells is severely compromised.

9 galitarian, Dynein transport into the oocyte is severely compromised.

10 nic elongation fails, junctional recruitment is severely compromised.

11 application in pharmaceuticals and cosmetics is severely compromised.

12 cluster, and GABAergic synaptic transmission is severely compromised.

13 gc-1(c) pups, indicating that erythropoiesis is severely compromised.

14 a mutant's ability to cause invasive disease is severely compromised.

15 5750 to a preformed enzyme-substrate complex is severely compromised.

16 sensitized, but development of T-cell memory is severely compromised.

17 t pollen, indicating that chx21 chx23 pollen is severely compromised.

18 In contrast, Hsp40 interaction is severely compromised.

19 ed under conditions where global translation is severely compromised.

20 ATP hydrolysis and helicase II stimulation, are severely compromised.

21 ut that their subunit association properties are severely compromised.

22 ompetence and infectivity of nascent virions are severely compromised.

23 ditions where the dynamics of thermal motion are severely compromised.

24 lt, cardiomyocyte respiration and ATP output are severely compromised.

25 genesis in which the body's immune functions are severely compromised.

26 ive cell migration and 3D spheroid formation are severely compromised.

27 ll as embryonic and postembryonic patterning are severely compromised.

28 bs with dynamic cytoskeletal properties that are severely compromised.

29 ests that one or more key cellular processes are severely compromised.

30 deficient allele, however, allelic exclusion was severely compromised.

31 the competitive fitness of peripheral Tregs was severely compromised.

32 e/+) SRC-2(flox/flox) mouse uterine function was severely compromised.

33 atically disrupted and keratinocyte adhesion was severely compromised.

34 its ability to cause plant tissue maceration was severely compromised.

35 lular Ca(2+) ([Ca(2+)](o)), but its function was severely compromised.

36 ondividing cells, and plaque-forming ability was severely compromised.

37 o grow within this macrophage-like cell line was severely compromised.

38 duced epidermal fluorescence 3, plant growth was severely compromised.

39 duced and the physical condition of the cows was severely compromised.

40 lular metabolic substrates, NADPH generation was severely compromised.

41 to Apc(+/DeltaIEC) mice, and their survival was severely compromised.

42 of virulence proteins in the hha sepB mutant was severely compromised.

43 in low-inorganic-phosphate (P(i)) conditions was severely compromised.

44 d and that from alpha-granules and lysosomes was severely compromised.

45 cell subsets or even when TH2 cell functions were severely compromised.

46 ever, hair cycle and wound healing processes were severely compromised.

47 me mice, virus-specific CD4 T cell responses were severely compromised.

48 rough 24 weeks, even though immune functions were severely compromised.

49 e outgrowth from mutant midbrain progenitors were severely compromised.

50 sphingolipids, and their lysosomal functions were severely compromised.

51 arization of antigen-specific CD4(+) T cells were severely compromised after treatment with a soluble

52 e capacity to form stable end-on attachments was severely compromised, all kinetochores nevertheless

53 c analyses demonstrate that the R303M mutant is severely compromised, although active, with k(cat) =

54 ses of CD40L-deficient mice to these viruses were severely compromised, although moderate titres of a

55 n, an assembly factor for MO15 and cyclin H) are severely compromised and display a significant furth

56 In disease states in which liver function is severely compromised and both zinc and vitamin A meta

57 epsilon-deficient cells, PER phosphorylation is severely compromised and nonrhythmic, and the PER pro

58 gest that neuronal mitochondrial respiration is severely compromised and there is a compensatory swit

59 and nuclear export of influenza virus M mRNA were severely compromised and caused a disruption in the

60 llowing a period of disuse, yet mobility may be severely compromised, and recovery is commonly delaye

61 Photoautotrophic growth of the double mutant is severely compromised, and its photosynthetic capacity

62 uced, but cell adhesion to ICAM-1 and ICAM-2 is severely compromised, and Jbeta2.7 cells expressing R

63 in primary cultures, induction of astrocytes was severely compromised, and the few astrocytes generat

64 es demonstrated that cytochrome b6f function was severely compromised, and the levels of transcripts

