ライフサイエンスコーパス: beacon

1 ce or absence information about alleles in a beacon.

2 ven individual is present in a given genetic beacon.

3 ing a single (universal) strand displacement beacon.

4 nsmitted, in addition to the location of the beacon.

5 be superior to the corresponding Cy3B/DABCYL Beacon.

6 ndmark protein that functions as a molecular beacon.

7 y and dynamic range of a fluorescent aptamer beacon.

8 tal defects possibly caused by the molecular beacon.

9 m the Personal Genome Project in an existing beacon.

10 Relatives can also be identified in the beacon.

11 that they are important chromatin regulatory beacons.

12 son as potential binding pockets and aptamer beacons.

13 variability in discriminating two identical beacons.

14 s using isotachophoresis (ITP) and molecular beacons.

15 plification primers or fluorescent molecular beacons.

16 rease the detection sensitivity of molecular beacons.

17 ty ratios reported for traditional molecular beacons.

18 s in a sparse virtual environment with three beacons.

19 enosensors exploiting MB-labeled hairpin DNA beacons.

20 Beacon 10 also shared short sequence segments with other

21 Beacon 10 did not respond strongly to a variety of other

22 orescent double-looped structure, designated Beacon 10.

23 ntegral to the immune response and acts as a beacon, a second messenger, that guides both immune syst

24 the rational design of cooperative molecular beacons, a widely employed DNA sensor, using a generaliz

25 by changing the sequence of the nucleic acid beacon according to the corresponding aptamer.

26 Genomic data-sharing beacons aim to provide a secure, easy to implement and s

27 nt improvement over the equivalent molecular beacon alone.

28 ism of signaling utilized with the unblocked beacons also plays a significant role with the blocked b

29 reatment and associated with a DNA molecular beacon and applied to cancer cell detection by the trans

30 ystem, and this nicks the duplex between the beacon and ligated product while recycling the free liga

31 i PodJ1 protein appears to act as a polarity beacon and localizes to the newer cell pole.

32 s including Taqman, 3'-MGB-Taqman, Molecular Beacon and Scorpion primers.

33 ibrium between stochastically open molecular beacon and target-bound molecular beacon in the detectio

34 Molecular beacons and a 16 nt RNA derived from the Hfq binding sit

35 polymer and various forms of DNA (molecular beacons and its open state; single-stranded DNA and doub

36 so plays a significant role with the blocked beacons and represents a new and effective strategy for

37 h as not allowing anonymous pings of genetic beacons and requiring minimum beacon sizes.

38 The assay consists of six molecular beacons and two oligonucleotide primer pairs, allowing f

39 us and Esophageal Adenocarcinoma Consortium (BEACON), and discovered three loci simultaneously intera

40 Thus, 1 functions as a molecular peptide beacon, and as it is easily taken up by cells, 1 can als

41 obes (such as hairpin (HP) probes, molecular beacons, and G- quadruplex) that mediate cyclic cascade

42 Using a beacon architecture that masks the catalytic template, w

43 or "no." Here, we show that individuals in a beacon are susceptible to re-identification even if the

44 ncrease by 40-200-fold when the nanoparticle beacons are activated by plasmonic coupling, much higher

45 The beacons are based on colloidal gold nanocrystals in two

46 As beacons are generally associated with sensitive phenotyp

47 mismatch selectivity, whereas the unblocked beacons are simpler in design.

48 Molecular-beacons are single-stranded hairpin shaped nucleic acid

49 Various studies showed that beacons are vulnerable to re-identification (or membersh

50 Beacons are web servers that answer allele-presence quer

51 Using a fluorescent molecular beacon as a reporter, we observed RNA duplex formation w

52 ined from our sequential strand displacement beacon assay are consistent with those obtained from the

53 This new sloppy molecular beacon assay should greatly simplify rifampin resistance

54 We describe a sequential strand displacement beacon assay that is able to quantify specific DNA seque

55 Here, we used a fluorometric RNAP molecular beacon assay to discern partial RNAP-promoter interactio

56 Here, we used an RNAP molecular beacon assay to investigate interdependencies of RNAP in

57 Using a highly sensitive RNAP beacon assay, we performed quantitative real-time measur

58 w fluorescent assay, which we call a protein beacon assay, will be instrumental in quantitative disse

59 We used a "beacon" assay that measures the relative affinities of D

60 adigm that allowed us to distinguish between beacon, associative cue, and place strategies, we invest

61 Therefore, this molecular-beacon based microfluidic system presents a potentially

62 In this context, molecular beacon based sensors have emerged as powerful, no-wash i

63 e context of a possible dissociation between beacon-based and associative-cue-based response learning

64 These results suggest that the molecular beacon-based approach to assess miRNA expression and dis

65 he development of high-performance molecular beacon-based biosensing systems.

