ライフサイエンスコーパス: beagle

1 collected by Darwin during the voyage of the Beagle.

2 used as input to imputation methods such as Beagle.

3 fying forelimb muscle synergies of a walking Beagle.

4 putational thread and 15x more CPU time than Beagle.

5 p to 400 times faster with findhap than with Beagle.

6 from the population-based imputation program BEAGLE.

7 associated neurological dysfunction in this Beagle.

8 ribed in several canine breeds including the Beagle.

9 Purpose-bred, 1- to 2-yr-old, 10- to 12-kg beagles.

10 468 and from day 46 until day 159 in the two beagles.

11 for 8 weeks in five normal adult laboratory beagles.

12 atin rectangle design was used with 10 adult beagles.

13 ss-sectional study of 74 laboratory research beagles.

14 D8 ratio is significantly lower in Geriatric beagles.

15 re significantly lower in Aged and Geriatric beagles.

16 gnificantly lower in both Aged and Geriatric beagles.

17 n of ADAMTS10 as the likely cause of POAG in beagles.

18 bing (%BOP) were observed in placebo-treated beagles.

19 In this study, 13 pathogen-free beagles, 12 to 26 weeks old, were infected with Borrelia

20 phy from a longitudinal study in middle-aged beagles (36 females, 7 males) undergoing behavioral enri

21 Phasing these with Beagle 5 takes 4.3 CPU days, followed by either Refined

22 We compare Beagle 5.2 and SHAPEIT 4.2.1 by using expanding subsets

23 ing method is implemented in the open-source Beagle 5.2 software package.

24 Ten female retired breeder beagles, 7 to 8 years old, with naturally occurring mode

25 To test this hypothesis, we immunized aged beagles (8.4-12.4 years) with fibrillar Abeta(1-42) form

26 In one of these models (Beagles), AD can be reliably reproduced upon allergen ch

27 he-art existing statistics methods including Beagle and fastPhase.

28 We use the genotype likelihood input mode in Beagle and filter for confident genotypes as the input t

29 p imputation by the state-of-the-art methods Beagle and FImpute.

30 In this paper, we extend the BEAGLE API to a multiple Field Programmable Gate Array (

31 Affected Beagles are unable to ambulate normally from the onset o

32 ne infusion was successfully performed in 16 beagles; both procedures were performed simultaneously i

33 gher-order diffusion MRI, in the middle-aged beagle brain (n = 30, male and female).

34 ex, and prefrontal cortex of the middle-aged beagle brain, with no noticeable adverse effects.

35 Source code provided in BEAGLE: Broad-platform Evolutionary Analysis General Lik

36 cerebral amyloidosis, Caribbean vervets, and beagle canines.

37 h ancient and modern marine species from the Beagle Channel were used to compare the structure of Lat

38 productivity during the Late Holocene in the Beagle Channel.

39 nd are available by anonymous ftp from ftp://beagle.colorado.edu/pub/consensus.

40 Although placebo-treated beagles demonstrated %BOP scores of 43% at week 8, GED-

41 ives a slightly lower switch-error rate than Beagle does and is more than six times faster.

42 and completely converted to cinnarizine in a beagle dog following iv administration.

43 ss in a ligature-induced periodontal disease beagle dog model.

44 hic alveolar bone loss in a ligature-induced beagle dog model.

45 several human-like clinical situations in a beagle dog model.

46 A four-week old Beagle dog presented with progressive signs of cerebella

47 f submerged and nonsubmerged implants in the beagle dog.

48 igature-induced gingival inflammation in the beagle dog.

49 orhexidine-induced tooth stain coverage in a beagle dog.

50 cantly reduce experimental gingivitis in the beagle dog.

51 In 15 healthy Beagle dogs (average weight 9.3 kg), we compared insulin

52 left ventricular endocardium in anesthetized beagle dogs (n=11) in vivo.