65 a/Pf4Delta) Mcl-1(Pf4Delta/Pf4Delta) embryos was severely compromised, and these animals exhibited ec

66 the function of proteins modified by HNE can be severely compromised as previously demonstrated for g

67 ncreasing mechanical demands, heart function is severely compromised as evidenced by the onset of car

68 lopment of long-term tumor immunity (memory) was severely compromised as reflected by diminished CD8

69 ine phosphorylation and calcium mobilization were severely compromised, as seen in Lyn-deficient cell

70 vered a regime in which E. coli NO. defenses were severely compromised, as well as conditions that ex

71 thologs, including the widely used LbCas12a, is severely compromised at temperatures below 37 degrees

72 could occur, but viability of these embryos was severely compromised at an early stage of developmen

73 ionally deficient mice after phenylhydrazine is severely compromised because of their inability to mo

74 l stem cells (NSCs) after spinal cord injury is severely compromised because the hostile niche at the

75 bacteria, but Cox17-mediated copper transfer was severely compromised both in vitro and in a yeast cy

76 es where a resin's vibrational signature has been severely compromised, both the Raman and infrared b

77 orebrain-specific deletion of LMO4 (LMO4 KO) was severely compromised but could be restored by single

78 P1 and RP2 respectively, the kinase reaction was severely compromised but phosphotransferase activity

79 y of the NAM protection network is likely to be severely compromised by a changing climate.

80 of amyloid inhibition by these compounds can be severely compromised by background signals and compet

81 erties measured on as-prepared nanotubes may be severely compromised by extrinsic air exposure effect

82 In chemical gas sensors odor recognition can be severely compromised by poor signal stability, partic

83 er activation when the TcpP-binding site has been severely compromised by mutation.

84 ey clinical therapy, their effectiveness has been severely compromised by the development of drug res

85 nufacturing (AM) of structural materials-has been severely compromised by their disappointing fatigue

86 We suggest that stony coral resilience is severely compromised by chronic environmental disturb

87 In utero parthenote development is severely compromised by defective organogenesis and i

88 r efficacy against M. abscessus lung disease is severely compromised by intrabacterial ADP-ribosylati

89 Pregnancy outcome is severely compromised by intrauterine infections and i

90 partner of the myogenic regulatory factors, is severely compromised by MEKK1-initiated signaling.

91 repair in human adult articular chondrocytes is severely compromised by minimal exposure to bFGF beca

92 Hippocampal function is severely compromised by prolonged, uncontrollable str

93 erved, suggesting that nuclear import of PIC was severely compromised by GRL-142.

94 5) by an independent HHCC domain (Cdelta232) was severely compromised by NEM modification of either s

95 f plo1(+) overexpression to induce septation was severely compromised by SIN inactivation.

96 Teeth were severely compromised by the presence of CAL loss of

97 ficient (NPCD) cells, wherein these pathways are severely compromised, causing massive accumulation o

98 rom mastocytosis patients during anaphylaxis is severely compromised compared to DAO from pregnancy s

99 pid kinetics but typically their performance is severely compromised compared to heterogeneous assay

100 e coimmunoprecipitation of Trt1 and Polalpha was severely compromised compared to those in the wild-t

101 the DS Env on both cell surfaces and virions was severely compromised compared with that of the unmod

102 learning abilities and exploratory behaviors were severely compromised compared with control males.

103 endogenous PER abundance and phosphorylation were severely compromised, demonstrating that CKIdelta/e

104 structure activity relationship studies has been severely compromised due to the uncertain compound

105 challenge in patients whose thymic function is severely compromised due to age or cytoreductive cond

106 During aging, adaptive immunity is severely compromised, due in part to decreased produc

107 Here we report that Rif1(-/-) mice are severely compromised for 53BP1-dependent class switc

108 to knock-down translation of GATA-6 protein, are severely compromised for heart development.

109 Furthermore, polyribosome association is severely compromised for both truncated proteins.

110 a mutant virus that does not express E4 ORF3 is severely compromised for replication.

