ライフサイエンスコーパス: be substituted by

1 uded in the model, the final three compounds were substituted by 24-methylene-cholesterol/stigmastero

2 e ions adsorbed on the colloid nanoparticles are substituted by 4-ABT, the colloid aggregates, formin

3 Individual pyrimidine nucleosides were substituted by 4-thiouridine, O4-methyluridine, O2-

4 trate stem-loop, in which the target uridine is substituted by 5-fluorouridine (5-FU), reveals a cova

5 nd to the isolated stem-loop, in which U2604 is substituted by 5-fluorouridine to prevent catalytic t

6 ginase remaining in patients' treatment plan was substituted by 6 doses of intramuscular (IM) JZP458

7 ate is absent when one of the two G residues is substituted by 8-oxo-7,8-dihydroguanine, a modificati

8 Typically, such MVs are substituted by a minimum value, which may lead to di

9 Typically, such MVs are substituted by a minimum value, which may lead to se

10 were not clearly identified in teleosts and are substituted by a related ligand, TNF-New; 4) as many

11 he rhythmicity of heart contractions and can be substituted by a battery-operated device as a last re

12 quired for mobilization of pLV22a, but could be substituted by a C-terminal deletion mutant of the F

13 However, these motifs can be substituted by a heterologous H/ACA family RNA.

14 diate protection, a live virus vaccine could be substituted by a safe subunit protein-based vaccine a

15 ve complexes behave as electrophiles and can be substituted by a wide range of heteroatom nucleophile

16 d RNA in which the ribose-phosphate backbone is substituted by a backbone held together by amide bond

17 nal ethynyl addition to 1,2-diethynylbenzene is substituted by a barrierless addition of a cyano (CN)

18 nt wherein the N-terminal nucleophile Thr152 is substituted by a cysteine.

19 talytic tetrad, His(120) (AKR1D1 numbering), is substituted by a glutamate in AKR1D1.

20 e residue (Phe-394) in SOAR1, which in SOAR2 is substituted by a leucine residue.

21 n an actin peptide in which the target His73 is substituted by a lysine.

22 ng analog, in which the sulfur of methionine is substituted by a methylene group (-CH2-).

23 isostructural analogues where the boryl unit is substituted by a phenyl or amine donor, a phenomenon

24 g-closed state remains stable while the bond is substituted by a salt bridge or disulfide bond, where

25 However, when Leu-41 is substituted by a smaller side chain, either Ala or Va

26 al.mol(-1) when the catalytic water molecule is substituted by a sulfuric acid molecule or one of its

27 at position 71 along the pore helix in KcsA is substituted by a valine conserved in most Kv channels

28 which a fragment of the endogenous sequence was substituted by a ccdB cassette flanked by two BsaI s

29 ve of HMPA in which one of the methyl groups was substituted by a CH2CH2OH unit was synthesized.

30 onding to the extra cysteine residue of 1Dx5 was substituted by a cysteine codon through site-directe

31 ized human IL-13 in which Glu at position 13 was substituted by a Lys residue.

32 bserved depending on whether the amino group was substituted by a phenyl or an alkyl (usually benzyl)

33 itiation codon for each of these viral genes was substituted by a translational termination codon or

34 and proposed channel lining sequence of Cx32 was substituted by a transmembrane sequence of the cysti

35 The helicene skeleton was substituted by a variety of O-, S-, N-, and C-center

36 carboxylate was critical, although it could be substituted by acid isosteres and amides.

37 androgen-producing fetal Leydig cells (FLC) are substituted by adult Leydig cells (ALC) during perin

38 tivity retention in a mutant where every Cys is substituted by Ala.

39 ctive site from solvent in the ground state, was substituted by Ala.

40 Ile-455, and Gly-457 of smooth muscle myosin were substituted by Ala, Met, and Ala, respectively, and

41 When these residues are substituted by alanine, the mutant CPSs produce ster

42 p53 in which Ser15 is substituted by alanine (S15A) fails to mediate p53-de

43 ng the FALS-linked mutation in which glycine is substituted by alanine at position 93.

