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5 ivalent inhibitors, where two pharmacophores are tethered to a single DFOSq ligand, have better tumor
8 hydrolysis, metal-coordinating peptides have been tethered to a DNA-intercalating rhodium complex to
10 allowed to attach to RGDS peptides that had been tethered to a silicone surface utilizing a previous
16 a dominant positive form of MyoD, one which is tethered to a partner, E47, activates muscle-specific
17 of cell cycle transcription factors--when Rb is tethered to a promoter through E2F, it not only block
18 omplex 3 was designed such that cytochrome c is tethered to a region of the peroxidase near Asp148 wh
19 oloenzyme reveals that a single PlyCA moiety is tethered to a ring-shaped assembly of eight PlyCB mol
21 domain establishes silent chromatin when it is tethered to a weakened HMR-E silencer, and it disrupt
22 h) receptor (nAChR), a rhodamine fluorophore was tethered to a Cys side chain introduced at the beta
23 ear matrix, and the hTSHbeta silencer region was tethered to a nuclear matrix of human cells in vivo,
25 quences of PAP binding to mRNAs in vivo, PAP was tethered to a reporter mRNA in resting oocytes using
26 the approach used in this study, the protein was tethered to a surface, allowing a freely diffusing f
29 ifferent orientations, and the ChlI subunits were tethered to a silica surface; the probability of su
30 polymerase I Klenow fragment (KF) molecules were tethered to a single-walled carbon nanotube field-e
31 ell's spectrin-actin network, nano-particles were tethered to actin nodes and their constrained therm
37 ein, Hir3p, to repress transcription when it was tethered to an HTA1-lacZ reporter gene, and Hir1p an
39 nts that focused the matrix into a mass that was tethered to, and suspended above, the light organ po
40 yclin A and its binding substrate, cdk2, can be tethered to beta-TrCP, ubiquitinated, and effectively
41 are still made with extensive manual labor, are tethered to bulky control systems, and have cumberso
43 y line strategy in which the growing peptide is tethered to carrier domains that deliver the intermed
44 mes into daughter cells during mitosis, they are tethered to cellular chromatin by the viral E2 prote
45 in of Ras homologue enriched in brain (Rheb) is tethered to cellular membranes through a prenylated c
49 e kinase receptor-associated protein (STRAP) is tethered to collagen mRNAs by interaction with LARP6.
50 investigate the dynamics of the RBD when it is tethered to CRD that is anchored to a POPC:POPS model
56 A polymerases are multiprotein machines that are tethered to DNA during chain extension by sliding cl
57 tivator in such experiments requires that it be tethered to DNA, a requirement that cannot be overcom
58 and the GAL11P mutation such that the latter is tethered to DNA and the former is attached to the hol
59 ata strongly support a model in which EBNA3A is tethered to DNA through a BATF-containing protein com
64 onsistent with a model in which the machines are tethered to each other to form 'gene expression fact
65 munication arise more readily when the sites are tethered to each other, either in cis on the same mo
66 ill undergo minor structural changes when it is tethered to either surface, and the structures differ
68 ng in approximately 50% fewer melanoma cells being tethered to endothelium and retained in lungs.
70 l motif is presented: DNA or chromatin loops are tethered to "factories" through the transcription ma
71 DNA through its ribbon-helix-helix motif and is tethered to FitB, the toxin, to form a heterodimer by
76 nd the filament, are known to rotate, having been tethered to glass or marked by latex beads, the rot
78 It further implies that G alpha subunits are tethered to Golgi membranes by posttranslational mod
79 pite recent advances, soft robots must still be tethered to hard robotic control systems and power so
80 covered that ERalpha-bound regulatory depots are tethered to heterochromatin protein 1 (HP1) for coor
81 associated herpesvirus (KSHV) latent genomes are tethered to host histones to form a minichromosome a
83 ependent adhesion was noted when the ligands were tethered to inert beads, simulating the physiologic
84 ata are consistent with a model in which Tpr is tethered to intranuclear filaments of the NPC by its
87 A nicotinic acid mononucleotide derivative is tethered to Lys(184) and forms a tridentate pincer co
91 nensine analogues in which a mannose residue was tethered to N-1 of kifunensine via a two-, three-, o
92 m robust intermolecular hydrogen bonding and are tethered to naphthalic anhydride with the ACQ (aggre
93 Collectively, our findings reveal that SENP2 is tethered to NPCs through a complex interplay of inter
94 of 2-ketoglutarate, suggesting that once PII was tethered to NRII the active conformation was stabili
98 n budding yeast mitosis, sister kinetochores are tethered to opposite poles and separated, stretching
101 ) in diderm, or Gram-negative, bacteria must be tethered to peptidoglycan for mechanical stability an
103 bacteria, including Escherichia coli, the OM is tethered to PG by an abundant OM lipoprotein, Lpp (or
107 denosine triphosphate, or carboxyfluorescein are tethered to plasmon-resonant hollow gold nanoshells
114 indicate that elongating nascent transcripts are tethered to RNAP II on the immobilized DNA template.