66 tly blunted nuclease activity in a molecular beacon-based fluorescence assay.

67 This study uses a newly developed molecular-beacon-based helicase assay (MBHA) to investigate how nu

68 Molecular beacon-based helicase assays were used to show that (BIP

69 ing to siRNA sites may not be good sites for beacon-based mRNA detection, and vice versa.

70 The beacon-based PCR assay designed in the present study is

71 -house, rapid, sensitive, specific molecular-beacon-based PCR assay, using primers against pfoB gene

72 ity by simply tuning the number of molecular beacon binding sites on the padlock probe without redesi

73 A catalytic beacon biosensor is designed by labeling a fluorophore a

74 A new class of molecular beacon biosensors based on the nanostructured aluminum o

75 abel, multicentre, randomised phase 3 study (BEACON; BrEAst Cancer Outcomes with NKTR-102), conducted

76 cluster-DNA conjugate acts like a molecular beacon but is distinguished because the cluster chromoph

77 er analyzed promising variants identified by BEACON by genotyping 10,158 patients with BE and 21,062

78 aptamer variant was then used to construct a beacon by hybridizing fluorophore-labeled aptamer with a

79 es in target-dependent cleavage of molecular beacons by a DNA nicking enzyme, through which one targe

80 This paper introduces the Beacon Calculus, a process algebra designed to simplify

81 gue that having multiple family members in a beacon can garble the information for attacks since a su

82 We also show that the designed molecular beacon can inhibit the function of miR-430 and cause dev

83 he detection of microRNAs in vivo, molecular beacons can also be employed to inhibit microRNAs in a s

84 Our results show that beacons can disclose membership and implied phenotypic i

85 Here, we demonstrate that molecular beacons can readily distinguish mature- and pre-miRNAs,

86 having one of the parents of a victim in the beacon causes (i) significant decrease in the power of a

87 Here, we present a cleavable hairpin beacon (CHB)-enhanced fluorescence detection for isother

88 his method uses a chimeric RNA-DNA molecular beacon (chMB).

89 ecular probe, termed a chameleon NanoCluster Beacon (cNCB), that lights up into different colors upon

90 ity is achieved by grafting either molecular beacons, complementary DNA, or proteins to a DNA molecul

91 t signal changes of the target DNA/molecular beacon complex in single droplets.

92 we developed DNA based label-free molecular beacons consisting of two regions: a signal-generating r

93 Furthermore, the targeted nanoparticle-beacon construct, once bound to the target mRNA sequence

94 In a beacon constructed with 65 European individuals from the

95 A molecular beacon containing three PS RNA modifications is designed

96 Over two summers, squirrels captured from beacon-dense and beacon-thin areas were tested in a radi

97 In both years squirrels from beacon-dense populations reached criterion faster than s

98 Possible beacon design rules are identified and approaches for en

99 tic code expansion labeling with a molecular beacon design.

100 Although bioluminescent molecular beacons designed around resonance quenchers have shown h

101 ingredients are involved: a soluto-inertial "beacon" designed to emit a steady flux of solute over lo

102 l information to inhibit selecting the decoy beacon, despite knowing the platform's actual spatial lo

103 -based amplification and real-time molecular beacon detection of hMPV were performed using a NucliSEN

104 ocal laser scanning microscopy for molecular beacon detection with a robust statistical pipeline for

105 cement for signal amplification in molecular beacon detection.

106 g of the dentate gyrus is linked to impaired beacon discrimination and compensatory use of allocentri

107 ction and neurogenesis genes correlated with beacon discrimination in middle-age animals.