44 e face of the FeMo-cofactor, and when valine is substituted by alanine at this position, the substitu

45 trogenase MoFe protein alpha-Val(70) residue is substituted by alanine or glycine, the resulting vari

46 affinity of a mutant TRH-R, in which Trp279 was substituted by alanine (W279A TRH-R), for most teste

47 A mutant form of ICER in which Ser-41 was substituted by alanine had a half-life 4-5 h longer

48 Ectopic expression of H2B in which Ser36 was substituted by alanine reduced transcription and RNA

49 Mutations were studied in which Asp 23 was substituted by alanine, asparagine, and nitrile alan

50 When Asp(374) was substituted by alanine, high affinity ligand binding

51 When the corresponding residues were substituted by alanine in native germinal and somat

52 d when the Asp and Glu residues in the motif were substituted by alanine.

53 Arginine or glutamine residues in the tail were substituted by alanine.

54 ational analysis in which 23 of 25 positions were substituted by alanine.

55 Surprisingly, most IGF-I residues could be substituted by alanines, resulting in less than 5-fol

56 hich the two phosphorylation serine residues were substituted by alanines, was used as a bait, wherea

57 are required for ATAD1's function and cannot be substituted by aliphatic amino acids.

58 nding and second messenger generation, Arg46 was substituted by all other 19 encoded amino acids.

59 is experimentally restored or if glutathione is substituted by alternate cellular antioxidants, confi

60 where the piperazine of LDK1203 and LDK1222 are substituted by an alkyl group and a tosyl group, res

61 shed in the food-safety applications, should be substituted by an acquisition at fixed incubation tim

62 alpha1,3-fucose on the reducing terminus can be substituted by an alpha-linked galactose.

63 in the second, the general acid Asp residue is substituted by an Ala (e.g., PTP1B/D181A).

64 second novel one in which the aspartic acid is substituted by an asparagine (Ac-LPFFN-NH2).

65 Pyruvate and 2-oxoglutarate dehydrogenases are substituted by 'ancient' CoA-dependent pyruvate and

66 nd positioning and that this function cannot be substituted by another residue at a nearby position.

67 riants where one of the coordinating ligands is substituted by another side chain capable of coordina

68 s (1572-1651) of the conventional alpha1C,77 were substituted by another 81 amino acids due to altern

69 importance for child survival and could not be substituted by any category of kin or nonkin.

70 P3beta3A subunit, affected in HPS2 patients, is substituted by AP3beta3B in the neuron-specific heter

71 he N-terminal short AGP motif was assumed to be substituted by arabinogalactans.

72 mutant Factor X in which the activation site was substituted by Arg196 --> Gln to prevent the proteol

73 All other lysyl residues are substituted by argynyls.

74 itrite reductase in which the distal His has been substituted by Asn.

75 Using site-directed mutagenesis, Ser-309 was substituted by aspartic acid to mimic the presence o

76 d regions of the transmembrane regions could be substituted by at least one other residue.

77 ous species Nicotiana benthamiana and cannot be substituted by AtEDS1-AtPAD4 with AtNRG1 or AtEDS1-At

78 this ternary complex requires ATP, which can be substituted by ATPgammaS, suggesting that ATP binding

79 To identify genes whose function can be substituted by Bcl-x(L) in a unicellular eukaryote, a

80 both expensive and difficult to obtain, can be substituted by beetroot peel extract, providing a che

81 unction in cardiac development, which cannot be substituted by BMP9.

82 With sp(2) C-F bonds being substituted by C-H bonds, the reductive defluorina

83 alogue of natrolite where all sodium cations are substituted by calcium and water molecules, reveal a

84 I-(CH(2))(3)-NH(2)(CH(3))(+) (MIPA), -CH(3) is substituted by -CH(2)I at one end, and -NH(3)(+) is s

85 sumed product all over the world which could be substituted by cheaper raw materials resulting in foo

86 site-directed AS-B mutants in which Glu-348 is substituted by conservative amino acid replacements.