111 nalysis reveals that one mutant, p53(25,26), is severely compromised for transactivation of most p53

112 One mutant, L314A, was severely compromised for replication and rapidly mut

113 afcat 14-3-3 binding mutant, B-Rafcat S728A, was severely compromised for the induction of PC12 cell

114 nsing cyclic guanine adenine synthase (cGAS) was severely compromised for the pUL25 mutant.

115 lity to cause mortality in a mouse model and were severely compromised for neuroinvasion.

116 These arguments are severely compromised if this signature was already a

117 nd events associated with class I crossovers are severely compromised in a cdkg1-1 mutant, they can b

118 n the hippocampus and cerebral cortex, which are severely compromised in Alzheimer's disease, showed

119 cell cycle arrest, and Rad55 phosphorylation are severely compromised in an FHA domain mutant of Dun1

120 urity 8 (eam8) mutations, also termed mat-a, are severely compromised in clock gene expression and cl

121 Learning and memory are severely compromised in dementias such as Alzheimer'

122 motif (ITAM)- and ITAM-like-mediated signals are severely compromised in FlnA-null platelets.

123 red that kinetochore-microtubule attachments are severely compromised in Ikbkap-deficient oocytes.

124 ETATION: Physical health and life expectancy are severely compromised in individuals who self-harm co

125 Mouse platelets that lack CalDAG-GEFI are severely compromised in integrin-dependent aggregati

126 or GDP-mannose transporter LPG2 lack PGs and are severely compromised in macrophage survival and indu

127 ondrocyte maturation and bone mineralization are severely compromised in Mia3-null embryos, leading t

128 that HDACi- and DNA damage-induced apoptosis are severely compromised in mouse embryonic fibroblasts

129 ial growth factor A, histamine, and thrombin are severely compromised in PPARbeta/delta-deficient mic

130 tivity but are unable to interact with SETD3 are severely compromised in RNA replication.

131 Hepatocyte function and regeneration are severely compromised in severe liver disease, and a

132 DA glutamatergic receptor (NMDAR) activities are severely compromised in synaptosomes prepared from A

133 able but fail to form a stable NuRD complex, are severely compromised in the ability to differentiate

134 Neonates are severely compromised in the ability to generate an i

135 s reveal that proprioceptive sensory neurons are severely compromised in the lumbar dorsal root gangl

136 suggest that cells from MDA5-deficient mice are severely compromised in the production of IFN-alpha

137 TH1 cells from GADD45gamma(-/-) mice are severely compromised in their abilities to activate

138 mice with targeted deletions in Ku70 or Ku86 are severely compromised in their ability to form coding

139 hat T. gondii tachyzoites depleted of TgAMA1 are severely compromised in their ability to invade host

140 Strikingly, however, cells expressing DM are severely compromised in their ability to present the

141 Escherichia coli strains lacking PriA are severely compromised in their ability to repair UV-d

142 in c-Rel, a member of the NF-kappaB family, are severely compromised in their ability to transcribe

143 HSCs from 12/15-LOX-deficient mice are severely compromised in their capacity to reconstitu

144 as Extra Vehicular Activity (EVA) suits has been severely compromised in the past as a result of dus

145 However, infectivity of BBS1 null parasites is severely compromised in a BALB/c mouse footpad model.

146 BQS is severely compromised in a human cancer cell line, sug

147 o induce p53 and its transcriptional targets is severely compromised in ARF-null cells, which remain

148 However, the stability of these structures is severely compromised in biological milieu due to thei

149 idol-induced apoptosis during S phase, which is severely compromised in cells homozygous for a nonfun

150 re we demonstrate that NK cell-mediated ADCC is severely compromised in chronic HIV infection.

151 the mitochondrial one-carbon metabolism that is severely compromised in CI mutant cells.

152 onstrate that HR repair of conventional DSBs is severely compromised in DEK-deficient cells.

153 hat the presynaptic microtubule architecture is severely compromised in DVAP-33A mutants.

154 ing and/or transducing abiotic stress, which is severely compromised in flp-1 myb88 mutants.