53 clinical response of periodontal pockets in beagle dogs after treatment with a biodegradable deliver

54 4 implants were placed in the mandibles of 4 beagle dogs and randomly assigned to 1 of 3 treatment gr

55 active for the release of growth hormone in beagle dogs at doses as low as 0.5 mg/kg.

56 Four beagle dogs completed the study and were used in a split

57 Seven male beagle dogs comprised the study group.

58 Preliminary animal studies in Beagle dogs conducted with lenses in which particles are

59 In six anaesthetized beagle dogs control contractions increased hindlimb bloo

60 gns of inflammation took place in any of the beagle dogs during the four months of implantation.

61 gene family of E. chaffeensis, sera from two beagle dogs experimentally infected with E. chaffeensis

62 Nine beagle dogs had all premolar teeth extracted and adjacen

63 Eight adult, female beagle dogs had generalized, severe periodontitis with p

64 CCL22) in ligature-induced periodontitis in beagle dogs leads to reduced clinical measures of inflam

65 tors following oral administration to either beagle dogs or CM-monkeys is described.

66 sensitivity model with the anterior teeth of beagle dogs showed newly formed tertiary dentin at the d

67 act lenses was then compared to eye drops in beagle dogs that suffer from spontaneous glaucoma.

68 Pharmacokinetic studies were performed in beagle dogs to evaluate bioavailability.

69 dies and in vivo pharmacodynamics studies in beagle dogs to evaluate the efficacy of glaucoma therapy

70 Seventeen skeletally mature male beagle dogs underwent 10 mm of bilateral interdental man

71 Adult female beagle dogs underwent 2-hr hepatic vascular exclusion wi

72 Ten beagle dogs underwent atraumatic bilateral second and fo

73 Under general anesthesia, 10 beagle dogs underwent atraumatic tooth extractions.

74 this strategy in a larger animal, we treated beagle dogs using intracisternal or intracerebroventricu

75 Borrelia burgdorferi infection in beagle dogs was studied quantitatively with skin punch b

76 Twenty 18-month-old female beagle dogs were brought to optimal periodontal health o

77 Eighteen healthy adult Beagle dogs were fed an isocaloric Western diet (WD) for

78 Pancreata removed from Beagle dogs were infused with University of Wisconsin so

79 Adult female beagle dogs were randomized into 4 dosage groups (5 anim

80 Fifteen purebred beagle dogs were subjected to a 14-day oral hygiene regi

81 Eighteen male beagle dogs were subjected to the creation of bilateral

82 Four beagle dogs were used and 32 interproximal intrabony def

83 Eleven male beagle dogs were used in the study.

84 Six beagle dogs were used in this study.

85 Beagle dogs were used in two distinct animal models of h

86 ith standardized periodontal bony defects in beagle dogs with and without diabetes.

87 It was concluded that, for the beagle dogs with severely infected periodontal pockets i

88 Four beagle dogs with streptozotocin (STZ)-induced diabetes a

89 ) and in the lungs of experimentally exposed beagle dogs with varying initial lung depositions were d

90 The procedures were performed in 8 female beagle dogs, 4 to 6 years old.

91 In eight beagle dogs, a critical-size labial GR defect was surgic

92 dyslipidemia using Syrian hamsters and male Beagle dogs, and all these compounds displayed excellent

93 re created in mandibular premolar teeth of 6 beagle dogs, followed by placement of membranes and woun

94 In neonatal female Beagle dogs, implantation of an EB-containing silicone c

95 In both the human case and beagle dogs, the appearance of retained plutonium within

96 tized, paralyzed and mechanically ventilated beagle dogs, we have studied involvement of glutamate an

97 on was surgically created in sexually mature beagle dogs.

98 dontal defects were created in 5 young adult beagle dogs.

99 reated at the mandibular premolar teeth in 9 beagle dogs.

100 sal pharmacodynamics in somatostatin-treated beagle dogs.