87 a-N-acetylgalactosamine (GalNAc) residues to be substituted by core 1 chains, a value in agreement wi

88 in which up to 50% of the sickle hemoglobin is substituted by cross-linked hemoglobin A, which does

89 to both onset and offset of plasticity, and was substituted by diazepam, which enhances GABA functio

90 ycine residues, in two canonical DTG triads, are substituted by different amino acid residues.

91 , where the naturally occurring FMN cofactor is substituted by different analogs, makes it possible t

92 iptional activation function of CONSTANS can be substituted by direct fusion of the EDLL activation m

93 or its interaction with BiP/GRP78 and cannot be substituted by E. coli DnaJ.

94 d to the B-cell lineage, a function that can be substituted by ectopic Bcl2 expression, and (2) to en

95 cription complexes in which E. coli RNAP had been substituted by either bacteriophage SP6 or T7 RNAP.

96 Ps in which every other C sp(2) nodal center is substituted by either a N or B atom.

97 Thr229 of rat p70s6k was substituted by either a neutral amino acid Ala (T229

98 at loss of activity was observed when Lys172 was substituted by either Ala or Cys, or when Gly137 was

99 Individual nucleosides were substituted by either a 2'-deoxy-nucleoside, an aba

100 Dicistronic vectors in which ORF1 and ORF2 were substituted by either two different fluorescent pro

101 droxylamines were obtained when nitrobenzene was substituted by electron-withdrawing groups.

102 ish such goals, given oxidants or reductants are substituted by electrons from a power source.

103 Importantly, Topo IIIalpha cannot be substituted by Escherichia coli Top3, and the Hollida

104 the synthesis of proteins with peptide bonds being substituted by ester bonds.

105 e enzyme from Pseudomonas stutzeri ATCC14405 were substituted by evolutionary conserved residues or a

106 find that the PGRP-SC1a amidase activity can be substituted by exogenous addition of free peptidoglyc

107 lp from CD4+ cells; this helper activity can be substituted by exogenous IL-2 or IL-4.

108 CLIP is substituted by exogenous peptidic fragments in an exc

109 injury depends on the generation of, and can be substituted by, exogenous CO.

110 are crucial for backbone hydrogen bonding), are substituted by fluorine atoms.

111 ayer perovskites in which some of the oxygen is substituted by fluorine.

112 ctures on model compounds, in which the TiPB are substituted by formate ligands, reveal that the HOMO

113 t ditetrelene R2 E=ER2 in which the E=E bond is substituted by four heteroatoms (other than Si) is de

114 branded dispensing requested by patients had been substituted by generics, the projected savings to t

115 gate the variants of this compound where tin is substituted by germanium or silicon and find that the

116 Glu275 was substituted by Gln, Asp, Ala, and Arg; none of these

117 D61 can be substituted by glutamate, but E63 appears to be invar

118 sidue at the conserved DXDXT signature motif was substituted by glutamic acid via site-directed mutag

119 orm for which the alpha-His(195) residue has been substituted by glutamine.

120 putative proton donor near the active site, is substituted by glutamine in combination with substitu

121 trate access channel of LiP, in which Glu146 was substituted by Gly (E146G LiPH8), showed substantial

122 Function of omega is known to be substituted by GroEL in omega-null strain, which thus

123 n length, in which one or more -F atoms have been substituted by -H atoms and/or -OH groups, can be f

124 hors, where the conserved GPI core structure is substituted by heterogeneous sialylated branched poly

125 Further opioids should not be substituted by high dose NSAIDs in the management of

126 on, but loss of the zinc hook connection can be substituted by higher levels of the complex.

127 acid within the MoFe protein (beta-98(Tyr)) is substituted by His, the resulting MoFe protein suppor

128 mple is a missense mutation where ARG531 has been substituted by HIS531.