108 re observed in neural circuits that underlie beacon discrimination performance and allocentric memory

109 c function and neurogenesis, correlated with beacon discrimination performance, suggesting that senes

110 We used a water maze beacon discrimination task to characterize young and mid

111 ever, older animals compensated for impaired beacon discrimination through greater reliance on spatia

112 r pair attached to the ends of the molecular beacon DNA strand.

113 By using four sloppy molecular beacons, each possessing a different probe sequence and

114 An electrochemically amplified molecular beacon (EAMB) biosensor is constructed using thiolated h

115 We demonstrate that these delivery beacons effectively bind and compact plasmid (p)DNA into

116 These delivery beacons efficiently deliver pDNA into cultured cells and

117 tive and selective electrochemical molecular beacon (eMB)-based DNA sensor has been developed.

118 sensitive plasmonic DNA biochip in molecular beacon fashion.

119 Using a protein beacon fluorescent method, we identify structural determ

120 nabled by appropriate selection of molecular beacon fluorophores.

121 f the present study was to design an aptamer beacon for fluorescence resonance energy transfer (FRET)

122 s in the dataset, by repeatedly querying the beacon for his/her single-nucleotide polymorphisms (SNPs

123 conclusion, we designed a FRET-based aptamer beacon for monitoring of an inflammatory cytokine-IFN-ga

124 pport a model in which m(6)A RNA serves as a beacon for the selective, rapid recruitment of Pol kappa

125 This system is engineered into a catalytic beacon for Tl(3+) with a detection limit of 1.5 nM, whic

126 These locations serve as beacons for additional factors, exemplified by liver X r

127 with receptors and targets, mitochondria are beacons for pharmaceutical modification.

128 sequence designed to interact in a molecular beacon format.

129 oth antigen transport by DCs and the crucial beacon function of CD4(+) cells for autoreactive CD8(+)

130 conveniently large, identifying a subset of "beacon genes" representing the largest changes will iden

131 sed to complete the picture outlined by the "beacon genes." This allow construction of a structured m

132 water maze task using two visually identical beacons, Grin1(DeltaDGCA1) mice were impaired at using s

133 onal DNAs include the fluorescence molecular beacon H(1) for TR recognition, H(2) for hybrid chain re

134 The surface immobilized aptamer beacon had a linear range from 5 to 100 nM and a lower l

135 d displacement of the ligated product by the beacon hairpin is, however, of limited efficiency.

136 ate subunits and the subsequent opening of a beacon hairpin probe by the ligated product.

137 Detection of nucleic acids using molecular beacons has been based on hybridization between target m

138 This class of SERS nanoparticle beacons has novel mechanisms for molecular detection and

139 Furthermore, we found that molecular beacons have the potential to distinguish miRNAs that ha

140 ow (<1 nM) concentrations in vitro, with RNA beacons having the highest detection sensitivity.

141 lecules, using differently labeled Molecular Beacons hybridizing to the same target, reveal a value b

142 Finally, newly designed sloppy molecular beacons identified many different mutations using a smal

143 's and Esophageal Adenocarcinoma Consortium (BEACON) identified risk loci for BE and esophageal adeno

144 molecular beacon and target-bound molecular beacon in the detection of E. coli 16s rRNA targets.

145 ation between target molecules and molecular beacons in a 1:1 stoichiometric ratio.

146 e allele discrimination ability of molecular beacons in a multiplex real-time PCR format.

147 Here we show that artificial sonar beacons inspired by floral shapes streamline the navigat

148 sis, and assembly of peptide-based molecular beacons into supramolecular protease sensors of either s

149 When compared with morpholino, molecular beacon is 2 orders of magnitude more potent in inhibitin

150 oligonucleotide sequences, such as molecular beacons, is that each target strand hybridizes with (and

151 ular nucleus (IPN) in 3 forms of navigation: beacon, landmark, and path integration.