116 (IGF-1)-IGF-1 receptor system, and IGF-1 can be tethered to self-assembling peptide nanofibers (NF-IG
117 igands to the T Cell Receptor and LFA-1 that are tethered to separate, closely juxtaposed regions of
118 rates an N-sulfonyl imine functionality that is tethered to Ser195, in accordance with the postulated
119 nt reporter molecule, acridinium ester (AE), was tethered to single-stranded oligonucleotide probes a
120 tronic technique in which lysozyme molecules were tethered to single-walled carbon nanotube field-eff
121 lent chromatin at non-centric locations, HP1 was tethered to sites within euchromatic regions of Dros
122 smids containing active partitioning systems are tethered to specific regions of the cell, and the nu
123 s a recognizable DNA-binding motif, how they are tethered to specific target promoters remains unknow
125 c activity of a fusion protein in which ExoI is tethered to SSB is nearly equivalent to that of SSB-s
126 eristics are upheld even when the DNA duplex is tethered to streptavidin or the mobility of the nitro
127 ure when binding substrate and suggest sHSPs are tethered to substrate at multiple sites that are loc
128 arrageen, pectin, and the fact that they can be tethered to surfaces without losing their antimicrobi
133 ing bilayers from cochleate cylinderss which are tethered to the aggregate by biotin-streptavidin cou
136 is that their cognate ligands, the ephrins, are tethered to the cell surface, in contrast to other R
137 suggest a difference in how chromatin loops are tethered to the chromosome axis, resulting in reduce
139 inamide adenine dinucleotide (NAD(+)) couple are tethered to the constituents of two different CDNs,
142 ger than the SMC coiled coil lumen when they are tethered to the extruded DNA by a single-stranded DN
145 arcoma-associated herpesvirus (KSHV) genomes are tethered to the host chromosomes and partitioned fai
146 gnals of both NF-kappaB p50 and p65 subunits are tethered to the IkappaBalpha amino-terminal ankyrin
150 skeleton consists of spectrin tetramers that are tethered to the lipid bilayer by ankyrin and by acti
151 ria involves synthesis of intermediates that are tethered to the lipid carrier undecaprenol-phosphate
153 (OM) lipoproteins in Gram-negative bacteria are tethered to the membrane via an attached lipid moiet
156 Mitochondrial ribosomes (mitoribosomes) are tethered to the mitochondrial inner membrane to faci
158 ers are based on azobenzene derivatives that are tethered to the nanopore interiors, while nanovalves
159 gel to incorporate thiophilic NPs, where NPs are tethered to the networks and, in turn, reinforce its
161 Furthermore, exogenous insulator sequences are tethered to the nucleolus in a CTCF-dependent manner
163 phatidylinositol-anchored proteins (GPI-APs) are tethered to the outer leaflet of the plasma membrane
164 mechanism whereby biosynthetic intermediates are tethered to the peptidyl carrier protein SgcC2.
167 electron microscopy techniques and show they are tethered to the plasma membrane in a highly speciali
168 ed that in the absence of VPU, HIV-1 virions are tethered to the plasma membrane in BST2-expressing H
169 lso binds to nuclear estrogen receptors that are tethered to the plasma membrane, resulting in acute
170 It is found that the amine functionalities are tethered to the PMMA backbone through an alkane brid
171 n Subzymes (universal substrate and DNAzyme) are tethered to the polystyrene magnetic microparticles
172 of nuclear microtubules (MTs) are capped and are tethered to the SPB inner plaque, whereas the majori
173 ation cascade where the target and ubiquitin are tethered to the split-CAT fragments results in ubiqu
174 unique fluorophores at opposite termini can be tethered to the cell surface and used to detect DNA c
176 n the outer leaflet, and RcsF was thought to be tethered to the inner leaflet by its lipidated N term
177 a periplasmic lipoprotein that is thought to be tethered to the inner membrane of this organism.
180 it is concluded that the fluorophore should be tethered to the metal-binding part of the sensor, and
181 l interact with ORF69 in the nucleus and can be tethered to the nuclear membrane by virtue of its int
183 L42 remained bound, suggesting that UL30 may be tethered to the replication fork by protein-protein i
184 ngside drug loading, functional proteins can be tethered to the surface utilizing bio-orthogonal "cli
185 Moreover, the coactivator HAT activity must be tethered to the template by Tax and CREB, since a p30
186 main of the glucocorticoid receptor (GR) has been tethered to the intercalating fluorophore thiazole
187 o the ligand-binding TCR-gammadelta subunits being tethered to the CD3 subunits by their transmembran
188 ss the physiological significance of primase being tethered to the eukaryotic replisome in this way.