129 it easy to prepare nonracemic helicenes that are substituted by hydroxyl groups at their 1,omega-posi

130 otential cytochrome P450 hydroxylation site, was substituted by I, Br, Cl, and F to potentially enhan

131 AR IDR can be substituted by IDRs from selective proteins for AR co

132 combination site (resF) which allows Hbsu to be substituted by IHF, binding specifically between site

133 CD28 costimulation, noteworthy, cannot be substituted by IL-2 to induce proliferation of Treg c

134 alytically active glutamate in alpha-tubulin was substituted by inactive amino acids (E254A and E254N

135 Isotope-effect measurements, in which atoms are substituted by isotopes of different mass to systema

136 ep6.1 has rod-specific functions that cannot be substituted by its canonical isoform.

137 We observed that human mtSSB can be substituted by its Drosophila homologue, and vice ver

138 ation by cholesterol, endogenous cholesterol was substituted by its optical isomer, epicholesterol.

139 ue in EL2, whereas the R7.39 in TM7 seems to be substituted by K7.35.

140 ty that KCNE1 in the IKs channel complex can be substituted by KCNE2 when the latter is available.

141 The conserved Phe and Arg in P450BM-3 were substituted by Leu112 and Asp439, respectively in P

142 ue in the Golgi GDP-fucose transporter (GFR) is substituted by leucine in nac(1) flies, which abolish

143 conserved valine in the A chain (residue A3) is substituted by leucine.

144 sphotyrosine in all other known SH2 domains, is substituted by leucine.

145 requires a divalent cation, Mg2+, which can be substituted by Mn2+.

146 e observe that the pai-stacking interactions are substituted by more favorable CH...pai contacts, all

147 fts (PDXs) stromal cells of the human tumour are substituted by murine counterparts, here we deploy h

148 tion of a critical arginine residue that has been substituted by mutagenesis is restored by GdmHCl.

149 3, and Gly-575 from the large subunit of CPS were substituted by mutagenesis with bulkier amino acids

150 The Cys(52) sulfinic acid moiety was substituted by mutating this residue to Asp, leading

151 engineered protein variants in which Trp496 was substituted by natural and non-natural amino acids.

152 infects men if N-acetyllactosamine residues are substituted by Neu5Ac during infection in women.

153 tituted by -CH(2)I at one end, and -NH(3)(+) is substituted by -NH(2)(CH(3))(+) at the other end.

154 els wherein the mouse telomeric protein TRF1 is substituted by NMR TRF1 or its mutant forms, we show

155 Two of these ligands can be substituted by non-native cysteine residues introduce

156 tic residues that line the active site gorge are substituted by nonaromatic residues, corresponding t

157 ginine or lysine residues in the zinc module were substituted by norleucine, an isostere that maintai

158 l and tautomerizable phenol derivatives have been substituted by O-, S-, N-, and C-centered nucleophi

159 M-9) in which only residues 341-454 of OCTN2 were substituted by OCTN1 had markedly reduced carnitine

160 use model in which the endogenous Trp53 gene is substituted by one encoding p53ER(TAM), a p53 fusion

161 he p-cymene ring and/or the chloride ligands are substituted by other ligands to modulate the steric

162 tion function of the 9-nt sequence could not be substituted by other 5'-terminal sequences.

163 Indeed, leucine could not be substituted by other amino acids in Galpha(13) withou

164 nctions in the virulent strain, which cannot be substituted by other kinases.

165 These arginines can be substituted by other residues, while still retaining

166 In contrast, Gly-22 in the motif could be substituted by other small residues such as Ala and S

167 Jumonji C protein JcdI, suggested that Skp1 was substituted by other factors in phyA-KO cells.

168 Then, commercial pectin was substituted by other gelling agents (pomegranate pee

169 f mutant enzymes in which this aspartic acid was substituted by other residues that change charge and

170 hat 22% of the reduction in firearm suicides was substituted by other suicide methods.

171 tex to induce polarity, but its function can be substituted by overexpressing Lgl.

172 ived from guanine in which the N(1)-nitrogen is substituted by oxygen.