152 ed DNA architecture, carrying five molecular beacon-like motifs, was constructed to display ten dengu

153 By equipping the hotspot with a molecular beacon-like structure, we combine the plasmonic signal e

154 acon structure, resulting in a LNA molecular beacon (LMB) with robust stability after surface immobil

155 terferon-gamma (IFN-gamma) molecular aptamer beacon (MAB) attached to a bioluminescent protein, Gauss

156 e, termed methyladenine-specific NanoCluster Beacon (maNCB), which can detect single m(6)A in DNA tar

157 er in the context of a fluorescent molecular beacon (MB) assay for detection of specific nucleic acid

158 To assess the clinical impact of a molecular beacon (MB) assay that detects multidrug-resistant tuber

159 ncogene as a model DNA molecule, a molecular beacon (MB) containing a 20-base loop, which is compleme

160 A molecular beacon (MB) is comprised of a fluorophore and a quencher

161 use of a novel dimerization-based molecular beacon (MB) probe consisting of two metallo-phthalocyani

162 ghly specific biotinylated DNA/LNA molecular beacon (MB) probe was conjugated with gold nanoparticles

163 s have been used in preparation of molecular beacon (MB) probes labeled with one or two pyrenes/quenc

164 t exploits the high specificity of molecular beacon (MB) probes with the speed and simplicity of loop

165 cological target for therapy and a Molecular Beacon (MB) specific for survivin mRNA is available.

166 en OSCS and the adenosine-repeated molecular beacon (MB) stem to coralyne in the presence of Ca(2+) i

167 study presents a thymine (T)-based molecular beacon (MB) used for probing S-adenosylhomocysteine hydr

168 on biosensor based on a label-free molecular beacon (MB) whose DNA hairpin structure terminal has a g

169 fficiency, while a signal reported molecular beacon (MB) with an endonuclease recognition site was de

170 A molecular beacon (MB) with stem-loop (hairpin) DNA structure and w

171 A molecular beacon (MB)-based sensor to offer a decisive answer in c

172 The application of molecular beacons (MB) that bind to precise sequences of mRNA prov

173 mass spectrometry (PCR/ESI-MS) and molecular beacons (MB), for detecting genes conferring resistance/

174 ultiplex real-time PCR assay using molecular beacons (MB-PCR) for rapid and accurate identification o

175 transcripts in living cells using molecular beacons (MBs) - fluorogenic oligonucleotide probes - wit

176 ction of Cu(2+) in solutions using molecular beacons (MBs) and graphene oxide (GO).

177 The sensing method employs molecular beacons (MBs) and two single-stranded helper DNA probes.

178 olarity-sensitive fluorophores and molecular beacons (MBs) are among the most popular approaches to p

179 Molecular beacons (MBs) are dual-labeled oligonucleotides that flu

180 how that when 2'-O-methyl-modified molecular beacons (MBs) are introduced into NIH/3T3 cells, they el

181 leotide polymorphisms (SNPs) using molecular beacons (MBs) by exploiting the dual-fluorescence of flu

182 lipoplex nanoparticles containing molecular beacons (MBs) can capture cancer cell-derived exosomes o

183 leic acids (LNA) to engineer novel molecular beacons (MBs) for long-term intracellular monitoring.

184 ribe the use of nuclease-resistant molecular beacons (MBs) for the real-time detection of coxsackievi

185 Specifically, molecular beacons (MBs) have been employed for this purpose; howev

186 Molecular beacons (MBs) have recently emerged as efficient probes

187 Molecular beacons (MBs) have shown great potential for the imaging

188 Molecular beacons (MBs) have the potential to provide a powerful t

189 fluorescence signal from 2'-deoxy molecular beacons (MBs) targeting K-ras and GAPDH mRNAs in living

190 With the use of molecular beacons (MBs) targeting specific mRNAs, we aimed to iden

191 RNA (sgRNA) to carry two distinct molecular beacons (MBs) that can undergo fluorescence resonance en

192 Numerous studies have utilized molecular beacons (MBs) to image RNA expression in living cells; h

193 nosensors based on oligonucleotide molecular beacons (MBs) with fluorescent or electrochemical transd

194 on by using two different types of molecular beacons (MBs), MB1 and MB2.

195 es that existing works require, to determine beacon membership under the same conditions.

196 of queries needed to confirm an individual's beacon membership.

197 labeled, the sequential strand displacement beacon method is able to quantify multiple unlabeled DNA

198 lass of mismatch-tolerant "sloppy" molecular beacons, modified them to provide an extended hybridizat

199 r highlight biosensing applications, aptamer beacon molecules were immobilized inside microfluidic ch

200 , through which one target DNA can open many beacon molecules, giving rise to amplification of fluore

201 target DNA leads to cleavage of hundreds of beacon molecules, increasing detection sensitivity by ne

202 avior of the three main class of the optical beacons namely phase conjugators, reflectors, and retror

203 d sequence-based amplification and molecular beacon (NASBA-MB) detection system in multiplex format w

204 landmark version of the water task, but left beacon navigation intact.

