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1 sidered unsuitable for standard chemotherapy because of a cardiac ejection fraction of less than 50%,
2 ve decline and is thought to arise, in part, because of a chronic pro-inflammatory state in the brain
3 . crescentus MreB over Escherichia coli MreB because of a closer match in the degree of opening with
4 It has been argued that psychosis may emerge because of a failure to learn sensory statistics, result
5 dy brings about resistance to chemotherapies because of a general feature of the aneuploid condition-
7 he facial and/or spinal accessory nerves and because of a likely margin-positive (R1 or R2) result.
12 -old who discontinued treatment after 3 days because of "abnormal drug taste." The most commonly repo
13 be killed by developmental alcohol exposure because of activation of microglial immune cells in the
18 g motif shown in experiments, but it rotates because of an electrostatic repulsion and forms a hydrop
19 gue that current drugs for AF are inadequate because of an oversimplified system for patient classifi
20 blockers reduce migration and invasion rates because of autophagy blockade only in BRAF(V600E)-mutant
21 or into deeper water when temperatures rise because of barriers, reduced light availability, altered
23 immense physical and psychological symptoms because of both their illness and often intensive treatm
24 tivity are difficult to study experimentally because of challenges in isolating a particular phosphor
25 s at large scale, but not mosquitoes, mainly because of challenges with consistent production and dis
26 is a perpetual concern in Arctic communities because of challenging climatic conditions, limited opti
27 murine b-wave in both genotypes, most likely because of chelating amino acids present in the murine n
28 et negative charges appeared self-inhibitory because of ClC-5's voltage-gated properties, but shunt c
29 uld not have met ZUMA-1 eligibility criteria because of comorbidities at the time of leukapheresis.
30 cancer in this population can be challenging because of competing health and ageing-related condition
33 mage and decline of cardiac function, likely because of dampened activation of cytotoxic CD8(+) T cel
37 compared with local field potential was not because of differences in low-level visual features capt
38 ntingent on early community states, not only because of differences in the species pool, but also bec
40 molecular details are only partly understood because of difficulties with experimentally accessing th
43 rk as effectively in female mice as in males because of estrogen regulation of G protein receptor kin
44 est stages of the CD8(+)T(M) recall response because of expeditious synthesis/secretion kinetics (CCL
45 years after his first facial transplantation because of extensive disfigurement from type 1 neurofibr
47 tients may still face progressive disability because of failure of myelin regeneration and loss of ne
50 how signs of deeper evolutionary integration because of functional, developmental or genetic constrai
51 sm type 2 (OCA2) is a gene of great interest because of genetic variation affecting normal pigmentati
53 ls from biorenewable and sustainable sources because of great concerns about the environment, waste a
56 growth in private insurers' overhead, mostly because of high overhead in their Medicare and Medicaid
57 ophenes bearing reactive groups is difficult because of high reactivity of organometallic reagents.
58 45% of 1103 United States kidneys discarded because of histologic findings could be accurately match
62 ammatory disease of the heart that may occur because of infections, immune system activation, or expo
63 esearch data do not provide database matches because of informatic artifacts, chemical contaminants,
64 chniques have limitations, particularly APT, because of insufficient understanding of void imaging.
65 anthracene-substituted derivatives, perhaps because of inter-arene torsions that emerge in theoretic
66 ransforming growth factor beta 1 (TGF-beta1) because of interleukin-4 (IL-4)- and signal transducer a
68 iagnosed on CT angiography (CTA) of the neck because of its ability to resolve calcium and create mul
69 of increase in brain Asp and NAA is possibly because of its active utilization by the aralar-KO brain
72 ere for engineering higher-valency molecules because of its compact size, simple structure, and natur
74 uced bioactivity compared with WT GH (GH-WT) because of its decreased ability to bind and activate th
76 al and biotechnological applications, mainly because of its effects on the cell plasma membrane, but
77 rus (AAV) is a promising gene therapy vector because of its efficient gene delivery and relatively mi
79 anding potential applications in biomedicine because of its high electrical conductivity and biocompa
81 en observed indirectly in the gas phase, and because of its high reactivity has eluded isolation in t
82 al 2D material predicted to be piezoelectric because of its highly directional properties and non-cen
85 cancer (PC) remains a therapeutic challenge because of its intrinsic and extrinsic chemoresistance m
86 enerated a lot of interest among researchers because of its involvement in both the normal aging proc
90 ZBP1 is unique among innate immune sensors because of its N-terminal Zalpha1 and Zalpha2 domains, w
92 ect-targeting of c-Myc poses special problem because of its non-enzymatic nature and certain amount o
94 ion among different data-sources is reliable because of its potential of unveiling new functionalitie
97 of treatment in adoptive cell therapy (ACT) because of its protumor effects and its role in the cyto
99 is of HCM-LVSD has reportedly been poor, but because of its relative rarity, the natural history rema
102 oved to be a promising tool for targeted EMB because of its sensitivity and specificity for identific
104 T182I resided predominantly on mitochondria, because of its slow retrotranslocation and mediated apop
106 Ubiquitin was chosen as the model protein because of its structural stability which allows the pro
107 est electrophysiologically studied jellyfish because of its system of giant axons and unique fast swi
108 difference in chloroplast morphology, likely because of K redistribution from vacuole to chloroplast.