173 nd polytellurophene, respectively, and N has been substituted by P and As in polypyrrole.

174 lmodulin, in which the four Ca(2+) ions have been substituted by Pb(2+), and a target peptide.

175 of the cocoa aspartic protease, which cannot be substituted by pepsin.

176 The radical and acidic properties of PhSH were substituted by Ph(2)S(2) and phosphoric acid.

177 otonation step; however, in 2-KPCC, the dyad is substituted by Phe-His.

178 erence for mFRT11 is nearly lost when Tyr-82 is substituted by Phe.

179 e predicted site of tyrosine phosphorylation is substituted by phenylalanine.

180 ouble, or triple mutations in which tyrosine was substituted by phenylalanine.

181 Position 4 of Kdo is substituted by phosphoethanolamine, also present in p

182 l globular domains of BclA from both species are substituted by polysaccharide-like O-linked glycans

183 tituted by either Ala or Cys, or when Gly137 was substituted by Pro.

184 eriodontal therapy in these defects, and can be substituted by probing bone measurements.

185 nsory analysis showed that wheat flour could be substituted by RBP up to 10% without compromising the

186 ly metal-coordinating residues H207 and Y220 were substituted by residues that should not coordinate

187 a distinct role in heterocysts which cannot be substituted by respiratory O2 uptake in the protectio

188 y introduced when one strand of a DNA duplex is substituted by RNA we find that six restriction enzym

189 Specifically, S has been substituted by Se and Te in polythiophene, leading

190 fitness effects of beneficial mutations that are substituted by selection are key to our understandin

191 It has been substituted by sentinel node biopsy with dissection

192 ere an interior cysteine residue (C6 or C39) is substituted by serine, a normal solvent effect is obs

193 solvent accessible surface cysteine residue is substituted by serine, the S covalency decreases upon

194 sidues of IIBMtl are denoted in italic type) was substituted by serine to permit the formation of a s

195 state and the active site Cys-10 of IIB(Chb) was substituted by serine to prevent intermolecular disu

196 2-C21S, in which the NH(2)-terminal cysteine was substituted by serine, lost their ability to activat

197 Akt1/PKBalpha (C224S), in which cysteine 224 was substituted by serine, was resistant to NO donor-ind

198 e protein for which the alphaGly(69) residue was substituted by serine.

199 olin alpha in which the N-terminal cysteines were substituted by serines (Cys4, Cys24, and Cys4/Cys24

200 ally, the two native cysteines found in CheB were substituted by serines and a cysteine was substitut

201 analog, where the cysteines (36, 41, and 46) were substituted by serines, is monomeric on SDS-polyacr

202 or interacts with the coenzyme, Trp-139 has been substituted by several different types of amino aci

203 Twenty different amino acids were substituted by site-directed mutagenesis for wild-t

204 tive site (Cys(284), Cys(330), and His(331)) were substituted by site-directed mutagenesis.

205 The four residues were substituted by site-directed mutagenesis.

206 Derivatives where CH units are substituted by sp(2) nitrogen atoms are rare but of

207 AT5 binding to a subset of mammary enhancers is substituted by STAT3.

208 The strontium-H332E mutant, in which calcium is substituted by strontium, confirms that strontium (ca

209 ore, the rate by which encapsulated chloride was substituted by sulfate or hydrogen phosphate was slo

210 2), and X(3) residues of hCG-alpha and -beta were substituted by swapping their respective cystine kn

211 the P-TEFb-recruitment function of Brd4 can be substituted by that of HIV-1 Tat, which recruits P-TE

212 c construct in which the C2AB domain of Syt1 was substituted by that of Doc2b did not support synchro

213 en the p53-binding sites in the p21 promoter are substituted by the Bax p53 site or by the region of

214 local wavelet coefficients of the PET image are substituted by the corresponding values of the MRI/C

215 oms in the central benzenoid (CB) ring of PH are substituted by the series of substituents with vario

216 for the enzyme (Kd = 0.5 muM) and could not be substituted by the acceptor ACP.