155 a pdtaS knockout in Mycobacterium smegmatis is severely compromised in growth on amino acid deficien

156 these data, we conclude that gluconeogenesis is severely compromised in HCC by IL6-Stat3-mediated act

157 Regulation of cutaneous immunity is severely compromised in inflammatory skin disease.

158 ecause FoxA2 bearing a mutation at this site is severely compromised in its ability to activate a rep

159 The mutated protein is severely compromised in its ability to form a stable

160 Indeed, a DC3000 catalase triple mutant is severely compromised in its ability to grow in planta

161 rowth suppressive activity, the R213Q mutant is severely compromised in its ability to induce p53-reg

162 h indicates that the K151L,K156Y derivative is severely compromised in its ability to interact with

163 on is enhanced at low pH, a mutant EnvA that is severely compromised in its ability to support infect

164 (D113E) exhibits reduced ATPase activity and is severely compromised in its DNA helicase activity.

165 However, male-typical sexual behavior is severely compromised in male and female ERalphaKOs.

166 and BDNF-inducible TrkB autophosphorylation is severely compromised in neurons lacking PS1.

167 as axon growth of Nkx6-positive motoneurons is severely compromised in Nkx6 mutant embryos.

168 While the floral meristem (FM) determinacy is severely compromised in null-allele jag and dl spikel

169 as well by albumin expression and secretion, is severely compromised in telomerase mutant cells with

170 Recruitment of TATA-binding protein (TBP) is severely compromised in the absence of functional Med

171 ween photoactivated rhodopsin and transducin is severely compromised in the absence of Gtbetagamma.

172 a major function of the Th2 response, which is severely compromised in the absence of IL-4, is to re

173 null mutant showed that resistance to TYLCV is severely compromised in the absence of TIP1:1.

174 Unexpectedly, mutant SRP(D251N) is severely compromised in the formation of an active SR

175 nding of high-affinity galactoside analogues is severely compromised in the mutants; the affinity of

176 multiplicity-dependent growth phenotype that is severely compromised in the rate of infectious-virus

177 e in LMO4 KO, confirming that CICR machinery is severely compromised in these neurons.

178 ptotic program induced by IGF-I but not PDGF is severely compromised in TSC2 null cells.

179 ls, viral capsid accumulation in the nucleus is severely compromised in UL92 mutant virus-infected ce

180 virus glycoprotein presented by Adhu5rab.gp was severely compromised in animals preexposed to the ho

181 genes of the psl cluster (PA2231 and PA2232) was severely compromised in biofilm initiation, as confi

182 e regulated secretion of milk-lipid droplets was severely compromised in both mutant mouse lines in c

183 g injection with allogeneic P815 tumor cells was severely compromised in CD154 knockout mice and wild

184 Regeneration was severely compromised in E2f1 null mice but not affec

185 The H71A Fpg mutant was severely compromised in enzyme turnover on the 8-oxo

186 ermore, induction of Nur77 expression by LPS was severely compromised in fibroblasts lacking the thre

187 However, the P216G mutant was severely compromised in folding into a catalytically

188 The in vivo cancer-initiating ability was severely compromised in HNSCC cells expressing phosp

189 -6 (-/-) SN pars compacta (pc), microgliosis was severely compromised in IL-6 (-/-) mice.

190 ines derived from knock-out mice, MyD88 S34Y was severely compromised in its ability to respond to al

191 lex substrates similar to wild-type BLM, but was severely compromised in its ability to unwind long D

192 However, Pho-20 was severely compromised in its ability to use iron pres

193 -erbalpha, Pgc1, Foxo1, Hnf4alpha, and Pck1) was severely compromised in Mc3r(-/-) mice during RF.

194 bine (2',2'-difluoro-2'-deoxycytidine; dFdC) was severely compromised in Mycoplasma hyorhinis-infecte

195 lication of a virus containing this mutation was severely compromised in peripheral blood mononuclear

196 a muris, in which IgA plays a dominant role, was severely compromised in pIgR-deficient mice despite

197 ytarabine to activate the S-phase checkpoint was severely compromised in Rad9(-/-) cells, whereas act

198 , virus from pHXB2(His-AC-TGT) with M184V RT was severely compromised in replication.