109 ds (44.4%) or a high suspicion of malignancy because of known pre-existing systemic malignancy or the
111 riation, but such calibrations are precluded because of lack of experimental relative permeability da
113 DNA sequencing are complex and compositional because of large numbers of detectable taxa, and because
116 ransplantation outcomes is poorly understood because of limitations of conventional SES measures.
118 econdary sources, has been uncertain in part because of limited knowledge of the precursor emissions
119 le in rejection is unknown, however, in part because of limited techniques for distinguishing recipie
120 adrant US examinations were mostly performed because of liver laboratory findings (87%, 32 of 37), an
122 ondria aggregate and depolarize after stress because of loss of activity of the mitochondrial fission
123 y, and six (17%) discontinued it prematurely because of loss to follow-up, withdrawal of consent, inv
124 enome sequencing of specimens is challenging because of low bacterial and high human DNA abundances.
125 lthough phylogenetic clustering is uncertain because of low virus genetic variation early in the pand
127 emodeling in which pulmonary arteries narrow because of medial thickening and occlusion by neointimal
128 rolled patients did not undergo the protocol because of medical complications unrelated to the study
134 Diagnosis of alveococcosis is difficult because of not typical clinical picture and irregular re
136 sis and phosphorylate most mitotic proteins, because of parallel PP2A:B55 phosphatase inactivation by
138 uronal function and survival remains unclear because of perinatal lethality exhibited by knockout mic
139 novo monogenic neurodevelopmental disorders because of phenotypic heterogeneity and the absence of l
140 th a 2-fold increased odds of being referred because of photography findings compared with standard c
141 in low diversity communities and especially because of plant diversity loss in initially high divers
142 ives as therapeutic agents has been hampered because of poor drug-like properties as well as syntheti
144 pharmacogenetic studies is often challenging because of poor reporting of key data in study reports.
146 ses severe disability and death of young men because of progressive muscle degeneration aggravated by
149 or cells, while IgE-ICs were noninflammatory because of reduced FcepsilonRI binding and enhanced CD23
150 ome countries and might not be generalisable because of regional differences in health-care infrastru
151 n health-care systems and society as a whole because of repeated consultations, unnecessary investiga
152 tenuated DOX-induced cardiac atrophy, likely because of repression of muscle RING finger 1 (MuRF1), a
153 , particularly type 2 myocardial infarction, because of respiratory failure with hypoxia and hemodyna
154 However, patient access remains limited because of restricted insurance coverage and a lack of g
155 de patients who are at high immunologic risk because of sensitization to alloantigens, including thos
156 design is preferable over monolithic sensors because of simpler assay optimization and improved selec
158 ish in their magnitude over time, especially because of soil acidification in low diversity communiti
159 modified clones; this is usually challenging because of sparse sampling of the various cell types dur
160 mice are not readily infected by SARS-CoV-2 because of species-specific differences in their angiote
161 ality failed to be statistically significant because of survey design or because participants use heu
164 icted to affect wild organisms, particularly because of the central role that light regimes play in d
165 either load-free or constant load conditions because of the complexity of the equipment required for
166 degradation products has proven challenging because of the complexity, transience, and low concentra
167 radictory results have been reported, mainly because of the complicated trap states characteristic of
170 bilayers, which form moire superlattices(6) because of the difference between the lattice constants
171 ly active heterosurfaces remains a challenge because of the difficulty in component tuning, morpholog
172 difficult to localize by conventional means because of the difficulty in specific targeting/delivery
173 rs in extinct vertebrates is rare, primarily because of the difficulty of identifying such behaviors
174 butene-1,2-dione from 2-diazo-1,3-indandione because of the difficulty of inducing the initial rearra
176 studies, however, are inherently problematic because of the discovery of excessive false positive (FP
178 diction of plant gas exchange is challenging because of the diversity of biological components regula
179 ced number of circulating white blood cells, because of the Duffy-null (CC) genotype at rs2814778 in
180 e kappa(latt) by effective phonon scattering because of the excess point defects and rich microstruct
181 patient, enteric derivation was not possible because of the extremely fragile intestinal tissue perio
183 rts have focused on those aspects, primarily because of the few animal models available as natural ho
185 0) crystallographic plane of the Li crystals because of the fine in-plane lattice matching between Li
189 represents an attractive treatment strategy because of the high-linear-energy transfer and short pat
190 ion enzymology has evaded detailed analysis, because of the historical unavailability of kinetically
191 is aggressive with a poor prognosis, partly because of the immunosuppressive microenvironment create
192 evel II, and 13 studies were rated level III because of the impact on the development and popularizat
193 tibiotics for these pathogens is challenging because of the inability of most small molecules to accu
194 ens as data are aggregated over larger areas because of the increasing diversity among farms, but at
195 phagocytic activity, both likely compromised because of the induction of antibodies that did not bind
196 DGAT2's acyl-donor specificity is not known because of the inherent challenges of predicting structu
197 ations have experienced declines of over 90% because of the introduced fungal pathogen that causes wh
198 aments are less stable than the ScRad51 ones because of the kinetically much reduced nucleation step.