217 Interestingly, the Ttk69 BTB can be substituted by the BTB of the human Bcl-6 protein, su

218 s are lacking in most archaea where they may be substituted by the chaperone prefoldin.

219 he GABAergic neurons, a function that cannot be substituted by the classical form of the bHLH heterod

220 embrane-binding domain of Rnd3, which cannot be substituted by the equivalent Cdc42 CAAX sequence.

221 physical interaction with RPA because it can be substituted by the Escherichia coli single strand DNA

222 -binding property, the N-terminal domain can be substituted by the influenza virus hemagglutinin fusi

223 ain of c-Ski, which is missing in v-Ski, can be substituted by the leucine zipper domain of GCN4.

224 nt role in the mouse intestine, which cannot be substituted by the other family kinases Fyn and Yes.

225 full-length DeltaNp63a isoform which cannot be substituted by the other isoforms (beta or gamma).

226 The effect of Rac or Cdc42 can be substituted by the Pak kinase, which is a direct down

227 h behaves as a transcription terminator, can be substituted by the trp transcription terminator witho

228 ch the GTPase center of E. coli 23S rRNA had been substituted by the corresponding domain from Saccha

229 nded dispensing requested by prescribers had been substituted by the corresponding generics, the proj

230 S-66271, in which the amino acids 22-31 have been substituted by the sequence E22-L-L-E-K-L-L-E-K-L31

231 103-105 to 104-106, and when the human tail is substituted by the C-terminal tail of murine S100A9.

232 s of the chicken ecto-ATP-diphosphohydrolase is substituted by the corresponding region of the human

233 s of the chicken ecto-ATP-diphosphohydrolase is substituted by the corresponding region of the human

234 eg1 becomes completely dispensable when Ceg1 is substituted by the mouse guanylyltransferase, which d

235 because it is reversed to activation when P2 is substituted by the P1 or p53 consensus sequences.

236 ry complexes in which the glucosyl component is substituted by the putative transition state analogue

237 anges dramatically when an "ideal" potential is substituted by the real one; (ii) the structures of s

238 f of the MADS domain of AP1, AP3, PI, and AG was substituted by the corresponding sequences of human

239 reporter enzyme in which the membrane anchor was substituted by the Escherichia coli chemotaxis recep

240 hNTS1-R212E mutant receptor, in which Arg212 was substituted by the negatively charged Glu residue.

241 along the A kinase binding domain of d-AKAP2 was substituted by the other 19 l-amino acids.

242 cted nonpolar residues on the surface of CAT were substituted by the corresponding polar residues in

243 ld be achieved if the high-cost generics had been substituted by their therapeutic alternatives.

244 Moreover, SmiA function could not be substituted by thermal denaturation of the substrate,

245 se proband in which one of these isoleucines was substituted by threonine (I317T).

246 suggest a unique role for TRbeta that cannot be substituted by TRalpha in the T3-dependent feedback r

247 f RNAP active centre, the trigger loop (TL), is substituted by transcription factor Gre.

248 K14Cre;pNog mice, in which Wnt signaling can be substituted by transgenic activation of Pitx2.

249 is dependent on NF-kappaB signals, which can be substituted by transgenic expression of the prosurviv

250 th the magnitude of change increasing as Trp is substituted by Tyr, Ala, Gly, and Glu.

251 RNA, where C2518 (C2499 in Escherichia coli) was substituted by U.

252 ous beta(1) subunits in the lateral membrane were substituted by unglycosylated beta(1) subunits disp

253 eries of modified analogues in which Phe(13) was substituted by unnatural amino acids.

254 Fossil fuels can be substituted by using wood products in place of altern

255 idue contributed by glycerol kinase (Glu478) is substituted by using site-directed mutagenesis to con

256 e (NL) largely untapped (e.g. 'glutamic acid was substituted by valine at residue 6').

257 La and M sites can be substituted by various metal ions leading to Li-rich

258 in the second step, the benzotriazole group is substituted by various nucleophiles with or without t