101 Four healthy, purpose-bred female beagle dogs.

102 dothelial cells were cultured from retina of beagle dogs.

103 lveolar crest on maxillary canine teeth in 6 beagle dogs.

104 nistration of 6 potently inhibits feeding in beagle dogs.

105 curring buccal Class II furcation defects in beagle dogs.

106 eliminated from the systemic circulation of beagle dogs.

107 glass-ceramic rods implanted in the jaws of beagle dogs.

108 piperine and curcumin, were investigated in beagle dogs.

109 human xenograft mouse models and in healthy beagle dogs.

110 armacokinetics of the CPP-lipid conjugate in Beagle dogs.

111 es by evaluating exposure of the API in male Beagle dogs.

112 activity and retard gingival inflammation in beagle dogs.

113 neonatal cerebellar cortical degeneration in Beagle dogs.

114 and increased as disease progressed in POAG beagle dogs.

115 nd mandible were obtained from 6 mature male beagle dogs.

116 frontal cortex, thalamus and spinal cord of beagle dogs.

117 he development of experimental gingivitis in beagle dogs.

118 were created bilaterally in seven 1-year-old beagle dogs: 3-walled intrabony defects distal of the ma

119 Adult beagle donors were subjected to explosive BD for 16 hr.

120 cores of 43% at week 8, GED- and MEG-treated beagles exhibited %BOP scores of 21% and 26%, respective

121 uth America between 1832 and 1833 during the Beagle expedition were examples of the large, heavily ar

122 We also found that Geriatric beagles experience hyperinsulinemia, while plasma adipon

123 82 postexposure serum samples) from 10 adult beagles experimentally inoculated with Bartonella spp.,

124 Male beagles fed a diet containing 30% galactose were periodi

125 Fifteen female, 1-year-old beagles first completed a 2-week dose-escalation experim

126 A full-length dog (beagle) flavin-containing monooxygenase 1 (FMO1) cDNA (d

127 pipeline uses BCFtools for marker filtering, Beagle for genotype phasing, and Tabix for VCF indexing.

128 ) were bilaterally placed in the tibia of 18 beagles for 1, 3, and 5 weeks.

129 h period, the assigned diets were fed to the beagles for 28 days after a 7-day wash out period.

130 WinPCA accepts variant data in either VCF or BEAGLE format and can generate rich plots for interactiv

131 iple input formats including BAM and imputed beagle genotype probability files.

132 On Day 0, beagles had an Escherichia coli-infected (septic) or ste

133 A general purpose API called BEAGLE has recently been developed that includes optimiz

134 Following the voyage of the Beagle, his focus on insects shifted from collecting spe

135 We employ a BEAGLE-implementation using the Bayesian phylogenetics f

136 s in the tracheobronchial lymph nodes of the beagles indicated the lymphatic system was effective in

137 In a beagle intramuscular model, the scaffold induced bone fo

138 However, for TOPMed sequence data, Beagle is more than 20 times faster than SHAPEIT, achiev

139 es complex' and since Darwin's voyage on the Beagle, it has been of great cytological, physiological

140 t with 16,353 samples, we compare HAPI-UR to Beagle, MaCH, IMPUTE2, and SHAPEIT and show that HAPI-UR

141 FDR are similar to that of the BCFtools and Beagle methods.

142 eviously, we mapped the disease locus in the beagle model of autosomal recessive primary open angle g

143 The beagle model of primary open-angle glaucoma (POAG) was u

144 2/IL-23p40; healthy NSDTRs (n = 16), healthy beagles (n = 16), NSDTRs autoimmune (n = 18) and NDSTRs

145 Two-year-old purpose-bred beagles (n = 24) infected with Staphylococcus aureus pne

146 olled blinded trial, 2-year-old purpose-bred beagles (n = 24), with Staphylococcus aureus pneumonia,

147 We demonstrate results similar to those from Beagle on another data set with a higher marker density.

148 e polymorphisms (SNPs) in other genes in the beagle POAG locus that segregate with disease.