201 ted systematically on this class of proteins because of the lack of an appropriate benchmark set.
202 d with caution, perhaps sparingly, primarily because of the lack of enough training data and computat
204 sites for NRR catalysis remains challenging because of the large distance between them, which signif
205 s to adult facilities is also a complex task because of the large number of distinct disorders, which
206 ever, the three studies were not independent because of the large overlap in their participants, and
207 nning patients in the first 2 d of treatment because of the larger degree of tracer clearance in this
209 unusual properties of water remains elusive because of the limited data at the temperatures and pres
211 ures of perfect absorption could be observed because of the localized surface plasmon resonance that
212 eptible to the low arginine microenvironment because of the low expression of the arginine resynthesi
213 s, the correlation was low (<0.80) primarily because of the low numbers of events recorded in these s
215 ons remain a leading threat to global health because of the misuse of antibiotics and the rise in dru
217 elective cancer surgery has become an issue because of the need to balance the requirement to treat
218 ng useful mathematical models is challenging because of the often different domains of knowledge requ
219 g receptors leads to LL HC hyperpolarization because of the opening of small-conductance Ca(2+)-activ
221 ve heat transfer in the ambient environment, because of the overlap with the atmospheric transmission
222 , the presence of arsenic can be problematic because of the potential for increased mobilization and
223 ion (TACE) in hepatocellular carcinoma (HCC) because of the potential for profound adverse events and
224 tion carried a substantial risk of morbidity because of the potential need to sacrifice the facial an
225 ons were less stable than in C(H)2s and m01s because of the presence of the N-terminal 3(10)-helix an
228 etic compartment reconstitution was improved because of the recovery of the supportive stromal ME.
229 generated by topoisomerases are short-lived because of the religation activity of these enzymes, whi
231 effects of contaminants remains challenging because of the sheer number of chemicals and their ambig
234 arantine, and population-level interventions because of the specific transmission kinetics of this vi
235 lded polypeptides remains highly challenging because of the stringent requirement for simultaneous re
236 anically bound Fe dominates with this effect because of the strong dependency of iron oxyhydroxide so
238 owing to the difficulty in identifying them because of the typically long interval between carcinoge
239 passive, and heterogeneity may be increased because of the underlying pathophysiology leading to Fon
242 simply infeasible for many taxa and settings because of the vast numbers of animals involved-hundreds
243 ce infection is established, and this may be because of the very early formation of a reservoir of la
245 , supercoil dynamics are difficult to access because of the wide range of relevant length and timesca
246 istent organic pollutants of global interest because of their associations with adverse health outcom
247 ctating seals to display energy compensation because of their breeding strategy of high energy transf
249 azardous substances to public health, mainly because of their carcinogenicity and oxidative potential
250 a spin splitting and anomalous Hall effects, because of their characteristic layered structures compo
252 tructure of depressive symptoms in late-life because of their distinct etiologic factors, clinical pr
254 hingolipid metabolites have gained attention because of their essential role in the pathogenesis and
255 gnetic systems have been studied for decades because of their extraordinary properties and promising
256 porated into billions of commercial products because of their good colour saturation, versatile form
257 mental waters is an alarming issue, not only because of their harmful effects in the environment but
258 e promising as strategies for drug delivery, because of their high drug loading capacity and low prem
260 of major environmental and practical concern because of their highly toxic effects on human health an
261 AFMs) possess great potential in spintronics because of their immunity to external magnetic disturban
262 attracted enormous interest in recent years because of their implications in many areas of chemistry
264 ignificant chemical and biological attention because of their intriguing carbogenic frameworks, react
266 are high-interest targets in drug discovery because of their involvement in numerous biological proc
267 is of cycloarenes in solution is challenging because of their low solubility and the often hindered c
274 has mainly focused on redox-active proteins because of their role in biological charge transport.
278 ations are an interesting part of this group because of their tendency to undergo rearrangement, some
280 es, NO, H(2)S, and CO occupy a special place because of their widely known physiological functions in
281 t adaptive behaviour in spite of, and indeed because of, their departure from veridical representatio
289 of age, at which point she was hospitalized because of three syncopal episodes that were not related
290 that cell contacts are highly heterogeneous because of topography- and protein-density-related proce
294 the transcriptome remain unclear, primarily because of uncertainty over the mechanism that detects t
295 ined efforts to target those at highest risk because of underlying conditions with a range of prevent
297 lectrochemical energy conversion and storage because of unique electronic and structural properties,