189 rs of FokI interact strongly, as a result of being tethered to the same molecule of DNA, and sequeste
190 model in which the pseudosubstrate of aPKCs is tethered to the acidic surface on p62, locking aPKC i
193 r 1,3-linked polyglycerolphosphate chain and is tethered to the bacterial membrane by a glycolipid (d
194 ed 2'-deoxyuridines in which the amino group is tethered to the base via a 3-carbon alkyl, Z- or E-al
195 (4:1 ratio), we show that, as expected, Kras is tethered to the bilayer surface by specific lysine-PO
196 R) molecule catalyzing methyl group transfer is tethered to the C terminus of a neighboring receptor.
197 e derivatives, the C-4 acetate of the taxane is tethered to the C-3' phenyl at ortho and meta positio
199 e produces a large extracellular domain that is tethered to the C-terminal stalk by disulfide bridges
200 construction, the octahedral Pt(IV) prodrug is tethered to the cancer cell targeting biotin ligand t
201 t proteins around the packaged genome, which is tethered to the capsid's inner surface by the DNA-bin
202 core region followed by a stalk region that is tethered to the cell membrane by a glycosyl-phosphati
203 s expressed as an N-terminal ectodomain that is tethered to the cell surface by a C-terminal transmem
205 extrachromosomal circular DNA (eccDNA) that is tethered to the chromosomes and passed to gametes at
206 strate that the native HelX in R. capsulatus is tethered to the cytoplasmic membrane via its uncleave
207 a consequence of this interaction, RARalpha is tethered to the DNA sites that are recognized and bou
211 that the cytosolic Hsc70-SGTA-Hsp105 complex is tethered to the ER membrane, where Hsp105 and SGTA fa
212 s a unique trypsin-like serine protease that is tethered to the extracellular membrane of cells throu
217 tR in which the core, inducer-binding domain is tethered to the helix-turn-helix, DNA-binding domain
222 x show that the 60 residue C-terminal domain is tethered to the main body of the enzyme via a flexibl
224 ng dual kinase/methyltransferase (WbdD) that is tethered to the membrane and recruits WbdA into an ac
225 is a cytoplasmic, N-terminal PAS domain that is tethered to the membrane by a 47-residue F1 linker.
227 sterol C4-demethylation enzyme complex that is tethered to the membrane by Ergosterol biosynthetic p
234 e E2 protein of bovine papillomavirus type 1 is tethered to the mitotic chromosomes via the cellular
235 he mRNA processing enzyme poly(A) polymerase is tethered to the much larger 3'-end processing complex
237 ns PomX and PomY form a large cluster, which is tethered to the nucleoid by the ATPase PomZ and moves
239 we present evidence that the assembling coat is tethered to the outer forespore membrane by a 26-amin
241 vated serine/threonine phosphoprotein (FAST) is tethered to the outer mitochondrial membrane, where i
245 croscopy probe miniSOG indicated that smAKAP is tethered to the plasma membrane and is particularly d
247 essive movement in stereocilia when its tail is tethered to the plasma membrane or F-actin in the pre
248 on suggesting that this region of the genome is tethered to the poles of the cell at a specific time
249 e EM reconstruction shows that the B subunit is tethered to the polymerase domain through a structure
250 cyclodextrin (alpha-CD) ring on a stalk that is tethered to the pore openings on the nanosphere, is s
251 ctivate E2F, but also we show that when p107 is tethered to the promoter through binding to E2F it fu
252 model in which one terminus of the substrate is tethered to the protease and the other terminus is en
253 ocyte chemoattractant protein-1 (MCP-1) that is tethered to the proteoglycans on the luminal side of
256 or type II depending on how the diene motif is tethered to the rest of the substrate (type I are tet
258 a mechanism in which the lead ribosome that is tethered to the RNAP by NusG suppresses spontaneous b
259 periments, it could be shown that the ligand is tethered to the second extracellular loop by hydropho
261 trin tetramers, and the lipid bilayer, which is tethered to the skeleton via, at least, ankyrin.
263 han 90% of G protein-coupled receptors, ECL2 is tethered to the third TM helix via a disulfide bond.
264 in HIGH CHLOROPHYLL FLUORESCENCE244 (HCF244) is tethered to the thylakoid membrane by the OHP heterod
266 y homologous to the G protein alpha subunit, is tethered to the top of the beta-propeller domain by a
270 s between a substrate where the alkoxy group was tethered to the acetal group by a five-membered ring
273 en Galphai2 yellow fluorescent protein (YFP) was tethered to the carboxyl terminus of the alpha2A adr
274 d networks of VWF multimers, and each string was tethered to the cell surface by a limited number of
277 changes in chromatin structure even when it was tethered to the HIV-1 core promoter upstream of the
279 2-terminal domain was retained in the ER and was tethered to the membrane by its own M1 transmembrane
281 ling copper ions to the mitochondrion, Cox17 was tethered to the mitochondrial inner membrane by a fu
285 mitotic cells, a portion of the mitochondria was tethered to the spindle-pole bodies and moved to the
287 (NH(3))(2)Cl(2)(OH)(O(2)CCH(2)CH(2)CO(2)H)], was tethered to the surface of DNA-Au NPs through amide
289 hell design, in which carboxylic acid groups were tethered to the core and silanol to the shell inter
290 d be significantly enhanced when DNP haptens were tethered to the end of very long hydrophilic PEG li
291 rved to sway in the oscillating flow as they were tethered to the surface by a capture antibody.
296 e probability of overt exploratory movements are tethered to theta-band activity (3-8Hz) in the atten
299 (diphenyl)urea hydrogen bonding synthon that is tethered to two BODIPY dyes featuring sterically bulk