199 The mutant subcomplex was severely compromised in the ability of both UL5 and

200 reas the CD3-mediated proliferative response was severely compromised in the absence of Itk, the calc

201 However, its potency was severely compromised in the muscle, because antigen-

202 oncentration citrate-nAg treatment alone but was severely compromised in the presence of predators (d

203 ligands that engage the NLRP3 inflammasome, was severely compromised in these cells.

204 expansion ability required for cargo capture was severely compromised in these mutants.

205 d to unwind a 92-base pair duplex region and was severely compromised in unwinding a 20-base pair dup

206 254E) mutant, whose biological functionality was severely compromised in vivo but remains catalytical

207 V(0) assembly was severely compromised in voa1 vma21QQ double mutants.

208 In contrast, murine mdr3 function was severely compromised in yeast mutants lacking the FK

209 The same mutants were the ones that were severely compromised in binding topo I.

210 bly of outer membrane beta-barrel precursors were severely compromised in CL-lacking cells.

211 Hdac3(-/-) stem cells were severely compromised in competitive bone marrow tra

212 (TNF-alpha), PMN adhesion and extravasation were severely compromised in HPK1-deficient mice.

213 ons in response to poly(I:C) stimulation and were severely compromised in immune defense against vira

214 eas NER-deficient XP-A, XP-C, and XP-F cells were severely compromised in their ability to repair chr

215 Purified mutant proteins were severely compromised in their GTPase activities, de

216 Rad54(-/-)Ku80(-/-) mice were severely compromised in their survival, such that f

217 L. monocytogenes prfA- and Deltahly mutants were severely compromised in this respect.

218 was inhibited, and that of the double mutant was severely compromised, indicating impairment of mitoc

219 ith disruption of pslA and pslB (DeltapslAB) was severely compromised, indicating that psl has a role

220 els, breathing, sighing, and neuromodulation are severely compromised, leading to early mortality.

221 identities, adaptive face-coding mechanisms are severely compromised, offering a new explanation for

222 ort DNA duplexes (</=71 base pairs (bp)) but is severely compromised on longer DNA duplexes (>/=259-b

223 d and dye coupling between these two neurons was severely compromised or absent.

224 In patients with multiple risk factors, TFS was severely compromised, regardless of the timing of S2

225 Once dissociated, the next cycle of loading is severely compromised, resulting in steady-state ATP h

226 ntenance in dicerex1/2 embryos and yolk sacs were severely compromised, suggesting a possible role fo

227 The embryos are severely compromised, surviving to the tenth day of

228 ative protein folding and other ER processes are severely compromised under hypoxia.

229 the angiogenic capacity of COX-deficient ECs is severely compromised under energetically demanding co

230 C, their vegetative and reproductive growth was severely compromised under chilling conditions.

231 oid lineages was also partially impaired and was severely compromised under competitive conditions.

232 The midcell localization of CrgA(MT) was severely compromised under conditions of FtsZ deplet

233 ermore, the random mobility of CTL on ICAM-1 was severely compromised using all three methods of disr

234 lysine 9 of histone H3 (H3-K9), its activity is severely compromised when compared to that of the ESE

235 ntation efficiency, and clinical engraftment is severely compromised when donor-cell numbers are limi

236 se localization defects, the cuticle barrier is severely compromised when NHR-23 is depleted.

237 t processing of lipid substrates by B4GALNT1 is severely compromised when surface loops flanking the

238 Synaptogenesis was severely compromised when agrin expression or functi

239 thermore, the production of infectious virus was severely compromised when IFN-alpha was present earl

240 n Mre11-D16A or Mre11-D16N and Rad50 or Xrs2 were severely compromised, whereas the mre11 alleles wit

241 mor-initiating ability of HPV-positive HNSCC is severely compromised with CH1 overexpression, in part

242 impaired at synapses and (2) AP propagation was severely compromised with >40% of axonal branches no

243 B- and T-cell development, however, was severely compromised with transitional block from pr

244 media containing select amino acids/peptides was severely compromised, with microscopic examination r

245 containing replication compartment formation was severely compromised, with the appearance of small r

246 chia coli survival under antibiotic pressure is severely compromised without adenine methylation at G