149 revalence of primary glaucoma in the general beagle population.

150 c analyses of 4,400 whines recorded from 220 Beagle puppies in 40 litters revealed litter and individ

151 Beagles randomly received 0.3% MEG, 0.3% GED, or placebo

152 gh for application to sequence data (IBDseq, Beagle Refined IBD, PLINK, and GERMLINE) under multiple

153 represents a ~40X speedup when compared with BEAGLE's CPU implementation on a dual Xeon 5520 and 3X s

154 on on a dual Xeon 5520 and 3X speedup versus BEAGLE's GPU implementation on a Tesla T10 GPU for very

155 sequence data from 50,000 reference samples, Beagle's throughput was more than 100x greater than Impu

156 enerated and characterized multiple lines of Beagle Shank3 (bShank3) mutants that have been propagate

157 liminary oral pharmacokinetics study in male beagles showed that 28 is superior to 27 and is an attra

158 better runtime scaling properties than does Beagle so that for larger data sets, HAPI-UR will be pra

159 tIBD is incorporated in the freely available Beagle software package.

160 typed, and haplotypes were inferred by using BEAGLE software.

161 He included microbes in his Beagle studies of the geographical distribution of organ

162 Charles Darwin's travels on HMS Beagle taught him that islands are an important source o

163 ts performance to the most recent version of BEAGLE that can perform this task.

164 Here, we infected 8 beagles through multiple experimental vector transmissio

165 We exposed lab raised beagles to varying densities of uninfected copepods in 2

166 In lab beagles, total lymphocytes, T-cells, CD4 T-cells, CD8 T-

167 Mean GI scores for beagles treated with GED or MEG gels remained at or belo

168 A total of 12 beagles underwent MR imaging and computed tomography (CT

169 ly661Arg variant of ADAMTS10 was an affected beagle, unrelated to the POAG colony.

170 ves imputation quality very close to that of BEAGLE, using one to two orders of magnitude less time,

171 We demonstrate that Beagle v.4.1 scales to much larger reference panels by p

172 We compare Beagle v.4.1 with Impute2 and Minimac3 by using 1000 Gen

173 the Li and Stephens model and implemented in Beagle v.4.1, is parallelized and memory efficient, maki

174 e an implementation of our GPU algorithms in BEAGLE v4.0.0, an open-source library for statistical ph

175 urate, and easy to use and is implemented in Beagle version 4.

176 findhap (version 4) had higher accuracy than Beagle (version 4); computing time was up to 400 times f

177 vels of IL-12/IL-23p40 in healthy NSDTRs and beagles versus NSDTRs with cancer or autoimmune disease.

178 Human insulin was administered to 13 beagles via inhalation (Exubera [insulin human (rDNA ori

179 Beagles were anaesthetized with thiopentone sodium (500

180 eriod randomized cross-over study design, 14 beagles were challenged with allergen and clinically mon

181 al dentin areas of 6 maxillary incisors of 5 beagles were exposed to a class V-like lesion, and 1 sid

182 Twenty 6-week-old specific-pathogen-free beagles were infected with Borrelia burgdorferi by tick

183 Sixteen specific-pathogen-free beagles were infected with Borrelia burgdorferi.

184 re exposed without any restorations, and all beagles were sacrificed after 4 wk.

185 Five beagles were scanned with (18)F-FDG PET/CT and MRI.

186 Dog kidneys (beagles) were exposed to 0, 60, or 75 min of in situ war

187 mRNA-seq) of cerebellum tissue from a single Beagle with neonatal cerebellar cortical degeneration as

188 Thirteen beagles with cervical cardiac allografts were studied fo

189 were evaluated at 3 concentrations in mature beagles with partial medial meniscectomy.

190 -error rate than do other methods except for Beagle; with the use of consensus phasing, running HAPI-

191 In 4 beagles without progressively worsening allograft reject