205 In beacon navigation, animals reach goals using cues direct

206 NanoCluster Beacons (NCBs) are collections of a small number of Ag a

207 t Pain with Computed Tomography Angiography [BEACON]; NCT01413282).

208 ealed that IFN-gamma binding with an aptamer beacon occurred within 15 min of analyte introduction--s

209 elongates, therefore behaving as a permanent beacon of division sites.

210 l prerequisites of life we call atmospheric "beacons of life" create a unique opportunity to perform

211 ons (CA) and abnormal mitoses are considered beacons of malignancy.

212 ce at the edges of the disturbance produced "beacons" of infrared emission and longitudinal temperatu

213 The blocked beacons offer better mismatch selectivity, whereas the u

214 Both the blocked and unblocked beacons offer nanomolar (femtomole) detection limits, re

215 e structure-switching biosensor, a molecular beacon, over 4 orders of magnitude.

216 on effect of the kinship relationships among beacon participants against re-identification attacks.

217 ls (Urocitellus beldingi) from areas rich in beacons perform differently in a task of spatial memory

218 Because of their versatility, these delivery beacons posses remarkable potential for tracking and und

219 Sloppy molecular beacons possess relatively long probe sequences, enablin

220 The sensor consists of a molecular beacon probe as a signal reporter and two DNA adaptor st

221 lopment of a fluorescence turn-on "molecular beacon" probe for the detection of glutathione (GSH) and

222 Molecular beacon probes (MBs) were used to demonstrate these point

223 ort here the use of novel "sloppy" molecular beacon probes in homogeneous PCR screening assays in whi

224 tive, as they do not consider the utility of beacon protocol.

225 Widely accepted 'genomic data sharing beacon' protocol provides a standardized and secure inte

226 We used a quantum reference beacon (QRB), consisting of solid-state quantum emitters

227 eles at positions of interest as well as the beacon query results with very high confidence.

228 imaging probe called ratiometric bimolecular beacon (RBMB), which combines functional elements of bot

229 leotide-based probe, ratiometric bimolecular beacon (RBMB), which generates a detectable fluorescent

230 We developed a rapid molecular beacon real-time PCR (MB-PCR) assay for staphylococcal c

231 A species-specific molecular beacon real-time PCR assay was developed for rapid diagn

232 ity of such a design by creating a molecular beacon reporter to detect amyloid-beta peptides, known t

233 Conventional molecular beacons require double-labeled DNA sequences, which are

234 target sequence to form a reverse molecular beacon (rMB), thus bringing Cy5 (donor) and Cy5.5 (accep

235 cy of LMBs against that of regular molecular beacons (RMBs), the properties of selectivity, sensitivi

236 ported in BE cases 3 risk SNPs identified by BEACON (rs2687201, rs11789015, and rs10423674).

237 or of ideal behavior, greatly steepening the beacon's binding curve relative to that of the parent re

238 This is mainly a consequence of the beacon's poor stability because of the hairpin structure

239 This is a new DNAzyme, and a catalytic beacon sensor is designed by attaching a fluorophore/que

240 A catalytic beacon sensor was designed with a detection limit of 1.6

241 w class of surface-enhanced Raman scattering beacons (SERS beacons) that can be turned on and off by

242 A primer-molecular beacon set targeting 28S rRNA was designed to detect Asp

243 erch with only a dim point light source as a beacon, showing that they do not need optic flow or a vi

244 4 mRNA using siRNA significantly reduced the beacon signals, demonstrating detection specificity.

245 ngs of genetic beacons and requiring minimum beacon sizes.

246 eloped a rapid, multiplexed sloppy molecular beacon (SMB) assay to identify these mutations and then

247 ollowed by probing with two sloppy molecular beacons (SMBs) spanning the entire QRDR.

248 cement of an oligonucleotide-bound molecular beacon so that rates of helicase translocation can be di

249 The beacon specificity was further confirmed using blocking

250 the dehybridization and dissociation of the beacon stem T-Hg(2+)-T due to the extraction of Hg(2+) i

251 ches in a DNA strand of the self-hybridizing beacon strand.

252 Instead, they continuously used a beacon strategy and showed no evidence of changing their

253 The specific preference for a beacon strategy is discussed in the context of a possibl

254 In this work, we utilized a molecular beacon strategy to examine the stability of the (CAG)(10

255 adds locked nucleic acid bases (LNAs) to the beacon structure, resulting in a LNA molecular beacon (L

256 reased sensitivity compared with fluorescent beacon systems, bioluminescence quenching is still compa

257 R assays with as few as six sloppy molecular beacons targeting bacterial 16S rRNA gene segments could

258 d variability in performance on a water maze beacon task and next-generation sequencing to test the h

259 These results indicate that the beacon task is sensitive to impairment in middle age, an

260 stdevaluation testing showed behavior on the beacon task to be habitual as well.

261 In a second cue-based "beacon" task requiring behavior initiation at the start

262 lation-sensitive endonucleases and molecular beacon technology.

263 s 1000-fold less accessible to the molecular beacon than an unstructured oligonucleotide, and Hfq acc

264 , the report of this study should serve as a beacon that will spark up strategic planning, comprehens

265 Here, we have developed polymer beacons that allow the delivery of nucleic acids to be v

266 leosome asymmetries might serve as molecular beacons that guide transcription.

267 igns for light-up nucleic acid hybridization beacons that utilize time-resolved Forster resonance ene

268 face-enhanced Raman scattering beacons (SERS beacons) that can be turned on and off by long-range pla

269 rs, squirrels captured from beacon-dense and beacon-thin areas were tested in a radial maze intersper

270 spatial memory compared with squirrels from beacon-thin areas.

271 reached criterion faster than squirrels from beacon-thin populations, and a weak rearing effect was p

272 nealing of a fluorescently labeled molecular beacon to a 16-nt RNA.

273 This study is aimed at using a molecular beacon to detect miR-430 in developing zebrafish embryos

274 Pioneering a novel RNA beacon to illuminate RNA trafficking in neurons, Alami e

275 EC, we propose that DHMA acts as a molecular beacon to target pathogens to their preferred sites of i

276 s process results in switching the molecular beacon to the "on" state.

277 tly from bacterial lysate and used molecular beacons to achieve detection of bacteria specific sequen

278 of a real-time PCR assay utilizing molecular beacons to assess triazole resistance markers in A. fumi

279 d the incorporation of hairpin DNA molecular beacons to confer high specificity and sensitivity to th

280 rs (MMCs) were functionalized with molecular beacons to enable miRNAs recognition and magnetic separa

281 The assay uses sloppy molecular beacons to probe an asymmetric PCR of the M. tuberculosi

282 a collaborative binding, providing molecular beacons to signal-dependent transcription factors (SDTFs

283 re tested in a radial maze interspersed with beacons, using number of trials to criterion as a measur

284 lization of the amplified product, molecular-beacon was designed and amplicons were visualized direct

285 A DNAzyme beacon was engineered detecting down to 1.7 nM Ce(3+) (2

286 utation detection, and a dual Cy3B Molecular Beacon was synthesized and found to be superior to the c

287 While searches were biased towards the beacons, we did not find any evidence that participants

288 labeled target DNA derivatives called "Cas9 beacons." We observed significant differences in the aff

289 pturing probes and fluorescent DNA molecular beacons were developed to rapidly detect NNV and iridovi

290 Sloppy molecular beacons were exceptionally versatile, and they were able

291 ed secure against re-identification attacks, beacons were shown to be vulnerable despite their string

292 These candidate beacons were synthesized with 5'-TYE 665 and 3'-Iowa Bla

293 The new beacons were tested with MDA-MB-231 cancer cells and use

294 duced distal allosteric sites into molecular beacons, which are optical sensors for the detection of

295 Through simulations, we showed that in a beacon with 1,000 individuals, re-identification is poss

296 We show that in a simulated beacon with 65 individuals from the European population,

297 t it is possible to detect membership in the beacon with just 250 SNPs.

298 We found that molecular beacons with DNA, RNA and combined locked nucleic acid (

299 ative to, for example, traditional molecular beacons without any significant restriction in the choic

300 This beacon yielded a lower limit of detection of 1 ng/mL in